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Post Info TOPIC: Alport syndrome: A case report


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Date: Wed Jun 9 6:46 PM, 2021
Alport syndrome: A case report

Alport syndrome: A case report

Iva Krolo 1, Aida Kasumovi 1, Ivana Radman 1, Pavao Pavi 2.

1) University Department of Ophthalmology, University Hospital Center Sestre milosrdnice, Zagreb, Croatia.

2) School of Medicine, University of Zagreb, Zagreb, Croatia.




Purpose: Ocular features of Alport syndrome include anterior lenticonus, posterior polymorphous corneal dystrophy, and fleck-and-dot retinopathy in most cases. Keratoconus in such patients has been rarely mentioned in previous studies. To our knowledge, this is the first report of corneal cross-linking for halting the progression of keratoconus in a patient with Alport syndrome.


Case report: A 22-year-old male was referred for his initial corneal topography, after he was already prescribed with rigid gas-permeable contact lenses. Alport syndrome was diagnosed in his infancy and gene COL4A5 mutation was confirmed. Ophthalmological evaluation confirmed keratoconus. One-year follow-up showed a progression on his right eye and standard corneal cross-linking was performed. Stabilization of the disease marked by normalization in visual function and corneal tomography values was noticed 1 year after the procedure.


Conclusions: When diagnosing ocular clinical findings of Alport syndrome, keratoconus should be considered. Standard corneal cross-linking protocol can halt its progression.



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Date: Thu Jun 10 2:57 PM, 2021

To find out more about Alport syndrome click here 10.12998/wjcc.v7.i19.3012

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