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[PDF] A Performance Evaluation of Large Language Model in Keratoconus: A Comparative Study of ChatGPT-3.5, ChatGPT-4.0, Gemini, Copilot, Chatsonic, and Perplexity
AH REYHAN, Ç MUTAF, U İrfan, F YÜKSEKYAYLA - 2024
Abstract Background: This study evaluates the ability of six popular chatbots;
ChatGPT-3.5, ChatGPT-4.0, Gemini, Copilot, Chatsonic, and Perplexity to provide
reliable answers to questions concerning keratoconus. Methods: Chatbots …
ChatGPT-3.5, ChatGPT-4.0, Gemini, Copilot, Chatsonic, and Perplexity to provide
reliable answers to questions concerning keratoconus. Methods: Chatbots …
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Clinical study on the difference of binocular biological parameters of the anterior segment in early diagnosis of keratoconus
YE Fan, J Xue - International Eye Science, 2024
AIM: To investigate the diagnostic value of the difference of binocular biological
parameters of the anterior segment in early keratoconus. METHODS: Retrospective
case-control study. A total of 183 patients (366 eyes) who visited our hospital from …
parameters of the anterior segment in early keratoconus. METHODS: Retrospective
case-control study. A total of 183 patients (366 eyes) who visited our hospital from …
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[HTML] A genetic investigation in five Chinese families with keratoconus
Q Lin, X Wang, X Peng, T Han, L Sun, X Zhang, X Zhou - PeerJ, 2024
Methods In the five families affected by KC, medical records, clinical observations,
and blood samples were collected from all individuals. All KC family members (n= 20)
underwent both whole exome sequencing of genomic DNA and Sanger sequencing …
and blood samples were collected from all individuals. All KC family members (n= 20)
underwent both whole exome sequencing of genomic DNA and Sanger sequencing …
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[HTML] Comparison of Pentacam data in patients with diagnostic criteria for keratoconus in only one eye
KA Carvalho, NAE Oliveira, RS Melice, RHMM Rocha… - Revista Brasileira de …, 2024
… This study reviewed charts of patients with keratoconus in one eye and forme
fruste keratoconus (FFKC) in the other, from January to December … Twenty-two
eyes of 11 patients were compared, and only one eye had established diagnostic …
fruste keratoconus (FFKC) in the other, from January to December … Twenty-two
eyes of 11 patients were compared, and only one eye had established diagnostic …
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Keratoconus: Optical and Surgical Management
M Mohammadpour, M Khorrami-Nejad - 2024
This is an updated and comprehensive treatise on optical, medical, and surgical
management of keratoconus with an exclusive panoramic view of all existing
modalities for confronting this serious disabling morbidity affecting people in their …
management of keratoconus with an exclusive panoramic view of all existing
modalities for confronting this serious disabling morbidity affecting people in their …
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Intra-Operative and Post-Operative Suture-Related Considerations and Complications of Corneal Graft for Keratoconus
A Peyman, A Aslani, M Pourazizi - Keratoconus, 2025
Corneal grafting, specifically penetrating keratoplasty (PK) and deep anterior
lamellar keratoplasty (DALK), are commonly used surgical interventions for
advanced keratoconus and corneal opacities. This chapter will review the …
lamellar keratoplasty (DALK), are commonly used surgical interventions for
advanced keratoconus and corneal opacities. This chapter will review the …
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Keratoconus Classification
M Ghoreishi, A Eslampoor - Keratoconus
… In the past, the path to keratoconus management was mainly limited to the
advanced forms of the disease with typical clinical findings (… This chapter reviews
different classification systems currently available for assessing keratoconus severity …
advanced forms of the disease with typical clinical findings (… This chapter reviews
different classification systems currently available for assessing keratoconus severity …
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Keratoconus Definition, Epidemiology, and Risk Factors
L Ghiasian - Keratoconus, 2025
… Most experts admit that a real unilateral keratoconus does not exist. Multiple
hypotheses have been proposed, including genetics, … may affect unknown
pathophysiology of the keratoconus.8 Despite many studies, the enigmatic …
hypotheses have been proposed, including genetics, … may affect unknown
pathophysiology of the keratoconus.8 Despite many studies, the enigmatic …
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New International Achievements in Modern Modalities of Keratoconus Treatment
