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[HTML] Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus
L Moon, P Kaur, J Wang, A Sodhi, C Eberhart… - … Ophthalmology & Visual …, 2025
… Here, we set out to determine how eye rubbing can influence keratoconus
progression by exploring the expression of known disease … in keratoconus
corneal epithelium. Both proteins have also been reported to be markedly reduced …
progression by exploring the expression of known disease … in keratoconus
corneal epithelium. Both proteins have also been reported to be markedly reduced …
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[PDF] Successful Management of a Keratoconus Patient With Rarely Used Large-Diameter Corneal RGP Contact Lenses: A Case Report
A Almaweri - Cureus, 2025
… a keratoconus patient with infrequently used large-diameter corneal RGP contact
lenses. This method of fitting provides remarkable stability and patient comfort. Here,
I describe a case of a 39-year-old man with a known history of keratoconus… in the …
lenses. This method of fitting provides remarkable stability and patient comfort. Here,
I describe a case of a 39-year-old man with a known history of keratoconus… in the …
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Spatial Transcriptomics and Single-Cell RNA-Sequencing Revealed Dendritic Cell-Mediated Inflammation in Keratoconus
S Luo, J Li, Y Yang, Y Jiang, Y Jie, W Ge - The Ocular Surface, 2025
Keratoconus (KC) is a corneal disorder characterized by central corneal protrusion
and thinning. In this study, spatial transcriptomics was employed to investigate
molecular and cellular variations in KC, revealing a distinct pattern of inflammatory …
and thinning. In this study, spatial transcriptomics was employed to investigate
molecular and cellular variations in KC, revealing a distinct pattern of inflammatory …
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[HTML] Topographic factors associated with anterior chamber angle narrowing in patients with keratoconus
H Soltan-Dehghan, A Farzaneh, H Hashemi… - International Journal of …, 2025
AIM To identify topographic determinants of the anterior chamber angle (ACA) in
patients with keratoconus (KCN). METHODS Four hundred and ten eyes of 294
patients with KCN were recruited for this study. First, complete ocular examinations …
patients with keratoconus (KCN). METHODS Four hundred and ten eyes of 294
patients with KCN were recruited for this study. First, complete ocular examinations …
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[HTML] Retinal thickness and vascular density changes in Keratoconus: A systematic review and meta-analysis
H Vahedi, M Abdollahi, R Moshfeghinia, S Emami… - Heliyon, 2025
Purpose This systematic review and meta-analysis aimed to assess the changes in
retinal layer thickness and vascular density in patients diagnosed with keratoconus (KC).
Methods We conducted a thorough search in PubMed, Scopus, Embase, and Web …
retinal layer thickness and vascular density in patients diagnosed with keratoconus (KC).
Methods We conducted a thorough search in PubMed, Scopus, Embase, and Web …
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[HTML] Corneal hydrops secondary to advanced keratoconus. Published online August 8, 2019
A Tharayil, N Gaines - Consultant
… , have a higher risk of developing keratoconus. Pediatric keratoconus tends to be
more aggressive than adult keratoconus, and although it usually … However, with
pediatric keratoconus, the diagnosis often is not made until the disease has …
more aggressive than adult keratoconus, and although it usually … However, with
pediatric keratoconus, the diagnosis often is not made until the disease has …
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[HTML] Prevalence of keratoconus and keratoconus suspect, and their characteristics on corneal tomography in a population-based study
H Namba, N Maeda, H Utsunomiya, Y Kaneko… - PLOS ONE, 2025
Keratoconus (KC) is a progressive corneal disorder resulting in severe visual
impairment. We aimed to determine the prevalence and corneal tomographic
characteristics of KC and keratoconus suspect (KCS) in a population-based study …
impairment. We aimed to determine the prevalence and corneal tomographic
characteristics of KC and keratoconus suspect (KCS) in a population-based study …
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Assessment of Awareness of Keratoconus and its Relation to Eye Rubbing Among Saudi Arabia Population Supervisor/Primary Investigator
NA Alqasimi, LH Aljohani, R Ambrósio Jr, B AlQahtani… - Frontiers in Ophthalmology
Keratoconus (KC) is a bilateral, asymmetric, progressive thinning of the cornea that
causes a decrease in optical quality due to induced myopia, irregular astigmatism,
and higher-order aberrations.Keratoconus affects 1.38 per 1,000 individuals globally …
causes a decrease in optical quality due to induced myopia, irregular astigmatism,
and higher-order aberrations.Keratoconus affects 1.38 per 1,000 individuals globally …
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[PDF] Case Study: Optical Rehabilitation Remedies for a Patient with Keratoconus and Esophoria with Biochemical Aspects
AIA Al Ibrahim, AMA Aboalqasim, LA Namazi… - 2024
… Keratoconus and esophoria are eye disorders associated with eye alignment that
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
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[PDF] VISUAL OUTCOME OF SIMULTANEOUS PHOTOREFRACTIVE KERATECTOMY AND CORNEAL COLLAGEN CROSS LINKING (PRK CXL) IN KERATOCONUS …
A Ahmed, A Alaskary, S Ahmed
… treatments for keratoconus. The therapy for keratoconus is dependent upon the
illness severity and the degree of disease progression [3]. Eyeglasses and rigid gas
permeability contact lenses are traditional techniques for treating mild to moderate …
illness severity and the degree of disease progression [3]. Eyeglasses and rigid gas
permeability contact lenses are traditional techniques for treating mild to moderate …
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[PDF] Case Study: Optical Rehabilitation Remedies for a Patient with Keratoconus and Esophoria with Biochemical Aspects
AIA Al Ibrahim, AMA Aboalqasim, LA Namazi… - 2024
… Keratoconus and esophoria are eye disorders associated with eye alignment that
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
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[PDF] VISUAL OUTCOME OF SIMULTANEOUS PHOTOREFRACTIVE KERATECTOMY AND CORNEAL COLLAGEN CROSS LINKING (PRK CXL) IN KERATOCONUS …
A Ahmed, A Alaskary, S Ahmed
… treatments for keratoconus. The therapy for keratoconus is dependent upon the
illness severity and the degree of disease progression [3]. Eyeglasses and rigid gas
permeability contact lenses are traditional techniques for treating mild to moderate …
illness severity and the degree of disease progression [3]. Eyeglasses and rigid gas
permeability contact lenses are traditional techniques for treating mild to moderate …
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[HTML] Strategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques
A Gideon Abou Said, J Gispets, E Shneor - Journal of Clinical Medicine, 2025
Keratoconus is a progressive corneal disorder that can lead to irreversible visual …
These technologies are essential for identifying early-stage keratoconus, yet their
high cost limits … ensure accurate and effective detection of early keratoconus. This …
These technologies are essential for identifying early-stage keratoconus, yet their
high cost limits … ensure accurate and effective detection of early keratoconus. This …
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[HTML] Repeatability of Pentacam HR in Keratoconus According to Two Different Scan Protocols: 25-3D Scan and 50-Cornea Fine
D Romano, G Coco, A Borgia, S Calza, S Kaye… - Journal of Clinical Medicine, 2025
Background: This study aims to evaluate the repeatability of the Pentacam HR,
comparing two different measurement modes (50-cornea fine and 25-3D scan) in
patients affected by keratoconus. Methods: Multicenter retrospective study …
comparing two different measurement modes (50-cornea fine and 25-3D scan) in
patients affected by keratoconus. Methods: Multicenter retrospective study …
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Keratoconus classification
AN Jinabhai - Optician, 2024
… ECPs typically find it relatively straightforward to identify moderate to severe
keratoconus, due to its classical topographical appearance (outlined later in this article)
and characteristic clinical signs. These clinical signs include: … The purpose of this …
keratoconus, due to its classical topographical appearance (outlined later in this article)
and characteristic clinical signs. These clinical signs include: … The purpose of this …
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[PDF] Long-Term Effectiveness of Scleral Lens Treatment in the Management of Keratoconus: A Systematic Review
A Mushtaq, I Alvi - Cureus, 2025
This systematic review evaluates the long-term effectiveness of scleral lenses in
improving visual outcomes, patient satisfaction, and safety in patients with
keratoconus. A systematic search of six databases (PubMed, Embase, Web of …
improving visual outcomes, patient satisfaction, and safety in patients with
keratoconus. A systematic search of six databases (PubMed, Embase, Web of …
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Non-genetic risk factors for keratoconus and its progression
IMY Cheung, L Angelo, A Gokul, M Ziaei - Clinical and Experimental Optometry, 2025
Keratoconus is a multifaceted corneal ectatic disorder characterized by a range of
genetic and environmental risk factors. While genetic predisposition significantly
influences global disease prevalence rates as well as severity and progression rates …
genetic and environmental risk factors. While genetic predisposition significantly
influences global disease prevalence rates as well as severity and progression rates …
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[HTML] Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population
Y Yao, X Li, L Wu, J Zhang, Y Gui, X Yu, Y Zhou, X Li… - Eye and Vision, 2025
Background Keratoconus (KC) is a prevalent corneal condition with a modest
genetic basis. Recent studies have reported significant genetic associations in multi-ethnic
cohorts. However, the situation in the Chinese population remains unknown. This …
genetic basis. Recent studies have reported significant genetic associations in multi-ethnic
cohorts. However, the situation in the Chinese population remains unknown. This …
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Correction: Computational approaches for identifications of altered ion channels in keratoconus
KB Gaikwad, JS Babu, KTS Parthasarathi, J Narayanan… - Eye (London, England), 2025
Correction: Computational approaches for identifications of altered ion channels in
keratoconus Correction: Computational approaches for identifications of altered ion
channels in keratoconus Eye (Lond). 2025 Jan 2. doi: 10.1038/s41433-024-03493-4 …
keratoconus Correction: Computational approaches for identifications of altered ion
channels in keratoconus Eye (Lond). 2025 Jan 2. doi: 10.1038/s41433-024-03493-4 …
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Correction: Computational approaches for identifications of altered ion channels in keratoconus
KB Gaikwad, JS Babu, KTS Parthasarathi, J Narayanan… - Eye (London, England), 2025
Correction: Computational approaches for identifications of altered ion channels in
keratoconus Correction: Computational approaches for identifications of altered ion
channels in keratoconus Eye (Lond). 2025 Jan 2. doi: 10.1038/s41433-024-03493-4 …
keratoconus Correction: Computational approaches for identifications of altered ion
channels in keratoconus Eye (Lond). 2025 Jan 2. doi: 10.1038/s41433-024-03493-4 …
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Keratoconus in children in Tunisia: Epidemiological, clinical and therapeutic features
S Kammoun, K Maaloul, M Rekik, K Chaabouni…
Methods: Retrospective study focusing on patients aged less than 18 years,
presenting with KC and followed in a tertiary reference center in Sfax, Tunisia.
Results: Our study involved 38 eyes of 20 children. We found a mean age of 12.8 …
presenting with KC and followed in a tertiary reference center in Sfax, Tunisia.
Results: Our study involved 38 eyes of 20 children. We found a mean age of 12.8 …
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Comfort in Keratoconus
Z Tajbakhsh - Journal of Ophthalmic and Vision Research, 2024
Purpose: To compare rigid gas permeable (RGP) contact lens comfort in patients
with keratoconus who underwent corneal cross-linking (CXL) versus those without
CXL surgery. Methods: This prospective study was carried out on 41 eyes (25 …
with keratoconus who underwent corneal cross-linking (CXL) versus those without
CXL surgery. Methods: This prospective study was carried out on 41 eyes (25 …
SD Joshi, NV Gundecha - Journal of Clinical Ophthalmology and Research, 2025
Purpose: The purpose of this study was to describe the refractive outcomes and finer
aspects of visual acuity such as contrast, aberrations, and quality of vision after
keratoplasty for keratoconus. Design: This was a longitudinal clinical study of 50 …
aspects of visual acuity such as contrast, aberrations, and quality of vision after
keratoplasty for keratoconus. Design: This was a longitudinal clinical study of 50 …
MΜΛΝ Lubbad - 2024
… relevant corneal shape parameters for accurate keratoconus diagnosis. The study
raises questions about the necessary corneal shape indexes for precise
keratoconus diagnosis and the significance of specific corneal shape parameters for …
raises questions about the necessary corneal shape indexes for precise
keratoconus diagnosis and the significance of specific corneal shape parameters for …
Z Özer Özcan, M Berhuni, A Mete, K Güngör - Kocaeli Medical Journal
METHODS: The word "keratoconus" was searched in the Web of Science database.
The articles published in ophthalmology journals between 2010 and 2020 were
filtered. The traditional metric and altmetric data of the most cited 100 articles were …
The articles published in ophthalmology journals between 2010 and 2020 were
filtered. The traditional metric and altmetric data of the most cited 100 articles were …
AIA Al Ibrahim, AMA Aboalqasim, LA Namazi… - Egyptian Journal of …, 2024
… Keratoconus and esophoria are eye disorders associated with eye alignment that
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
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[PDF] Implantation of 320˚-Arc Length Intrastromal Corneal Ring Segments in Keratoconus, A prospective study
MA El-Malah, MMA Ibrahim, HME El Ghoneimy… - Al-Azhar International …, 2024
… The purpose of this study is to assess the clinical results in keratoconus patients'
eyes … both central and paracentral steepening in keratoconus patterns with low or
high topographic … history of any corneal abnormalities other than keratoconus (KC) …
eyes … both central and paracentral steepening in keratoconus patterns with low or
high topographic … history of any corneal abnormalities other than keratoconus (KC) …
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[PDF] Assessment of the Effect of Corneal Collagen Cross-Linking on Corneal Endothelium in Patients with Keratoconus
SH Elsayed, MS Badawy, AA Abdel-Ghany… - The Egyptian Journal of Hospital …
… of progressive keratoconus. Patients and methods: Included 30 eyes from twenty-four
individuals diagnosed with keratoconus. Endothelial cell … Furthermore, the
correlation between keratoconus stage and changes in CCT, HEX, and CV didn`t …
individuals diagnosed with keratoconus. Endothelial cell … Furthermore, the
correlation between keratoconus stage and changes in CCT, HEX, and CV didn`t …
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Corneal epithelium is altered in keratoconus and forme fruste keratoconus
N Sukhee, H Namba, M Ikeda, S Ichinohasama… - 2025
This study investigated the corneal epithelial thickness and its distribution in
keratoconus (KC) and forme fruste keratoconus (FFK). We recruited 144 KC eyes
and 27 FFK eyes from 76 participants (50 men and 26 women) who underwent …
keratoconus (KC) and forme fruste keratoconus (FFK). We recruited 144 KC eyes
and 27 FFK eyes from 76 participants (50 men and 26 women) who underwent …
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Porcine Collagen Implants in Advanced Keratoconus: Outcomes at 1 Year
R Deshmukh, RM Mohan, V Madonadi Kuniyil… - Journal of Refractive …, 2025
… DISCUSSION The current study reports the results of 9 eyes with advanced
keratoconus that underwent Xenia lenticule implantation. Two … 's layer
transplantation to improve the biomechanical strength in keratoconus.Patients with …
keratoconus that underwent Xenia lenticule implantation. Two … 's layer
transplantation to improve the biomechanical strength in keratoconus.Patients with …
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Non-corneal Intraocular Higher Order Aberrations in Eyes With Keratoconus Versus Normal Myopic Eyes
K Kozhaya, CJ Mehanna, L Asroui, R Bejjani… - Journal of Refractive …, 2025
… Patients with diagnosed keratoconus who presented for evaluation at our center
and patients … Keratoconus diagnosis was confirmed according to previously
described standards.These … , highly sensitive and specific for the diagnosis of …
and patients … Keratoconus diagnosis was confirmed according to previously
described standards.These … , highly sensitive and specific for the diagnosis of …
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[HTML] Pilot Programme for Keratoconus Screening and Management in Adolescents with Down Syndrome
B Power, KAJ Stephenson, D Malata, C Murphy, B Quill… - Diagnostics, 2025
… ) screened had tomographic evidence of keratoconus requiring treatment at their
first review. We found an increased incidence of keratoconus in European
individuals with … We advocate tomographic keratoconus screening for individuals …
first review. We found an increased incidence of keratoconus in European
individuals with … We advocate tomographic keratoconus screening for individuals …
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[HTML] Population Effect of Croslinking Treatment for Keratoconus in a Pediatric Population
B Pandurevic, M Ahmedbegovic-Pjano, S Grisevic… - Acta Informatica Medica, 2024
… The aim of this study was to evaluate the effectiveness of the accelerated
crosslinking treatment for keratoconus in the pediatric population… keratoconus
patient, thus early diagnosis is imperative. Crosslinking is a safe procedure and the …
crosslinking treatment for keratoconus in the pediatric population… keratoconus
patient, thus early diagnosis is imperative. Crosslinking is a safe procedure and the …
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A Cross-sectional Analysis of Vision Related Quality of Life in Adult Patients With Keratoconus in Nairobi
GG Ngare - 2024
… scores in adult patients with keratoconus. Recommendation: This study
recommends the formation of adult keratoconus support groups targeting patients
under 30 year, an emphasis psychological counselling during eye care for all …
recommends the formation of adult keratoconus support groups targeting patients
under 30 year, an emphasis psychological counselling during eye care for all …
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Digital Transformation of Care for Keratoconus Patients: ML Modelling Structural Outcomes of Corneal Collagen Cross-Linking
Y Statsenko, D Smetanina, R Voitetskii, G Simiyu… - Frontiers in Medicine
Background: Structural outcomes of corneal collagen cross-linking (CXL) have not
been thoroughly investigated. Clinical risk assessment would benefit from a reliable
prognosis of postoperative minimal (MCT) and central corneal thickness (CCT) …
been thoroughly investigated. Clinical risk assessment would benefit from a reliable
prognosis of postoperative minimal (MCT) and central corneal thickness (CCT) …
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[PDF] Hydrops as a Presenting Sign of Keratoconus in Down Syndrome: Case Report, Literature Review, and the Need for a Public Health Strategy
A Barbara, C Mazzotta, M Sinjab, R Barbara - International Journal of Keratoconus …, 2025
… sign of keratoconus in the left eye and concurrent keratoconus in the right eye.
