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Combined approach to cataract surgery in keratoconus
YN Yusef, GA Osipyan, K Khraystin, VV Averich… - Vestnik oftalmologii, 2024
Preparation for cataract surgery in patients with keratoconus (KC) is associated with
particular challenges: calculating the optical power of the intraocular lens (IOL),
selecting the appropriate IOL model, and considering additional interventions aimed …
particular challenges: calculating the optical power of the intraocular lens (IOL),
selecting the appropriate IOL model, and considering additional interventions aimed …
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[PDF] Tinjauan Sistematis Hubungan Diabetes Mellitus dengan Keratoconus
A Shafi, T Ahmad, K Satari - Oftalmologi Jurnal Kesehatan Mata Indonesia, 2024
… keratoconus in the current review. There are still conflicting results which support
and against diabetes mellitus correlation to keratoconus. … diabetes mellitus ini
terhadap angka kejadian keratoconus dan derajat keparahan yang membahas …
and against diabetes mellitus correlation to keratoconus. … diabetes mellitus ini
terhadap angka kejadian keratoconus dan derajat keparahan yang membahas …
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[PDF] Postoperative corneal remodeling after corneal allograft intrastromal ring segment (CAIRS) implantation for keratoconus: An OCT study
B Yakut, C Tanriverdi, FFNK Perk, SA Nacaroglu… - Indian Journal of …, 2024
… [10‑13] Given the importance of corneal remodeling in keratoconus treatment, this
study aims to evaluate the changes in corneal epithelial and stromal thicknesses
after CAIRS implantation by using anterior‑segment optical coherence tomography (AS‑OCT) …
study aims to evaluate the changes in corneal epithelial and stromal thicknesses
after CAIRS implantation by using anterior‑segment optical coherence tomography (AS‑OCT) …
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Quality and readability of online information on Keratoconus in Portugal and Brazil
C Costa, RS Oliveira, J Gil, E Costa, C Tavares, A Rosa… - European Journal of …, 2024
… We aim to evaluate the quality and readability of the online information regarding
keratoconus in Portugal and Brazil. … of keratoconus (for eg: we excluded an article
on topography-guided cross-linking outcomes but didn't exclude a thesis on general …
keratoconus in Portugal and Brazil. … of keratoconus (for eg: we excluded an article
on topography-guided cross-linking outcomes but didn't exclude a thesis on general …
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[HTML] Custom-shaped CAIRS for personalized treatment of Keratoconus
S Jacob - Indian Journal of Ophthalmology, 2025
Corneal allogeneic intrastromal ring segments (CAIRS) refer to intracorneal
placement of allogeneic ring segments of any type, eg, fresh, unprocessed,
processed, preserved, or packaged segments with or without shelf‑life.[1‑10] Both …
placement of allogeneic ring segments of any type, eg, fresh, unprocessed,
processed, preserved, or packaged segments with or without shelf‑life.[1‑10] Both …
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[PDF] The role of ego-resiliency in patients with keratoconus
S Florek, P Gościniewicz, P Dębski…
… keratoconus with psychiatric disorders. None of these address the role of ego-resiliency,
which may prove crucial in coping with chronic illness. MATERIAL AND METHODS:
74 participants with keratoconus … role of ER among patients with keratoconus in …
which may prove crucial in coping with chronic illness. MATERIAL AND METHODS:
74 participants with keratoconus … role of ER among patients with keratoconus in …
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Automated feature selection for early keratoconus screening optimization
A Chaari, IF Kallel, H Daoud, I Omri, S Kammoun… - Biomedical Physics & …, 2024
In this paper, an automated feature selection (FS) method is presented to optimize
machine learning (ML) models' performances, enhancing early keratoconus
screening. A total of 448 parameters were analyzed from a dataset comprising 3162 …
machine learning (ML) models' performances, enhancing early keratoconus
screening. A total of 448 parameters were analyzed from a dataset comprising 3162 …
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U-shaped Association Between Residential Greenness and Keratoconus
L Li, W Cheng, W Wang, G Dong, L Liang - Environmental Research, 2024
Keratoconus is a blinding corneal disorder influenced by genetic factors. Whether
environmental factors influence it remains unclear. Here, we observed a U-shaped
association between residential greenness and keratoconus, with increased odds …
environmental factors influence it remains unclear. Here, we observed a U-shaped
association between residential greenness and keratoconus, with increased odds …
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[HTML] Eccentric Pathology in Keratoconus Exhibits Stiffer Biomechanical Response Than Central Pathology
CD Bruner, AM Mahmoud, CJ Roberts - Ophthalmology Science, 2024
… Corneal stiffness increases as the distance of the cone from the center increases,
consistent with focal nature of keratoconus. Central stiffness decreases as cone
curvature (disease severity) increases. It is recommended to use zonal values with …
consistent with focal nature of keratoconus. Central stiffness decreases as cone
curvature (disease severity) increases. It is recommended to use zonal values with …
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[HTML] Clinical outcomes of two symmetrical Kera-rings implanted in grade three keratoconus: a retrospective nonrandomized study
A Mounir, I Awny, I Amer, A Mahmoud, EAM Mossa - BMC Ophthalmology, 2024
To evaluate the clinical outcomes of implanting two symmetrical Kerarings via a
femtosecond laser in grade three keratoconus. This was a retrospective
nonrandomized controlled clinical study. The study included one eye from each of …
femtosecond laser in grade three keratoconus. This was a retrospective
nonrandomized controlled clinical study. The study included one eye from each of …
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[PDF] Superior Keratoconus in Attention-Deficit Hyperactivity Disorder (ADHD): A Case Report and Literature Review
E Assayag, D Zadok, M Carmel, A Abulafia, Y Weill - Cureus, 2024
Keratoconus is a progressive corneal ectasia that may lead to severe visual
impairment. Superior keratoconus (SK) is an uncommon form of the disease, and
few cases have been reported thus far. We present an unusual SK case and a …
impairment. Superior keratoconus (SK) is an uncommon form of the disease, and
few cases have been reported thus far. We present an unusual SK case and a …
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A Finite Element Approach Towards Patient-Specific Biomechanical Modeling of Keratoconus
NT SALIM - 2024
Keratoconus (KC) is a progressive corneal disorder characterized by corneal
thinning, weakening, and conical deformation, which severely impairs vision.
Accurate biomechanical modeling is essential for understanding the progression of …
thinning, weakening, and conical deformation, which severely impairs vision.
Accurate biomechanical modeling is essential for understanding the progression of …
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[PDF] Co-occurrence of Kimura's Disease and Keratoconus: A Case Report
SMA Alosaimi, HMN Ali, AK Alshaibani - International Journal of Scientific Research …, 2024… Keratoconus is a disorder where both corneas get steeper and vision is reduced.
It is not … The diagnosis of Keratoconus was verified by the examination of the
topography. Considering … of Kimura disease, specifically in relation to keratoconus …
It is not … The diagnosis of Keratoconus was verified by the examination of the
topography. Considering … of Kimura disease, specifically in relation to keratoconus …
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[PDF] A Case of Infectious Keratitis Associated with Rigid Gas Permeable Contact Lens Use in a Keratoconus Patient
H Salam, R Wati - Bioscientia Medicina: Journal of Biomedicine and …, 2024… keratoconus; however, improper use can lead to complications such as infectious
keratitis. Case presentation: We present a case of a 25-year-old female with
keratoconus … The patient was diagnosed with bilateral keratoconus, bilateral …
keratitis. Case presentation: We present a case of a 25-year-old female with
keratoconus … The patient was diagnosed with bilateral keratoconus, bilateral …
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[PDF] AI-Based Vision Screening Tool for Keratoconus
R Rahman, P Kumar, YK Sharma, M Sharma… - Anuradha Tomar Sukumar Mishra …Keratoconus affects millions of people all over the globe, and the threat of disease is
a concern and should be given attention. It does not just threaten corneal changes
but can also play with visual pathways. It has evidence of disturbed binocularity …
a concern and should be given attention. It does not just threaten corneal changes
but can also play with visual pathways. It has evidence of disturbed binocularity …
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Effects of customized corneal cross-linking on higher-order aberrations in progressive keratoconus and low-grade myopia
J Hayek, A Viberg, S Elving, A Fredriksson, A Behndig - Acta ophthalmologicaObjective To evaluate the effects of customized corneal collagen cross-linking (CXL)
on higher-order aberrations (HOAs) in keratoconus (KC): vertical coma (VC),
horizontal coma (HC), spherical aberration (SA), trefoil (TF) and astigmatism …
on higher-order aberrations (HOAs) in keratoconus (KC): vertical coma (VC),
horizontal coma (HC), spherical aberration (SA), trefoil (TF) and astigmatism …
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[HTML] Characteristics of corneal aberration in patients with bilateral keratoconus and unilateral corneal Vogt's striae
SS Wei, Y Li, ZQ Wu, JG Liu, J Du, J Li, YH Zhang - International Journal of …, 2024
AIM To assess the corneal high-order aberration (HOA) and its correlation with
corneal morphological parameters in patients with bilateral keratoconus (KCN) and
unilateral Vogt's striae. METHODS A total of 168 eyes of 84 patients with KCN …
corneal morphological parameters in patients with bilateral keratoconus (KCN) and
unilateral Vogt's striae. METHODS A total of 168 eyes of 84 patients with KCN …
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Effect of Corneal vs Scleral Rigid Gas Permeable (RGP) Lenses on corneal curvature and thickness in patients of Keratoconus
AEK Niazi, S Anwar, S Fatima, AH Shahid, M Ali - Medical Journal of South Punjab, 2024
Objective: To investigate the changes in corneal curvature and thickness in patients
of Keratoconus, wearing Rose k2 corneal and XL (scleral lenses) from last three
months. Methodology: Interventional study was conducted at The Keratoconus Clinic …
of Keratoconus, wearing Rose k2 corneal and XL (scleral lenses) from last three
months. Methodology: Interventional study was conducted at The Keratoconus Clinic …
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[PDF] … biomechanical parameters between two generations of dynamic bidirectional air-puff tonometers in subjects with central and peripheral keratoconus and in healthy …
MM Fortman - 2024
… approach to supplement our ability to detect early keratoconus. Therefore, the
initial aims of … keratoconus and controls; and 2) to evaluate the performance of the
original KMI in identifying keratoconic eyes when applied to G3 ORA measurement …
initial aims of … keratoconus and controls; and 2) to evaluate the performance of the
original KMI in identifying keratoconic eyes when applied to G3 ORA measurement …
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Inhibition of matrix metalloproteases by a chemical cross-linker to halt the corneal degradation in keratoconus
AS Gopalakrishnan, S Sirajuddeen, N Banu, J Nunes… - Experimental Eye Research, 2024
The need for better and simpler alternative crosslinking strategies to treat
keratoconus (KC) is becoming essential as there is only a single approved way to
treat it. Recently, conventional UV-A Riboflavin crosslinking is proven to have some …
keratoconus (KC) is becoming essential as there is only a single approved way to
treat it. Recently, conventional UV-A Riboflavin crosslinking is proven to have some …
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Role of m6A methyltransferase METTL3 in Keratoconus pathogenesis
H Yu, S Dou, H Wang, Y Sun, J Qu, T Liu, X Liu, C Wei… - Experimental Eye Research, 2024
Keratoconus (KC) is the most common ectatic corneal disease with unknown
pathogenesis. This study aimed to investigate the role of methyltransferase-like
enzyme 3 (METTL3) in KC pathogenesis. In the present study, we examined the …
pathogenesis. This study aimed to investigate the role of methyltransferase-like
enzyme 3 (METTL3) in KC pathogenesis. In the present study, we examined the …
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Demographic and topographic findings suggesting poor response to crosslinking-iontophoresis in patients with progressive keratoconus
RT Peralba, JR Lago, D Lamas-Francis… - 2024
… Progression criteria based on the ABCD system, changes in asphericity (Q),
demographic factors and keratoconus phenotypes were evaluated. Subjects were
followed … A family history of corneal ectasia and subtype 4 keratoconus predicted …
demographic factors and keratoconus phenotypes were evaluated. Subjects were
followed … A family history of corneal ectasia and subtype 4 keratoconus predicted …
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AI-Based Vision Screening Tool for Keratoconus
R Rahman, P Kumar, YK Sharma, M Sharma… - Anuradha Tomar Sukumar Mishra …
Keratoconus affects millions of people all over the globe, and the threat of disease is
a concern and should be given attention. It does not just threaten corneal changes
but can also play with visual pathways. It has evidence of disturbed binocularity …
a concern and should be given attention. It does not just threaten corneal changes