K Jadidi, SA Mosavi - Keratoconus, 2024
… disorders such as keratoconus but can rarely be used for severe keratoconus, 7
and is not a solution for all keratoconus cases. According … development of new
devices and methods can provide further help in treating keratoconus on a wider …
and is not a solution for all keratoconus cases. According … development of new
devices and methods can provide further help in treating keratoconus on a wider …
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Complete 360-Degree Intrastromal Corneal Rings with and without Corneal Cross-Linking in the Management of Keratoconus
M Khorrami-Nejad, M Mohammadpour, R Abulhosein - Keratoconus, 2024
An effective therapeutic option for individuals with keratoconus (KCN) is the
intrastromal corneal ring (ICR), a type of implant that is either segmental arc-shaped
or 360-degree annular-shaped. 1 , 2 ICRs were initially designed by Barraquer (1949) …
intrastromal corneal ring (ICR), a type of implant that is either segmental arc-shaped
or 360-degree annular-shaped. 1 , 2 ICRs were initially designed by Barraquer (1949) …
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Management of Keratoconus with Contact Lenses
M Khorrami-Nejad, YA Shakor - Keratoconus, 2025
Keratoconus (KCN) is a type of corneal disease that does not involve inflammation
but is characterized by the protrusion of a cone-shaped area and gradual thinning of
the cornea.1–3 The thinnest location is usually found at the corneal apex, which is …
but is characterized by the protrusion of a cone-shaped area and gradual thinning of
the cornea.1–3 The thinnest location is usually found at the corneal apex, which is …
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Ocular Surface Considerations in Corneal Transplantation in Keratoconus
S Zarei-Ghanavati, MM Shariati - Keratoconus, 2025
Keratoconus (KC) is an asymmetric bilateral ocular disease, characterized by
progressive corneal thinning and steepening. 1 Changes in the curvature and
thickness of the cornea cause irregular astigmatism and visual impairment …
progressive corneal thinning and steepening. 1 Changes in the curvature and
thickness of the cornea cause irregular astigmatism and visual impairment …
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[HTML] Pulsed corneal crosslinking in the treatment of Keratoconus: a systematic review and meta-analysis
M Qureshi, SL Watson, H Kandel - Graefe's Archive for Clinical and Experimental …, 2024
… into P-CXL as an emerging option in the treatment of progressive keratoconus.
The primary objective of this systematic review was to investigate the effectiveness
of P-CXL in treating keratoconus and to determine whether it exhibits superior …
The primary objective of this systematic review was to investigate the effectiveness
of P-CXL in treating keratoconus and to determine whether it exhibits superior …
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[HTML] Implantable collamer lens for visual rehabilitation in keratoconus-a narrative review of visual and refractive outcomes
R Fairaq, HB Helayel, H Abdulhadi, SM Almuwarraee… - JFO Open Ophthalmology, 2024
… Keratoconus (KC) is a progressive corneal degeneration characterized by … in
keratoconus and the timing between ICL implantation and corneal crosslinking and/or
intrastromal corneal ring segment procedures. Additionally, we review challenges …
keratoconus and the timing between ICL implantation and corneal crosslinking and/or
intrastromal corneal ring segment procedures. Additionally, we review challenges …
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Vision Improvement in Keratoconus Patients Trained with Perceptual Learning: A Randomized Controlled Trial
XH Tang, MY Wang, JY Jiang, FQ Zhou, D Li, SS Chen… - American Journal of …, 2024
Background Keratoconus (KC) is a corneal ectasia disease in which the vision of
some patients cannot achieve satisfaction by spectacle corrections. However, not
everyone can embrace contact lenses to achieve better vision. Perceptual learning (PL) …
some patients cannot achieve satisfaction by spectacle corrections. However, not
everyone can embrace contact lenses to achieve better vision. Perceptual learning (PL) …
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Managing A Middle-aged Patient with Bilateral Neglected Keratoconus: A Rare Case Report
PA Universade, C Aritonang - International journal of health sciences
… and being noncontact for keratoconus screening. However, several developing
countries have delayed keratoconus management due to … Here we report a case
of underdiagnosed and mistreated by high astigmatism, leading to a neglected case …
countries have delayed keratoconus management due to … Here we report a case
of underdiagnosed and mistreated by high astigmatism, leading to a neglected case …
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Deep Anterior Lamellar Keratoplasty in Keratoconus