The discussion stresses the frequent occurrence of keratoconus … associated with
keratoconus in this population. Keywords: Case report, Central corneal thickness …
The discussion stresses the frequent occurrence of keratoconus … associated with
keratoconus in this population. Keywords: Case report, Central corneal thickness …
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Optimizing riboflavin delivery with co-crystal and in situ hydrogel formulations for management of keratoconus: A comprehensive investigation with in vitro, ex vivo and …
E Aytekin, MZ Kaya, GE İlkar, HK Polat, N Öztürk… - International Journal of …, 2025
Keratoconus is a progressive disease characterized by corneal thinning and conical
deformation. Corneal cross-linking, a common treatment, strengthens collagen fibers
using vitamin B2 (riboflavin) and UVA light. However, the surgical removal of the …
deformation. Corneal cross-linking, a common treatment, strengthens collagen fibers
using vitamin B2 (riboflavin) and UVA light. However, the surgical removal of the …
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[HTML] Corneal Infection Complicating Acute Corneal Hydrops in Keratoconus Patients
K Kitazawa, R Kozaki, Y Yamashita, T Aichi, M Itoi… - American Journal of …, 2025
Purpose Acute corneal hydrops (ACH) occurs during the follow-up of keratoconus,
presenting as severe corneal edema due to Descemet's membrane rupture.
Infectious keratitis can cause corneal edema accompanied by corneal infiltrations …
presenting as severe corneal edema due to Descemet's membrane rupture.
Infectious keratitis can cause corneal edema accompanied by corneal infiltrations …
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Keratoconus & Corneal Ectasia
L Barros, AB da Costa Neto, G Portas-Almeida… - Cornea Casebook, 2025
Keratoconus is the most common of the primary ectasia and is characterized by
bulging and thinning of the central cornea. Having a multifactorial nature (intrinsic
biomechanical susceptibility and environmental factors), its evolution is markedly …
bulging and thinning of the central cornea. Having a multifactorial nature (intrinsic
biomechanical susceptibility and environmental factors), its evolution is markedly …
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Novel variations in the PLOD1, COL1A1, COL5A2 and COL4A1 genes related to keratoconus
X Zhou, X Wang, X Peng, T Han, L Sun, X Zhang - Frontiers in Genetics
Purpose: To investigate the genetic characteristics of four Chinese families affected
by keratoconus (KC).Methods: In the four families affected by KC, medical records,
clinical observations, and blood samples were collected from all individuals. One …
by keratoconus (KC).Methods: In the four families affected by KC, medical records,
clinical observations, and blood samples were collected from all individuals. One …
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[HTML] Epithelial Mapping Efficacy for Subclinical Keratoconus Identification
BAL Dutra, B Hammoud, BN Susanna, L Asroui… - American Journal of …
… Epithelial thickness patterns were not effective as a primary metric to identify
subclinical keratoconus. Scheimpflug metrics and regional … Epithelial mapping
metrics thus appear significantly less sensitive than predicted for subclinical …
subclinical keratoconus. Scheimpflug metrics and regional … Epithelial mapping
metrics thus appear significantly less sensitive than predicted for subclinical …
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Is there a predisposition for developing corneal hydrops in keratoconus?-Tomographic and biomechanical analysis of the fellow eyes
V Bosic, H Mudassar, B Seitz, E Flockerzi - Acta ophthalmologica
Aim Fellow eyes (FE) of 73 keratoconus (KC) patients with acute corneal hydrops (ACH)
and 130 KC patients without ACH (total 236 eyes, 110 more severely affected),
serving as control groups, were retrospectively analysed to identify potential risk …
and 130 KC patients without ACH (total 236 eyes, 110 more severely affected),
serving as control groups, were retrospectively analysed to identify potential risk …
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[HTML] A Review of Keratoconus Cross-Linking Treatment Methods
N Papachristoforou, A Ueno, K Ledwos, J Bartuś… - Journal of Clinical Medicine, 2025
Corneal collagen cross-linking (CXL) is a therapeutic intervention that utilizes
riboflavin photochemical activation with ultraviolet-A (UV-A) light to induce covalent
cross-links within the stromal corneal fibers, effectively increasing corneal …
riboflavin photochemical activation with ultraviolet-A (UV-A) light to induce covalent
cross-links within the stromal corneal fibers, effectively increasing corneal …
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[PDF] A Study on Visual Outcome of Patients with Keratoconus after Corneal Collagen Crosslinking
BB Ahmed, TM Hassan, BQ Hamasalih - AMJ (Advanced Medical Journal), 2025
… B2) and UV-A light have been shown to be effective at stopping progression of
keratoconus. … When used in treating keratoconus patients the main aim was to
stop progression, and help … study is to evaluate the effects of corneal collagen …
keratoconus. … When used in treating keratoconus patients the main aim was to
stop progression, and help … study is to evaluate the effects of corneal collagen …
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[PDF] Influencing Factors in Corneal Densitometry Recovery After Accelerated Cross‐Linking for Keratoconus
KI Huang, CY Yeh, CC Hu, SF Cheng - Journal of Ophthalmology, 2025
This study examines corneal densitometry recovery and influencing factors following
accelerated corneal cross‐linking (CXL) for progressive keratoconus. Corneal
densitometry, measured using Scheimpflug tomography, provides an objective …
accelerated corneal cross‐linking (CXL) for progressive keratoconus. Corneal
densitometry, measured using Scheimpflug tomography, provides an objective …
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An Integrated Approach to Keratoconus Management to Reduce Eye Health Inequity: Investigating Diagnosis, Referral, and Cost
L Angelo - 2024
… and lifetime costs of subjects with keratoconus. Data was collected prospectively
through … when diagnosing or monitoring subjects with keratoconus. Only 56% of
optometrists owned a … for patients with keratoconus was estimated to be NZD …
through … when diagnosing or monitoring subjects with keratoconus. Only 56% of
optometrists owned a … for patients with keratoconus was estimated to be NZD …
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[HTML] Subclinical parents assist in the detection of genetic variants in keratoconus by trio-based whole-exome sequencing
X Li, Y Yao, S Xing, S Ma, S Pang, Y Zhou, S Chen - 2025
Methods: Trio-based whole-exome sequencing was performed in 14 keratoconus
trios containing subclinical parents. The variants identified in candidate genes of
keratoconus were analyzed by multiple bioinformatics tools. Results: We identified …
trios containing subclinical parents. The variants identified in candidate genes of
keratoconus were analyzed by multiple bioinformatics tools. Results: We identified …
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Three-year Results of Customized Corneal Collagen Cross-linking for Keratoconus Patients in Oman
R Al Saidi, D Deshmukh, A Bandara, J Babu… - … Journal of Keratoconus and …, 2025
Purpose: This 3-year study examined the safety and efficacy of customized corneal
collagen cross-linking (CuRV) for keratoconus in patients from Oman. Methods:
Corneal collagen cross-linking was initiated by the application of 0.1% riboflavin …
collagen cross-linking (CuRV) for keratoconus in patients from Oman. Methods:
Corneal collagen cross-linking was initiated by the application of 0.1% riboflavin …
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[HTML] Histopathological characteristics of keratoconus
M Mazza, S Bergeron, D Cheema, J Coblentz… - The Pan-American Journal …, 2025
Purpose: Keratoconus (KC) is a bilateral and asymmetrical corneal ectasia that
affects vision. In this study, we performed a histopathological analysis of 150 cases
of KC, to document and catalogue the primary morphological features of cornea with …
affects vision. In this study, we performed a histopathological analysis of 150 cases
of KC, to document and catalogue the primary morphological features of cornea with …
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Efficacy of Customized Photorefractive Keratectomy with Cross-Linking vs. Cross-Linking Alone in Progressive Keratoconus: A Systematic Review and Meta-analysis
H Zhang, M Cantó-Cerdán, B Félix-Espinar… - American Journal of …, 2025
TOPIC This review evaluates the effectiveness and safety of combining cPRK with
CXL versus CXL alone in improving visual outcomes for patients with progressive
keratoconus. DESIGN Systematic Review and Meta-Analysis CLINICAL …
CXL versus CXL alone in improving visual outcomes for patients with progressive
keratoconus. DESIGN Systematic Review and Meta-Analysis CLINICAL …
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[HTML] Repeatability and agreement of a new anterior segment optical coherence tomography with standard devices in normal, keratoconus, and post-refractive eyes
G Kundu, N Shetty, D Modak, L Kaweri, P Khamar… - Indian Journal of …, 2025
… Bland–Altman plots showing agreement between Eyestar 900, Pentacam AXL
Wave, Anterion, and MS-39 for Sim K, pK, TCT, and ACD in keratoconus eyes. The
solid line represents the mean difference, and the dotted line represents the 95 …
Wave, Anterion, and MS-39 for Sim K, pK, TCT, and ACD in keratoconus eyes. The
solid line represents the mean difference, and the dotted line represents the 95 …
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Long-term effects and prognostic factors of accelerated cross-linking with retention ring-assisted riboflavin application on keratoconus progression
S Kim, WJ Choi, CH Yoon, MK Kim - Korean journal of ophthalmology: KJO
Purpose To evaluate the long-term efficacy, safety, and prognostic factors of pulsed-light
accelerated corneal collagen cross-linking (A-CXL) with continuous riboflavin
application to halt keratoconus progression. Methods A-CXL with retention ring-assisted …
accelerated corneal collagen cross-linking (A-CXL) with continuous riboflavin
application to halt keratoconus progression. Methods A-CXL with retention ring-assisted …
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Response to letter for article "Evaluation of neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, and mean platelet volume levels in pediatric keratoconus patients"
M Toprak, Ö Altıntaş, Ö Yendur, BY Tuğan - Saudi Journal of Ophthalmology, 2025
In our analysis, we performed a receiver operating characteristic (ROC) curve
analysis to determine the diagnostic utility of PLR and MPV in keratoconus. Using
Youden's index, we identified optimal cutoff values for these biomarkers. For PLR …
analysis to determine the diagnostic utility of PLR and MPV in keratoconus. Using
Youden's index, we identified optimal cutoff values for these biomarkers. For PLR …
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Comparison of Keratoconus Progression Rate between Adolescents Aged 19–24 Years and Young Adults: Impact on Indication for Crosslinking
P Kosekahya, E Flockerzi, C Munteanu, H Sideroudi… - Current Eye Research, 2025
… In light of this information, it is thought that the inclusion of adolescents in adult
keratoconus studies without age grouping may lead to an underestimation of
disease severity and progression in adolescent keratoconus patients. As far as the …
keratoconus studies without age grouping may lead to an underestimation of
disease severity and progression in adolescent keratoconus patients. As far as the …
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[HTML] Untargeted Tear Proteomics in a Large South-Asian Cohort Reveals Inflammatory Signaling, ECM Remodeling, and Altered Metabolism in Keratoconus
R Kannan, R Shetty, T Panigrahi, SK Koh, P Khamar… - … Ophthalmology & Visual …, 2025
Purpose: Keratoconus (KC), a progressive corneal degenerative disease, is
characterized by focal thinning and weakening, and the molecular pathways driving
such changes are still being discovered. The progression-related pathologic …
characterized by focal thinning and weakening, and the molecular pathways driving
such changes are still being discovered. The progression-related pathologic …
| | | |
[HTML] An IoT-Enabled mHealth Sensing Approach for Remote Detection of Keratoconus Using Smartphone Technology
B Askarian, A Askarian, F Tabei, JW Chong - Sensors, 2025
Keratoconus (KC) is a progressive eye disease and a major cause of vision
impairment and blindness worldwide. Early diagnosis is crucial for effective
management, yet conventional diagnostic methods rely on expensive and bulky …
impairment and blindness worldwide. Early diagnosis is crucial for effective
management, yet conventional diagnostic methods rely on expensive and bulky …
| | | |
Study on the role of sex hormones and prolactin induced proteins in keratoconus
Z Chen, W Zhang, L Gao, N Zhang, LI Jixin - International Eye Science, 2025
Keratoconus (KC) is a blinding eye disease caused by a variety of factors, with its
pathogenesis still not well understood. In recent years, it has been discovered that
sex hormones and prolactin-induced protein (PIP) have a profound impact on the …
pathogenesis still not well understood. In recent years, it has been discovered that
sex hormones and prolactin-induced protein (PIP) have a profound impact on the …
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One-year clinical observation of epithelial-off accelerated corneal collagen cross-linking on the treatment of progressive keratoconus
LU Jing, MA Ping, C Lan - International Eye Science, 2025
AIM: To assess the clinical efficacy and safety of epithelial-off accelerated corneal
collagen cross-linking (CXL) in the management of progressive keratoconus over 1
a period. METHODS: A retrospective pre-post self-controlled study. Data were …
collagen cross-linking (CXL) in the management of progressive keratoconus over 1
a period. METHODS: A retrospective pre-post self-controlled study. Data were …
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Optical coherence tomography and pentacam imaging of concurrent keratoconus and granular corneal dystrophy
W Xie, YF Yao - Clinical and Experimental Optometry, 2025
Keratoconus, a progressive bilateral corneal ectatic disorder characterised by
stromal thinning and protrusion, typically manifests … of keratoconus and granular
corneal dystrophy is a rare phenomenon. This case report presents a young male …
stromal thinning and protrusion, typically manifests … of keratoconus and granular
corneal dystrophy is a rare phenomenon. This case report presents a young male …
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A new morphological classification of keratoconus using few-shot learning in candidates for intrastromal corneal ring implants
Z Agharezaei, M Shirshekar, R Firouzi, S Hassanzadeh… - … Signal Processing and …, 2025
In the field of ophthalmology, the accurate classification of different types of
keratoconus (KCN) is vital for effective surgical planning and the successful
implantation of intracorneal ring segments (ICRS). During the diagnostic process …
keratoconus (KCN) is vital for effective surgical planning and the successful
implantation of intracorneal ring segments (ICRS). During the diagnostic process …
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[HTML] Biometry and keratometry measurements after intracorneal ring segment implantation in keratoconus patients: a pilot comparison between Pentacam AXL and IOL …
S Bamdad, A Fathian, MR Khalili, M Mohammadi… - BMC Ophthalmology, 2025
… After a while using these rings was suggested for keratoconus correction and
seemed to be an alternative option for corneal transplantation or postponing this
procedure [5,6,7]. Patients with keratoconus who have undergone ICRS …
seemed to be an alternative option for corneal transplantation or postponing this
procedure [5,6,7]. Patients with keratoconus who have undergone ICRS …
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Relevance of mitochondrial morphological changes in keratoconus patients undergoing collagen cross-linking and deep anterior lamellar keratoplasty
S Sharma, L Singh, TC Nag, S Kashyap, S Sen… - Human Cell, 2025
Keratoconus (KC) is characterised by corneal stromal thinning and irregular
astigmatism, resulting in diminution of vision. Underlying aetiology remains poorly
understood. Recent evidence suggests dysregulation of oxidative balance and …
astigmatism, resulting in diminution of vision. Underlying aetiology remains poorly
understood. Recent evidence suggests dysregulation of oxidative balance and …
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[PDF] Knowledge, experience and practices of optometrists in Uganda about keratoconus
G Wanok, S Arunga, B Dhillon, N Nsubuga - African Vision and Eye Health, 2025
… I also recommend review depending on the extent of the keratoconus, and then
the severity. The number of reviews may differ for example if it is mild keratoconus, I
would tell them a review of 6 months to a year …' (Participant 1, private stand-alone …
the severity. The number of reviews may differ for example if it is mild keratoconus, I
would tell them a review of 6 months to a year …' (Participant 1, private stand-alone …
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[PDF] Comparison of three measurement methods of intraocular pressure in patients with keratoconus undergoing MyoRing implantation
M Naderi, K Jadidi, SA Mosavi, AH Mohammadi… - Malaysian Journal of …, 2025
Purpose: This study aimed to assess intraocular pressure (IOP) before and after
MyoRing implantation in keratoconus patients. Methods: IOP was measured in 13
eyes before and six months after MyoRing implantation using Goldmann …
MyoRing implantation in keratoconus patients. Methods: IOP was measured in 13
eyes before and six months after MyoRing implantation using Goldmann …
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[HTML] Corneal Epithelial Thickness Maps in Eyes with Mild and Moderate Keratoconus
P Mlyniuk, M Kaszuba-Modrzejewska… - Journal of Clinical Medicine, 2025
… keratoconus, using optical coherence tomography (OCT). Methods: Fifty-two
healthy eyes (group 0), forty-one eyes with mild keratoconus (group I), and thirty
eyes with moderate keratoconus (… parameters linked with the severity of …
healthy eyes (group 0), forty-one eyes with mild keratoconus (group I), and thirty
eyes with moderate keratoconus (… parameters linked with the severity of …
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Progression of keratoconus secondary to thyroid eye disease: a case report
BA Carbonell, A Storch, C Gore - Journal of American Association for Pediatric …, 2025
… keratoconus changes secondary to Graves' ophthalmopathy. To our knowledge,
concurrent keratoconus and thyroid eye disease (TED) in a child has not been
reported in the literature. Nor are there reports of rapid development of keratoconus …
concurrent keratoconus and thyroid eye disease (TED) in a child has not been
reported in the literature. Nor are there reports of rapid development of keratoconus …
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Penetrating Keratoplasty versus Deep Anterior Lamellar Keratoplasty for Keratoconus: A Systematic Review and Meta-Analysis of 27,018 Eyes
A A. Awad, A M. Elettreby, A A. Abo Elnaga… - Seminars in Ophthalmology, 2025
… According to the aim of the work, we included studies directed towards patients
diagnosed with keratoconus who underwent DALK or PK; we included all
randomized controlled trials or observational studies that compare these two …
diagnosed with keratoconus who underwent DALK or PK; we included all
randomized controlled trials or observational studies that compare these two …
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Ethnicity optimized indices enhance the diagnostic efficiency of early Keratoconus: A multicenter validation study
Y Huo, R Xie, J Li, J Hou, H Zou, Y Wang - Contact Lens and Anterior Eye, 2025
Purpose This study aimed to evaluate the effectiveness of an ethnically-optimized
corneal tomography and biomechanics index using artificial intelligence (AI)
techniques for diagnosing early ectasia in Chinese populations and determine the …
corneal tomography and biomechanics index using artificial intelligence (AI)
techniques for diagnosing early ectasia in Chinese populations and determine the …
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Optical quality of the cornea one year after Cretan protocol plus in eyes with keratoconus
D Özkoyuncu Kocabaş, F Yavrum, K Özülken - Clinical and Experimental Optometry, 2025
… The clinical diagnosis of keratoconus was based on Sirius corneal topography.