but can also play with visual pathways. It has evidence of disturbed binocularity …
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[HTML] Eye-Rubbing Detection Tool Using Artificial Intelligence on a Smartwatch in the Management of Keratoconus
I Drira, A Louja, L Sliman, V Soler, M Noor, A Jamali… - Translational Vision Science …, 2024
… of keratoconus has since been established by numerous studies. Some authors
have described eye rubbing in keratoconus patients as … We aimed to demonstrate
a novel solution for quantifying and preventing eye rubbing in patients with …
have described eye rubbing in keratoconus patients as … We aimed to demonstrate
a novel solution for quantifying and preventing eye rubbing in patients with …
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[HTML] Machine learning model for predicting corneal stiffness and identifying keratoconus based on ocular structures
L Li, Y Xiang, X Chen, D Lin, L Zhao, J Xiao, Z Lin… - Intelligent Medicine, 2024
Background Corneal stiffness abnormalities play an important role in the onset and
progression of keratoconus. However, the limited availability of specialty devices for
measuring corneal stiffness restricts their application in clinical practice. This study …
progression of keratoconus. However, the limited availability of specialty devices for
measuring corneal stiffness restricts their application in clinical practice. This study …
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[PDF] Case Report: Implantable Collamer Lens for Keratoconus with Splinter Cataract
D Aldahan, S AlHilali - International Medical Case Reports Journal, 2024
… Citation3 Eye rubbing, a known risk factor for keratoconus progression, generates
mechanical … Alternative treatments for keratoconus with coexisting cataracts, such
as keratoplasty or … This case report describes the successful implantation of an …
mechanical … Alternative treatments for keratoconus with coexisting cataracts, such
as keratoplasty or … This case report describes the successful implantation of an …
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[PDF] Case Report: Implantable Collamer Lens for Keratoconus with Splinter Cataract
D Aldahan, S AlHilali - International Medical Case Reports Journal, 2024
… Citation3 Eye rubbing, a known risk factor for keratoconus progression, generates
mechanical … Alternative treatments for keratoconus with coexisting cataracts, such
as keratoplasty or … This case report describes the successful implantation of an …
mechanical … Alternative treatments for keratoconus with coexisting cataracts, such
as keratoplasty or … This case report describes the successful implantation of an …
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Variation of Bruch's membrane opening in response to intraocular pressure change during scleral lens wear, in a population with keratoconus
L Michaud, S Balourdet, D Samaha - Ophthalmic & physiological optics: the journal of the …
Purpose The present study aimed to determine the potential impact of scleral lenses
on intraocular pressure (IOP) by analysing the Bruch's membrane opening-minimum
rim width (BMO-MRW) while the lenses are worn, in a population with keratoconus …
on intraocular pressure (IOP) by analysing the Bruch's membrane opening-minimum
rim width (BMO-MRW) while the lenses are worn, in a population with keratoconus …
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A novel combined oxidative stress and extracellular matrix related predictive gene signature for keratoconus
Z Cheng, J Hao, S Cai, P Feng, W Chen, X Ma, X Li - Biochemical and Biophysical …, 2024
… Oxidative stress (OS) and extracellular matrix (ECM) remodeling play critical roles
in keratoconus development. Here, based on keratoconus … signature showed
excellent performance for keratoconus prediction, providing beneficial perspectives …
in keratoconus development. Here, based on keratoconus … signature showed
excellent performance for keratoconus prediction, providing beneficial perspectives …
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Evaluation of indices for the assessment and classification of keratoconus based on optical coherence tomography and Scheimpflug technology
R Herber, J Lenk, L Ramm, D Wittig, MM Patzner… - … optics: the journal of the British …
Purpose To compare the parameters and indices of a novel swept-source optical
coherence tomography device (SS-OCT, ANTERION) with those of a rotating
Scheimpflug camera (RSC)-based tomograph (Pentacam) in normal and …
coherence tomography device (SS-OCT, ANTERION) with those of a rotating
Scheimpflug camera (RSC)-based tomograph (Pentacam) in normal and …
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Intraocular lens power calculation accuracy in patients with keratoconus: Network meta-analysis and systematic review
O Reitblat, R Sella, R Zlatkin, I Bahar, TT Lerman - Clinical & experimental ophthalmology
Background Accurate intraocular lens (IOL) calculation in eyes with keratoconus (KCN)
poses significant challenges. While various formulas, including KCN-specific ones,
have been investigated, the optimal calculation method remains inconclusive …
poses significant challenges. While various formulas, including KCN-specific ones,
have been investigated, the optimal calculation method remains inconclusive …
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Explainable XceptionNet-Based Keratoconus Detection Using Infrared Images and Edge Computing
K Devkar, S Arunkumar, T Bhakta, SR Bharadwaj… - IEEE Sensors Letters, 2024
… Abstract—Keratoconus is a progressive eye disease affecting the cornea,
potentially leading to … In this study, we utilized a customized explainable Xception
network for keratoconus detection. … Results show that the proposed approach is …
potentially leading to … In this study, we utilized a customized explainable Xception
network for keratoconus detection. … Results show that the proposed approach is …
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[PDF] A Unique Retinoscopic Reflex Pattern in the Initial Stages of Keratoconus and Its Clinical Significance for Early Keratoconus Detection: A Case Report
A Almaweri, A Almaweri Sr - Cureus, 2024
… This case report offers a novel clinical presentation that underscores the
diagnostic challenges in the initial stages of keratoconus, making it a … This study
presents a rare and practical model for the early detection of keratoconus. Early …
diagnostic challenges in the initial stages of keratoconus, making it a … This study
presents a rare and practical model for the early detection of keratoconus. Early …
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[PDF] Success Rates and Prognostic Factors in the Management of Keratoconus: A 10-Year Retrospective Cohort Study at Siriraj Hospital
A Thuangtong, T Phongsuphan - Siriraj Medical Journal, 2024
… The aim of this study research was to analyze the success rate of keratoconus
treatment at Siriraj Hospital, representing a Thai population, … keratoconus was
diagnosed in an eye with an early stage of keratoconus with undetectable clinical …
treatment at Siriraj Hospital, representing a Thai population, … keratoconus was
diagnosed in an eye with an early stage of keratoconus with undetectable clinical …
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Hyperopic Keratoconus, or Is This Something Else?
M Eiampikul, EJ Kaufman - International Journal of Keratoconus and Ectatic …, 2024
… The purpose of this paper is to describe a case of keratoconus with high hyperopia, a
condition typically associated with high myopia. This case led to the diagnosis of
nanophthalmos and possibly Leber's congenital amaurosis. … Lebers congenital …
condition typically associated with high myopia. This case led to the diagnosis of
nanophthalmos and possibly Leber's congenital amaurosis. … Lebers congenital …
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Advancing keratoconus treatment: the impact of bioengineered porcine constructs on corneal reshaping and visual acuity
M Khan, D Fatima - Eye, 2024
… Keratoconus, characterized by corneal thinning and steepening, significantly
impacts visual … most in need, addressing the increasing prevalence of
keratoconus in the region [6]. The … In conclusion, the BPCDX study offers a …
impacts visual … most in need, addressing the increasing prevalence of
keratoconus in the region [6]. The … In conclusion, the BPCDX study offers a …
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Changes of corneal densitometry in patients with keratoconus after corneal collagen cross-linking
LI Shuai, Y Gao, MA Limei, LI Rui, Y Qin, C Sun, Y Han… - International Eye Science, 2024
AIM: To observe the changes of corneal densitometry (CD) in patients with
keratoconus after corneal cross-linking (CXL). METHODS: Retrospective study. A
total of 32 patients (43 eyes) with keratoconus in Ningxia Eye Hospital from April …
keratoconus after corneal cross-linking (CXL). METHODS: Retrospective study. A
total of 32 patients (43 eyes) with keratoconus in Ningxia Eye Hospital from April …
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Socioeconomic and Demographic Disparities in Keratoconus Treatment
R Erukulla, M Soleimani, M Woodward, N Karnik… - American Journal of …
… Keratoconus (KCN) is estimated to have a prevalence ranging from 1:375 to 1:2000
globally. There has been conflicting results about whether prevalence is higher in
men or women. KCN has the highest prevalence in individuals from 18 to 39 years …
globally. There has been conflicting results about whether prevalence is higher in
men or women. KCN has the highest prevalence in individuals from 18 to 39 years …
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Safety and Efficacy of Posterior Chamber Phakic Implantable Collamer Lenses in Patients with Keratoconus: A Systematic Review and Meta-Analysis
AA Alkhabbaz, MH Karam, AS Pollmann, S Nath… - American Journal of …, 2024
Purpose To assess the safety and efficacy of phakic implantable collamer lenses (ICLs)
in patients with keratoconus. Design Systematic review and meta-analysis. Methods
We conducted a pre- and post-intervention single-arm systematic review and meta-analysis …
in patients with keratoconus. Design Systematic review and meta-analysis. Methods
We conducted a pre- and post-intervention single-arm systematic review and meta-analysis …
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[HTML] Cost-Effectiveness of Corneal Collagen Crosslinking for Progressive Keratoconus: A Brazilian Unified Health System Perspective
LO Hansen, R Garcia, AAM Torricelli, SJ Bechara - International Journal of …, 2024
Keratoconus is a burden to health systems and patients worldwide. Corneal
collagen … with the conventional treatment for progressive keratoconus from the
Brazilian Unified Health … a highly cost-effective intervention for progressive …
collagen … with the conventional treatment for progressive keratoconus from the
Brazilian Unified Health … a highly cost-effective intervention for progressive …
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Thickness Speed Progression Index (TSPI): Machine Learning Approach for Keratoconus Detection: Thickness-based machine learning model for KC detection
ST Awwad, B Hammoud, JF Assaf, L Asroui… - American Journal of …
… of 349 patients with normal, frank keratoconus (KC), and keratoconus suspect (KCS)
corneas. KCS corneas included topographically/tomographically normal (TNF) and
borderline fellow eyes (TBF) of patients with asymmetric keratoconus. Six …
corneas. KCS corneas included topographically/tomographically normal (TNF) and
borderline fellow eyes (TBF) of patients with asymmetric keratoconus. Six …
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[HTML] Machine learning methods to identify risk factors for corneal graft rejection in keratoconus
S Feizi, MA Javadi, K Bayat, M Arzaghi, A Rahdar… - Scientific Reports, 2024
… with graft rejection after corneal transplantation for keratoconus. The study
included all keratoconus eyes that underwent primary corneal … A total of 1214
consecutive eyes of 985 keratoconus patients were included in the study, and the …
included all keratoconus eyes that underwent primary corneal … A total of 1214
consecutive eyes of 985 keratoconus patients were included in the study, and the …
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[PDF] Corneal endothelial iayer changes in various stages of keratoconus and their correlation with topographic findings: a cross-sectional study
R Sorkhabi, S Asghari, A Arasteh, A Jafari, MH Ahoor - Med J Tabriz Uni Med …, 2024
Background. Keratoconus (KCN) is a multifactorial progressive corneal disease that
leads to significant disturbances in visual function. Various layers of the cornea,
such as the endothelium, are affected by this condition. This study aimed to evaluate …
leads to significant disturbances in visual function. Various layers of the cornea,
such as the endothelium, are affected by this condition. This study aimed to evaluate …
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Gender-specific Association of STON2 rs2371597 Polymorphism in Keratoconus patients of Saudi origin
AA Kondkar, T Sultan, TA Azad, T Khatlani, GP Lobo… - Frontiers in Genetics
Objective: To investigate the association of specific genetic polymorphisms (rs2371597
in STON2, rs11720822 in PDIA5, rs387907358 in WNT1, and rs77542162 in ABCA6)
in a Saudi cohort of keratoconus (KC) patients compared to controls.Methods: A …
in STON2, rs11720822 in PDIA5, rs387907358 in WNT1, and rs77542162 in ABCA6)
in a Saudi cohort of keratoconus (KC) patients compared to controls.Methods: A …
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[PDF] Comparison of Belin-Ambrosio between Normal and Keratoconus (KC) using Pentacam HR for Saudi's patients aged 6-21
H Alfarhan
Objectives: The research compels to compare between normal and KC corneas
using Belin-Ambrosio indices on Saudi's patients aged between 6-21 years in
Riyadh. This research helps differentiate normal from KC cornea. Method: The …