B Dave, D Patel, J Bavishi, V Hadvani - International journal of health sciences
… keratoconus in terms of best corrected and uncorrected visual acuity, average K
and topographic astigmatism. Settings and design: Prospective interventional case
series study Material and methods: 28 eyes of 28 patients diagnosed with …
and topographic astigmatism. Settings and design: Prospective interventional case
series study Material and methods: 28 eyes of 28 patients diagnosed with …
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Tomographic and topographic predictive factors of big bubble formation during deep anterior lamellar keratoplasty in keratoconus
L Lucchino, G Visioli, F Scarinci, RAMC Gisoldi… - British Journal of …, 2024
… Big bubble (BB) formation in deep anterior lamellar keratoplasty for keratoconus (KC)
can be influenced by surgical technique and corneal … . Influence of graft-host
interface on the quality of vision after deep anterior lamellar keratoplasty in patients …
can be influenced by surgical technique and corneal … . Influence of graft-host
interface on the quality of vision after deep anterior lamellar keratoplasty in patients …
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Big bubble formation in deep anterior lamellar keratoplasty may be more successful in early keratoconus eyes
HS Son, U Soiberman - British Journal of Ophthalmology, 2024
… The study provides topographic evidence for a higher BB success rate among
earlier stages of keratoconus, as … early keratoconus eyes with no tomographic
signs of posterior stromal scars.1 The authors postulate that the significant corneal …
earlier stages of keratoconus, as … early keratoconus eyes with no tomographic
signs of posterior stromal scars.1 The authors postulate that the significant corneal …
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[PDF] Assessment of OCT and Angio-OCT Parameters in Keratoconus Patients with and without Penetrating Keratoplasty
AM Gadamer, P Miklaszewski, D Janiszewska-Bil… - J. Clin. Med, 2024
… in keratoconus patients after penetrating keratoplasty, highlighting RPCs inside
the disc as a potential diagnostic tool for further assessment of keratoconus. … This
study evaluated the RPCs in keratoconus patients with and without PKP using OCT …
the disc as a potential diagnostic tool for further assessment of keratoconus. … This
study evaluated the RPCs in keratoconus patients with and without PKP using OCT …
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Macular choroidal thickness in keratoconus
A Abbasi Mehrabadi, J Sadeghi, N Shoeibi… - Clinical and Experimental …, 2024
… This study aimed to compare the difference in choroidal thickness between
keratoconus patients and two control groups of myopic-… A case-control study was
undertaken which included 50 patients with keratoconus, 50 with myopic-astigmatism …
keratoconus patients and two control groups of myopic-… A case-control study was
undertaken which included 50 patients with keratoconus, 50 with myopic-astigmatism …
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[HTML] Gene‒Environment Interaction Between CAST Gene and Eye-Rubbing in the Chinese Keratoconus Cohort Study: A Case-Only Study
S Yin, L Xu, K Yang, Q Fan, Y Gu, C Yin, Y Zang… - … Ophthalmology & Visual …, 2024
Purpose: Keratoconus (KC), characterized by progressive corneal protrusion and
thinning, is a complex disease influenced by the combination of genetic and
environmental factors. The purpose of this study was to explore potential gene‒environment …
thinning, is a complex disease influenced by the combination of genetic and
environmental factors. The purpose of this study was to explore potential gene‒environment …
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[HTML] Longitudinal assessment of the progression of severe keratoconus based on corneal topography
XD Yang, YR Wang, YY Liu, Y Lyu, WQ Wang - Scientific Reports, 2024
We aimed to assess long-term disease progression in patients with severe
keratoconus (KC). Clinical records of 125 patients (201 eyes) with severe KC
followed-up for > 12 months were retrospectively analyzed. From these, 28 patients (31 …
keratoconus (KC). Clinical records of 125 patients (201 eyes) with severe KC
followed-up for > 12 months were retrospectively analyzed. From these, 28 patients (31 …
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[HTML] Expression of matrix metalloproteinases and their inhibitors in corneal stromal fibroblasts and keratocytes from healthy and keratoconus corneas
T Berger, E Flockerzi, M Berger, N Chai, T Stachon… - Graefe's Archive for Clinical …, 2024
… (TIMP) in corneal stromal cells by distinguishing between fibroblasts and
keratocytes of healthy and keratoconus (KC) corneas. … Table 1 Descriptive data of