Progressive keratoconus has been defined as the presence of at least one of the
following changes in the last year: an increase of ≥ 1.0 diopter (D) in the Kmax value …
Progressive keratoconus has been defined as the presence of at least one of the
following changes in the last year: an increase of ≥ 1.0 diopter (D) in the Kmax value …
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[HTML] Debunking myths about keratoconus
S Gromacki - 2025
I have been caring for patients with keratoconus (KC) for 30 years. During that time,
technology and the standard of care have improved. However, the nuances of early
diagnosis can still be tricky to understand. One way to address this is by debunking …
technology and the standard of care have improved. However, the nuances of early
diagnosis can still be tricky to understand. One way to address this is by debunking …
| | | |
[HTML] Climate Determinants of Keratoconus: Insights From a Systematic Review of Prevalence
H Shabani, J De Ridder, MA Asaad, WM Bramer… - … Ophthalmology & Visual …, 2025
Purpose: The reported prevalence of keratoconus varies widely worldwide, but the
causes of this variation are not well understood. We therefore aimed to explore the
potential impact of local climate variables on keratoconus prevalence. Methods: The …
causes of this variation are not well understood. We therefore aimed to explore the
potential impact of local climate variables on keratoconus prevalence. Methods: The …
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[PDF] Efficacy and Safety of Accelerated Transepithelial Corneal Crosslinking in Non-Pediatric Patients with Progressive Keratoconus: Insights from a Retrospective Cohort …
AC Chiraples, M Munteanu, HT Stanca, DM Darabus… - 2025
Background/Objectives: transepithelial accelerated corneal crosslinking (TE-ACXL)
is a minimally invasive approach for stabilizing progressive keratoconus while
preserving the corneal epithelium. This study aims to evaluate changes in visual …
is a minimally invasive approach for stabilizing progressive keratoconus while
preserving the corneal epithelium. This study aims to evaluate changes in visual …
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Evaluation of neutrophil–lymphocyte ratio, platelet–lymphocyte ratio, and mean platelet volume levels in pediatric keratoconus patients
MD Al-Mendalawi - Saudi Journal of Ophthalmology
… [1] reported that platelet–lymphocyte ratio (PLR) and mean platelet volume (MPV)
might be new biomarkers in evaluating keratoconus among … Consequently, the
clinical applicability of study results among Turkish pediatric keratoconus patients …
might be new biomarkers in evaluating keratoconus among … Consequently, the
clinical applicability of study results among Turkish pediatric keratoconus patients …
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[HTML] New technique for enhancing the astigmatic correction of intracorneal ring segments in keratoconus eyes with a central cone
Y Bteich, CJ Mehanna, MA Fattah, A Saad, R Antonios… - Saudi Journal of Ophthalmology
… Intrastromal corneal ring segments (ICRSs) have been used extensively in
patients with keratoconus. … We evaluate our new technique in a small case series
of eyes with keratoconus with central … Results were analyzed and compared to …
patients with keratoconus. … We evaluate our new technique in a small case series
of eyes with keratoconus with central … Results were analyzed and compared to …
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Extremely asymmetric ectasia: Tomographically unilateral keratoconus
H Shabani, WD Ramdas, MA Meester-Smoor… - Acta ophthalmologica
Purpose To investigate the characteristics of apparently stable forms of
tomographically unilateral keratoconus (KC). Methods In this retrospective case-control
study, strict unilaterality criteria were applied to select tomographically unilateral …
tomographically unilateral keratoconus (KC). Methods In this retrospective case-control
study, strict unilaterality criteria were applied to select tomographically unilateral …
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[HTML] Brown-McLean syndrome secondary keratoconus
Q Wan, L Chen, R Wei, Y Deng, K Ma, J Tang - BMC Ophthalmology, 2025
… Syndrome combined with bilateral keratoconus [6]. Observing the presence of
Brown-McLean Syndrome with keratoconus again in this … leading to deformation
under the pressure of the upper and lower eyelids, resulting in central protrusion …
Brown-McLean Syndrome with keratoconus again in this … leading to deformation
under the pressure of the upper and lower eyelids, resulting in central protrusion …
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A novel metric to monitor early progression in keratoconus: Epithelial backscatter
I Toprak, CE Gunes, C Martin-Seker, O Parca - 2025
Purpose To assess the progression of keratoconus over the course of one-year
using epithelia and anterior stromal backscatter, Belin ABCD progression display,
and various Pentacam® parameters and to determine whether backscatter …
using epithelia and anterior stromal backscatter, Belin ABCD progression display,
and various Pentacam® parameters and to determine whether backscatter …
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[HTML] Effect of selective suture removal on graft astigmatism after corneal transplantation in keratoconus
S Feizi, MA Javadi, Z Karjou, N Nouri, M Oraeeyazdani… - Therapeutic Advances in …, 2025
… We included all patients who underwent their initial corneal transplant for
keratoconus between February 25, 1994 and January 27, 2020 … Exclusion criteria
comprised preoperative corneal vascularization, additional ocular diseases besides …
keratoconus between February 25, 1994 and January 27, 2020 … Exclusion criteria
comprised preoperative corneal vascularization, additional ocular diseases besides …
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[PDF] Posterior chamber phakic intraocular lenses for correcting ametropia in stable keratoconus
O Berger, N Garikapati, H Naveed, A Hajjar-Sese… - Ophthalmic Research, 2025
Introduction: The use of posterior chamber phakic intraocular lenses are a
reasonable option in the armamentarium to treat refractive error in patients with
keratoconus. We present our experience with the use of posterior chamber phakic …
reasonable option in the armamentarium to treat refractive error in patients with
keratoconus. We present our experience with the use of posterior chamber phakic …
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[HTML] Keratoconus with two consecutive re-emergences: a case report
P Zhang, Y Wu, L Ma, D Wang - BMC ophthalmology, 2025
… emergence of keratoconus is due to chronic mechanical damage to the cornea [3].
For the first time, we reported a case of consecutive keratoconus recurrence after
two consecutive deep anterior lamellar keratoplasty(DALK). Our findings suggest …
For the first time, we reported a case of consecutive keratoconus recurrence after
two consecutive deep anterior lamellar keratoplasty(DALK). Our findings suggest …
| | | |
Can Chatbots Be Used for Keratoconus Patient Education?
OD Melissa Barnett - Contact Lens Spectrum, 2025
In most scleral lens practices, keratoconus (KC) is one of the top indications for
scleral lens fitting. In addition to correcting corneal irregularity and visual
improvement scleral lenses can delay or reduce the need for corneal transplantation …
scleral lens fitting. In addition to correcting corneal irregularity and visual
improvement scleral lenses can delay or reduce the need for corneal transplantation …
| | | |
[PDF] Sociodemographic predictors of acute corneal hydrops in patients with unstable keratoconus.
LN Kanu, N Boychev, M Fry, L Margolis, C Le… - medRxiv, 2025
… with unstable keratoconus. Design Retrospective case control study Subjects All
patients diagnosed with unstable keratoconus at Mass Eye … Results Of 762
patients diagnosed with unstable keratoconus, we identified 128 episodes of …
patients diagnosed with unstable keratoconus at Mass Eye … Results Of 762
patients diagnosed with unstable keratoconus, we identified 128 episodes of …
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[HTML] Molecular Subtype Identification and Potential Drug Prediction Based on Anoikis-Related Genes Expression in Keratoconus
Z Jiang, B Zhang, S Jia, X Yuan - Investigative Ophthalmology & Visual Science, 2025
Purpose: Anoikis is a special apoptosis accompanied by the loss of extracellular
matrix (ECM) environment and the decomposition of ECM is an important process in
the occurrence of keratoconus (KC). This study aims to describe the expression …
matrix (ECM) environment and the decomposition of ECM is an important process in
the occurrence of keratoconus (KC). This study aims to describe the expression …
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[HTML] Socioeconomic Factors Associated With Differential Access to Treatment in Patients With Keratoconus at a US Urban Safety-Net Hospital
OC Ihionu, JK Samra, RM Rashad, MA Arsiwala… - Cornea Open, 2025
… between ADI and keratoconus treatment access, we found lower rates of CXL and
CL treatment of keratoconus and worse severity on … Keratoconus is a progressive
corneal disease characterized by bulging and thinning of the cornea, a …
CL treatment of keratoconus and worse severity on … Keratoconus is a progressive
corneal disease characterized by bulging and thinning of the cornea, a …
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[HTML] Is there a relationship between keratoconus and diabetes?
A Chous - 2024
… of keratoconus in (predominantly type 2) diabetes without complications were 20%
less likely to occur, with a 52% lower odds of keratoconus … As for some reports
linking increased risk of keratoconus to diabetes, diabetes diagnosis came after the …
less likely to occur, with a 52% lower odds of keratoconus … As for some reports
linking increased risk of keratoconus to diabetes, diabetes diagnosis came after the …
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[PDF] DETECTION OF KERATOCONUS DISEASE DEPENDING ON CORNEAL TOPOGRAPHY USING DEEP LEARNING
AA Hashim, M Mazinani
… for keratoconus identification using corneal topography pictures. Images from 170
keratoconus patients, 28 subclinical keratoconus patients, … The datasets were
collected from more than 1900 keratoconus patients in the keratoconus center of the …
keratoconus patients, 28 subclinical keratoconus patients, … The datasets were
collected from more than 1900 keratoconus patients in the keratoconus center of the …
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[HTML] Coinfection of Herpes Simplex virus 2 and Mycobacterium chelonae in Acute Hydrops Associated with Keratoconus: A Case Report
P Marques-Couto, A Gama-Castro, T Carvalho… - IDCases, 2025
… Our hypothesis is that this complication of keratoconus disrupts the normal
corneal barrier function, thereby increasing the susceptibility to infections including
those caused by nontuberculous mycobacteria similar to what might be observed …
corneal barrier function, thereby increasing the susceptibility to infections including
those caused by nontuberculous mycobacteria similar to what might be observed …
| | | |
Sleeping Behavior and Keratoconus: A Scoping Review
A Tello, AP Navarro, A Pedraza-Concha, JV Sylvia… - Ceska a slovenska …, 2025
Aims This study was planned to explore the efficacy of autologous blood as a
stabilizing agent for graft surgery in pterygium. Material and methods For this
observational, non-comparative, interventional study, the hospital data of patients …
stabilizing agent for graft surgery in pterygium. Material and methods For this
observational, non-comparative, interventional study, the hospital data of patients …
| | | |
Evaluating the Influence of Eye Rubbing and Genetic Predisposition on Keratoconus in Bucaramanga (Colombia): A Case-control Study
ML Duarte-Bueno, A Tello, AL Diaz-Martínez… - Ceska a slovenska …, 2025
… Conclusion: Eye rubbing and family history of keratoconus were the most
important risk factors for keratoconus in our population. Although … of keratoconus.
Other factors, such as sun exposure, sleeping position, and atopy, may play a role in …
important risk factors for keratoconus in our population. Although … of keratoconus.
Other factors, such as sun exposure, sleeping position, and atopy, may play a role in …
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Enhancing early detection of keratoconus suspects using interocular corneal tomography asymmetry
S Li, Y Huo, R Xie, Y Han, H Zou, Y Wang - International Ophthalmology, 2025
… The global consensus on corneal ectasia is that it is a bilateral disease, and true
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
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[HTML] Accuracy of keratoconus-specific formulae compared to standard formulae for intraocular lens power calculation in patients with keratoconus
N Kahuam-López, JYM Ling, A Iovieno, SN Yeung - Canadian Journal of Ophthalmology
… -specific formulae would result in improved refractive outcomes compared with
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
| | | |
tomography asymmetry
S Li, Y Huo, R Xie, Y Han, H Zou, Y Wang - International Ophthalmology, 2025
… The global consensus on corneal ectasia is that it is a bilateral disease, and true
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
unilateral keratoconus does not exist [14]. We believe that bilateral asymmetry is a
key feature for the early diagnosis of keratoconus. Interocular asymmetries in clinical …
| | | |
[HTML] Accuracy of keratoconus-specific formulae compared to standard formulae for intraocular lens power calculation in patients with keratoconus
N Kahuam-López, JYM Ling, A Iovieno, SN Yeung - Canadian Journal of Ophthalmology
… -specific formulae would result in improved refractive outcomes compared with
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
standard formulae and a machine learning-based thick IOL calculation formula for
IOL power estimation in keratoconus in a large cohort of keratoconus patients who …
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[HTML] Proteomics Reveals Mechanisms of Delayed Keratoconus Progression: A Study of Corneas Following Two Light-Activated Crosslinking Treatments
DHJ Vogels, J Brekelmans, R Mohren, NRN Vos… - … Ophthalmology & Visual …, 2025
Purpose: This study aims to elucidate on changes in biological pathways in rabbit
corneas induced by two methods of light-activated corneal stiffening: topical
application of riboflavin with dextran (RF-D) or WST11 with dextran (WST-D) …
corneas induced by two methods of light-activated corneal stiffening: topical
application of riboflavin with dextran (RF-D) or WST11 with dextran (WST-D) …
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[HTML] Corneal biomechanics: A diagnostic tool for differentiating high astigmatism and mild keratoconus
N Razak, WHWA Halim, B Mohd-Ali - African Vision and Eye Health, 2025
Background: High astigmatism (HA) can be misinterpreted as keratoconus (KCN), is
highly prone to developing KCN and is normally reconfirmed using corneal
topography. Aim: To determine the diagnostic value of corneal biomechanical …
highly prone to developing KCN and is normally reconfirmed using corneal
topography. Aim: To determine the diagnostic value of corneal biomechanical …
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[HTML] Diagnostic performance of corneal epithelium-and Bowman's layer thickness mapping in patients with unilateral Keratoconus
N Pircher, R Kilian, F Beer, R Donner, P Roberts… - Graefe's Archive for Clinical …, 2025
… Several publications have described cases of unilateral keratoconus (UKC),
where only one eye presents with clinical KC, whereas the fellow eye (FE) shows no
topographic signs of corneal ectasia [16, 18]. Since many of the FE will go on …
where only one eye presents with clinical KC, whereas the fellow eye (FE) shows no
topographic signs of corneal ectasia [16, 18]. Since many of the FE will go on …
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Self-reported prevalence and risk factors associated with keratoconus among the adult population of Trinidad and Tobago: a cross-sectional study
NE Ezinne, MA Kwarteng, KP Mashige, VR Moodley - International Ophthalmology, 2025
… Early screening for keratoconus in this country is strongly recommended to
facilitate prompt … across 15 countries estimated the global prevalence of
keratoconus to be 138 per 100,000 [8]. The … Keratoconus is one of the major …
facilitate prompt … across 15 countries estimated the global prevalence of
keratoconus to be 138 per 100,000 [8]. The … Keratoconus is one of the major …
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Corneal stromal cells from patients with keratoconus exhibit alterations in the ESCRT-dependent machinery responsible for multivesicular body formation
N Blanco-Agudín, S Ye, I Alcalde, MD Corte-Torres… - Experimental Eye Research, 2025
Previous studies have reported that exosomes produced by corneal stromal cells
from keratoconus patients exhibit a molecular content distinct from those produced
by cells from healthy donors. This study investigates differences in the expression of …
from keratoconus patients exhibit a molecular content distinct from those produced
by cells from healthy donors. This study investigates differences in the expression of …
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[PDF] Management of advanced keratoconus using a semi-scleral contact lens: A non-surgical option
ZA Rashid, VR Moodley, ZA Rashid
… CLs in a patient with advanced keratoconus. A 23-year-old female, referred for CL
fitting, presented with advanced keratoconus with minimal … report shows that semi-scleral
CLs provide a satisfactory, non-surgical alternative to improve VA in patients with …
fitting, presented with advanced keratoconus with minimal … report shows that semi-scleral
CLs provide a satisfactory, non-surgical alternative to improve VA in patients with …
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[HTML] Topographic Pattern-Based Nomogram to Guide Keraring Implantation in Eyes with Mild to Moderate Keratoconus: Visual and Refractive Outcome
U de Sanctis, P Caselgrandi, C Gennaro, C Tosi… - Journal of Clinical Medicine, 2025
Background: To assess the outcome of Keraring (Mediphacos, Brazil) implantation
according to a topographic pattern-based nomogram in eyes with mild to moderate
keratoconus. Materials and Methods: A topographic pattern-based nomogram was …
according to a topographic pattern-based nomogram in eyes with mild to moderate
keratoconus. Materials and Methods: A topographic pattern-based nomogram was …
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[HTML] Different keratoconus definitions can lead to substantial prevalence disparities in population-based studies
H Shabani, BTH van Dooren, MA Meester-Smoor… - Scientific Reports, 2025
… This report explores the prevalence of keratoconus in a population-based cohort
of adults aged 40 or older according to ten different … Suspected keratoconus was
defined as having at least one eye with a final D-index (BAD-D) ≥ 2.6. Manifest …
of adults aged 40 or older according to ten different … Suspected keratoconus was
defined as having at least one eye with a final D-index (BAD-D) ≥ 2.6. Manifest …
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[HTML] The cellular response of lipopolysaccharide-induced inflammation in keratoconus human corneal fibroblasts to RB-PDT: Insights into cytokines, chemokines and …
N Chai, T Stachon, S Häcker, T Berger, Z Li, M Amini… - PloS one, 2025
Purpose Rose Bengal Photodynamic Therapy (RB-PDT) offers dual therapeutic
benefits by enhancing corneal stiffness and providing antibacterial activity,
presenting significant potential for patients with keratoconus complicated by keratitis …
benefits by enhancing corneal stiffness and providing antibacterial activity,
presenting significant potential for patients with keratoconus complicated by keratitis …
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[HTML] Distinct Ocular Surface Microbiome in Keratoconus Patients Correlate With Local Immune Dysregulation
NR Kumar, P Khamar, R Kannan, A Padmanabhan… - … Ophthalmology & Visual …, 2025
Purpose: Keratoconus (KC) is characterized by irregular astigmatism along with
corneal stromal weakness and is associated with altered immune status. Tissue
resident microbiomes are known to influence the immune status in other organs, but …
corneal stromal weakness and is associated with altered immune status. Tissue
resident microbiomes are known to influence the immune status in other organs, but …
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Advanced Keratoconus with Hydrops: Light at the End of the Tunnel
K Bhardwaj, T Chauhan, S Vohra, G Dabas… - Resolving Dilemmas in …, 2025
The rupture of the Descemet membrane in an acute setting leads to a condition
called acute corneal hydrops. While its incidence is low, it can be encountered in
those with weakened and thin corneas such as those with advanced keratoconus …
called acute corneal hydrops. While its incidence is low, it can be encountered in
those with weakened and thin corneas such as those with advanced keratoconus …
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A Stitch in Time Saves Nine: Optic Neuritis in a Keratoconus Patient
S Monga - … in Ophthalmology: Challenging Cases, Diagnosis and …, 2025
This chapter narrates the experience of managing a severe visual deficit due to
atypical optic neuritis, in a middle-aged male who was a known case of keratoconus.
