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Post Info TOPIC: Collagen crosslinking with riboflavin and UVA-light in keratoconus

Phase Two

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Posts: 482
Date: Fri Sep 5 1:16 AM, 2008
Collagen crosslinking with riboflavin and UVA-light in keratoconus

Collagen crosslinking with riboflavin and UVA-light in keratoconus


Reduced corneal mechanical stability in keratoconus and similar corneal diseases can be treated by photooxidative crosslinking of the corneal collagen. This method is currently undergoing clinical evaluation worldwide. To achieve high absorption of the irradiation energy in the cornea, riboflavin at a concentration of 0.1% and UVA light at a wavelength of 370 nm corresponding to the relative maximum of absorption of riboflavin (vitamin B2) is used. These therapeutic parameters were experimentally tested and have been proven clinically. Current data demonstrate that the therapeutic crosslinking procedure is safe when the important theoretical and clinical parameters are observed, and that progression of keratoconus can be prevented. In all, 80% of the published cases show a decrease in corneal curvature of about 2 D, which leads not only to stabilisation but also to an increase in visual acuity.

Ophthalmologe. 2008 Aug;105(8):785-96

-- Edited by QuintriX at 01:19, 2008-09-05


Veteran Member

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Posts: 84
Date: Sat Sep 12 8:10 AM, 2020

Things has come a long way and in leaps and bounds - its continues to get optimized and studies continue (such as with oxygen supplementation).



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Posts: 16
Date: Tue Sep 22 10:28 PM, 2020

A Not For Profit and the Worlds First Ever Eye Hospitals (Moorfields - NHS)

Keratoconus Treatment (NHS) Educational Video

Its good to be told of the risks. The risks are not often talked about at the outset from other providers videos so this is good, as well as it was nice seeing the straightforwardness, with what we here has known, that its ethnic minorities which have Keratoconus more.



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