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Post Info TOPIC: Predictors of progression in untreated keratoconus: a Save Sight Keratoconus Registry study


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Date: Sun Apr 11 12:01 AM, 2021
Predictors of progression in untreated keratoconus: a Save Sight Keratoconus Registry study
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Predictors of progression in untreated keratoconus: a Save Sight Keratoconus Registry study

Abstract

 

Aims: We set out to identify risk factors for progression in untreated keratoconus patients from 34 centres across Australia, New Zealand, Spain and Italy.

 

Methods: Patients were divided into ‘progressors’ and ‘stable’ patients for each clinical parameter: visual acuity (VA), steepest keratometry (maximum keratometry (Max-K)) and thinnest corneal thickness (TCT). Primary outcomes were the proportion of eyes with sustained progression in VA, Max-K or TCT within 3 years. Secondary outcomes included predictors of progression.

 

Results: There were 3994 untreated eyes from 2283 patients. The proportion of eyes with VA, Max-K and TCT progression at 1year were 3.2%, 6.6% and 3.1% respectively. Factors associated with VA loss were higher baseline VA (HR 1.15 per logMAR line increase in VA; p<0.001) and steeper baseline Max-K (HR 1.07 per 1D increase; p<0.001). Younger baseline age was associated with Max-K steepening (HR 0.96 per year older; p=0.001). Thicker baseline TCT, steeper baseline Max-K and younger baseline age were associated with TCT thinning: (HR 1.08 per 10µm increase in TCT; p<0.001), (HR 1.03 per 1D increase; p=0.02) and (HR 0.98 per year younger; p=0.01), respectively.

 

Conclusions: Steeper Max-K and younger age were the most clinically useful baseline predictors of progression as they were associated with worsening of two clinical parameters. Every 1D steeper Max-K was associated with a 7% and 3% greater risk of worsening VA and thinning TCT, respectively. Each 1year younger was associated with a 4% and 2% greater risk of steepening Max-K and thinning TCT, respectively.

 

Data availability statement

Data are available upon reasonable request. Deidentified participant data are available upon reasonable request.

 

http://dx.doi.org/10.1136/bjophthalmol-2020-317547



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Date: Sun Apr 11 12:09 AM, 2021
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More common too as well as its rate of development than usually thought.....



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We are all patients or will be (!) So put patients first!


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Date: Sun Apr 11 12:17 AM, 2021
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Its good news that the truth is getting out!



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