The emphasis is on the importance of good clinical examination to elucidate the …
atypical optic neuritis, in a middle-aged male who was a known case of keratoconus.
The emphasis is on the importance of good clinical examination to elucidate the …
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Keratoconus staging, monitoring & corvis biomechanical analysis
E Flockerzi, B Seitz - Acta Ophthalmologica, 2025
… reported to enable distinction between healthy and keratoconus corneas. The
main Corneal Visualization … keratoconus corneas in a quasi‐binary manner,
whereas the Biomechanical E‐Staging is based on the linear term of the CBI and …
main Corneal Visualization … keratoconus corneas in a quasi‐binary manner,
whereas the Biomechanical E‐Staging is based on the linear term of the CBI and …
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Gene expression profiling of oxidative and anti‐oxidative genes in keratoconus patients
S Sharma, L Singh, S Kashyap, S Sen, N Sharma - Acta Ophthalmologica, 2025
Aims/Purpose: Keratoconus (KC) is thinning of corneal stroma & irregular
astigmatism, resulting in diminution of vision. Despite its prevalence, the underlying
etiology is poorly understood. Emerging evidence suggests a dysregulation of …
astigmatism, resulting in diminution of vision. Despite its prevalence, the underlying
etiology is poorly understood. Emerging evidence suggests a dysregulation of …
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Topographic determinants of anterior chamber angle narrowing in patients with keratoconus
P Nabovati, H Soltan‐Dehghan, A Farzaneh… - Acta Ophthalmologica, 2025
… visited a tertiary eye hospital and were diagnosed with keratoconus, were
recruited for this study. First… The keratoconus was diagnosed based on distorted
keratometric mires, scissoring of … with keratoconus as well as the presence of at …
recruited for this study. First… The keratoconus was diagnosed based on distorted
keratometric mires, scissoring of … with keratoconus as well as the presence of at …
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[PDF] Managing Bilateral Vernal Keratoconjunctivitis, Keratoconus, and Steroid-Induced Glaucoma: A Threefold Struggle
NH Maffar, Y Azhany, NASM Ghazali, J Muhammed… - Cureus, 2025
… In this case report, we present a young Malay girl with VKC complicated by
progressive keratoconus and steroid-induced glaucoma, … 2), and marked
progression of keratoconus with thin corneal thickness in the right eye and minimal …
progressive keratoconus and steroid-induced glaucoma, … 2), and marked
progression of keratoconus with thin corneal thickness in the right eye and minimal …
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Optimizing keratoconus treatment with AI‐driven lenticule matching using pentacam indices
F Doroodgar, S Niazi, H Nematy - Acta Ophthalmologica, 2025
Aims/Purpose: The aim of this study is to develop an advanced artificial intelligence (AI)
methodology to optimize the matching of donor and recipient lenticules for the
treatment of keratoconus. This approach leverages Pentacam indices related to …
methodology to optimize the matching of donor and recipient lenticules for the
treatment of keratoconus. This approach leverages Pentacam indices related to …
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Vitamin D supplementation modifies clinical and biological markers of keratoconus progression
G Ferrari, S Palombella, N Bartolomeo, G Tilaro… - Acta Ophthalmologica, 2025
Aims/Purpose: evaluation of vitamin D (Vit D) supplementation on clinical
progression and systemic biomarkers in adolescent patients affected by keratoconus
(KC) and Vit D insufficiency. Methods: forty adolescent patients (age range: 12–19) …
progression and systemic biomarkers in adolescent patients affected by keratoconus
(KC) and Vit D insufficiency. Methods: forty adolescent patients (age range: 12–19) …
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Computational and experimental mechanical characterization of a novel corneal implant for the treatment of keratoconus
GM Ragonese, D Carbonaro, S Zambon, E Villa… - Acta Ophthalmologica, 2025
Aims/Purpose: Current treatment options of keratoconus have several limitations.
These limitations have been addressed by developing a novel nitinol GROSSO®
implant, that restores the physiological curvature of the cornea by virtue of a dome‐shaped …
These limitations have been addressed by developing a novel nitinol GROSSO®
implant, that restores the physiological curvature of the cornea by virtue of a dome‐shaped …
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Understanding structural changes in keratoconus: Anterior scleral and choroidal thickness analysis using swept source optical coherence tomography
A Hassairi, C Ahmed, O Mehdi, R Limaiem - Acta Ophthalmologica, 2025
Aims/Purpose: The study aims to investigate the anterior scleral thickness (AST)
profile and choroidal thickness (CT) variations in keratoconus (KC) patients
compared to healthy controls, with the objective of providing a comprehensive …
profile and choroidal thickness (CT) variations in keratoconus (KC) patients
compared to healthy controls, with the objective of providing a comprehensive …
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Tear proteomics for the understanding of corneal biomechanical weakness in offspring of keratoconus patients
M López‐López, T Alvite‐Piñeiro, Y Pastoriza, I Lema… - Acta Ophthalmologica, 2025
Aim: To analyze the tear proteome of offspring of keratoconus patients (O‐KC) to
elucidate the molecular mechanisms involved in corneal weakening in high‐risk
individuals. Methods: 80 O‐KC young participants matched with 42 control subjects …
elucidate the molecular mechanisms involved in corneal weakening in high‐risk
individuals. Methods: 80 O‐KC young participants matched with 42 control subjects …
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Intraocular lens power calculation in cataract patients with keratoconus: Bayesian network meta-analysis
ZY Tian, M Li, JS Zhang, YY Mao, ZX Guo, X Zheng… - International Ophthalmology, 2025
… for keratoconus predicted posterior corneal astigmatism (Barrett KC P-PCA),
EVO2. 0, and Barrett True-K formula for keratoconus measured … In the range of±1.00
D, the top three formulas were Barrett KC P-PCA, Barrett KC M-PCA and Kane for …
EVO2. 0, and Barrett True-K formula for keratoconus measured … In the range of±1.00
D, the top three formulas were Barrett KC P-PCA, Barrett KC M-PCA and Kane for …
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[HTML] Ineffectiveness of KeraVio Treatment with Violet Light-Emitting Glasses Without Riboflavin Drops for Progressive Keratoconus
H Kobashi, T Kumanomido, T Ide, N Kato, J Shimazaki… - Journal of Clinical Medicine, 2025
… This study aimed to report the clinical outcomes of KeraVio with VL irradiation
without the administration of riboflavin drops in patients with progressive keratoconus. …
This may suggest that KeraVio treatment with VL alone was not effective in preventing …
without the administration of riboflavin drops in patients with progressive keratoconus. …
This may suggest that KeraVio treatment with VL alone was not effective in preventing …
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[HTML] Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus
L Moon, P Kaur, J Wang, A Sodhi, C Eberhart… - … Ophthalmology & Visual …, 2025
… Here, we set out to determine how eye rubbing can influence keratoconus
progression by exploring the expression of known disease … in keratoconus
corneal epithelium. Both proteins have also been reported to be markedly reduced …
progression by exploring the expression of known disease … in keratoconus
corneal epithelium. Both proteins have also been reported to be markedly reduced …
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[PDF] Successful Management of a Keratoconus Patient With Rarely Used Large-Diameter Corneal RGP Contact Lenses: A Case Report
A Almaweri - Cureus, 2025
… a keratoconus patient with infrequently used large-diameter corneal RGP contact
lenses. This method of fitting provides remarkable stability and patient comfort. Here,
I describe a case of a 39-year-old man with a known history of keratoconus… in the …
lenses. This method of fitting provides remarkable stability and patient comfort. Here,
I describe a case of a 39-year-old man with a known history of keratoconus… in the …
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Spatial Transcriptomics and Single-Cell RNA-Sequencing Revealed Dendritic Cell-Mediated Inflammation in Keratoconus
S Luo, J Li, Y Yang, Y Jiang, Y Jie, W Ge - The Ocular Surface, 2025
Keratoconus (KC) is a corneal disorder characterized by central corneal protrusion
and thinning. In this study, spatial transcriptomics was employed to investigate
molecular and cellular variations in KC, revealing a distinct pattern of inflammatory …
and thinning. In this study, spatial transcriptomics was employed to investigate
molecular and cellular variations in KC, revealing a distinct pattern of inflammatory …
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[HTML] Topographic factors associated with anterior chamber angle narrowing in patients with keratoconus
H Soltan-Dehghan, A Farzaneh, H Hashemi… - International Journal of …, 2025
AIM To identify topographic determinants of the anterior chamber angle (ACA) in
patients with keratoconus (KCN). METHODS Four hundred and ten eyes of 294
patients with KCN were recruited for this study. First, complete ocular examinations …
patients with keratoconus (KCN). METHODS Four hundred and ten eyes of 294
patients with KCN were recruited for this study. First, complete ocular examinations …
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[HTML] Retinal thickness and vascular density changes in Keratoconus: A systematic review and meta-analysis
H Vahedi, M Abdollahi, R Moshfeghinia, S Emami… - Heliyon, 2025
Purpose This systematic review and meta-analysis aimed to assess the changes in
retinal layer thickness and vascular density in patients diagnosed with keratoconus (KC).
Methods We conducted a thorough search in PubMed, Scopus, Embase, and Web …
retinal layer thickness and vascular density in patients diagnosed with keratoconus (KC).
Methods We conducted a thorough search in PubMed, Scopus, Embase, and Web …
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[HTML] Corneal hydrops secondary to advanced keratoconus. Published online August 8, 2019
A Tharayil, N Gaines - Consultant
… , have a higher risk of developing keratoconus. Pediatric keratoconus tends to be
more aggressive than adult keratoconus, and although it usually … However, with
pediatric keratoconus, the diagnosis often is not made until the disease has …
more aggressive than adult keratoconus, and although it usually … However, with
pediatric keratoconus, the diagnosis often is not made until the disease has …
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[HTML] Prevalence of keratoconus and keratoconus suspect, and their characteristics on corneal tomography in a population-based study
H Namba, N Maeda, H Utsunomiya, Y Kaneko… - PLOS ONE, 2025
Keratoconus (KC) is a progressive corneal disorder resulting in severe visual
impairment. We aimed to determine the prevalence and corneal tomographic
characteristics of KC and keratoconus suspect (KCS) in a population-based study …
impairment. We aimed to determine the prevalence and corneal tomographic
characteristics of KC and keratoconus suspect (KCS) in a population-based study …
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Assessment of Awareness of Keratoconus and its Relation to Eye Rubbing Among Saudi Arabia Population Supervisor/Primary Investigator
NA Alqasimi, LH Aljohani, R Ambrósio Jr, B AlQahtani… - Frontiers in Ophthalmology
Keratoconus (KC) is a bilateral, asymmetric, progressive thinning of the cornea that
causes a decrease in optical quality due to induced myopia, irregular astigmatism,
and higher-order aberrations.Keratoconus affects 1.38 per 1,000 individuals globally …
causes a decrease in optical quality due to induced myopia, irregular astigmatism,
and higher-order aberrations.Keratoconus affects 1.38 per 1,000 individuals globally …
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[PDF] Case Study: Optical Rehabilitation Remedies for a Patient with Keratoconus and Esophoria with Biochemical Aspects
AIA Al Ibrahim, AMA Aboalqasim, LA Namazi… - 2024
… Keratoconus and esophoria are eye disorders associated with eye alignment that
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
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[PDF] VISUAL OUTCOME OF SIMULTANEOUS PHOTOREFRACTIVE KERATECTOMY AND CORNEAL COLLAGEN CROSS LINKING (PRK CXL) IN KERATOCONUS …
A Ahmed, A Alaskary, S Ahmed
… treatments for keratoconus. The therapy for keratoconus is dependent upon the
illness severity and the degree of disease progression [3]. Eyeglasses and rigid gas
permeability contact lenses are traditional techniques for treating mild to moderate …
illness severity and the degree of disease progression [3]. Eyeglasses and rigid gas
permeability contact lenses are traditional techniques for treating mild to moderate …
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[PDF] Case Study: Optical Rehabilitation Remedies for a Patient with Keratoconus and Esophoria with Biochemical Aspects
AIA Al Ibrahim, AMA Aboalqasim, LA Namazi… - 2024
… Keratoconus and esophoria are eye disorders associated with eye alignment that
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
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[PDF] VISUAL OUTCOME OF SIMULTANEOUS PHOTOREFRACTIVE KERATECTOMY AND CORNEAL COLLAGEN CROSS LINKING (PRK CXL) IN KERATOCONUS …
A Ahmed, A Alaskary, S Ahmed
… treatments for keratoconus. The therapy for keratoconus is dependent upon the
illness severity and the degree of disease progression [3]. Eyeglasses and rigid gas
permeability contact lenses are traditional techniques for treating mild to moderate …
illness severity and the degree of disease progression [3]. Eyeglasses and rigid gas
permeability contact lenses are traditional techniques for treating mild to moderate …
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[HTML] Strategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques
A Gideon Abou Said, J Gispets, E Shneor - Journal of Clinical Medicine, 2025
Keratoconus is a progressive corneal disorder that can lead to irreversible visual …
These technologies are essential for identifying early-stage keratoconus, yet their
high cost limits … ensure accurate and effective detection of early keratoconus. This …
These technologies are essential for identifying early-stage keratoconus, yet their
high cost limits … ensure accurate and effective detection of early keratoconus. This …
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[HTML] Repeatability of Pentacam HR in Keratoconus According to Two Different Scan Protocols: 25-3D Scan and 50-Cornea Fine
D Romano, G Coco, A Borgia, S Calza, S Kaye… - Journal of Clinical Medicine, 2025
Background: This study aims to evaluate the repeatability of the Pentacam HR,
comparing two different measurement modes (50-cornea fine and 25-3D scan) in
patients affected by keratoconus. Methods: Multicenter retrospective study …
comparing two different measurement modes (50-cornea fine and 25-3D scan) in
patients affected by keratoconus. Methods: Multicenter retrospective study …
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Keratoconus classification
AN Jinabhai - Optician, 2024
… ECPs typically find it relatively straightforward to identify moderate to severe
keratoconus, due to its classical topographical appearance (outlined later in this article)
and characteristic clinical signs. These clinical signs include: … The purpose of this …
keratoconus, due to its classical topographical appearance (outlined later in this article)
and characteristic clinical signs. These clinical signs include: … The purpose of this …
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[PDF] Long-Term Effectiveness of Scleral Lens Treatment in the Management of Keratoconus: A Systematic Review
A Mushtaq, I Alvi - Cureus, 2025
This systematic review evaluates the long-term effectiveness of scleral lenses in
improving visual outcomes, patient satisfaction, and safety in patients with
keratoconus. A systematic search of six databases (PubMed, Embase, Web of …
improving visual outcomes, patient satisfaction, and safety in patients with
keratoconus. A systematic search of six databases (PubMed, Embase, Web of …
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Non-genetic risk factors for keratoconus and its progression
IMY Cheung, L Angelo, A Gokul, M Ziaei - Clinical and Experimental Optometry, 2025
Keratoconus is a multifaceted corneal ectatic disorder characterized by a range of
genetic and environmental risk factors. While genetic predisposition significantly
influences global disease prevalence rates as well as severity and progression rates …
genetic and environmental risk factors. While genetic predisposition significantly
influences global disease prevalence rates as well as severity and progression rates …
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[HTML] Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population
Y Yao, X Li, L Wu, J Zhang, Y Gui, X Yu, Y Zhou, X Li… - Eye and Vision, 2025
Background Keratoconus (KC) is a prevalent corneal condition with a modest
genetic basis. Recent studies have reported significant genetic associations in multi-ethnic
cohorts. However, the situation in the Chinese population remains unknown. This …
genetic basis. Recent studies have reported significant genetic associations in multi-ethnic
cohorts. However, the situation in the Chinese population remains unknown. This …
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Correction: Computational approaches for identifications of altered ion channels in keratoconus
KB Gaikwad, JS Babu, KTS Parthasarathi, J Narayanan… - Eye (London, England), 2025
Correction: Computational approaches for identifications of altered ion channels in
keratoconus Correction: Computational approaches for identifications of altered ion
channels in keratoconus Eye (Lond). 2025 Jan 2. doi: 10.1038/s41433-024-03493-4 …
keratoconus Correction: Computational approaches for identifications of altered ion
channels in keratoconus Eye (Lond). 2025 Jan 2. doi: 10.1038/s41433-024-03493-4 …
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Correction: Computational approaches for identifications of altered ion channels in keratoconus
KB Gaikwad, JS Babu, KTS Parthasarathi, J Narayanan… - Eye (London, England), 2025
Correction: Computational approaches for identifications of altered ion channels in
keratoconus Correction: Computational approaches for identifications of altered ion
channels in keratoconus Eye (Lond). 2025 Jan 2. doi: 10.1038/s41433-024-03493-4 …
keratoconus Correction: Computational approaches for identifications of altered ion
channels in keratoconus Eye (Lond). 2025 Jan 2. doi: 10.1038/s41433-024-03493-4 …
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Keratoconus in children in Tunisia: Epidemiological, clinical and therapeutic features
S Kammoun, K Maaloul, M Rekik, K Chaabouni…
Methods: Retrospective study focusing on patients aged less than 18 years,
presenting with KC and followed in a tertiary reference center in Sfax, Tunisia.