the keratoconus patients including the keratoconus ABCD grading system with the …
keratocytes of healthy and keratoconus (KC) corneas. … Table 1 Descriptive data of
the keratoconus patients including the keratoconus ABCD grading system with the …
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[PDF] Assessment of Corneal Cross-Linking Effect on Progressive Keratoconus by Using the ABCD Grading System
M Alzahrani, O Alammari, A Binyamin, R Alsulami… - Clinical Ophthalmology, 2024
Purpose The aim of this study was to assess changes in corneal parameters 6
months after corneal cross-linking for progressive keratoconus, using the ABCD
system. Patients and Methods This retrospective study was conducted at the King …
months after corneal cross-linking for progressive keratoconus, using the ABCD
system. Patients and Methods This retrospective study was conducted at the King …
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[PDF] Comparative Performance Analysis of Transformer-Based Pre-Trained Models for Detecting Keratoconus Disease
N Ahmed, MM Rahman, MF Ishrak, MIK Joy… - arXiv preprint arXiv …, 2024
… accurate and reliable keratoconus detection model. The study will also evaluate
the difficulties of differentiating keratoconus from other corneal … This research
compares different models to determine the best deep learning methods for …
the difficulties of differentiating keratoconus from other corneal … This research
compares different models to determine the best deep learning methods for …
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[PDF] Clinical Efficacy of Pocketing Air-Visco Expanding Detachment Deep Lamellar Keratoplasty for Keratoconus with Scars after Acute Hydrops
W Binghong, X Wenjia, Y Luyi, Z Yuanfang, Q Wenya - 2024
Background To analyze the clinical efficacy of PAVED (Pocketing Air-Visco
Expanding Detachment) deep anterior lamellar keratoplasty (DALK) for the
treatment of keratoconus with scarring after acute hydrops Methods 50 eyes from 50 …
Expanding Detachment) deep anterior lamellar keratoplasty (DALK) for the
treatment of keratoconus with scarring after acute hydrops Methods 50 eyes from 50 …
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Diagnostic ability of the corneal anterior and posterior surface area calculated by corneal modelling approach in early stage keratoconus patients
B Özelbaykal, O Kaya, B Kasım, T Birkandan, Y Koçluk - European Journal of …, 2024
… In this retrospective study, 116 eyes of 116 normal individuals and 366 eyes of
366 keratoconus patients were included. Keratoconus patients were divided into six
groups according to the topographic keratoconus classification of Pentacam …
366 keratoconus patients were included. Keratoconus patients were divided into six
groups according to the topographic keratoconus classification of Pentacam …
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Modeling biological growth of human keratoconus: On the effect of tissue degradation, location and size
B Fantaci, B Calvo, JF Rodríguez - Computers in biology and medicine
… keratoconus histopathology has been widely described in literature, its etiology is
still not clear. Being able to fully understand keratoconus … This work proposes a
novel continuum-based keratoconus growth model. The proposed framework …
still not clear. Being able to fully understand keratoconus … This work proposes a
novel continuum-based keratoconus growth model. The proposed framework …
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Risk factors for keratoconus in Pakistani population: A case control study
UG Khalid, A Zahid, F Akhtar, MA Ashraf, L ullah Khan - Rawal Medical Journal, 2024
… Controls were evaluated by an ophthalmologist and was declared as having no
signs of keratoconus. Controls was age and sex matched. … 30 were keratoconus
patients and 30 were general patients presenting Eye OPD. Data of 30 patients were …
signs of keratoconus. Controls was age and sex matched. … 30 were keratoconus
patients and 30 were general patients presenting Eye OPD. Data of 30 patients were …
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In silico characterization of the interaction of corneal tissue with a nitinol intracorneal implant for the treatment of keratoconus
A Patrissi - 2024
Keratoconus is a progressive bilateral and asymmetric eye disease of the cornea. It
causes progressive corneal thinning and a cone-… digital keratoconus cornea was
developed starting from a healthy 3D corneal model. The mechanical behaviour of …
causes progressive corneal thinning and a cone-… digital keratoconus cornea was
developed starting from a healthy 3D corneal model. The mechanical behaviour of …
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[HTML] … Automated Objective Measurements Acquired at the Preoperative Stage Estimate the Corrected Distance Visual Acuity after Corneal Cross-Linking in Keratoconus?