using Belin-Ambrosio indices on Saudi's patients aged between 6-21 years in
Riyadh. This research helps differentiate normal from KC cornea. Method: The …
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[PDF] Outcomes of Iontophoresis Cross-Linking in Asymmetric Keratoconus: A Retrospective Analysis of High Visual Acuity Eyes Under 25 Years Old
V Ferraro, F Santoru, G Barone, P Rosetta - Clinical Ophthalmology, 2024
… In this study, we included the fellow less advanced keratoconus eye of patients
with bilateral, asymmetric keratoconus under the age of 25 who underwent to CXL at
Humanitas San Pio X, Milan, Italy, between 2015 and 2020. As stated in Articles 6 …
with bilateral, asymmetric keratoconus under the age of 25 who underwent to CXL at
Humanitas San Pio X, Milan, Italy, between 2015 and 2020. As stated in Articles 6 …
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[HTML] Allergic disease and keratoconus: A two-sample univariable and multivariable Mendelian randomization study
H Xu, Y Wen, H Zheng, D Jiang, W Chen - World Allergy Organization Journal, 2024
Background There is accumulating evidence that allergy is a risk factor for
keratoconus. Nonetheless the association between allergic disease and
keratoconus remains controversial. We performed a two-sample Mendelian …
keratoconus. Nonetheless the association between allergic disease and
keratoconus remains controversial. We performed a two-sample Mendelian …
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Scleral lenses in corneal dystrophies, specifically keratoconus
M Tatiana
… lenses in the visual rehabilitation of individuals with keratoconus. Material and
Method. A … The mean severity score of keratoconus at initial assessment was 3.6 ±
1.0. The lenses used were … excellent safety and effectiveness of scleral contact …
Method. A … The mean severity score of keratoconus at initial assessment was 3.6 ±
1.0. The lenses used were … excellent safety and effectiveness of scleral contact …
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… and agreement of biometric measurements using spectral domain anterior segment optical coherence tomography and Scheimpflug tomography in keratoconus
Y Li, A Gokul, C McGhee, M Ziaei - PloS one, 2024
In Table 2, the data listed in the precison and repeatability column of Pentacam-AXL
under TCT (μm) Group A is incorrect. The correct precision is 5.84 and the
repeatability is 8.26. Also, the data listed in the ICC 95% Confidence Interval column …
under TCT (μm) Group A is incorrect. The correct precision is 5.84 and the
repeatability is 8.26. Also, the data listed in the ICC 95% Confidence Interval column …
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[HTML] Enhancing keratoconus detection with transformer technology and multi-source integration
O Ismael - Artificial Intelligence Review, 2025
… Keratoconus is a progressive eye disease characterized by the thinning and
conical … -stage keratoconus due to their subjective nature and limited scope. In
this research, we present a novel multi-source detection approach utilizing …
conical … -stage keratoconus due to their subjective nature and limited scope. In
this research, we present a novel multi-source detection approach utilizing …
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Aberrometry in the diagnosis and treatment of keratoconus
SI Anisimov, S Micovic, NS Anisimova - Vestnik oftalmologii, 2024
Keratoconus (KC) is a bilateral progressive disease that often begins in young
adulthood. Advanced KC significantly impairs patients' quality of life, making early
detection of the condition a critical goal for specialists. Early identification of KC …
adulthood. Advanced KC significantly impairs patients' quality of life, making early
detection of the condition a critical goal for specialists. Early identification of KC …
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[HTML] Intrastromal graft of anterior lens capsule. A substitute for Bowman layer graft transplantation for keratoconus
CA Rodríguez-Barrientos, A Translateur-Grynspan… - PloS one, 2024
Purpose The shortage of donor corneas limits Bowman layer transplantation for
keratoconus. In this study, we evaluate the clinical outcome of porcine anterior lens
capsule (xenograft) transplantation in the corneal stroma of a rabbit model as …
keratoconus. In this study, we evaluate the clinical outcome of porcine anterior lens
capsule (xenograft) transplantation in the corneal stroma of a rabbit model as …
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Intense pulsed light alleviates keratoconus by improving the local corneal microenvironment
Z Zhao, Y Liu, Y Zou, Y Liu, M Yu - Medical Hypotheses, 2024
Keratoconus (KC) is a corneal ectasia with a complex etiology, and its pathogenesis
remains incompletely understood. Research indicates that the development of KC is
closely linked to inflammation and local oxidative stress (OS) triggered by alterations …
remains incompletely understood. Research indicates that the development of KC is
closely linked to inflammation and local oxidative stress (OS) triggered by alterations …
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[PDF] Efficacy of the Keratoconus Risk Investigative Survey (KRIS) in Detecting Keratoconus in a Secondary School Population
ND CHAURASIA, VR Moodley, KP Mashige - 2024
(1) Background: Keratoconus (KC) is a progressive corneal disorder that begins in
adolescence and can lead to significant vision loss if undetected. Early identification
of at-risk individuals through efficient screening tools like Keratoconus Risk …
adolescence and can lead to significant vision loss if undetected. Early identification
of at-risk individuals through efficient screening tools like Keratoconus Risk …
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[HTML] Densitometry Changes After Corneal Collagen Cross-Linking With Riboflavin and UVA Light in Patients With Keratoconus
M Peskina, DA Kaufman, C O'Brien, A Miele, C Lym… - Cornea Open, 2024
… may lead to a greater flattening of the cornea in patients with more advanced
keratoconus. … of keratoconus, with post-CXL stabilization or reduction indicative of
treatment success. Our aim was to assess the impact of CXL on corneal steepness …
keratoconus. … of keratoconus, with post-CXL stabilization or reduction indicative of
treatment success. Our aim was to assess the impact of CXL on corneal steepness …
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[HTML] Double intrastromal corneal ring segment implantation: a new approach for improved clinical outcomes in keratoconus patients
S Coscarelli, R de Oliveira Sieiro, VM Fernandes… - International Journal of …, 2024
… implant in keratoconus patients. METHODS This retrospective single-arm cohort
study evaluated 25 eyes of 21 keratoconus patients implanted … of 2 different
ICRSs can efficiently regularize the cornea, reduce the SE, and improve visual …
study evaluated 25 eyes of 21 keratoconus patients implanted … of 2 different
ICRSs can efficiently regularize the cornea, reduce the SE, and improve visual …
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Total keratometry versus standard keratometry for intraocular lens power calculation in eyes with keratoconus
C Parra-Bernal, R Villaseñor-García… - International ophthalmology, 2024
… RPE in patients with keratoconus was < 1.00 D with all formulas. Barrett True-K
keratoconus with predicted PCA registered the lowest MAE and … Conclusions:
Barrett True-K for keratoconus showed the highest accuracy, closely followed by …
keratoconus with predicted PCA registered the lowest MAE and … Conclusions:
Barrett True-K for keratoconus showed the highest accuracy, closely followed by …
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Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case-Control Study Utilizing the All of Us Database
C Beatty, A Estes, H Xu, Y Liu - Translational vision science & technology, 2024
Purpose We aimed to identify clinical factors associated with keratoconus (KC) risk
in the All of Us database. Methods This retrospective matched case-control study
utilized patient data from the All of Us Research Program. All patients with a KC …
in the All of Us database. Methods This retrospective matched case-control study
utilized patient data from the All of Us Research Program. All patients with a KC …
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Assessment of ICD FlexFit Scleral Lens Fitting Characteristics and on Eye Performance in Patients with Keratoconus
Ö Gündüz, B Kılıç
… Fourteen patient eyes had stage IV, 1 patient eye had stage III, 5 patient eyes had
stage II, and 1 patient eye had stage I keratoconus according to Amsler Krumeich
classification. The mean uncorrected and corrected visual acuities were 1.15±0.46 …
stage II, and 1 patient eye had stage I keratoconus according to Amsler Krumeich
classification. The mean uncorrected and corrected visual acuities were 1.15±0.46 …
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Accelerated versus conventional corneal collagen cross-linking for keratoconus: A meta-analysis of randomized controlled trials
CY Yeh, KC Chen, YJ Chen, SF Cheng - European Journal of Ophthalmology, 2024
… This systematic review and meta-analysis compared ACXL with CCXL for
progressive keratoconus treatment by including RCTs and … comparing the two
CXL techniques for treating progressive keratoconus and a better understanding of …
progressive keratoconus treatment by including RCTs and … comparing the two
CXL techniques for treating progressive keratoconus and a better understanding of …
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Analysis of candidate variants in a Chinese family with monozygotic twins with keratoconus: a case report
C Song, K Wang, L Li, L Hu, J Bai, L Zhao, C Liu, S Li - Ophthalmic Genetics, 2024
Background Keratoconus (KC) is an asymmetrical bilateral corneal ectasia, of which
the pathogenesis is unknown. Moreover, genetic factors play an important role. We
reported ophthalmic findings in a Chinese family with monozygotic twins with KC to …
the pathogenesis is unknown. Moreover, genetic factors play an important role. We
reported ophthalmic findings in a Chinese family with monozygotic twins with KC to …
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[HTML] Advanced crosslinking for keratoconus and low-grade myopia
S Elving - 2024
Corneal crosslinking (CXL) is an established treatment for progressive keratoconus (KC).
In this thesis, Advanced CXL refers to a further development of conventional CXL,
which aims to improve the treatment outcomes in KC and can also be used as a …
In this thesis, Advanced CXL refers to a further development of conventional CXL,
which aims to improve the treatment outcomes in KC and can also be used as a …
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Developing and validating a comprehensive polygenic risk score to enhance keratoconus risk prediction
W He, U Võsa, T Palumaa, JS Ong, SD Torres… - Human Molecular Genetics, 2024
… While participants with thin corneas or low CRF may be particularly prone to
developing keratoconus, we show that including a PRS improves the prediction of
keratoconus risk and enables the risk stratification for keratoconus, over and above …
developing keratoconus, we show that including a PRS improves the prediction of
keratoconus risk and enables the risk stratification for keratoconus, over and above …
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The role of corneal epithelial thickness map in detecting early keratoconus
Z Wang, R Dong, Y Yuan, Y Zhang, Y Chen - Graefe's Archive for Clinical and …, 2024
… The corneal epithelial parameters play an important auxiliary role in the diagnosis
of keratoconus and the screening of subclinical keratoconus. Combination of
epithelial parameters and tomographic parameters can improve the sensitivity of …
of keratoconus and the screening of subclinical keratoconus. Combination of
epithelial parameters and tomographic parameters can improve the sensitivity of …
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Keratoconus: current diagnostic approach
LS Pateyuk - Journal of Clinical Practice, 2024
… Keratoconus is an ectatic … the keratoconus diagnosis, outlines current
approaches to patients examining and diagnostics results assessing. The clinical
manifestations (complaints, anamnesis data, visometry and autorefractokeratometry …
approaches to patients examining and diagnostics results assessing. The clinical
manifestations (complaints, anamnesis data, visometry and autorefractokeratometry …
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[HTML] Quantifying choroidal and retinal thicknesses variations via optical coherence tomography in different stages of pediatric keratoconus
A Mohammadi, N Masihpour, M Feghhi… - BMC Ophthalmology, 2024
Keratoconus (KCN) is characterized by corneal thinning and bulging, leading to
vision impairment. Assessing choroidal thickness (CT) in pediatric KCN ( pKCN)
patients can provide insights for better understanding and managing the disease …
vision impairment. Assessing choroidal thickness (CT) in pediatric KCN ( pKCN)
patients can provide insights for better understanding and managing the disease …
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[HTML] Artificial intelligence versus conventional methods for RGP lens fitting in keratoconus
J Abadou, S Dahan, J Knoeri, L Leveziel… - Contact Lens and Anterior …, 2024
… This retrospective study included 197 keratoconus eyes of 135 patients fitted with
Rose K2® (Menicon®, Nagoya, Japan) rigid contact lenses with one or more
topographies available (MS39®, CSO®, Ferrara, Italy) between January 2020 and …
Rose K2® (Menicon®, Nagoya, Japan) rigid contact lenses with one or more
topographies available (MS39®, CSO®, Ferrara, Italy) between January 2020 and …
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[PDF] A Novel Corneal Remodeling Technique of Laser Asymmetric Keratectomy in Keratoconus Suspect: A Retrospective Case Control Study
JS Min, BM Min - Clinical Ophthalmology, 2024
… Keratoconus suspect (KCS) has been one type of three earliest stage keratoconus.