Results: Our study involved 38 eyes of 20 children. We found a mean age of 12.8 …
presenting with KC and followed in a tertiary reference center in Sfax, Tunisia.
Results: Our study involved 38 eyes of 20 children. We found a mean age of 12.8 …
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Comfort in Keratoconus
Z Tajbakhsh - Journal of Ophthalmic and Vision Research, 2024
Purpose: To compare rigid gas permeable (RGP) contact lens comfort in patients
with keratoconus who underwent corneal cross-linking (CXL) versus those without
CXL surgery. Methods: This prospective study was carried out on 41 eyes (25 …
with keratoconus who underwent corneal cross-linking (CXL) versus those without
CXL surgery. Methods: This prospective study was carried out on 41 eyes (25 …
SD Joshi, NV Gundecha - Journal of Clinical Ophthalmology and Research, 2025
Purpose: The purpose of this study was to describe the refractive outcomes and finer
aspects of visual acuity such as contrast, aberrations, and quality of vision after
keratoplasty for keratoconus. Design: This was a longitudinal clinical study of 50 …
aspects of visual acuity such as contrast, aberrations, and quality of vision after
keratoplasty for keratoconus. Design: This was a longitudinal clinical study of 50 …
MΜΛΝ Lubbad - 2024
… relevant corneal shape parameters for accurate keratoconus diagnosis. The study
raises questions about the necessary corneal shape indexes for precise
keratoconus diagnosis and the significance of specific corneal shape parameters for …
raises questions about the necessary corneal shape indexes for precise
keratoconus diagnosis and the significance of specific corneal shape parameters for …
Z Özer Özcan, M Berhuni, A Mete, K Güngör - Kocaeli Medical Journal
METHODS: The word "keratoconus" was searched in the Web of Science database.
The articles published in ophthalmology journals between 2010 and 2020 were
filtered. The traditional metric and altmetric data of the most cited 100 articles were …
The articles published in ophthalmology journals between 2010 and 2020 were
filtered. The traditional metric and altmetric data of the most cited 100 articles were …
AIA Al Ibrahim, AMA Aboalqasim, LA Namazi… - Egyptian Journal of …, 2024
… Keratoconus and esophoria are eye disorders associated with eye alignment that
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
affect children and teenagers. However, keratoconus may not be noticed at a tender
age, while esophoria can be identified early in childhood. Keratoconus results from …
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[PDF] Implantation of 320˚-Arc Length Intrastromal Corneal Ring Segments in Keratoconus, A prospective study
MA El-Malah, MMA Ibrahim, HME El Ghoneimy… - Al-Azhar International …, 2024
… The purpose of this study is to assess the clinical results in keratoconus patients'
eyes … both central and paracentral steepening in keratoconus patterns with low or
high topographic … history of any corneal abnormalities other than keratoconus (KC) …
eyes … both central and paracentral steepening in keratoconus patterns with low or
high topographic … history of any corneal abnormalities other than keratoconus (KC) …
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Combined approach to cataract surgery in keratoconus
YN Yusef, GA Osipyan, K Khraystin, VV Averich… - Vestnik oftalmologii, 2024
Preparation for cataract surgery in patients with keratoconus (KC) is associated with
particular challenges: calculating the optical power of the intraocular lens (IOL),
selecting the appropriate IOL model, and considering additional interventions aimed …
particular challenges: calculating the optical power of the intraocular lens (IOL),
selecting the appropriate IOL model, and considering additional interventions aimed …
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[PDF] Tinjauan Sistematis Hubungan Diabetes Mellitus dengan Keratoconus
A Shafi, T Ahmad, K Satari - Oftalmologi Jurnal Kesehatan Mata Indonesia, 2024
… keratoconus in the current review. There are still conflicting results which support
and against diabetes mellitus correlation to keratoconus. … diabetes mellitus ini
terhadap angka kejadian keratoconus dan derajat keparahan yang membahas …
and against diabetes mellitus correlation to keratoconus. … diabetes mellitus ini
terhadap angka kejadian keratoconus dan derajat keparahan yang membahas …
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[PDF] Postoperative corneal remodeling after corneal allograft intrastromal ring segment (CAIRS) implantation for keratoconus: An OCT study
B Yakut, C Tanriverdi, FFNK Perk, SA Nacaroglu… - Indian Journal of …, 2024
… [10‑13] Given the importance of corneal remodeling in keratoconus treatment, this
study aims to evaluate the changes in corneal epithelial and stromal thicknesses
after CAIRS implantation by using anterior‑segment optical coherence tomography (AS‑OCT) …
study aims to evaluate the changes in corneal epithelial and stromal thicknesses
after CAIRS implantation by using anterior‑segment optical coherence tomography (AS‑OCT) …
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Quality and readability of online information on Keratoconus in Portugal and Brazil
C Costa, RS Oliveira, J Gil, E Costa, C Tavares, A Rosa… - European Journal of …, 2024
… We aim to evaluate the quality and readability of the online information regarding
keratoconus in Portugal and Brazil. … of keratoconus (for eg: we excluded an article
on topography-guided cross-linking outcomes but didn't exclude a thesis on general …
keratoconus in Portugal and Brazil. … of keratoconus (for eg: we excluded an article
on topography-guided cross-linking outcomes but didn't exclude a thesis on general …
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[HTML] Custom-shaped CAIRS for personalized treatment of Keratoconus
S Jacob - Indian Journal of Ophthalmology, 2025
Corneal allogeneic intrastromal ring segments (CAIRS) refer to intracorneal
placement of allogeneic ring segments of any type, eg, fresh, unprocessed,
processed, preserved, or packaged segments with or without shelf‑life.[1‑10] Both …
placement of allogeneic ring segments of any type, eg, fresh, unprocessed,
processed, preserved, or packaged segments with or without shelf‑life.[1‑10] Both …
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[PDF] The role of ego-resiliency in patients with keratoconus
S Florek, P Gościniewicz, P Dębski…
… keratoconus with psychiatric disorders. None of these address the role of ego-resiliency,
which may prove crucial in coping with chronic illness. MATERIAL AND METHODS:
74 participants with keratoconus … role of ER among patients with keratoconus in …
which may prove crucial in coping with chronic illness. MATERIAL AND METHODS:
74 participants with keratoconus … role of ER among patients with keratoconus in …
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Automated feature selection for early keratoconus screening optimization
A Chaari, IF Kallel, H Daoud, I Omri, S Kammoun… - Biomedical Physics & …, 2024
In this paper, an automated feature selection (FS) method is presented to optimize
machine learning (ML) models' performances, enhancing early keratoconus
screening. A total of 448 parameters were analyzed from a dataset comprising 3162 …
machine learning (ML) models' performances, enhancing early keratoconus
screening. A total of 448 parameters were analyzed from a dataset comprising 3162 …
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U-shaped Association Between Residential Greenness and Keratoconus
L Li, W Cheng, W Wang, G Dong, L Liang - Environmental Research, 2024
Keratoconus is a blinding corneal disorder influenced by genetic factors. Whether
environmental factors influence it remains unclear. Here, we observed a U-shaped
association between residential greenness and keratoconus, with increased odds …
environmental factors influence it remains unclear. Here, we observed a U-shaped
association between residential greenness and keratoconus, with increased odds …
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[HTML] Eccentric Pathology in Keratoconus Exhibits Stiffer Biomechanical Response Than Central Pathology
CD Bruner, AM Mahmoud, CJ Roberts - Ophthalmology Science, 2024
… Corneal stiffness increases as the distance of the cone from the center increases,
consistent with focal nature of keratoconus. Central stiffness decreases as cone
curvature (disease severity) increases. It is recommended to use zonal values with …
consistent with focal nature of keratoconus. Central stiffness decreases as cone
curvature (disease severity) increases. It is recommended to use zonal values with …
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[HTML] Clinical outcomes of two symmetrical Kera-rings implanted in grade three keratoconus: a retrospective nonrandomized study
A Mounir, I Awny, I Amer, A Mahmoud, EAM Mossa - BMC Ophthalmology, 2024
To evaluate the clinical outcomes of implanting two symmetrical Kerarings via a
femtosecond laser in grade three keratoconus. This was a retrospective
nonrandomized controlled clinical study. The study included one eye from each of …
femtosecond laser in grade three keratoconus. This was a retrospective
nonrandomized controlled clinical study. The study included one eye from each of …
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[PDF] Superior Keratoconus in Attention-Deficit Hyperactivity Disorder (ADHD): A Case Report and Literature Review
E Assayag, D Zadok, M Carmel, A Abulafia, Y Weill - Cureus, 2024
Keratoconus is a progressive corneal ectasia that may lead to severe visual
impairment. Superior keratoconus (SK) is an uncommon form of the disease, and
few cases have been reported thus far. We present an unusual SK case and a …
impairment. Superior keratoconus (SK) is an uncommon form of the disease, and
few cases have been reported thus far. We present an unusual SK case and a …
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A Finite Element Approach Towards Patient-Specific Biomechanical Modeling of Keratoconus
NT SALIM - 2024
Keratoconus (KC) is a progressive corneal disorder characterized by corneal
thinning, weakening, and conical deformation, which severely impairs vision.
Accurate biomechanical modeling is essential for understanding the progression of …
thinning, weakening, and conical deformation, which severely impairs vision.
Accurate biomechanical modeling is essential for understanding the progression of …
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[PDF] Co-occurrence of Kimura's Disease and Keratoconus: A Case Report
SMA Alosaimi, HMN Ali, AK Alshaibani - International Journal of Scientific Research …, 2024… Keratoconus is a disorder where both corneas get steeper and vision is reduced.