F Gilevska, A Biscevic, M Bohac, S Patel - Ophthalmology and Therapy, 2024
Introduction Objective markers describing corneal optical density (COD), thinnest
corneal thickness (TCT), and anterior (ARC) and posterior (PRC) surface radii over
the 3 mm thinnest region of the cornea were investigated to provide a model for …
corneal thickness (TCT), and anterior (ARC) and posterior (PRC) surface radii over
the 3 mm thinnest region of the cornea were investigated to provide a model for …
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Profile and Visual Outcome of Patients having Keratoconus Attending Tertiary Eye Hospital, Nepal
PR Adhikari, N Chaudhary, RR Karn - Journal of Nobel Medical College, 2024
… The aim of the study is to find out the clinical profile and visual outcome of the
patient having Keratoconus. … All the diagnosed Keratoconus patients referred from
cornea clinic to contact lens clinic for contact lens trial were included in this study …
patient having Keratoconus. … All the diagnosed Keratoconus patients referred from
cornea clinic to contact lens clinic for contact lens trial were included in this study …
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Evaluation of a new corneal scleral contact lens design in keratoconus
A Rotondi, C Stratta, M Frisani - Contact Lens and Anterior Eye, 2024
… keratoconus who are intolerant to RGP corneal CLs and unable to wear RGP
scleral CLs. Method: 23 eyes of 14 subjects (8 female, mean age 32, min 19 max 68
years) with keratoconus (… proven useful in visual rehabilitation in keratoconus and …
scleral CLs. Method: 23 eyes of 14 subjects (8 female, mean age 32, min 19 max 68
years) with keratoconus (… proven useful in visual rehabilitation in keratoconus and …
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[PDF] Comparative comparison of quality of life status of patients with myopia and keratoconus, Before and after surgery
N Ramezanghorbani, L Lotfi, N Morovati, N Morovati… - Koomesh, 2024
: Introduction: Visual impairment affects the quality of life of a person and endangers
his mental and social health and reduces his social activities and independence.
Therefore, clinical assessment of health-related quality of life in ocular patients is …
his mental and social health and reduces his social activities and independence.
Therefore, clinical assessment of health-related quality of life in ocular patients is …
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Long-term follow-up of repeated corneal cross-linking for progressive keratoconus in young patients
VGR Borges, LRS Stival, APA Nassaralla… - Rev. bras. oftalmol., 2024
… ) with progressive keratoconus underwent primary corneal cross-linking from
2009 to 2011. Despite the stability achieved with the epi-off corneal cross-linking,
keratoconus continued to progress after some time. Mean time to documented …
2009 to 2011. Despite the stability achieved with the epi-off corneal cross-linking,
keratoconus continued to progress after some time. Mean time to documented …
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[PDF] Evaluation of Macular and Choroidal Thickness in Patients with Subclinical Keratoconus
GD Arslan, D Özcan - COMPREHENSIVE MEDICINE
… in the tears of SKC and keratoconus eyes in patients diagnosed with unilateral
keratoconus supported the role of inflammation in the pathophysiology of
keratoconus.[13] Theories that claim a role for inflammation in the pathophysiology …
keratoconus supported the role of inflammation in the pathophysiology of
keratoconus.[13] Theories that claim a role for inflammation in the pathophysiology …
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Mendelian randomization analysis does not reveal a causal influence between keratoconus and three major mental disorders
X Zhang, Q Wang, F Cui, X Wu, C Zhang - Frontiers in Psychiatry
BackgroundObservational studies have suggested at a possible link between
keratoconus (KC) and various mental disorders, but the exact direction of causation
in these associations remains unclear. This study aims to investigate the potential …
keratoconus (KC) and various mental disorders, but the exact direction of causation
in these associations remains unclear. This study aims to investigate the potential …
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[HTML] Psychological and Psychiatric Characteristics of People with Keratoconus
S Florek, P Gościniewicz, M Suszka… - Reports, 2024
… with keratoconus is needed. The purpose of the present study was to determine