Referring to the earliest stage keratoconus, three names were widely encountered in
the literature: forme fruste keratoconus (FFKC), preclinical or subclinical keratoconus …
Referring to the earliest stage keratoconus, three names were widely encountered in
the literature: forme fruste keratoconus (FFKC), preclinical or subclinical keratoconus …
R Herber, D Wittig, F Lochmann, LE Pillunat, F Raiskup - Translational Vision Science …, 2024
Purpose: The purpose of this study was to investigate corneal stiffening after
epithelium-off accelerated corneal cross-linking (CXL; 9 mW/cm²) in progressive
keratoconus (KC) with different methods of epithelial debridement. Methods: This …
epithelium-off accelerated corneal cross-linking (CXL; 9 mW/cm²) in progressive
keratoconus (KC) with different methods of epithelial debridement. Methods: This …
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[HTML] Effects and safety of combined corneal collagen crosslinking and intrastromal corneal ring segment treatment in patients with keratoconus: a retrospective study
A Dal, M Canleblebici, B Kutluksaman, M Erdağ - BMC Ophthalmology, 2024
… This study included 69 eyes of 69 patients with keratoconus who underwent ICRS
and CXL treatment at an Eye Hospital between March 2020 and March 2023. The
patients were divided into two groups: Group 1 (n = 33 eyes of 33 patients), which …
and CXL treatment at an Eye Hospital between March 2020 and March 2023. The
patients were divided into two groups: Group 1 (n = 33 eyes of 33 patients), which …
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Detection and understanding the role of Ultraviolet Radiation in Keratoconus
A Taher - 2024
… early keratoconus and to provide a framework for investigating the role of
ultraviolet radiation in the pathogenesis of keratoconus. Methods … Conclusion The
Belin Ambrósio enhanced ectasia display had the highest discriminative power in …
ultraviolet radiation in the pathogenesis of keratoconus. Methods … Conclusion The
Belin Ambrósio enhanced ectasia display had the highest discriminative power in …
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[PDF] Prevalence of Keratoconus and Keratoconus Suspect among a sample of Iraqi Children with Refractive Errors: A Cross-Sectional Study
AS Rashak, NA Abdulateef, S Abdulkareem - Al-Rafidain Journal of Medical Sciences …, 2024
Background: Keratoconus (KC) is a chronic, bilateral, non-inflammatory
degenerative condition with severe consequences. Objective: To assess the
prevalence of KC and Keratoconus Suspect (KCS) in a pediatric population with …
degenerative condition with severe consequences. Objective: To assess the
prevalence of KC and Keratoconus Suspect (KCS) in a pediatric population with …
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Evaluating the reliability of the responses of large language models to keratoconus-related questions
M Kayabaşı, S Köksaldı, C Durmaz Engin - Clinical and Experimental Optometry, 2024
Clinical relevance Artificial intelligence has undergone a rapid evolution and large
language models (LLMs) have become promising tools for healthcare, with the
ability of providing human-like responses to questions. The capabilities of these …
language models (LLMs) have become promising tools for healthcare, with the
ability of providing human-like responses to questions. The capabilities of these …
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[PDF] Prevalence and demographic pro le of keratoconus among high school students in Kenya
ZA Rashid, VR Moodley, KP Mashige
… Keratoconus (KC) is a corneal disorder that usually presents in adolescence. The
prevalence of KC in Western countries [1–6] and North and East Asia [7–10] is
generally < 1.3% with one exception where Chan et al. [11] recently reported a …
prevalence of KC in Western countries [1–6] and North and East Asia [7–10] is
generally < 1.3% with one exception where Chan et al. [11] recently reported a …
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Keratoconus
RB Singh, S Koh, N Sharma, FA Woreta, F Hafezi… - Nature Reviews Disease …, 2024
… Interestingly, in a study in Lebanon, 12% of patients with keratoconus had a
family history of keratoconus, and eye rubbing was not an … of association between
keratoconus and eye rubbing 52,89 . Thus, a two-hit model has been suggested for …
family history of keratoconus, and eye rubbing was not an … of association between
keratoconus and eye rubbing 52,89 . Thus, a two-hit model has been suggested for …
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[HTML] Visual rehabilitation using rigid gas permeable contact lenses after femtosecond laser-assisted minimally invasive lamellar keratoplasty in patients with keratoconus
J Zhang, X Lin, Z Li, X Zhong, W Shi, X Du, H Gao - Scientific Reports, 2024
This study aims to observe the clinical efficacy and safety of rigid gas permeable
corneal contact lenses (RGP-CLs) wearing after femtosecond laser-assisted
minimally invasive lamellar keratoplasty (FL-MILK) in progressive and advanced …
corneal contact lenses (RGP-CLs) wearing after femtosecond laser-assisted
minimally invasive lamellar keratoplasty (FL-MILK) in progressive and advanced …
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[HTML] Evaluation of parameters for early detection of pediatric keratoconus
SH Zhao, C Berkowitz, H Ralay Ranaivo, K Laurenti… - BMC ophthalmology, 2024
Background Keratoconus in children is often more severe and rapidly progressive
compared to adults. While Scheimpflug imaging (Pentacam) improves screening,
there are no established pediatric guidelines. Due to challenges in diagnosis, we …
compared to adults. While Scheimpflug imaging (Pentacam) improves screening,
there are no established pediatric guidelines. Due to challenges in diagnosis, we …
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[HTML] Impact of Keratoconus on Contrast Sensitivity
LY Zhen, FS Barodawala - Journal of Health Science and Medical Research, 2024
Objective: Keratoconus (KC) disrupts corneal shape, leading to irregular
astigmatism and increased higher-order aberrations (HOA), ultimately affecting
visual quality. While visual acuity (VA) remains the standard, its limitations in early …
astigmatism and increased higher-order aberrations (HOA), ultimately affecting
visual quality. While visual acuity (VA) remains the standard, its limitations in early …
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Retraction Note: Detection and evaluation of Keratoconus (corneal topography) by using the image classifier techniques
R Kanimozhi, R Gayathri - 2024
Retraction Note: Detection and evaluation of Keratoconus (corneal topography) by
using the image classifier techniques | Soft Computing … Retraction Note: Detection
and evaluation of Keratoconus (corneal topography) by using the image classifier …
using the image classifier techniques | Soft Computing … Retraction Note: Detection
and evaluation of Keratoconus (corneal topography) by using the image classifier …
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[HTML] Late corneal ectasia after penetrating and deep anterior lamellar keratoplasty for keratoconus
B Yüksel, AE Kocakaya, T Küsbeci, F Gümüş - International Journal of …, 2024
… keratoconus recurrence in the donor button, progression of keratoconus in the
host rim with consequent graft-host interface thinning and misalignment, or less likely;
grafting a donor cornea with undiagnosed keratoconus… late ectasia after …
host rim with consequent graft-host interface thinning and misalignment, or less likely;
grafting a donor cornea with undiagnosed keratoconus… late ectasia after …
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[HTML] Comparison of the quantitative contrast sensitivity function between early keratoconus and normal eyes
Y Xian, Y Ye, L Sun, Y Shen, X Zhang, ZL Lu, X Zhou… - BMC Ophthalmology, 2024
To compare the characteristics of the quantitative contrast sensitivity function (qCSF)
in eyes with early keratoconus (Early-KC) and normal control (NC) eyes and
investigate the associated factors. A cross-sectional study. This study included 43 …
in eyes with early keratoconus (Early-KC) and normal control (NC) eyes and
investigate the associated factors. A cross-sectional study. This study included 43 …
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[HTML] Computational approaches for identifications of altered ion channels in keratoconus
KB Gaikwad, JS Babu, KTS Parthasarathi, J Narayanan… - Eye, 2024… give crucial information to understand keratoconus aetiology [26, 27]. There is no
study to the best of our knowledge that describes alterations in ion channels in
patients with keratoconus. Here, the transcriptome of patients with keratoconus was …
study to the best of our knowledge that describes alterations in ion channels in
patients with keratoconus. Here, the transcriptome of patients with keratoconus was …
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[HTML] Agreement in anterior segment measurements between swept-source optical coherence and dual Scheimpflug tomography devices in keratoconus eyes
Y Lee, JY Oh, HJ Choi, MK Kim, CH Yoon - Scientific Reports, 2024… This study analyzed the agreement between Casia 2 and Galilei G6 in
keratoconus. For most parameters used to diagnose keratoconus and assess
disease progression, the agreement between the two devices was not excellent and …
keratoconus. For most parameters used to diagnose keratoconus and assess
disease progression, the agreement between the two devices was not excellent and …
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[HTML] Tear levels of apoptotic, matrix-degrading and antioxidant biomarkers in patients with and without keratoconus: A cross sectional study
AM Roszkowska, U Camellin, F Franchina… - Contact Lens and Anterior Eye… keratoconus and 33 were age-matched healthy subjects. The linear combination
of the three tear biomarkers levels (AUC = 0.811; CI 95 %: 0.712–0.911) accurately
indicated the existence of keratoconus; … ) were significantly associated with a …
of the three tear biomarkers levels (AUC = 0.811; CI 95 %: 0.712–0.911) accurately
indicated the existence of keratoconus; … ) were significantly associated with a …
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[PDF] Patient evaluated economic impact of keratoconus in New Zealand
L Angelo, A Gokul, I Samuels, CNJ McGhee, M Ziaei - Clinical and Experimental …, 2024… by keratoconus subjects, to estimate the lifetime per capita cost and the total costs
of keratoconus per year in Auckland, New Zealand. … the total out-of-pocket spend
for keratoconus is less in New Zealand despite having a higher prevalence of …
of keratoconus per year in Auckland, New Zealand. … the total out-of-pocket spend
for keratoconus is less in New Zealand despite having a higher prevalence of …
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[PDF] Keratoconus: modern diagnostic approach
L Pateyuk - Journal of Clinical Practice, 2024… Keratoconus is an ectatic … the keratoconus diagnosis, outlines current
approaches to patients examining and diagnostics results assessing. The clinical
manifestations (complaints, anamnesis data, visometry and autorefractokeratometry …
approaches to patients examining and diagnostics results assessing. The clinical
manifestations (complaints, anamnesis data, visometry and autorefractokeratometry …
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Thyroid gland dysfunction and keratoconus
OM Said, M Iqbal, A El-Massry, ME Elgharieb, M Mady… - … hypothesis discovery and …, 2024… Background: The association between keratoconus and thyroid gland dysfunction
(TGD) remains controversial. We aimed to determine the frequency of keratoconus
among patients with laboratory-confirmed, treatment-naive TGD compared with that …
(TGD) remains controversial. We aimed to determine the frequency of keratoconus
among patients with laboratory-confirmed, treatment-naive TGD compared with that …
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After all, Doctor: Does my Child have Keratoconus or Not?