It is not … The diagnosis of Keratoconus was verified by the examination of the
topography. Considering … of Kimura disease, specifically in relation to keratoconus …
It is not … The diagnosis of Keratoconus was verified by the examination of the
topography. Considering … of Kimura disease, specifically in relation to keratoconus …
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[PDF] A Case of Infectious Keratitis Associated with Rigid Gas Permeable Contact Lens Use in a Keratoconus Patient
H Salam, R Wati - Bioscientia Medicina: Journal of Biomedicine and …, 2024… keratoconus; however, improper use can lead to complications such as infectious
keratitis. Case presentation: We present a case of a 25-year-old female with
keratoconus … The patient was diagnosed with bilateral keratoconus, bilateral …
keratitis. Case presentation: We present a case of a 25-year-old female with
keratoconus … The patient was diagnosed with bilateral keratoconus, bilateral …
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[PDF] AI-Based Vision Screening Tool for Keratoconus
R Rahman, P Kumar, YK Sharma, M Sharma… - Anuradha Tomar Sukumar Mishra …Keratoconus affects millions of people all over the globe, and the threat of disease is
a concern and should be given attention. It does not just threaten corneal changes
but can also play with visual pathways. It has evidence of disturbed binocularity …
a concern and should be given attention. It does not just threaten corneal changes
but can also play with visual pathways. It has evidence of disturbed binocularity …
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Effects of customized corneal cross-linking on higher-order aberrations in progressive keratoconus and low-grade myopia
J Hayek, A Viberg, S Elving, A Fredriksson, A Behndig - Acta ophthalmologicaObjective To evaluate the effects of customized corneal collagen cross-linking (CXL)
on higher-order aberrations (HOAs) in keratoconus (KC): vertical coma (VC),
horizontal coma (HC), spherical aberration (SA), trefoil (TF) and astigmatism …
on higher-order aberrations (HOAs) in keratoconus (KC): vertical coma (VC),
horizontal coma (HC), spherical aberration (SA), trefoil (TF) and astigmatism …
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[HTML] Characteristics of corneal aberration in patients with bilateral keratoconus and unilateral corneal Vogt's striae
SS Wei, Y Li, ZQ Wu, JG Liu, J Du, J Li, YH Zhang - International Journal of …, 2024
AIM To assess the corneal high-order aberration (HOA) and its correlation with
corneal morphological parameters in patients with bilateral keratoconus (KCN) and
unilateral Vogt's striae. METHODS A total of 168 eyes of 84 patients with KCN …
corneal morphological parameters in patients with bilateral keratoconus (KCN) and
unilateral Vogt's striae. METHODS A total of 168 eyes of 84 patients with KCN …
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Effect of Corneal vs Scleral Rigid Gas Permeable (RGP) Lenses on corneal curvature and thickness in patients of Keratoconus
AEK Niazi, S Anwar, S Fatima, AH Shahid, M Ali - Medical Journal of South Punjab, 2024
Objective: To investigate the changes in corneal curvature and thickness in patients
of Keratoconus, wearing Rose k2 corneal and XL (scleral lenses) from last three
months. Methodology: Interventional study was conducted at The Keratoconus Clinic …
of Keratoconus, wearing Rose k2 corneal and XL (scleral lenses) from last three
months. Methodology: Interventional study was conducted at The Keratoconus Clinic …
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[PDF] … biomechanical parameters between two generations of dynamic bidirectional air-puff tonometers in subjects with central and peripheral keratoconus and in healthy …
MM Fortman - 2024
… approach to supplement our ability to detect early keratoconus. Therefore, the
initial aims of … keratoconus and controls; and 2) to evaluate the performance of the
original KMI in identifying keratoconic eyes when applied to G3 ORA measurement …
initial aims of … keratoconus and controls; and 2) to evaluate the performance of the
original KMI in identifying keratoconic eyes when applied to G3 ORA measurement …
| | | |
Inhibition of matrix metalloproteases by a chemical cross-linker to halt the corneal degradation in keratoconus
AS Gopalakrishnan, S Sirajuddeen, N Banu, J Nunes… - Experimental Eye Research, 2024
The need for better and simpler alternative crosslinking strategies to treat
keratoconus (KC) is becoming essential as there is only a single approved way to
treat it. Recently, conventional UV-A Riboflavin crosslinking is proven to have some …
keratoconus (KC) is becoming essential as there is only a single approved way to
treat it. Recently, conventional UV-A Riboflavin crosslinking is proven to have some …
| | | |
Role of m6A methyltransferase METTL3 in Keratoconus pathogenesis
H Yu, S Dou, H Wang, Y Sun, J Qu, T Liu, X Liu, C Wei… - Experimental Eye Research, 2024
Keratoconus (KC) is the most common ectatic corneal disease with unknown
pathogenesis. This study aimed to investigate the role of methyltransferase-like
enzyme 3 (METTL3) in KC pathogenesis. In the present study, we examined the …
pathogenesis. This study aimed to investigate the role of methyltransferase-like
enzyme 3 (METTL3) in KC pathogenesis. In the present study, we examined the …
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Demographic and topographic findings suggesting poor response to crosslinking-iontophoresis in patients with progressive keratoconus
RT Peralba, JR Lago, D Lamas-Francis… - 2024
… Progression criteria based on the ABCD system, changes in asphericity (Q),
demographic factors and keratoconus phenotypes were evaluated. Subjects were
followed … A family history of corneal ectasia and subtype 4 keratoconus predicted …
demographic factors and keratoconus phenotypes were evaluated. Subjects were
followed … A family history of corneal ectasia and subtype 4 keratoconus predicted …
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AI-Based Vision Screening Tool for Keratoconus
R Rahman, P Kumar, YK Sharma, M Sharma… - Anuradha Tomar Sukumar Mishra …
Keratoconus affects millions of people all over the globe, and the threat of disease is
a concern and should be given attention. It does not just threaten corneal changes
but can also play with visual pathways. It has evidence of disturbed binocularity …
a concern and should be given attention. It does not just threaten corneal changes
but can also play with visual pathways. It has evidence of disturbed binocularity …
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[HTML] Eye-Rubbing Detection Tool Using Artificial Intelligence on a Smartwatch in the Management of Keratoconus
I Drira, A Louja, L Sliman, V Soler, M Noor, A Jamali… - Translational Vision Science …, 2024
… of keratoconus has since been established by numerous studies. Some authors
have described eye rubbing in keratoconus patients as … We aimed to demonstrate
a novel solution for quantifying and preventing eye rubbing in patients with …
have described eye rubbing in keratoconus patients as … We aimed to demonstrate
a novel solution for quantifying and preventing eye rubbing in patients with …
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[HTML] Machine learning model for predicting corneal stiffness and identifying keratoconus based on ocular structures
L Li, Y Xiang, X Chen, D Lin, L Zhao, J Xiao, Z Lin… - Intelligent Medicine, 2024
Background Corneal stiffness abnormalities play an important role in the onset and
progression of keratoconus. However, the limited availability of specialty devices for
measuring corneal stiffness restricts their application in clinical practice. This study …
progression of keratoconus. However, the limited availability of specialty devices for
measuring corneal stiffness restricts their application in clinical practice. This study …
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[PDF] Case Report: Implantable Collamer Lens for Keratoconus with Splinter Cataract
D Aldahan, S AlHilali - International Medical Case Reports Journal, 2024
… Citation3 Eye rubbing, a known risk factor for keratoconus progression, generates
mechanical … Alternative treatments for keratoconus with coexisting cataracts, such
as keratoplasty or … This case report describes the successful implantation of an …
mechanical … Alternative treatments for keratoconus with coexisting cataracts, such
as keratoplasty or … This case report describes the successful implantation of an …
| | | |
[PDF] Case Report: Implantable Collamer Lens for Keratoconus with Splinter Cataract
D Aldahan, S AlHilali - International Medical Case Reports Journal, 2024
… Citation3 Eye rubbing, a known risk factor for keratoconus progression, generates
mechanical … Alternative treatments for keratoconus with coexisting cataracts, such
as keratoplasty or … This case report describes the successful implantation of an …
mechanical … Alternative treatments for keratoconus with coexisting cataracts, such
as keratoplasty or … This case report describes the successful implantation of an …
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Variation of Bruch's membrane opening in response to intraocular pressure change during scleral lens wear, in a population with keratoconus
L Michaud, S Balourdet, D Samaha - Ophthalmic & physiological optics: the journal of the …
Purpose The present study aimed to determine the potential impact of scleral lenses
on intraocular pressure (IOP) by analysing the Bruch's membrane opening-minimum
rim width (BMO-MRW) while the lenses are worn, in a population with keratoconus …
on intraocular pressure (IOP) by analysing the Bruch's membrane opening-minimum
rim width (BMO-MRW) while the lenses are worn, in a population with keratoconus …
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A novel combined oxidative stress and extracellular matrix related predictive gene signature for keratoconus
Z Cheng, J Hao, S Cai, P Feng, W Chen, X Ma, X Li - Biochemical and Biophysical …, 2024
… Oxidative stress (OS) and extracellular matrix (ECM) remodeling play critical roles
in keratoconus development. Here, based on keratoconus … signature showed
excellent performance for keratoconus prediction, providing beneficial perspectives …
in keratoconus development. Here, based on keratoconus … signature showed
excellent performance for keratoconus prediction, providing beneficial perspectives …
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Evaluation of indices for the assessment and classification of keratoconus based on optical coherence tomography and Scheimpflug technology
R Herber, J Lenk, L Ramm, D Wittig, MM Patzner… - … optics: the journal of the British …
Purpose To compare the parameters and indices of a novel swept-source optical
coherence tomography device (SS-OCT, ANTERION) with those of a rotating
Scheimpflug camera (RSC)-based tomograph (Pentacam) in normal and …
coherence tomography device (SS-OCT, ANTERION) with those of a rotating
Scheimpflug camera (RSC)-based tomograph (Pentacam) in normal and …
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Intraocular lens power calculation accuracy in patients with keratoconus: Network meta-analysis and systematic review
O Reitblat, R Sella, R Zlatkin, I Bahar, TT Lerman - Clinical & experimental ophthalmology
Background Accurate intraocular lens (IOL) calculation in eyes with keratoconus (KCN)
poses significant challenges. While various formulas, including KCN-specific ones,
have been investigated, the optimal calculation method remains inconclusive …
poses significant challenges. While various formulas, including KCN-specific ones,
have been investigated, the optimal calculation method remains inconclusive …
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Explainable XceptionNet-Based Keratoconus Detection Using Infrared Images and Edge Computing
K Devkar, S Arunkumar, T Bhakta, SR Bharadwaj… - IEEE Sensors Letters, 2024
… Abstract—Keratoconus is a progressive eye disease affecting the cornea,
potentially leading to … In this study, we utilized a customized explainable Xception
network for keratoconus detection. … Results show that the proposed approach is …
potentially leading to … In this study, we utilized a customized explainable Xception
network for keratoconus detection. … Results show that the proposed approach is …
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[PDF] A Unique Retinoscopic Reflex Pattern in the Initial Stages of Keratoconus and Its Clinical Significance for Early Keratoconus Detection: A Case Report
A Almaweri, A Almaweri Sr - Cureus, 2024
… This case report offers a novel clinical presentation that underscores the
diagnostic challenges in the initial stages of keratoconus, making it a … This study
presents a rare and practical model for the early detection of keratoconus. Early …
diagnostic challenges in the initial stages of keratoconus, making it a … This study
presents a rare and practical model for the early detection of keratoconus. Early …
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[PDF] Success Rates and Prognostic Factors in the Management of Keratoconus: A 10-Year Retrospective Cohort Study at Siriraj Hospital
A Thuangtong, T Phongsuphan - Siriraj Medical Journal, 2024
… The aim of this study research was to analyze the success rate of keratoconus
treatment at Siriraj Hospital, representing a Thai population, … keratoconus was
diagnosed in an eye with an early stage of keratoconus with undetectable clinical …
treatment at Siriraj Hospital, representing a Thai population, … keratoconus was
diagnosed in an eye with an early stage of keratoconus with undetectable clinical …
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Hyperopic Keratoconus, or Is This Something Else?
M Eiampikul, EJ Kaufman - International Journal of Keratoconus and Ectatic …, 2024
… The purpose of this paper is to describe a case of keratoconus with high hyperopia, a
condition typically associated with high myopia. This case led to the diagnosis of
nanophthalmos and possibly Leber's congenital amaurosis. … Lebers congenital …
condition typically associated with high myopia. This case led to the diagnosis of
nanophthalmos and possibly Leber's congenital amaurosis. … Lebers congenital …
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Advancing keratoconus treatment: the impact of bioengineered porcine constructs on corneal reshaping and visual acuity
M Khan, D Fatima - Eye, 2024
… Keratoconus, characterized by corneal thinning and steepening, significantly
impacts visual … most in need, addressing the increasing prevalence of
keratoconus in the region [6]. The … In conclusion, the BPCDX study offers a …
impacts visual … most in need, addressing the increasing prevalence of
keratoconus in the region [6]. The … In conclusion, the BPCDX study offers a …
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Changes of corneal densitometry in patients with keratoconus after corneal collagen cross-linking
LI Shuai, Y Gao, MA Limei, LI Rui, Y Qin, C Sun, Y Han… - International Eye Science, 2024
AIM: To observe the changes of corneal densitometry (CD) in patients with
keratoconus after corneal cross-linking (CXL). METHODS: Retrospective study. A
total of 32 patients (43 eyes) with keratoconus in Ningxia Eye Hospital from April …
keratoconus after corneal cross-linking (CXL). METHODS: Retrospective study. A
total of 32 patients (43 eyes) with keratoconus in Ningxia Eye Hospital from April …
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Socioeconomic and Demographic Disparities in Keratoconus Treatment
R Erukulla, M Soleimani, M Woodward, N Karnik… - American Journal of …
… Keratoconus (KCN) is estimated to have a prevalence ranging from 1:375 to 1:2000
globally. There has been conflicting results about whether prevalence is higher in
men or women. KCN has the highest prevalence in individuals from 18 to 39 years …
globally. There has been conflicting results about whether prevalence is higher in
men or women. KCN has the highest prevalence in individuals from 18 to 39 years …
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Safety and Efficacy of Posterior Chamber Phakic Implantable Collamer Lenses in Patients with Keratoconus: A Systematic Review and Meta-Analysis
AA Alkhabbaz, MH Karam, AS Pollmann, S Nath… - American Journal of …, 2024
Purpose To assess the safety and efficacy of phakic implantable collamer lenses (ICLs)
in patients with keratoconus. Design Systematic review and meta-analysis. Methods
We conducted a pre- and post-intervention single-arm systematic review and meta-analysis …
in patients with keratoconus. Design Systematic review and meta-analysis. Methods
We conducted a pre- and post-intervention single-arm systematic review and meta-analysis …
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[HTML] Cost-Effectiveness of Corneal Collagen Crosslinking for Progressive Keratoconus: A Brazilian Unified Health System Perspective
LO Hansen, R Garcia, AAM Torricelli, SJ Bechara - International Journal of …, 2024
Keratoconus is a burden to health systems and patients worldwide. Corneal
collagen … with the conventional treatment for progressive keratoconus from the
Brazilian Unified Health … a highly cost-effective intervention for progressive …
collagen … with the conventional treatment for progressive keratoconus from the
Brazilian Unified Health … a highly cost-effective intervention for progressive …
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Thickness Speed Progression Index (TSPI): Machine Learning Approach for Keratoconus Detection: Thickness-based machine learning model for KC detection
ST Awwad, B Hammoud, JF Assaf, L Asroui… - American Journal of …
… of 349 patients with normal, frank keratoconus (KC), and keratoconus suspect (KCS)
corneas. KCS corneas included topographically/tomographically normal (TNF) and
borderline fellow eyes (TBF) of patients with asymmetric keratoconus. Six …
corneas. KCS corneas included topographically/tomographically normal (TNF) and
borderline fellow eyes (TBF) of patients with asymmetric keratoconus. Six …
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[HTML] Machine learning methods to identify risk factors for corneal graft rejection in keratoconus
S Feizi, MA Javadi, K Bayat, M Arzaghi, A Rahdar… - Scientific Reports, 2024
… with graft rejection after corneal transplantation for keratoconus. The study
included all keratoconus eyes that underwent primary corneal … A total of 1214
consecutive eyes of 985 keratoconus patients were included in the study, and the …
included all keratoconus eyes that underwent primary corneal … A total of 1214
consecutive eyes of 985 keratoconus patients were included in the study, and the …
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[PDF] Corneal endothelial iayer changes in various stages of keratoconus and their correlation with topographic findings: a cross-sectional study
R Sorkhabi, S Asghari, A Arasteh, A Jafari, MH Ahoor - Med J Tabriz Uni Med …, 2024
Background. Keratoconus (KCN) is a multifactorial progressive corneal disease that
leads to significant disturbances in visual function. Various layers of the cornea,
such as the endothelium, are affected by this condition. This study aimed to evaluate …
leads to significant disturbances in visual function. Various layers of the cornea,
such as the endothelium, are affected by this condition. This study aimed to evaluate …
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Gender-specific Association of STON2 rs2371597 Polymorphism in Keratoconus patients of Saudi origin
AA Kondkar, T Sultan, TA Azad, T Khatlani, GP Lobo… - Frontiers in Genetics
Objective: To investigate the association of specific genetic polymorphisms (rs2371597
in STON2, rs11720822 in PDIA5, rs387907358 in WNT1, and rs77542162 in ABCA6)
in a Saudi cohort of keratoconus (KC) patients compared to controls.Methods: A …
in STON2, rs11720822 in PDIA5, rs387907358 in WNT1, and rs77542162 in ABCA6)
in a Saudi cohort of keratoconus (KC) patients compared to controls.Methods: A …
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[PDF] Comparison of Belin-Ambrosio between Normal and Keratoconus (KC) using Pentacam HR for Saudi's patients aged 6-21
H Alfarhan
Objectives: The research compels to compare between normal and KC corneas
using Belin-Ambrosio indices on Saudi's patients aged between 6-21 years in
Riyadh. This research helps differentiate normal from KC cornea. Method: The …
using Belin-Ambrosio indices on Saudi's patients aged between 6-21 years in
Riyadh. This research helps differentiate normal from KC cornea. Method: The …
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[PDF] Outcomes of Iontophoresis Cross-Linking in Asymmetric Keratoconus: A Retrospective Analysis of High Visual Acuity Eyes Under 25 Years Old
V Ferraro, F Santoru, G Barone, P Rosetta - Clinical Ophthalmology, 2024
… In this study, we included the fellow less advanced keratoconus eye of patients
with bilateral, asymmetric keratoconus under the age of 25 who underwent to CXL at
Humanitas San Pio X, Milan, Italy, between 2015 and 2020. As stated in Articles 6 …
with bilateral, asymmetric keratoconus under the age of 25 who underwent to CXL at
Humanitas San Pio X, Milan, Italy, between 2015 and 2020. As stated in Articles 6 …
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[HTML] Allergic disease and keratoconus: A two-sample univariable and multivariable Mendelian randomization study
H Xu, Y Wen, H Zheng, D Jiang, W Chen - World Allergy Organization Journal, 2024
Background There is accumulating evidence that allergy is a risk factor for
keratoconus. Nonetheless the association between allergic disease and
keratoconus remains controversial. We performed a two-sample Mendelian …
keratoconus. Nonetheless the association between allergic disease and
keratoconus remains controversial. We performed a two-sample Mendelian …
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Scleral lenses in corneal dystrophies, specifically keratoconus
M Tatiana
… lenses in the visual rehabilitation of individuals with keratoconus. Material and
Method. A … The mean severity score of keratoconus at initial assessment was 3.6 ±
1.0. The lenses used were … excellent safety and effectiveness of scleral contact …
Method. A … The mean severity score of keratoconus at initial assessment was 3.6 ±
1.0. The lenses used were … excellent safety and effectiveness of scleral contact …
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… and agreement of biometric measurements using spectral domain anterior segment optical coherence tomography and Scheimpflug tomography in keratoconus
Y Li, A Gokul, C McGhee, M Ziaei - PloS one, 2024
In Table 2, the data listed in the precison and repeatability column of Pentacam-AXL
under TCT (μm) Group A is incorrect. The correct precision is 5.84 and the
repeatability is 8.26. Also, the data listed in the ICC 95% Confidence Interval column …
under TCT (μm) Group A is incorrect. The correct precision is 5.84 and the
repeatability is 8.26. Also, the data listed in the ICC 95% Confidence Interval column …
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[HTML] Enhancing keratoconus detection with transformer technology and multi-source integration