the links between the presence of keratoconus and … For the present study, an
exploratory hypothesis was developed that keratoconus patients are over-represented …
the links between the presence of keratoconus and … For the present study, an
exploratory hypothesis was developed that keratoconus patients are over-represented …
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[PDF] Efficacy of corneal collagen crosslinking procedure (C3-R) as a therapeutic modality in keratoconus patients
M Vyas
… Due to its advanced stage at diagnosis, paediatric keratoconus bears a higher
risk of severe visual impairment due to irregular astigmatism… Because of the
patients young age, keratoconus often has a significant negative effect on their …
risk of severe visual impairment due to irregular astigmatism… Because of the
patients young age, keratoconus often has a significant negative effect on their …
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[PDF] Evaluation of ophthalmic healthcare professional-led keratoconus management service in the United Kingdom
M Bourlaki, M Khan, S Bandyopadhyay, R Sahota… - 2024
… been established, including the setup of virtual keratoconus clinics and CXL
services led by … effectiveness and safety of OHP-led keratoconus service in
Birmingham and Midland Eye … We included 170 patients with suspected/confirmed …
services led by … effectiveness and safety of OHP-led keratoconus service in
Birmingham and Midland Eye … We included 170 patients with suspected/confirmed …
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… Photorefractive Keratectomy Combined with Accelerated Corneal Collagen Cross-linking versus Cross-Linking Alone for Progressive Keratoconus: A Long-Term …
Z Dai, Z Liu, Y Zhang, Y Yuan, Y Liu, Y Wang, S Yu… - Frontiers in Medicine
Purpose: To comprehensively compare the long-term outcome of the combined
topography guided photorefractive keratectomy (TG-PRK) with accelerated corneal
cross-linking (ACXL) and ACXL alone in eyes with progressive keratoconus. The …
topography guided photorefractive keratectomy (TG-PRK) with accelerated corneal
cross-linking (ACXL) and ACXL alone in eyes with progressive keratoconus. The …
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Performance Comparison of Machine Learning Algorithms for Keratoconus Detection
ZJ Muhsin, R Qahwaji, I Ghafir, M Al Bdour, S AlRyalat… - 2024 IEEE 30th …, 2024
This paper provides an in-depth examination of eight Machine Learning (ML)
algorithms commonly employed in diagnosing keratoconus (KC) over the past
decade. The analysis is conducted using a clinical dataset accumulated by the …
algorithms commonly employed in diagnosing keratoconus (KC) over the past
decade. The analysis is conducted using a clinical dataset accumulated by the …
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[HTML] OPPORTUNITIES FOR IMPROVING THE LONG-TERM MANAGEMENT OF KERATOCONUS PATIENTS
A Nau, C Nau, E Shorter, M Schornack, J Fogt… - Journal of Contact lens …, 2024
Background and Objective: This study determined whether practitioners specializing
in keratoconus (KC) adhere to published guidelines for disease management and to
what extent comorbid conditions of dry eye, contact lens tolerance, and …
in keratoconus (KC) adhere to published guidelines for disease management and to
what extent comorbid conditions of dry eye, contact lens tolerance, and …
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Cell Volume Regulation of Endothelial Cells Is Impaired in Keratoconus Cornea
IM Kuseina, LE Katkova, GS Baturina, IG Palchikova… - Biologičeskie membrany, 2024
… with keratoconus was investigated. The endothelial cells were obtained from
surgery material. Measurements of osmotic aqueous permeability (Pf) of endothelial
cells in normal and in keratoconus … in cell volume regulating mechanism in …
surgery material. Measurements of osmotic aqueous permeability (Pf) of endothelial
cells in normal and in keratoconus … in cell volume regulating mechanism in …
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[HTML] Triad of benign fleck retina with keratoconus with myopia–A rare case report
A Gupta, V Agrawal - Indian Journal of Ophthalmology-Case Reports, 2024
… keratoconus is quoted in the literature as fairly rare. [ 6 ] There also seemed to be
a link between the severity of the retinal degeneration and the frequency of the
keratoconus; the more severe cases appeared to be more prone to developing …
a link between the severity of the retinal degeneration and the frequency of the