FBD Da Silva - Highlights of Ophthalmology, 2024Establishing the diagnosis of a disease that can impact the vision and life of a
patient (such as keratoconus) is a moment of great responsibility. Therefore,
ophthalmology has been looking for to integrate the results provided by the most …
patient (such as keratoconus) is a moment of great responsibility. Therefore,
ophthalmology has been looking for to integrate the results provided by the most …
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[HTML] Optimizing UV-A Irradiation Profiles in Crosslinking for Keratoconus: Comparison of Outcomes After Standard Accelerated and Topography-Guided Protocols
T Cortinhal, J Gil, A Rosa, MJ Quadrado, J Murta - Revista Sociedade Portuguesa de …, 2024INTRODUÇÃO: O objetivo do presente estudo é comparar resultados refrativos e
tomográficos do crosslinking corneano no queratocone, utilizando laser excimer
para remoção do epitélio e irradiação central uniforme (C-CXL) ou irradiação …
tomográficos do crosslinking corneano no queratocone, utilizando laser excimer
para remoção do epitélio e irradiação central uniforme (C-CXL) ou irradiação …
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Pediatric Keratoconus
Y Gupta, C Devi, K Priyadarshini, S Mandal, R Tandon… - Survey of Ophthalmology, 2024
Keratoconus is a common pediatric corneal disease, leading to vision impairment
and amblyopia. Compared to its adult counterpart, pediatric keratoconus has an
advanced presentation, rapid progression, higher incidence of complications such …
and amblyopia. Compared to its adult counterpart, pediatric keratoconus has an
advanced presentation, rapid progression, higher incidence of complications such …
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[HTML] Cessation of contact lenses prior to corneal tomography for keratoconus monitoring: results from a clinician survey
C McAlinden, D Lockington - Eye, 2024
… Corneal tomography is essential in diagnosing and monitoring corneal ectasias,
including keratoconus. Monitoring may be necessary to … precision is more
challenging in eyes with keratoconus [2]. Visual improvement in eyes keratoconus is …
including keratoconus. Monitoring may be necessary to … precision is more
challenging in eyes with keratoconus [2]. Visual improvement in eyes keratoconus is …
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[HTML] Mendelian randomization reveals that abnormal lipid metabolism mediates the causal relationship between body mass index and keratoconus
J Wang, F Liu, D Gong, J Su, F Zheng, S Ding, J Mo… - Scientific Reports, 2024
Previous studies suggest that a high body mass index (BMI) may be a risk factor for
keratoconus (KC), but the causal relationship remains unclear. This study used
Mendelian randomization (MR) to investigate this connection and explore the …
keratoconus (KC), but the causal relationship remains unclear. This study used
Mendelian randomization (MR) to investigate this connection and explore the …
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Air Pollution and the Prevalence of Keratoconus: Is There a Connection?
T Jurkiewicz, AS Marty - Ophthalmic Epidemiology, 2024
… Keratoconus is a progressive, asymmetrical corneal ectasia with multifactorial
origin. Three identified risk factors for keratoconus include … Other factors like
pollution would play a role in the physiopathology of keratoconus. In this study we …
origin. Three identified risk factors for keratoconus include … Other factors like
pollution would play a role in the physiopathology of keratoconus. In this study we …
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Transcriptomic analysis of Keratoconus in Han Chinese patients: Insights into differential gene expression and ethnic-specific patterns
Y Li, Y Dai, J Xu, J Zhang - Experimental Eye Research, 2024
Keratoconus (KC) is a progressive corneal ectatic disorder with a high prevalence
among Asians. This study aimed to explore the differential gene expression patterns
in Han Chinese patients with KC, focusing on mRNAs and long noncoding RNAs (lncRNAs) …
among Asians. This study aimed to explore the differential gene expression patterns
in Han Chinese patients with KC, focusing on mRNAs and long noncoding RNAs (lncRNAs) …
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Experimental Models for Keratoconus: Insights and challenges
S Shankar, R Deshmukh, T Pingali, R Sonar, S Basu… - Experimental Eye Research, 2024
… Keratoconus, a progressive corneal disorder characterized by the thinning and
conical protrusion of the cornea because of collagen degradation, poses significant
challenges to patients and clinicians. Most successful animal models in keratoconus …
conical protrusion of the cornea because of collagen degradation, poses significant
challenges to patients and clinicians. Most successful animal models in keratoconus …
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[HTML] Comparison of a Scheimpflug imaging with other screening indices in diagnosing keratoconus and keratoconus suspect
Y Huo, R Xie, X Chen, S Li, H Zou, Y Liu, Y Wang - Scientific Reports, 2024
Keratoconus (KC) is an irreversible blinding eye disease; therefore, early screening
of KC suspects (KCS) is crucial for protecting patients' quality of life. Scheimpflug
imaging is a commonly used screening device in clinical practice. We aimed to …
of KC suspects (KCS) is crucial for protecting patients' quality of life. Scheimpflug
imaging is a commonly used screening device in clinical practice. We aimed to …
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[HTML] Inflammatory and genomic interactions within keratoconus susceptible patients: a nationwide registered case–control study
F Doroodgar, F Alizadeh, S Niazi, SM Razavi, N Jalilian… - Eye and Vision, 2024
Purpose This study aimed to investigate the association between variants in the
interleukin (IL)-1 gene cluster and susceptibility to keratoconus (KC) in an Iranian
population. Methods In the case group, there were 188 KC patients diagnosed by …
interleukin (IL)-1 gene cluster and susceptibility to keratoconus (KC) in an Iranian
population. Methods In the case group, there were 188 KC patients diagnosed by …
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Associations between endothelial cell characteristics and corneal topography findings in different stages of keratoconus
AH Reyhan, AS Karadağ, A Şimşek - International Ophthalmology, 2024
… This study aimed to compare and correlate specular microscope indices and
corneal topography indices in different stages of keratoconus… progression of
keratoconus. It appears that as keratoconus index values increase, NUM may …
corneal topography indices in different stages of keratoconus… progression of
keratoconus. It appears that as keratoconus index values increase, NUM may …
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[PDF] One-Year Results of a Posterior Chamber Toric Phakic Intraocular Lens Implantation in Patients with Keratoconus
K Balparda, M Escobar Giraldo, YM Valencia Gómez… - Clinical Ophthalmology, 2024
Purpose To determine clinical and refractive results after the implantation of EyeCryl
Phakic Toric intraocular lens in patients with stable keratoconus. Methods The study
included all patients diagnosed with keratoconus who underwent implantation of an …
Phakic Toric intraocular lens in patients with stable keratoconus. Methods The study
included all patients diagnosed with keratoconus who underwent implantation of an …
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Keratoconus classification using a novel convolutional neural network architecture and corneal curvature maps
LO de Oliveira, FM de Carvalho Taguchi… - Applications of Machine …, 2024
… keratoconus, 91.24% for keratoconus, and 99.58% for severe keratoconus).
Additionally, the model achieved AUC scores of 0.97, 0.92, 0.90, 0.98, and 0.94 for
normal eye, suspect eye, subclinical keratoconus, keratoconus, and severe …
Additionally, the model achieved AUC scores of 0.97, 0.92, 0.90, 0.98, and 0.94 for
normal eye, suspect eye, subclinical keratoconus, keratoconus, and severe …
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Enhanced keratoconus care through optometry-led services at the West of England Eye Unit, Exeter
J Isaac, E Tutchings, Z Smith, L Isaac, C Newitt, A Loft… - Eye, 2024
… -led' keratoconus (KC) management at The Birmingham and Midland Eye Centre (BMEC)
[1]. … 2: Flowchart depicting outcomes of new suspect keratoconus referrals into the
new optometry … -led KC service provides a prompt and holistic approach to …
[1]. … 2: Flowchart depicting outcomes of new suspect keratoconus referrals into the
new optometry … -led KC service provides a prompt and holistic approach to …
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[PDF] Change in Tear Layer Thickness under Scleral Contact Lenses in Keratoconus Patients and Normal Cornea Volunteers
A Thuangtong, N Taetrongchit, R Kemahayung - Siriraj Medical Journal, 2024
Objective: To quantify rate of post-lens tear thickness change under scleral contact
lenses in keratoconus patients and normal cornea volunteers. Materials and
Methods: We conducted a prospective observational study where semi-scleral …
lenses in keratoconus patients and normal cornea volunteers. Materials and
Methods: We conducted a prospective observational study where semi-scleral …
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[PDF] Efficacy of KeraVio with Irradiation via Violet Light-Emitting Glasses without the Administration of Riboflavin Drops for Progressive Keratoconus Treatment
H Kobashi, T Kumanomido, T Ide, N Kato, J Shimazaki… - 2024
KeraVio is a new portable corneal cross-linking (CXL) treatment modality in which
violet light (VL)-emitting spectacles are used along with topical transepithelial
riboflavin. We preliminarily identified endogenous riboflavin in the human cornea …
violet light (VL)-emitting spectacles are used along with topical transepithelial
riboflavin. We preliminarily identified endogenous riboflavin in the human cornea …
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Is there a relationship between the keratoconus and the peripapillary choroidal vasculature?
K Gahramanov, M Unlu, F Ozer, H Sener, K Erkilic - International Ophthalmology, 2024
Purpose To evaluate the peripapillary/parapapillary choroidal vascular parameters
in the keratoconus (KC) and to determine the relationship between topography
parameters and the peripapillary/parapapillary choroidal vascular parameters …
in the keratoconus (KC) and to determine the relationship between topography
parameters and the peripapillary/parapapillary choroidal vascular parameters …
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[HTML] Save Sight Keratoconus Registry Study: Transepithelial versus Epithelium-off Corneal Crosslinking
GA Borchert, H Kandel, A Gupta, JY Chen, Y Kerdraon… - AJO International, 2024
Purpose Corneal collagen crosslinking (CXL) is the primary treatment for
progressive keratoconus and can be performed with the epithelium on or off.
Evidence is needed to guide clinicians and patients on whether they should have …
progressive keratoconus and can be performed with the epithelium on or off.
Evidence is needed to guide clinicians and patients on whether they should have …
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[PDF] A Theoretical Approach for Diagnosing Keratoconus Using Purkinje Image Geometry: An Accessible Method for Low-Cost and Early Detection
M Sharifzadeh - 2024
… keratoconus severity, with higher scores indicating greater deviation from normal
corneal profiles. Conclusions: This study presents a promising, low-cost approach to
diagnosing keratoconus … diagnostic tool for early keratoconus detection …
corneal profiles. Conclusions: This study presents a promising, low-cost approach to
diagnosing keratoconus … diagnostic tool for early keratoconus detection …
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[PDF] Reliability of Scheimpflug versus anterior segment optical coherence tomography after epithelial_off crosslinking in keratoconus
H Elgazzar, AS Mostafa, TK Eleiwa, KM Elgabry - Benha Medical Journal, 2024
… Second, these topography-based techniques have trouble differentiating between
keratoconus … These may cause false diagnosis of keratoconus or potential to hide
real keratoconus. … each keratoconus grade, and there was excellent reliability for …
keratoconus … These may cause false diagnosis of keratoconus or potential to hide
real keratoconus. … each keratoconus grade, and there was excellent reliability for …
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[PDF] Keratoconus Disease Prediction by Utilizing Feature-Based Recurrent Neural Network
SH Musa, QJM Alhaidar, MMB Elmi
… for detecting Keratoconus from clinical … with keratoconus six and twelve months
after the Kraring ring implantation using RNN are 9.82% and 9.29%, respectively.
The average error of estimating characteristics of predicting the visual characteristics …
after the Kraring ring implantation using RNN are 9.82% and 9.29%, respectively.