O Ismael - Artificial Intelligence Review, 2025
… Keratoconus is a progressive eye disease characterized by the thinning and
conical … -stage keratoconus due to their subjective nature and limited scope. In
this research, we present a novel multi-source detection approach utilizing …
conical … -stage keratoconus due to their subjective nature and limited scope. In
this research, we present a novel multi-source detection approach utilizing …
| | | |
Aberrometry in the diagnosis and treatment of keratoconus
SI Anisimov, S Micovic, NS Anisimova - Vestnik oftalmologii, 2024
Keratoconus (KC) is a bilateral progressive disease that often begins in young
adulthood. Advanced KC significantly impairs patients' quality of life, making early
detection of the condition a critical goal for specialists. Early identification of KC …
adulthood. Advanced KC significantly impairs patients' quality of life, making early
detection of the condition a critical goal for specialists. Early identification of KC …
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[HTML] Intrastromal graft of anterior lens capsule. A substitute for Bowman layer graft transplantation for keratoconus
CA Rodríguez-Barrientos, A Translateur-Grynspan… - PloS one, 2024
Purpose The shortage of donor corneas limits Bowman layer transplantation for
keratoconus. In this study, we evaluate the clinical outcome of porcine anterior lens
capsule (xenograft) transplantation in the corneal stroma of a rabbit model as …
keratoconus. In this study, we evaluate the clinical outcome of porcine anterior lens
capsule (xenograft) transplantation in the corneal stroma of a rabbit model as …
| | | |
Intense pulsed light alleviates keratoconus by improving the local corneal microenvironment
Z Zhao, Y Liu, Y Zou, Y Liu, M Yu - Medical Hypotheses, 2024
Keratoconus (KC) is a corneal ectasia with a complex etiology, and its pathogenesis
remains incompletely understood. Research indicates that the development of KC is
closely linked to inflammation and local oxidative stress (OS) triggered by alterations …
remains incompletely understood. Research indicates that the development of KC is
closely linked to inflammation and local oxidative stress (OS) triggered by alterations …
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[PDF] Efficacy of the Keratoconus Risk Investigative Survey (KRIS) in Detecting Keratoconus in a Secondary School Population
ND CHAURASIA, VR Moodley, KP Mashige - 2024
(1) Background: Keratoconus (KC) is a progressive corneal disorder that begins in
adolescence and can lead to significant vision loss if undetected. Early identification
of at-risk individuals through efficient screening tools like Keratoconus Risk …
adolescence and can lead to significant vision loss if undetected. Early identification
of at-risk individuals through efficient screening tools like Keratoconus Risk …
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[HTML] Densitometry Changes After Corneal Collagen Cross-Linking With Riboflavin and UVA Light in Patients With Keratoconus
M Peskina, DA Kaufman, C O'Brien, A Miele, C Lym… - Cornea Open, 2024
… may lead to a greater flattening of the cornea in patients with more advanced
keratoconus. … of keratoconus, with post-CXL stabilization or reduction indicative of
treatment success. Our aim was to assess the impact of CXL on corneal steepness …
keratoconus. … of keratoconus, with post-CXL stabilization or reduction indicative of
treatment success. Our aim was to assess the impact of CXL on corneal steepness …
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[HTML] Double intrastromal corneal ring segment implantation: a new approach for improved clinical outcomes in keratoconus patients
S Coscarelli, R de Oliveira Sieiro, VM Fernandes… - International Journal of …, 2024
… implant in keratoconus patients. METHODS This retrospective single-arm cohort
study evaluated 25 eyes of 21 keratoconus patients implanted … of 2 different
ICRSs can efficiently regularize the cornea, reduce the SE, and improve visual …
study evaluated 25 eyes of 21 keratoconus patients implanted … of 2 different
ICRSs can efficiently regularize the cornea, reduce the SE, and improve visual …
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Total keratometry versus standard keratometry for intraocular lens power calculation in eyes with keratoconus
C Parra-Bernal, R Villaseñor-García… - International ophthalmology, 2024
… RPE in patients with keratoconus was < 1.00 D with all formulas. Barrett True-K
keratoconus with predicted PCA registered the lowest MAE and … Conclusions:
Barrett True-K for keratoconus showed the highest accuracy, closely followed by …
keratoconus with predicted PCA registered the lowest MAE and … Conclusions:
Barrett True-K for keratoconus showed the highest accuracy, closely followed by …
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Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case-Control Study Utilizing the All of Us Database
C Beatty, A Estes, H Xu, Y Liu - Translational vision science & technology, 2024
Purpose We aimed to identify clinical factors associated with keratoconus (KC) risk
in the All of Us database. Methods This retrospective matched case-control study
utilized patient data from the All of Us Research Program. All patients with a KC …
in the All of Us database. Methods This retrospective matched case-control study
utilized patient data from the All of Us Research Program. All patients with a KC …
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Assessment of ICD FlexFit Scleral Lens Fitting Characteristics and on Eye Performance in Patients with Keratoconus
Ö Gündüz, B Kılıç
… Fourteen patient eyes had stage IV, 1 patient eye had stage III, 5 patient eyes had
stage II, and 1 patient eye had stage I keratoconus according to Amsler Krumeich
classification. The mean uncorrected and corrected visual acuities were 1.15±0.46 …
stage II, and 1 patient eye had stage I keratoconus according to Amsler Krumeich
classification. The mean uncorrected and corrected visual acuities were 1.15±0.46 …
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Accelerated versus conventional corneal collagen cross-linking for keratoconus: A meta-analysis of randomized controlled trials
CY Yeh, KC Chen, YJ Chen, SF Cheng - European Journal of Ophthalmology, 2024
… This systematic review and meta-analysis compared ACXL with CCXL for
progressive keratoconus treatment by including RCTs and … comparing the two
CXL techniques for treating progressive keratoconus and a better understanding of …
progressive keratoconus treatment by including RCTs and … comparing the two
CXL techniques for treating progressive keratoconus and a better understanding of …
| | | |
Analysis of candidate variants in a Chinese family with monozygotic twins with keratoconus: a case report
C Song, K Wang, L Li, L Hu, J Bai, L Zhao, C Liu, S Li - Ophthalmic Genetics, 2024
Background Keratoconus (KC) is an asymmetrical bilateral corneal ectasia, of which
the pathogenesis is unknown. Moreover, genetic factors play an important role. We
reported ophthalmic findings in a Chinese family with monozygotic twins with KC to …
the pathogenesis is unknown. Moreover, genetic factors play an important role. We
reported ophthalmic findings in a Chinese family with monozygotic twins with KC to …
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[HTML] Advanced crosslinking for keratoconus and low-grade myopia
S Elving - 2024
Corneal crosslinking (CXL) is an established treatment for progressive keratoconus (KC).
In this thesis, Advanced CXL refers to a further development of conventional CXL,
which aims to improve the treatment outcomes in KC and can also be used as a …
In this thesis, Advanced CXL refers to a further development of conventional CXL,
which aims to improve the treatment outcomes in KC and can also be used as a …
| | | |
Developing and validating a comprehensive polygenic risk score to enhance keratoconus risk prediction
W He, U Võsa, T Palumaa, JS Ong, SD Torres… - Human Molecular Genetics, 2024
… While participants with thin corneas or low CRF may be particularly prone to
developing keratoconus, we show that including a PRS improves the prediction of
keratoconus risk and enables the risk stratification for keratoconus, over and above …
developing keratoconus, we show that including a PRS improves the prediction of
keratoconus risk and enables the risk stratification for keratoconus, over and above …
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The role of corneal epithelial thickness map in detecting early keratoconus
Z Wang, R Dong, Y Yuan, Y Zhang, Y Chen - Graefe's Archive for Clinical and …, 2024
… The corneal epithelial parameters play an important auxiliary role in the diagnosis
of keratoconus and the screening of subclinical keratoconus. Combination of
epithelial parameters and tomographic parameters can improve the sensitivity of …
of keratoconus and the screening of subclinical keratoconus. Combination of
epithelial parameters and tomographic parameters can improve the sensitivity of …
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Keratoconus: current diagnostic approach
LS Pateyuk - Journal of Clinical Practice, 2024
… Keratoconus is an ectatic … the keratoconus diagnosis, outlines current
approaches to patients examining and diagnostics results assessing. The clinical
manifestations (complaints, anamnesis data, visometry and autorefractokeratometry …
approaches to patients examining and diagnostics results assessing. The clinical
manifestations (complaints, anamnesis data, visometry and autorefractokeratometry …
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[HTML] Quantifying choroidal and retinal thicknesses variations via optical coherence tomography in different stages of pediatric keratoconus
A Mohammadi, N Masihpour, M Feghhi… - BMC Ophthalmology, 2024
Keratoconus (KCN) is characterized by corneal thinning and bulging, leading to
vision impairment. Assessing choroidal thickness (CT) in pediatric KCN ( pKCN)
patients can provide insights for better understanding and managing the disease …
vision impairment. Assessing choroidal thickness (CT) in pediatric KCN ( pKCN)
patients can provide insights for better understanding and managing the disease …
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[HTML] Artificial intelligence versus conventional methods for RGP lens fitting in keratoconus
J Abadou, S Dahan, J Knoeri, L Leveziel… - Contact Lens and Anterior …, 2024
… This retrospective study included 197 keratoconus eyes of 135 patients fitted with
Rose K2® (Menicon®, Nagoya, Japan) rigid contact lenses with one or more
topographies available (MS39®, CSO®, Ferrara, Italy) between January 2020 and …
Rose K2® (Menicon®, Nagoya, Japan) rigid contact lenses with one or more
topographies available (MS39®, CSO®, Ferrara, Italy) between January 2020 and …
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[PDF] A Novel Corneal Remodeling Technique of Laser Asymmetric Keratectomy in Keratoconus Suspect: A Retrospective Case Control Study
JS Min, BM Min - Clinical Ophthalmology, 2024
… Keratoconus suspect (KCS) has been one type of three earliest stage keratoconus.
Referring to the earliest stage keratoconus, three names were widely encountered in
the literature: forme fruste keratoconus (FFKC), preclinical or subclinical keratoconus …
Referring to the earliest stage keratoconus, three names were widely encountered in
the literature: forme fruste keratoconus (FFKC), preclinical or subclinical keratoconus …
R Herber, D Wittig, F Lochmann, LE Pillunat, F Raiskup - Translational Vision Science …, 2024
Purpose: The purpose of this study was to investigate corneal stiffening after
epithelium-off accelerated corneal cross-linking (CXL; 9 mW/cm²) in progressive
keratoconus (KC) with different methods of epithelial debridement. Methods: This …
epithelium-off accelerated corneal cross-linking (CXL; 9 mW/cm²) in progressive
keratoconus (KC) with different methods of epithelial debridement. Methods: This …
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[HTML] Effects and safety of combined corneal collagen crosslinking and intrastromal corneal ring segment treatment in patients with keratoconus: a retrospective study
A Dal, M Canleblebici, B Kutluksaman, M Erdağ - BMC Ophthalmology, 2024
… This study included 69 eyes of 69 patients with keratoconus who underwent ICRS
and CXL treatment at an Eye Hospital between March 2020 and March 2023. The
patients were divided into two groups: Group 1 (n = 33 eyes of 33 patients), which …
and CXL treatment at an Eye Hospital between March 2020 and March 2023. The
patients were divided into two groups: Group 1 (n = 33 eyes of 33 patients), which …
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Detection and understanding the role of Ultraviolet Radiation in Keratoconus
A Taher - 2024
… early keratoconus and to provide a framework for investigating the role of
ultraviolet radiation in the pathogenesis of keratoconus. Methods … Conclusion The
Belin Ambrósio enhanced ectasia display had the highest discriminative power in …
ultraviolet radiation in the pathogenesis of keratoconus. Methods … Conclusion The
Belin Ambrósio enhanced ectasia display had the highest discriminative power in …
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[PDF] Prevalence of Keratoconus and Keratoconus Suspect among a sample of Iraqi Children with Refractive Errors: A Cross-Sectional Study
AS Rashak, NA Abdulateef, S Abdulkareem - Al-Rafidain Journal of Medical Sciences …, 2024
Background: Keratoconus (KC) is a chronic, bilateral, non-inflammatory
degenerative condition with severe consequences. Objective: To assess the
prevalence of KC and Keratoconus Suspect (KCS) in a pediatric population with …
degenerative condition with severe consequences. Objective: To assess the
prevalence of KC and Keratoconus Suspect (KCS) in a pediatric population with …
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Evaluating the reliability of the responses of large language models to keratoconus-related questions
M Kayabaşı, S Köksaldı, C Durmaz Engin - Clinical and Experimental Optometry, 2024
Clinical relevance Artificial intelligence has undergone a rapid evolution and large
language models (LLMs) have become promising tools for healthcare, with the
ability of providing human-like responses to questions. The capabilities of these …
language models (LLMs) have become promising tools for healthcare, with the
ability of providing human-like responses to questions. The capabilities of these …
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[PDF] Prevalence and demographic pro le of keratoconus among high school students in Kenya
ZA Rashid, VR Moodley, KP Mashige
… Keratoconus (KC) is a corneal disorder that usually presents in adolescence. The
prevalence of KC in Western countries [1–6] and North and East Asia [7–10] is
generally < 1.3% with one exception where Chan et al. [11] recently reported a …
prevalence of KC in Western countries [1–6] and North and East Asia [7–10] is
generally < 1.3% with one exception where Chan et al. [11] recently reported a …
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Keratoconus
RB Singh, S Koh, N Sharma, FA Woreta, F Hafezi… - Nature Reviews Disease …, 2024
… Interestingly, in a study in Lebanon, 12% of patients with keratoconus had a
family history of keratoconus, and eye rubbing was not an … of association between
keratoconus and eye rubbing 52,89 . Thus, a two-hit model has been suggested for …
family history of keratoconus, and eye rubbing was not an … of association between
keratoconus and eye rubbing 52,89 . Thus, a two-hit model has been suggested for …
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[HTML] Visual rehabilitation using rigid gas permeable contact lenses after femtosecond laser-assisted minimally invasive lamellar keratoplasty in patients with keratoconus
J Zhang, X Lin, Z Li, X Zhong, W Shi, X Du, H Gao - Scientific Reports, 2024
This study aims to observe the clinical efficacy and safety of rigid gas permeable
corneal contact lenses (RGP-CLs) wearing after femtosecond laser-assisted
minimally invasive lamellar keratoplasty (FL-MILK) in progressive and advanced …
corneal contact lenses (RGP-CLs) wearing after femtosecond laser-assisted
minimally invasive lamellar keratoplasty (FL-MILK) in progressive and advanced …
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[HTML] Evaluation of parameters for early detection of pediatric keratoconus
SH Zhao, C Berkowitz, H Ralay Ranaivo, K Laurenti… - BMC ophthalmology, 2024
Background Keratoconus in children is often more severe and rapidly progressive
compared to adults. While Scheimpflug imaging (Pentacam) improves screening,
there are no established pediatric guidelines. Due to challenges in diagnosis, we …
compared to adults. While Scheimpflug imaging (Pentacam) improves screening,
there are no established pediatric guidelines. Due to challenges in diagnosis, we …
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[HTML] Impact of Keratoconus on Contrast Sensitivity
LY Zhen, FS Barodawala - Journal of Health Science and Medical Research, 2024
Objective: Keratoconus (KC) disrupts corneal shape, leading to irregular
astigmatism and increased higher-order aberrations (HOA), ultimately affecting
visual quality. While visual acuity (VA) remains the standard, its limitations in early …
astigmatism and increased higher-order aberrations (HOA), ultimately affecting
visual quality. While visual acuity (VA) remains the standard, its limitations in early …
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Retraction Note: Detection and evaluation of Keratoconus (corneal topography) by using the image classifier techniques
R Kanimozhi, R Gayathri - 2024
Retraction Note: Detection and evaluation of Keratoconus (corneal topography) by
using the image classifier techniques | Soft Computing … Retraction Note: Detection
and evaluation of Keratoconus (corneal topography) by using the image classifier …
using the image classifier techniques | Soft Computing … Retraction Note: Detection
and evaluation of Keratoconus (corneal topography) by using the image classifier …
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[HTML] Late corneal ectasia after penetrating and deep anterior lamellar keratoplasty for keratoconus
B Yüksel, AE Kocakaya, T Küsbeci, F Gümüş - International Journal of …, 2024
… keratoconus recurrence in the donor button, progression of keratoconus in the
host rim with consequent graft-host interface thinning and misalignment, or less likely;
grafting a donor cornea with undiagnosed keratoconus… late ectasia after …
host rim with consequent graft-host interface thinning and misalignment, or less likely;
grafting a donor cornea with undiagnosed keratoconus… late ectasia after …
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[HTML] Comparison of the quantitative contrast sensitivity function between early keratoconus and normal eyes
Y Xian, Y Ye, L Sun, Y Shen, X Zhang, ZL Lu, X Zhou… - BMC Ophthalmology, 2024
To compare the characteristics of the quantitative contrast sensitivity function (qCSF)
in eyes with early keratoconus (Early-KC) and normal control (NC) eyes and
investigate the associated factors. A cross-sectional study. This study included 43 …
in eyes with early keratoconus (Early-KC) and normal control (NC) eyes and
investigate the associated factors. A cross-sectional study. This study included 43 …
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[HTML] Computational approaches for identifications of altered ion channels in keratoconus
KB Gaikwad, JS Babu, KTS Parthasarathi, J Narayanan… - Eye, 2024… give crucial information to understand keratoconus aetiology [26, 27]. There is no
study to the best of our knowledge that describes alterations in ion channels in
patients with keratoconus. Here, the transcriptome of patients with keratoconus was …
study to the best of our knowledge that describes alterations in ion channels in
patients with keratoconus. Here, the transcriptome of patients with keratoconus was …
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[HTML] Agreement in anterior segment measurements between swept-source optical coherence and dual Scheimpflug tomography devices in keratoconus eyes
Y Lee, JY Oh, HJ Choi, MK Kim, CH Yoon - Scientific Reports, 2024… This study analyzed the agreement between Casia 2 and Galilei G6 in
keratoconus. For most parameters used to diagnose keratoconus and assess
disease progression, the agreement between the two devices was not excellent and …
keratoconus. For most parameters used to diagnose keratoconus and assess
disease progression, the agreement between the two devices was not excellent and …
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[HTML] Tear levels of apoptotic, matrix-degrading and antioxidant biomarkers in patients with and without keratoconus: A cross sectional study
AM Roszkowska, U Camellin, F Franchina… - Contact Lens and Anterior Eye… keratoconus and 33 were age-matched healthy subjects. The linear combination
of the three tear biomarkers levels (AUC = 0.811; CI 95 %: 0.712–0.911) accurately
indicated the existence of keratoconus; … ) were significantly associated with a …
of the three tear biomarkers levels (AUC = 0.811; CI 95 %: 0.712–0.911) accurately
indicated the existence of keratoconus; … ) were significantly associated with a …
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[PDF] Patient evaluated economic impact of keratoconus in New Zealand
L Angelo, A Gokul, I Samuels, CNJ McGhee, M Ziaei - Clinical and Experimental …, 2024… by keratoconus subjects, to estimate the lifetime per capita cost and the total costs
of keratoconus per year in Auckland, New Zealand. … the total out-of-pocket spend
for keratoconus is less in New Zealand despite having a higher prevalence of …
of keratoconus per year in Auckland, New Zealand. … the total out-of-pocket spend
for keratoconus is less in New Zealand despite having a higher prevalence of …
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[PDF] Keratoconus: modern diagnostic approach
L Pateyuk - Journal of Clinical Practice, 2024… Keratoconus is an ectatic … the keratoconus diagnosis, outlines current
approaches to patients examining and diagnostics results assessing. The clinical
manifestations (complaints, anamnesis data, visometry and autorefractokeratometry …
approaches to patients examining and diagnostics results assessing. The clinical
manifestations (complaints, anamnesis data, visometry and autorefractokeratometry …
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Thyroid gland dysfunction and keratoconus
OM Said, M Iqbal, A El-Massry, ME Elgharieb, M Mady… - … hypothesis discovery and …, 2024… Background: The association between keratoconus and thyroid gland dysfunction
(TGD) remains controversial. We aimed to determine the frequency of keratoconus
among patients with laboratory-confirmed, treatment-naive TGD compared with that …
(TGD) remains controversial. We aimed to determine the frequency of keratoconus
among patients with laboratory-confirmed, treatment-naive TGD compared with that …
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After all, Doctor: Does my Child have Keratoconus or Not?