keratoconus; the more severe cases appeared to be more prone to developing …
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[HTML] Tear meniscus particle analysis with anterior segment optical coherence tomography in keratoconus
SA Seyyar, Ş Büyükbayram, GG Soysal, S Ayla… - Indian Journal of …, 2024
… tear film in keratoconus patients, with higher TMT and lower POAP levels in the
keratoconus group compared to the healthy control group. … the tear meniscus in
keratoconus. The effect of increased inflammatory mediators in the tears of patients …
keratoconus group compared to the healthy control group. … the tear meniscus in
keratoconus. The effect of increased inflammatory mediators in the tears of patients …
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Correction: Evaluation of ophthalmic healthcare professional-led keratoconus management service in the United Kingdom: the Birmingham and Midland Eye Centre …
M Bourlaki, M Khan, S Bandyopadhyay, R Sahota… - Eye, 2024
The term "allied health professional (s)" was replaced with "ophthalmic healthcare
professional (s)" in the title and throughout the main text of this article. The
terminology "allied health professionals" refers to a distinct group of healthcare …
professional (s)" in the title and throughout the main text of this article. The
terminology "allied health professionals" refers to a distinct group of healthcare …
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[PDF] Femtosecond Laser Assisted Deep Anterior Lamellar Keratoplasty versus Manual Technique for Treatment of Keratoconus
A Nooreldin, AMG EL-Kareem - The Egyptian Journal of Hospital Medicine (July 2024)
Background: DALK is agolden method for treatment of keratoconus with
preservation of endothelium. femtosecond laser-assisted DALK (F-DALK) is a new
technique used nowadays to overcome difficulties of an old one. Aims: To contrast …
preservation of endothelium. femtosecond laser-assisted DALK (F-DALK) is a new
technique used nowadays to overcome difficulties of an old one. Aims: To contrast …
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[HTML] Inflammation and keratoconus: A comprehensive bidirectional Mendelian randomization analysis
X Zhang, F Cui, Q Wang, C Zhang - Medicine, 2024
An increasing body of evidence supports the involvement of inflammation and
immune responses in the occurrence and development of keratoconus (KC).
However, the causal relationship between inflammatory factors and KC remains …
immune responses in the occurrence and development of keratoconus (KC).
However, the causal relationship between inflammatory factors and KC remains …
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Comparisons of corneal biomechanical and higher-order aberrations between thin normal cornea and Forme Fruste keratoconus
M Liu, X Liu, X Liu, T Chen, C Liu, G Tian - 2024
… keratoconus of the contralateral eye [9] . By improving the diagnostic rate of
identifying potentially high-risk corneas or early keratoconus, … It has been shown [11]
that changes in the biomechanical characteristics of keratoconus may precede …
identifying potentially high-risk corneas or early keratoconus, … It has been shown [11]
that changes in the biomechanical characteristics of keratoconus may precede …
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[HTML] Impacts of keratoconus on quality of life: a qualitative study
L Fan, H Kandel, SL Watson - Eye, 2024
… reported in this study on patients receiving a single type of treatment for their
keratoconus [15]. Knowledge of the patient experience of … QoL impacts of
keratoconus in the real-world, this study aimed to evaluate the patient experience of …
keratoconus [15]. Knowledge of the patient experience of … QoL impacts of
keratoconus in the real-world, this study aimed to evaluate the patient experience of …
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Repeatability and agreement of two ocular biometers with single and dual Scheimpflug cameras in keratoconus eyes
C Lwowski, D Krüger, T Kohnen - Graefe's Archive for Clinical and Experimental …, 2024
Background To evaluate the repeatability and agreement of two different ocular
biometers and Scheimpflug devices in keratoconus eyes. Methods This prospective,
comparative trial took place at the University hospital, Goethe University, Frankfurt …
biometers and Scheimpflug devices in keratoconus eyes. Methods This prospective,
comparative trial took place at the University hospital, Goethe University, Frankfurt …