The average error of estimating characteristics of predicting the visual characteristics …
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[HTML] EyeWorld Journal Club review:"Prediction of the small aperture intraocular lens on visual acuity in patients with keratoconus"
R Wallace, S Gupta
Methods This study was a retrospective chart review of all patients with keratoconus
seen at Storm Eye Institute, Medical University of South Carolina between July 2016
and October 2022. The IC-8 Apthera IOL received pre-market approval from the FDA …
seen at Storm Eye Institute, Medical University of South Carolina between July 2016
and October 2022. The IC-8 Apthera IOL received pre-market approval from the FDA …
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Comment on: intraocular pressure after combined photorefractive keratectomy and corneal collagen cross linking for keratoconus
SK Chaurasiya, R Ray, M Singh - International Ophthalmology, 2024
… Ethnic and genetic factors can influence the presentation and progression of eye
conditions like keratoconus [3]… keratoconus. This information can be valuable for
understanding the impact of surgical procedures on IOP and guiding clinical …
conditions like keratoconus [3]… keratoconus. This information can be valuable for
understanding the impact of surgical procedures on IOP and guiding clinical …
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Trio-based whole-exome sequencing of 200 Chinese patients with keratoconus
X Li, Y Yao, S Xing, YH Zheng, Y Zhou, X Yu, J Su… - Experimental Eye Research, 2024
… in 200 patients with sporadic keratoconus and their unaffected parents. The
variants identified in candidate genes for keratoconus were analyzed using multiple
bioinformatics tools. Finally, we identified 7 variants in 5 candidate genes for …
variants identified in candidate genes for keratoconus were analyzed using multiple
bioinformatics tools. Finally, we identified 7 variants in 5 candidate genes for …
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[PDF] Harnessing Corneal Stromal Regeneration for Vision Restoration: A Comprehensive Review of the Emerging Treatment Techniques for Keratoconus
Z Javed, S Daigavane - Cureus, 2024
Keratoconus is a progressive corneal disorder characterized by thinning and conical
protrusion, leading to visual impairment that often necessitates advanced treatment
strategies. Traditional management options, including corrective lenses, corneal …
protrusion, leading to visual impairment that often necessitates advanced treatment
strategies. Traditional management options, including corrective lenses, corneal …
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Depression among Keratoconus (KC) Patients: A Systematic Review and Meta-Analysis
R Moshfeghinia, A Arman, N Sobhi… - Frontiers in Public Health
Background: Keratoconus (KC) is a chronic corneal disease that typically presents in
early adulthood, and may potentially result in poor mental health in affected
individuals. The evidence regarding the association of depression with KC is …
early adulthood, and may potentially result in poor mental health in affected
individuals. The evidence regarding the association of depression with KC is …
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Exploring the Accuracy and Readability of ChatGPT in Providing Information to Patients With Keratoconus
E Assayag, D Zadok, L Berkovitz, Y Weill - Journal of Pediatric Ophthalmology & …, 2024
Patients with keratoconus may lack sufficient understanding of their illness. The
authors assessed the accuracy and readability of ChatGPT (OpenAI) responses to
common questions regarding keratoconus and found that the provided data are …
authors assessed the accuracy and readability of ChatGPT (OpenAI) responses to
common questions regarding keratoconus and found that the provided data are …
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Multi-dataset identification of innovative feature genes and molecular mechanisms in keratoconus
N Lyu, Y Dai, J Wu, Y Fan, Z Lyu, J Gu, J Cheng, J Xu - Journal of cellular and …, 2024
This study aimed to identify feature genes and explore the molecular mechanisms of
keratoconus (KC). We downloaded data files from NCBI GEO public database. The
Limma package was used for differential expression analysis of gene profiles. Lasso …
keratoconus (KC). We downloaded data files from NCBI GEO public database. The
Limma package was used for differential expression analysis of gene profiles. Lasso …
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Distinguishing Subclinical from Clinical Keratoconus by Corneal Measurements
C Nicula, KU Horvath, AP Nicula, AE Bulboacă… - Frontiers in Medicine
Purpose: The study aimed to determine the stability of topographic and tomographic
indices measured with Pentacam and to evaluate the biomechanical parameters
measured with Corvis ST in the diagnosis of subclinical (sKCN) and clinical …
indices measured with Pentacam and to evaluate the biomechanical parameters
measured with Corvis ST in the diagnosis of subclinical (sKCN) and clinical …
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Prediction model for treatment outcomes 3 years after corneal cross-linking for keratoconus
Y Li, C Qiao, H Wang, Y Liu, MY Qi, L Ke, Y Zhou… - International Ophthalmology, 2024
… indicators to evaluate the progress of keratoconus or the postoperative efficacy of
CXL [5, 10,… keratoconus in our hospital who were treated with either accelerated
transepithelial or epithelium-off CXL between 2014 and 2019. The inclusion criteria …
CXL [5, 10,… keratoconus in our hospital who were treated with either accelerated
transepithelial or epithelium-off CXL between 2014 and 2019. The inclusion criteria …
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[HTML] Cochrane corner: artificial intelligence for keratoconus
EWW Tiong, SH Liu, DSJ Ting - Eye, 2024
… Keratoconus typically presents in the second to third … keratoconus [1]. This can
be aided by several advanced analytical techniques such as Belin Ambrosio
Enhanced Ectasia Display (for keratoconus detection) and Belin ABCD progression …
be aided by several advanced analytical techniques such as Belin Ambrosio
Enhanced Ectasia Display (for keratoconus detection) and Belin ABCD progression …
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Static magnetic field effects on the secondary structure and elasticity of collagen molecules; a possible biophysical approach to treat keratoconus
M Akbari, H Mobasheri, F Noorizadeh, SH Daryabari… - … and Biophysical Research …, 2024
Type I collagen is among the major extracellular proteins that play a significant role
in the maintenance of the cornea's structural integrity and is essential in cell
adhesion, differentiation, growth, and integrity. Here, we investigated the effect of …
in the maintenance of the cornea's structural integrity and is essential in cell
adhesion, differentiation, growth, and integrity. Here, we investigated the effect of …
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Role of genes in the pathogenesis of keratoconus
C Liu, F Yang - International Eye Science, 2024
Keratoconus (KC) is a disease characterized by limited corneal cone-like
protrusions accompanied by thinning of the corneal stroma in the area of protrusion,
which commonly occurs before and after puberty, manifests itself bilaterally, and is a …
protrusions accompanied by thinning of the corneal stroma in the area of protrusion,
which commonly occurs before and after puberty, manifests itself bilaterally, and is a …
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Diagnostic efficiency evaluation of visualized corneal biomechanical analysis combined with Pentacam on different stages of keratoconus
LI Dong, X Sheng - International Eye Science, 2024
… related-index in the diagnosis of subclinical keratoconus and forme fruste
keratoconus, and to provide evidence for early screening and diagnosis of
keratoconus.METHODS: A total of 65 patients(128 eyes)with keratoconus in Ningxia …
keratoconus, and to provide evidence for early screening and diagnosis of
keratoconus.METHODS: A total of 65 patients(128 eyes)with keratoconus in Ningxia …
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SCREENING FOR KERATOCONUS IN THE EARLY STAGES OF THE DISEASE
MQ Mamasoli o'g'li, NZ Isomiddinovna, AF Odilovich - TADQIQOTLAR, 2024
… Keratoconus is a progressive, degenerative disorder of the cornea characterized
by thinning … This article reviews the methods of screening for keratoconus in its
early stages, emphasizing … improve clinical outcomes and reduce the burden of …
by thinning … This article reviews the methods of screening for keratoconus in its
early stages, emphasizing … improve clinical outcomes and reduce the burden of …
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[PDF] A hybrid Transformers-based convolutional neural network model for keratoconus detection in Scheimpflug-based dynamic corneal deformation videos
H Abdelmotaal, R Hazarbasanov, R Salouti… - 2024
… We retrospectively analyzed datasets with records of 821 nonconsecutive, refractive
surgery candidates, and patients with unilateral or bilateral keratoconus, in these two
centers located on two different continents, which ensured the ethnic diversity of …
surgery candidates, and patients with unilateral or bilateral keratoconus, in these two
centers located on two different continents, which ensured the ethnic diversity of …
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Incidence and presenting clinical features of pediatric keratoconus in a US population
MK Farazdaghi, ED Bothun, M Tran, DO Hodge… - Journal of American …, 2024
… with keratoconus while residing in Olmsted County, Minnesota, from January 1,
1975, through December 31, 2019, were retrospectively reviewed. The records of
patients <19 years with keratoconus … <19 years of age diagnosed with …
1975, through December 31, 2019, were retrospectively reviewed. The records of
patients <19 years with keratoconus … <19 years of age diagnosed with …
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Visual, topographic, and refractive outcomes of the implantation of asymmetric segments of the intrastromal corneal ring in keratoconus.
ER Diniz, AS Moriyama, JCB Torres, ACI Horita… - Revista Brasileira de …, 2024
Objetivo: Avaliar os resultados visuais, topográficos e refrativos do implante de
segmentos assimétricos (AS) de anel intracorneano (ICRS) em olhos com
ceratocone e astigmatismo irregular/assimétrico (fenótipos tipo 2 Duck e 3 …
segmentos assimétricos (AS) de anel intracorneano (ICRS) em olhos com
ceratocone e astigmatismo irregular/assimétrico (fenótipos tipo 2 Duck e 3 …
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[PDF] Corneal densitometry changes post-CXL for keratoconus: Comparative evaluation of epithelium-off, contact lens-assisted, and transepithelial techniques
B Gupta, C Malhotra, S Dhar, K Abhyapal, AK Jain… - Indian Journal of …, 2024
… Purpose: To evaluate changes in corneal backscattering after collagen cross‑linking
(CXL) for progressive keratoconus and compare its course with different techniques
– standard epithelium‑off CXL (SCXL), contact lens‑assisted CXL (CACXL), and …
(CXL) for progressive keratoconus and compare its course with different techniques
– standard epithelium‑off CXL (SCXL), contact lens‑assisted CXL (CACXL), and …
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[PDF] Misclassification of Eyes With Progressive Keratoconus Using the KISA% Index
B Hammoud, WJ Dupps Jr, G Scarcelli, JB Randleman - Journal of Refractive Surgery, 2024
… This was a retrospective case-control study of consecutive patients with confirmed
progressive keratoconus and a contemporaneous … KISA% index and inferior-superior
(IS) values were obtained from the Pentacam topometric/keratoconus staging map …
progressive keratoconus and a contemporaneous … KISA% index and inferior-superior
(IS) values were obtained from the Pentacam topometric/keratoconus staging map …
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[PDF] Comparing the Postoperative Outcomes of Intrastromal Corneal Ring Segments in Three Different Topographic Patterns of Eccentric Keratoconus
MO Yousif, RS Elkitkat, A Elmassry, MN Hamza… - Journal of Refractive …, 2024
… The study included patients with keratoconus who had implantation of
KERATACx ring segments. Three groups were segregated based on topographic
keratoconus patterns using the Sirius CSO Topographer (CSO Italia): type I ectasia …
KERATACx ring segments. Three groups were segregated based on topographic
keratoconus patterns using the Sirius CSO Topographer (CSO Italia): type I ectasia …
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Meibomian Gland Alterations in Keratoconus Patients After Corneal Cross-Linking
G Özkan, S Akkaya Turhan - Beyoglu Eye Journal
OBJECTIVES: To evaluate the changes in the meibomian glands (MGs) and ocular
surface parameters after corneal cross-linking (CXL) in keratoconus patients.
METHODS: Forty-eight eyes of 48 keratoconus patients that underwent epi-off CXL …
surface parameters after corneal cross-linking (CXL) in keratoconus patients.
METHODS: Forty-eight eyes of 48 keratoconus patients that underwent epi-off CXL …
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[HTML] Scleral lens surface crazing in an eye with giant papillary conjunctivitis and keratoconus: Outcome of lens surface polishing
S Sadhu, A Iqbal, B Srinivasan, P Padmanabhan - Journal of Clinical Ophthalmology …, 2024… in a patient with keratoconus (KC) and chronic giant papillary conjunctivitis (GPC).