FBD Da Silva - Highlights of Ophthalmology, 2024Establishing the diagnosis of a disease that can impact the vision and life of a
patient (such as keratoconus) is a moment of great responsibility. Therefore,
ophthalmology has been looking for to integrate the results provided by the most …
patient (such as keratoconus) is a moment of great responsibility. Therefore,
ophthalmology has been looking for to integrate the results provided by the most …
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[HTML] Optimizing UV-A Irradiation Profiles in Crosslinking for Keratoconus: Comparison of Outcomes After Standard Accelerated and Topography-Guided Protocols
T Cortinhal, J Gil, A Rosa, MJ Quadrado, J Murta - Revista Sociedade Portuguesa de …, 2024INTRODUÇÃO: O objetivo do presente estudo é comparar resultados refrativos e
tomográficos do crosslinking corneano no queratocone, utilizando laser excimer
para remoção do epitélio e irradiação central uniforme (C-CXL) ou irradiação …
tomográficos do crosslinking corneano no queratocone, utilizando laser excimer
para remoção do epitélio e irradiação central uniforme (C-CXL) ou irradiação …
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Pediatric Keratoconus
Y Gupta, C Devi, K Priyadarshini, S Mandal, R Tandon… - Survey of Ophthalmology, 2024
Keratoconus is a common pediatric corneal disease, leading to vision impairment
and amblyopia. Compared to its adult counterpart, pediatric keratoconus has an
advanced presentation, rapid progression, higher incidence of complications such …
and amblyopia. Compared to its adult counterpart, pediatric keratoconus has an
advanced presentation, rapid progression, higher incidence of complications such …
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[HTML] Cessation of contact lenses prior to corneal tomography for keratoconus monitoring: results from a clinician survey
C McAlinden, D Lockington - Eye, 2024
… Corneal tomography is essential in diagnosing and monitoring corneal ectasias,
including keratoconus. Monitoring may be necessary to … precision is more
challenging in eyes with keratoconus [2]. Visual improvement in eyes keratoconus is …
including keratoconus. Monitoring may be necessary to … precision is more
challenging in eyes with keratoconus [2]. Visual improvement in eyes keratoconus is …
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[HTML] Mendelian randomization reveals that abnormal lipid metabolism mediates the causal relationship between body mass index and keratoconus
J Wang, F Liu, D Gong, J Su, F Zheng, S Ding, J Mo… - Scientific Reports, 2024
Previous studies suggest that a high body mass index (BMI) may be a risk factor for
keratoconus (KC), but the causal relationship remains unclear. This study used
Mendelian randomization (MR) to investigate this connection and explore the …
keratoconus (KC), but the causal relationship remains unclear. This study used
Mendelian randomization (MR) to investigate this connection and explore the …
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Air Pollution and the Prevalence of Keratoconus: Is There a Connection?
T Jurkiewicz, AS Marty - Ophthalmic Epidemiology, 2024
… Keratoconus is a progressive, asymmetrical corneal ectasia with multifactorial
origin. Three identified risk factors for keratoconus include … Other factors like
pollution would play a role in the physiopathology of keratoconus. In this study we …
origin. Three identified risk factors for keratoconus include … Other factors like
pollution would play a role in the physiopathology of keratoconus. In this study we …
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Transcriptomic analysis of Keratoconus in Han Chinese patients: Insights into differential gene expression and ethnic-specific patterns
Y Li, Y Dai, J Xu, J Zhang - Experimental Eye Research, 2024
Keratoconus (KC) is a progressive corneal ectatic disorder with a high prevalence
among Asians. This study aimed to explore the differential gene expression patterns
in Han Chinese patients with KC, focusing on mRNAs and long noncoding RNAs (lncRNAs) …
among Asians. This study aimed to explore the differential gene expression patterns
in Han Chinese patients with KC, focusing on mRNAs and long noncoding RNAs (lncRNAs) …
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Experimental Models for Keratoconus: Insights and challenges
S Shankar, R Deshmukh, T Pingali, R Sonar, S Basu… - Experimental Eye Research, 2024
… Keratoconus, a progressive corneal disorder characterized by the thinning and
conical protrusion of the cornea because of collagen degradation, poses significant
challenges to patients and clinicians. Most successful animal models in keratoconus …
conical protrusion of the cornea because of collagen degradation, poses significant
challenges to patients and clinicians. Most successful animal models in keratoconus …
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[HTML] Comparison of a Scheimpflug imaging with other screening indices in diagnosing keratoconus and keratoconus suspect
Y Huo, R Xie, X Chen, S Li, H Zou, Y Liu, Y Wang - Scientific Reports, 2024
Keratoconus (KC) is an irreversible blinding eye disease; therefore, early screening
of KC suspects (KCS) is crucial for protecting patients' quality of life. Scheimpflug
imaging is a commonly used screening device in clinical practice. We aimed to …
of KC suspects (KCS) is crucial for protecting patients' quality of life. Scheimpflug
imaging is a commonly used screening device in clinical practice. We aimed to …
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[HTML] Inflammatory and genomic interactions within keratoconus susceptible patients: a nationwide registered case–control study
F Doroodgar, F Alizadeh, S Niazi, SM Razavi, N Jalilian… - Eye and Vision, 2024
Purpose This study aimed to investigate the association between variants in the
interleukin (IL)-1 gene cluster and susceptibility to keratoconus (KC) in an Iranian
population. Methods In the case group, there were 188 KC patients diagnosed by …
interleukin (IL)-1 gene cluster and susceptibility to keratoconus (KC) in an Iranian
population. Methods In the case group, there were 188 KC patients diagnosed by …
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Associations between endothelial cell characteristics and corneal topography findings in different stages of keratoconus
AH Reyhan, AS Karadağ, A Şimşek - International Ophthalmology, 2024
… This study aimed to compare and correlate specular microscope indices and
corneal topography indices in different stages of keratoconus… progression of
keratoconus. It appears that as keratoconus index values increase, NUM may …
corneal topography indices in different stages of keratoconus… progression of
keratoconus. It appears that as keratoconus index values increase, NUM may …
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[PDF] One-Year Results of a Posterior Chamber Toric Phakic Intraocular Lens Implantation in Patients with Keratoconus
K Balparda, M Escobar Giraldo, YM Valencia Gómez… - Clinical Ophthalmology, 2024
Purpose To determine clinical and refractive results after the implantation of EyeCryl
Phakic Toric intraocular lens in patients with stable keratoconus. Methods The study
included all patients diagnosed with keratoconus who underwent implantation of an …
Phakic Toric intraocular lens in patients with stable keratoconus. Methods The study
included all patients diagnosed with keratoconus who underwent implantation of an …
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Keratoconus classification using a novel convolutional neural network architecture and corneal curvature maps
LO de Oliveira, FM de Carvalho Taguchi… - Applications of Machine …, 2024
… keratoconus, 91.24% for keratoconus, and 99.58% for severe keratoconus).
Additionally, the model achieved AUC scores of 0.97, 0.92, 0.90, 0.98, and 0.94 for
normal eye, suspect eye, subclinical keratoconus, keratoconus, and severe …
Additionally, the model achieved AUC scores of 0.97, 0.92, 0.90, 0.98, and 0.94 for
normal eye, suspect eye, subclinical keratoconus, keratoconus, and severe …
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Enhanced keratoconus care through optometry-led services at the West of England Eye Unit, Exeter
J Isaac, E Tutchings, Z Smith, L Isaac, C Newitt, A Loft… - Eye, 2024
… -led' keratoconus (KC) management at The Birmingham and Midland Eye Centre (BMEC)
[1]. … 2: Flowchart depicting outcomes of new suspect keratoconus referrals into the
new optometry … -led KC service provides a prompt and holistic approach to …
[1]. … 2: Flowchart depicting outcomes of new suspect keratoconus referrals into the
new optometry … -led KC service provides a prompt and holistic approach to …
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[PDF] Change in Tear Layer Thickness under Scleral Contact Lenses in Keratoconus Patients and Normal Cornea Volunteers
A Thuangtong, N Taetrongchit, R Kemahayung - Siriraj Medical Journal, 2024
Objective: To quantify rate of post-lens tear thickness change under scleral contact
lenses in keratoconus patients and normal cornea volunteers. Materials and
Methods: We conducted a prospective observational study where semi-scleral …
lenses in keratoconus patients and normal cornea volunteers. Materials and
Methods: We conducted a prospective observational study where semi-scleral …
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[PDF] Efficacy of KeraVio with Irradiation via Violet Light-Emitting Glasses without the Administration of Riboflavin Drops for Progressive Keratoconus Treatment
H Kobashi, T Kumanomido, T Ide, N Kato, J Shimazaki… - 2024
KeraVio is a new portable corneal cross-linking (CXL) treatment modality in which
violet light (VL)-emitting spectacles are used along with topical transepithelial
riboflavin. We preliminarily identified endogenous riboflavin in the human cornea …
violet light (VL)-emitting spectacles are used along with topical transepithelial
riboflavin. We preliminarily identified endogenous riboflavin in the human cornea …
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Is there a relationship between the keratoconus and the peripapillary choroidal vasculature?
K Gahramanov, M Unlu, F Ozer, H Sener, K Erkilic - International Ophthalmology, 2024
Purpose To evaluate the peripapillary/parapapillary choroidal vascular parameters
in the keratoconus (KC) and to determine the relationship between topography
parameters and the peripapillary/parapapillary choroidal vascular parameters …
in the keratoconus (KC) and to determine the relationship between topography
parameters and the peripapillary/parapapillary choroidal vascular parameters …
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[HTML] Save Sight Keratoconus Registry Study: Transepithelial versus Epithelium-off Corneal Crosslinking
GA Borchert, H Kandel, A Gupta, JY Chen, Y Kerdraon… - AJO International, 2024
Purpose Corneal collagen crosslinking (CXL) is the primary treatment for
progressive keratoconus and can be performed with the epithelium on or off.
Evidence is needed to guide clinicians and patients on whether they should have …
progressive keratoconus and can be performed with the epithelium on or off.
Evidence is needed to guide clinicians and patients on whether they should have …
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[PDF] A Theoretical Approach for Diagnosing Keratoconus Using Purkinje Image Geometry: An Accessible Method for Low-Cost and Early Detection
M Sharifzadeh - 2024
… keratoconus severity, with higher scores indicating greater deviation from normal
corneal profiles. Conclusions: This study presents a promising, low-cost approach to
diagnosing keratoconus … diagnostic tool for early keratoconus detection …
corneal profiles. Conclusions: This study presents a promising, low-cost approach to
diagnosing keratoconus … diagnostic tool for early keratoconus detection …
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[PDF] Reliability of Scheimpflug versus anterior segment optical coherence tomography after epithelial_off crosslinking in keratoconus
H Elgazzar, AS Mostafa, TK Eleiwa, KM Elgabry - Benha Medical Journal, 2024
… Second, these topography-based techniques have trouble differentiating between
keratoconus … These may cause false diagnosis of keratoconus or potential to hide
real keratoconus. … each keratoconus grade, and there was excellent reliability for …
keratoconus … These may cause false diagnosis of keratoconus or potential to hide
real keratoconus. … each keratoconus grade, and there was excellent reliability for …
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[PDF] Keratoconus Disease Prediction by Utilizing Feature-Based Recurrent Neural Network
SH Musa, QJM Alhaidar, MMB Elmi
… for detecting Keratoconus from clinical … with keratoconus six and twelve months
after the Kraring ring implantation using RNN are 9.82% and 9.29%, respectively.
The average error of estimating characteristics of predicting the visual characteristics …
after the Kraring ring implantation using RNN are 9.82% and 9.29%, respectively.
The average error of estimating characteristics of predicting the visual characteristics …
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[HTML] EyeWorld Journal Club review:"Prediction of the small aperture intraocular lens on visual acuity in patients with keratoconus"
R Wallace, S Gupta
Methods This study was a retrospective chart review of all patients with keratoconus
seen at Storm Eye Institute, Medical University of South Carolina between July 2016
and October 2022. The IC-8 Apthera IOL received pre-market approval from the FDA …
seen at Storm Eye Institute, Medical University of South Carolina between July 2016
and October 2022. The IC-8 Apthera IOL received pre-market approval from the FDA …
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Comment on: intraocular pressure after combined photorefractive keratectomy and corneal collagen cross linking for keratoconus
SK Chaurasiya, R Ray, M Singh - International Ophthalmology, 2024
… Ethnic and genetic factors can influence the presentation and progression of eye
conditions like keratoconus [3]… keratoconus. This information can be valuable for
understanding the impact of surgical procedures on IOP and guiding clinical …
conditions like keratoconus [3]… keratoconus. This information can be valuable for
understanding the impact of surgical procedures on IOP and guiding clinical …
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Trio-based whole-exome sequencing of 200 Chinese patients with keratoconus
X Li, Y Yao, S Xing, YH Zheng, Y Zhou, X Yu, J Su… - Experimental Eye Research, 2024
… in 200 patients with sporadic keratoconus and their unaffected parents. The
variants identified in candidate genes for keratoconus were analyzed using multiple
bioinformatics tools. Finally, we identified 7 variants in 5 candidate genes for …
variants identified in candidate genes for keratoconus were analyzed using multiple
bioinformatics tools. Finally, we identified 7 variants in 5 candidate genes for …
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[PDF] Harnessing Corneal Stromal Regeneration for Vision Restoration: A Comprehensive Review of the Emerging Treatment Techniques for Keratoconus
Z Javed, S Daigavane - Cureus, 2024
Keratoconus is a progressive corneal disorder characterized by thinning and conical
protrusion, leading to visual impairment that often necessitates advanced treatment
strategies. Traditional management options, including corrective lenses, corneal …
protrusion, leading to visual impairment that often necessitates advanced treatment
strategies. Traditional management options, including corrective lenses, corneal …
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Depression among Keratoconus (KC) Patients: A Systematic Review and Meta-Analysis
R Moshfeghinia, A Arman, N Sobhi… - Frontiers in Public Health
Background: Keratoconus (KC) is a chronic corneal disease that typically presents in
early adulthood, and may potentially result in poor mental health in affected
individuals. The evidence regarding the association of depression with KC is …
early adulthood, and may potentially result in poor mental health in affected
individuals. The evidence regarding the association of depression with KC is …
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