A 45-year-old Asian male with known keratoconus (KC) … Scleral lenses are widely
used in the management of patients with keratoconus (KC) and various ocular …
A 45-year-old Asian male with known keratoconus (KC) … Scleral lenses are widely
used in the management of patients with keratoconus (KC) and various ocular …
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Quantifying Choroidal and Retinal Thicknesses Variations via Optical Coherence Tomography in Different Stages of Pediatric Keratoconus
N Masihpour, M Feghhi, MRP Bazaz, AM Rad… - 2024Purpose: Keratoconus (KCN) is characterized by corneal thinning and bulging,
leading to vision impairment. Assessing choroidal thickness (CT) in pediatric KCN (pKCN)
patients can provide insights for better understanding and managing the disease …
leading to vision impairment. Assessing choroidal thickness (CT) in pediatric KCN (pKCN)
patients can provide insights for better understanding and managing the disease …
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[PDF] Intraocular Pressure Measurements After Corneal Collagen Crosslinking With Riboflavin and Ultraviolet A in Eyes with Keratoconus
S Mahmud, SA Robin, NM Khan, L Khabir…… For the treatment of corneal ectasias such as keratoconus, corneal collagen cross-linking
(CXL) using … In this study, 31 eyes from 30 patients receiving CXL treatment
because to keratoconus were … In eyes with keratoconus, riboflavin-UVA CXL …
(CXL) using … In this study, 31 eyes from 30 patients receiving CXL treatment
because to keratoconus were … In eyes with keratoconus, riboflavin-UVA CXL …
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Customized Corneal Cross-Linking with Microneedle-Mediated Riboflavin Delivery for Keratoconus Treatment
M Yang, H Pan, T Chen, X Chen, R Ning, Q Ye, A Chen… - Advanced materials (Deerfield …In this study, a novel customized corneal cross-linking (CXL) treatment is explored
that utilizes microneedles (MNs) for targeted riboflavin (RF) administration prior to
the CXL procedure. Unlike the conventional "one-size-fits-all" approach, this …
that utilizes microneedles (MNs) for targeted riboflavin (RF) administration prior to
the CXL procedure. Unlike the conventional "one-size-fits-all" approach, this …
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[HTML] Causal Association Between Atopic Dermatitis and Keratoconus: A Mendelian Randomization Study
Y Chang, T Huang, S Yang, Y Li, D Chen - Translational Vision Science & …, 2024
Purpose: Although many studies have indicated that atopic dermatitis (AD) could
contribute to the risk of keratoconus (KC), the causality between AD and KC remains
controversial. This study aimed to explore the potential causal associations between …
contribute to the risk of keratoconus (KC), the causality between AD and KC remains
controversial. This study aimed to explore the potential causal associations between …
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Refractive reconstruction of keratoconus
J Zhang, J Hou, Y Dong, Y Lei - International Eye Science, 2024
Keratoconus is a progressive disease that seriously affects the eyesight of young
people. Keratoconus often causes high myopia, irregular astigmatism, and some
patients with advanced corneal scar, visual acuity significantly decreased. In the …
people. Keratoconus often causes high myopia, irregular astigmatism, and some
patients with advanced corneal scar, visual acuity significantly decreased. In the …
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Advances in the mechanisms of keratoconus secondary to vernal keratoconjunctivitis
Q Luo, C Zhang - International Eye Science, 2024
… Keratoconus is a corneal disease characterized by a local cone-like corneal
deformation. … mechanisms of vernal keratoconjunctivitis and keratoconus and the
progressive risk factors, … keratoconus, so as to provide reference for the …
deformation. … mechanisms of vernal keratoconjunctivitis and keratoconus and the
progressive risk factors, … keratoconus, so as to provide reference for the …
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Application progress of artificial intelligence in keratoconus
Y Zhou, Q Zeng - International Eye Science, 2024
… Abstract: Keratoconus is a blinding corneal … in keratoconus, Artificial intelligence(AI)mainly
involves early screening and diagnosis, severity grading, progression prediction,
and outcomes prediction. In this paper, the main applications and research progress …
involves early screening and diagnosis, severity grading, progression prediction,
and outcomes prediction. In this paper, the main applications and research progress …
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Ocular surface changes in keratoconus after long-term wearing of rigid gas permeable contact lens
N Zhang, M Qian, L Yang, J Yang - International Eye Science, 2024
… A total of 113 keratoconus patients(213 eyes)fitted with RGPCL in the optometry
center of Gansu Provincial … of keratoconus, including 42 cases(80 eyes)in mild
keratoconus group, 54 cases(102 eyes)in moderate keratoconus group and 17 …
center of Gansu Provincial … of keratoconus, including 42 cases(80 eyes)in mild
keratoconus group, 54 cases(102 eyes)in moderate keratoconus group and 17 …
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Accelerated corneal cross-linking with application of isotonic riboflavin under pedicled corneal epithelial flap for thin keratoconus
L Guo, C Zhou - International Eye Science, 2024
… keratoconus (corneal thickness less than 400 μm after epithelial removal).
METHODS: Retrospective study. A total of 46 patients (74 eyes) with keratoconus …
feasible for patients with thin keratoconus, achieving similar control of keratoconus …
METHODS: Retrospective study. A total of 46 patients (74 eyes) with keratoconus …
feasible for patients with thin keratoconus, achieving similar control of keratoconus …
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[PDF] A Performance Evaluation of Large Language Model in Keratoconus: A Comparative Study of ChatGPT-3.5, ChatGPT-4.0, Gemini, Copilot, Chatsonic, and Perplexity
AH REYHAN, Ç MUTAF, U İrfan, F YÜKSEKYAYLA - 2024
Abstract Background: This study evaluates the ability of six popular chatbots;
ChatGPT-3.5, ChatGPT-4.0, Gemini, Copilot, Chatsonic, and Perplexity to provide
reliable answers to questions concerning keratoconus. Methods: Chatbots …
ChatGPT-3.5, ChatGPT-4.0, Gemini, Copilot, Chatsonic, and Perplexity to provide
reliable answers to questions concerning keratoconus. Methods: Chatbots …
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Clinical study on the difference of binocular biological parameters of the anterior segment in early diagnosis of keratoconus
YE Fan, J Xue - International Eye Science, 2024
AIM: To investigate the diagnostic value of the difference of binocular biological
parameters of the anterior segment in early keratoconus. METHODS: Retrospective
case-control study. A total of 183 patients (366 eyes) who visited our hospital from …
parameters of the anterior segment in early keratoconus. METHODS: Retrospective
case-control study. A total of 183 patients (366 eyes) who visited our hospital from …
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[HTML] A genetic investigation in five Chinese families with keratoconus
Q Lin, X Wang, X Peng, T Han, L Sun, X Zhang, X Zhou - PeerJ, 2024
Methods In the five families affected by KC, medical records, clinical observations,
and blood samples were collected from all individuals. All KC family members (n= 20)
underwent both whole exome sequencing of genomic DNA and Sanger sequencing …
and blood samples were collected from all individuals. All KC family members (n= 20)
underwent both whole exome sequencing of genomic DNA and Sanger sequencing …
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[HTML] Comparison of Pentacam data in patients with diagnostic criteria for keratoconus in only one eye
KA Carvalho, NAE Oliveira, RS Melice, RHMM Rocha… - Revista Brasileira de …, 2024
… This study reviewed charts of patients with keratoconus in one eye and forme
fruste keratoconus (FFKC) in the other, from January to December … Twenty-two
eyes of 11 patients were compared, and only one eye had established diagnostic …
fruste keratoconus (FFKC) in the other, from January to December … Twenty-two
eyes of 11 patients were compared, and only one eye had established diagnostic …
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Keratoconus: Optical and Surgical Management
M Mohammadpour, M Khorrami-Nejad - 2024
This is an updated and comprehensive treatise on optical, medical, and surgical
management of keratoconus with an exclusive panoramic view of all existing
modalities for confronting this serious disabling morbidity affecting people in their …
management of keratoconus with an exclusive panoramic view of all existing
modalities for confronting this serious disabling morbidity affecting people in their …
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Intra-Operative and Post-Operative Suture-Related Considerations and Complications of Corneal Graft for Keratoconus
A Peyman, A Aslani, M Pourazizi - Keratoconus, 2025
Corneal grafting, specifically penetrating keratoplasty (PK) and deep anterior
lamellar keratoplasty (DALK), are commonly used surgical interventions for
advanced keratoconus and corneal opacities. This chapter will review the …
lamellar keratoplasty (DALK), are commonly used surgical interventions for
advanced keratoconus and corneal opacities. This chapter will review the …
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Keratoconus Classification
M Ghoreishi, A Eslampoor - Keratoconus
… In the past, the path to keratoconus management was mainly limited to the
advanced forms of the disease with typical clinical findings (… This chapter reviews
different classification systems currently available for assessing keratoconus severity …
advanced forms of the disease with typical clinical findings (… This chapter reviews
different classification systems currently available for assessing keratoconus severity …
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Keratoconus Definition, Epidemiology, and Risk Factors
L Ghiasian - Keratoconus, 2025
… Most experts admit that a real unilateral keratoconus does not exist. Multiple
hypotheses have been proposed, including genetics, … may affect unknown
pathophysiology of the keratoconus.8 Despite many studies, the enigmatic …
hypotheses have been proposed, including genetics, … may affect unknown
pathophysiology of the keratoconus.8 Despite many studies, the enigmatic …
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New International Achievements in Modern Modalities of Keratoconus Treatment
K Jadidi, SA Mosavi - Keratoconus, 2024
… disorders such as keratoconus but can rarely be used for severe keratoconus, 7
and is not a solution for all keratoconus cases. According … development of new
devices and methods can provide further help in treating keratoconus on a wider …
and is not a solution for all keratoconus cases. According … development of new
devices and methods can provide further help in treating keratoconus on a wider …
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Complete 360-Degree Intrastromal Corneal Rings with and without Corneal Cross-Linking in the Management of Keratoconus
M Khorrami-Nejad, M Mohammadpour, R Abulhosein - Keratoconus, 2024
An effective therapeutic option for individuals with keratoconus (KCN) is the
intrastromal corneal ring (ICR), a type of implant that is either segmental arc-shaped
or 360-degree annular-shaped. 1 , 2 ICRs were initially designed by Barraquer (1949) …
intrastromal corneal ring (ICR), a type of implant that is either segmental arc-shaped
or 360-degree annular-shaped. 1 , 2 ICRs were initially designed by Barraquer (1949) …
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Management of Keratoconus with Contact Lenses
M Khorrami-Nejad, YA Shakor - Keratoconus, 2025
Keratoconus (KCN) is a type of corneal disease that does not involve inflammation
but is characterized by the protrusion of a cone-shaped area and gradual thinning of
the cornea.1–3 The thinnest location is usually found at the corneal apex, which is …
but is characterized by the protrusion of a cone-shaped area and gradual thinning of
the cornea.1–3 The thinnest location is usually found at the corneal apex, which is …
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Ocular Surface Considerations in Corneal Transplantation in Keratoconus
S Zarei-Ghanavati, MM Shariati - Keratoconus, 2025
Keratoconus (KC) is an asymmetric bilateral ocular disease, characterized by
progressive corneal thinning and steepening. 1 Changes in the curvature and
thickness of the cornea cause irregular astigmatism and visual impairment …
progressive corneal thinning and steepening. 1 Changes in the curvature and
thickness of the cornea cause irregular astigmatism and visual impairment …
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[HTML] Pulsed corneal crosslinking in the treatment of Keratoconus: a systematic review and meta-analysis
M Qureshi, SL Watson, H Kandel - Graefe's Archive for Clinical and Experimental …, 2024
… into P-CXL as an emerging option in the treatment of progressive keratoconus.
The primary objective of this systematic review was to investigate the effectiveness
of P-CXL in treating keratoconus and to determine whether it exhibits superior …
The primary objective of this systematic review was to investigate the effectiveness
of P-CXL in treating keratoconus and to determine whether it exhibits superior …
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[HTML] Implantable collamer lens for visual rehabilitation in keratoconus-a narrative review of visual and refractive outcomes
R Fairaq, HB Helayel, H Abdulhadi, SM Almuwarraee… - JFO Open Ophthalmology, 2024
… Keratoconus (KC) is a progressive corneal degeneration characterized by … in
keratoconus and the timing between ICL implantation and corneal crosslinking and/or
intrastromal corneal ring segment procedures. Additionally, we review challenges …
keratoconus and the timing between ICL implantation and corneal crosslinking and/or
intrastromal corneal ring segment procedures. Additionally, we review challenges …
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Vision Improvement in Keratoconus Patients Trained with Perceptual Learning: A Randomized Controlled Trial
XH Tang, MY Wang, JY Jiang, FQ Zhou, D Li, SS Chen… - American Journal of …, 2024
Background Keratoconus (KC) is a corneal ectasia disease in which the vision of
some patients cannot achieve satisfaction by spectacle corrections. However, not
everyone can embrace contact lenses to achieve better vision. Perceptual learning (PL) …
some patients cannot achieve satisfaction by spectacle corrections. However, not
everyone can embrace contact lenses to achieve better vision. Perceptual learning (PL) …
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Managing A Middle-aged Patient with Bilateral Neglected Keratoconus: A Rare Case Report
PA Universade, C Aritonang - International journal of health sciences
… and being noncontact for keratoconus screening. However, several developing
countries have delayed keratoconus management due to … Here we report a case
of underdiagnosed and mistreated by high astigmatism, leading to a neglected case …
countries have delayed keratoconus management due to … Here we report a case
of underdiagnosed and mistreated by high astigmatism, leading to a neglected case …
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Deep Anterior Lamellar Keratoplasty in Keratoconus
B Dave, D Patel, J Bavishi, V Hadvani - International journal of health sciences
… keratoconus in terms of best corrected and uncorrected visual acuity, average K
and topographic astigmatism. Settings and design: Prospective interventional case
series study Material and methods: 28 eyes of 28 patients diagnosed with …
and topographic astigmatism. Settings and design: Prospective interventional case
series study Material and methods: 28 eyes of 28 patients diagnosed with …
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Tomographic and topographic predictive factors of big bubble formation during deep anterior lamellar keratoplasty in keratoconus
L Lucchino, G Visioli, F Scarinci, RAMC Gisoldi… - British Journal of …, 2024
… Big bubble (BB) formation in deep anterior lamellar keratoplasty for keratoconus (KC)
can be influenced by surgical technique and corneal … . Influence of graft-host
interface on the quality of vision after deep anterior lamellar keratoplasty in patients …
can be influenced by surgical technique and corneal … . Influence of graft-host
interface on the quality of vision after deep anterior lamellar keratoplasty in patients …
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Big bubble formation in deep anterior lamellar keratoplasty may be more successful in early keratoconus eyes
HS Son, U Soiberman - British Journal of Ophthalmology, 2024
… The study provides topographic evidence for a higher BB success rate among
earlier stages of keratoconus, as … early keratoconus eyes with no tomographic
signs of posterior stromal scars.1 The authors postulate that the significant corneal …
earlier stages of keratoconus, as … early keratoconus eyes with no tomographic
signs of posterior stromal scars.1 The authors postulate that the significant corneal …
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[PDF] Assessment of OCT and Angio-OCT Parameters in Keratoconus Patients with and without Penetrating Keratoplasty
AM Gadamer, P Miklaszewski, D Janiszewska-Bil… - J. Clin. Med, 2024
… in keratoconus patients after penetrating keratoplasty, highlighting RPCs inside
the disc as a potential diagnostic tool for further assessment of keratoconus. … This
study evaluated the RPCs in keratoconus patients with and without PKP using OCT …
the disc as a potential diagnostic tool for further assessment of keratoconus. … This
study evaluated the RPCs in keratoconus patients with and without PKP using OCT …
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Macular choroidal thickness in keratoconus
A Abbasi Mehrabadi, J Sadeghi, N Shoeibi… - Clinical and Experimental …, 2024
… This study aimed to compare the difference in choroidal thickness between
keratoconus patients and two control groups of myopic-… A case-control study was
undertaken which included 50 patients with keratoconus, 50 with myopic-astigmatism …
keratoconus patients and two control groups of myopic-… A case-control study was
undertaken which included 50 patients with keratoconus, 50 with myopic-astigmatism …
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[HTML] Gene‒Environment Interaction Between CAST Gene and Eye-Rubbing in the Chinese Keratoconus Cohort Study: A Case-Only Study
S Yin, L Xu, K Yang, Q Fan, Y Gu, C Yin, Y Zang… - … Ophthalmology & Visual …, 2024
Purpose: Keratoconus (KC), characterized by progressive corneal protrusion and
thinning, is a complex disease influenced by the combination of genetic and
environmental factors. The purpose of this study was to explore potential gene‒environment …
thinning, is a complex disease influenced by the combination of genetic and
environmental factors. The purpose of this study was to explore potential gene‒environment …
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[HTML] Longitudinal assessment of the progression of severe keratoconus based on corneal topography
XD Yang, YR Wang, YY Liu, Y Lyu, WQ Wang - Scientific Reports, 2024
We aimed to assess long-term disease progression in patients with severe
keratoconus (KC). Clinical records of 125 patients (201 eyes) with severe KC
followed-up for > 12 months were retrospectively analyzed. From these, 28 patients (31 …
keratoconus (KC). Clinical records of 125 patients (201 eyes) with severe KC
followed-up for > 12 months were retrospectively analyzed. From these, 28 patients (31 …
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[HTML] Expression of matrix metalloproteinases and their inhibitors in corneal stromal fibroblasts and keratocytes from healthy and keratoconus corneas
T Berger, E Flockerzi, M Berger, N Chai, T Stachon… - Graefe's Archive for Clinical …, 2024
… (TIMP) in corneal stromal cells by distinguishing between fibroblasts and
keratocytes of healthy and keratoconus (KC) corneas. … Table 1 Descriptive data of
the keratoconus patients including the keratoconus ABCD grading system with the …
keratocytes of healthy and keratoconus (KC) corneas. … Table 1 Descriptive data of
the keratoconus patients including the keratoconus ABCD grading system with the …
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[PDF] Assessment of Corneal Cross-Linking Effect on Progressive Keratoconus by Using the ABCD Grading System
M Alzahrani, O Alammari, A Binyamin, R Alsulami… - Clinical Ophthalmology, 2024
Purpose The aim of this study was to assess changes in corneal parameters 6
months after corneal cross-linking for progressive keratoconus, using the ABCD
system. Patients and Methods This retrospective study was conducted at the King …
months after corneal cross-linking for progressive keratoconus, using the ABCD
system. Patients and Methods This retrospective study was conducted at the King …
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[PDF] Comparative Performance Analysis of Transformer-Based Pre-Trained Models for Detecting Keratoconus Disease
N Ahmed, MM Rahman, MF Ishrak, MIK Joy… - arXiv preprint arXiv …, 2024
… accurate and reliable keratoconus detection model. The study will also evaluate
the difficulties of differentiating keratoconus from other corneal … This research
compares different models to determine the best deep learning methods for …
the difficulties of differentiating keratoconus from other corneal … This research
compares different models to determine the best deep learning methods for …
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[PDF] Clinical Efficacy of Pocketing Air-Visco Expanding Detachment Deep Lamellar Keratoplasty for Keratoconus with Scars after Acute Hydrops
W Binghong, X Wenjia, Y Luyi, Z Yuanfang, Q Wenya - 2024
Background To analyze the clinical efficacy of PAVED (Pocketing Air-Visco
Expanding Detachment) deep anterior lamellar keratoplasty (DALK) for the
treatment of keratoconus with scarring after acute hydrops Methods 50 eyes from 50 …
Expanding Detachment) deep anterior lamellar keratoplasty (DALK) for the
treatment of keratoconus with scarring after acute hydrops Methods 50 eyes from 50 …
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Diagnostic ability of the corneal anterior and posterior surface area calculated by corneal modelling approach in early stage keratoconus patients
B Özelbaykal, O Kaya, B Kasım, T Birkandan, Y Koçluk - European Journal of …, 2024
… In this retrospective study, 116 eyes of 116 normal individuals and 366 eyes of
366 keratoconus patients were included. Keratoconus patients were divided into six
groups according to the topographic keratoconus classification of Pentacam …
366 keratoconus patients were included. Keratoconus patients were divided into six
groups according to the topographic keratoconus classification of Pentacam …
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Modeling biological growth of human keratoconus: On the effect of tissue degradation, location and size
B Fantaci, B Calvo, JF Rodríguez - Computers in biology and medicine
… keratoconus histopathology has been widely described in literature, its etiology is
still not clear. Being able to fully understand keratoconus … This work proposes a
novel continuum-based keratoconus growth model. The proposed framework …
still not clear. Being able to fully understand keratoconus … This work proposes a
novel continuum-based keratoconus growth model. The proposed framework …
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Risk factors for keratoconus in Pakistani population: A case control study
UG Khalid, A Zahid, F Akhtar, MA Ashraf, L ullah Khan - Rawal Medical Journal, 2024
… Controls were evaluated by an ophthalmologist and was declared as having no
signs of keratoconus. Controls was age and sex matched. … 30 were keratoconus
patients and 30 were general patients presenting Eye OPD. Data of 30 patients were …
signs of keratoconus. Controls was age and sex matched. … 30 were keratoconus
patients and 30 were general patients presenting Eye OPD. Data of 30 patients were …
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In silico characterization of the interaction of corneal tissue with a nitinol intracorneal implant for the treatment of keratoconus
A Patrissi - 2024
Keratoconus is a progressive bilateral and asymmetric eye disease of the cornea. It
causes progressive corneal thinning and a cone-… digital keratoconus cornea was
developed starting from a healthy 3D corneal model. The mechanical behaviour of …
causes progressive corneal thinning and a cone-… digital keratoconus cornea was
developed starting from a healthy 3D corneal model. The mechanical behaviour of …
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[HTML] … Automated Objective Measurements Acquired at the Preoperative Stage Estimate the Corrected Distance Visual Acuity after Corneal Cross-Linking in Keratoconus?
F Gilevska, A Biscevic, M Bohac, S Patel - Ophthalmology and Therapy, 2024
Introduction Objective markers describing corneal optical density (COD), thinnest
corneal thickness (TCT), and anterior (ARC) and posterior (PRC) surface radii over
the 3 mm thinnest region of the cornea were investigated to provide a model for …
corneal thickness (TCT), and anterior (ARC) and posterior (PRC) surface radii over
the 3 mm thinnest region of the cornea were investigated to provide a model for …
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Profile and Visual Outcome of Patients having Keratoconus Attending Tertiary Eye Hospital, Nepal
PR Adhikari, N Chaudhary, RR Karn - Journal of Nobel Medical College, 2024
… The aim of the study is to find out the clinical profile and visual outcome of the
patient having Keratoconus. … All the diagnosed Keratoconus patients referred from
cornea clinic to contact lens clinic for contact lens trial were included in this study …
patient having Keratoconus. … All the diagnosed Keratoconus patients referred from
cornea clinic to contact lens clinic for contact lens trial were included in this study …
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Evaluation of a new corneal scleral contact lens design in keratoconus
A Rotondi, C Stratta, M Frisani - Contact Lens and Anterior Eye, 2024
… keratoconus who are intolerant to RGP corneal CLs and unable to wear RGP
scleral CLs. Method: 23 eyes of 14 subjects (8 female, mean age 32, min 19 max 68
years) with keratoconus (… proven useful in visual rehabilitation in keratoconus and …
scleral CLs. Method: 23 eyes of 14 subjects (8 female, mean age 32, min 19 max 68
years) with keratoconus (… proven useful in visual rehabilitation in keratoconus and …
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[PDF] Comparative comparison of quality of life status of patients with myopia and keratoconus, Before and after surgery
N Ramezanghorbani, L Lotfi, N Morovati, N Morovati… - Koomesh, 2024
: Introduction: Visual impairment affects the quality of life of a person and endangers
his mental and social health and reduces his social activities and independence.
Therefore, clinical assessment of health-related quality of life in ocular patients is …
his mental and social health and reduces his social activities and independence.
Therefore, clinical assessment of health-related quality of life in ocular patients is …
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Long-term follow-up of repeated corneal cross-linking for progressive keratoconus in young patients
VGR Borges, LRS Stival, APA Nassaralla… - Rev. bras. oftalmol., 2024
… ) with progressive keratoconus underwent primary corneal cross-linking from
2009 to 2011. Despite the stability achieved with the epi-off corneal cross-linking,
keratoconus continued to progress after some time. Mean time to documented …
2009 to 2011. Despite the stability achieved with the epi-off corneal cross-linking,
keratoconus continued to progress after some time. Mean time to documented …
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[PDF] Evaluation of Macular and Choroidal Thickness in Patients with Subclinical Keratoconus
GD Arslan, D Özcan - COMPREHENSIVE MEDICINE
… in the tears of SKC and keratoconus eyes in patients diagnosed with unilateral
keratoconus supported the role of inflammation in the pathophysiology of
keratoconus.[13] Theories that claim a role for inflammation in the pathophysiology …
keratoconus supported the role of inflammation in the pathophysiology of
keratoconus.[13] Theories that claim a role for inflammation in the pathophysiology …
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Mendelian randomization analysis does not reveal a causal influence between keratoconus and three major mental disorders
X Zhang, Q Wang, F Cui, X Wu, C Zhang - Frontiers in Psychiatry
BackgroundObservational studies have suggested at a possible link between
keratoconus (KC) and various mental disorders, but the exact direction of causation
in these associations remains unclear. This study aims to investigate the potential …
keratoconus (KC) and various mental disorders, but the exact direction of causation
in these associations remains unclear. This study aims to investigate the potential …
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[HTML] Psychological and Psychiatric Characteristics of People with Keratoconus
S Florek, P Gościniewicz, M Suszka… - Reports, 2024
… with keratoconus is needed. The purpose of the present study was to determine
the links between the presence of keratoconus and … For the present study, an
exploratory hypothesis was developed that keratoconus patients are over-represented …
the links between the presence of keratoconus and … For the present study, an
exploratory hypothesis was developed that keratoconus patients are over-represented …
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[PDF] Efficacy of corneal collagen crosslinking procedure (C3-R) as a therapeutic modality in keratoconus patients
M Vyas
… Due to its advanced stage at diagnosis, paediatric keratoconus bears a higher
risk of severe visual impairment due to irregular astigmatism… Because of the
patients young age, keratoconus often has a significant negative effect on their …
risk of severe visual impairment due to irregular astigmatism… Because of the
patients young age, keratoconus often has a significant negative effect on their …
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