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Comparison of a Scheimpflug device and a spectral domain optical coherence tomography device for keratoconus detection/Author Honeder Andreas
A Honeder - 2024
… our keratoconus outpatient clinic in a retrospective fashion. In all cases, a
Scheimpflug measurement (Pentacam HR, Oculus, Germany) and a spectral domain
OCT (MS-39, CSI, Italy) was available. A detailed comparison including standard …
Scheimpflug measurement (Pentacam HR, Oculus, Germany) and a spectral domain
OCT (MS-39, CSI, Italy) was available. A detailed comparison including standard …
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[HTML] Detecting early changes in choroidal vascularity and thickness using optical coherence tomography in patients with corneal crosslinking for keratoconus
S Doganay, MO Kiristioglu, D Doganay, E Kacmaz - International Journal of …, 2024
AIM To investigate changes in choroidal thickness and vascularity in keratoconus
patients treated with corneal crosslinking. METHODS This study evaluated 28 eyes
of 22 patients with keratoconus who underwent corneal crosslinking. The choroidal …
patients treated with corneal crosslinking. METHODS This study evaluated 28 eyes
of 22 patients with keratoconus who underwent corneal crosslinking. The choroidal …
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[HTML] Improved Feature Fusion and Representation for Detecting Keratoconus from Corneal Maps
RM Hazarbassanov, L Al-Zubaidi, A Al-Timemy, C Arce… - … Ophthalmology & Visual …, 2024
Purpose: This study aims to develop and validate a hybrid model that integrates
deep learning, specifically feature fusion, for the detection of keratoconus (KC) using
corneal maps collected from a dual Scheimpflug analyzer. Methods: We collected …
deep learning, specifically feature fusion, for the detection of keratoconus (KC) using
corneal maps collected from a dual Scheimpflug analyzer. Methods: We collected …
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[HTML] Diagnosis of forme fruste keratoconus with scheimpflug photography in Ghanaian patients
S Lartey, E Appiagyei - BMC Ophthalmology, 2024
… myopic astigmatism from forme fruste keratoconus using Pentacam parameters
and develop a predictive model for early keratoconus detection. … a crucial role in
predicting forme fruste keratoconus, emphasizing its relevance as an early indicator …
and develop a predictive model for early keratoconus detection. … a crucial role in
predicting forme fruste keratoconus, emphasizing its relevance as an early indicator …
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Repeatability of Automatic Measurements by an Anterior Segment Swept-Source OCT Biometer in Patients With Keratoconus
I Abicca, D Schiano-Lomoriello, M Gilardi, D Giannini… - Journal of Refractive …, 2024
… The purpose of the current study was to investigate the repeatability of automatic
measurements by the ANTERION in eyes with keratoconus … III keratoconus
included in our study population. In the future, a larger number of eyes for each …
measurements by the ANTERION in eyes with keratoconus … III keratoconus
included in our study population. In the future, a larger number of eyes for each …
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[PDF] Progressive Keratoconus Treatment with Transepithelial 2-Step Phototherapeutic Keratectomy Combined with Corneal Cross-Linking (CXL): Clinical Outcomes and …
AJ Kanellopoulos, AJ Kanellopoulos - 2024
… , combined with higher fluence CXL in the effective management and visual
rehabilitation of progressive keratoconus. Methods: 17 cases with progressive
keratoconus were treated with a corneal surface excimer laser ablation …
rehabilitation of progressive keratoconus. Methods: 17 cases with progressive
keratoconus were treated with a corneal surface excimer laser ablation …
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[HTML] Elevating optometric keratoconus management
K Gilbert Spear - 2024
Disclaimer: The information in this article is provided for general informational
purposes only and may not reflect the current law in your jurisdiction. The
information contained in this article is not legal advice, and it is not intended to be a …
purposes only and may not reflect the current law in your jurisdiction. The
information contained in this article is not legal advice, and it is not intended to be a …
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[HTML] Inter-zonal epithelial thickness differences for early keratoconus detection using optical coherence tomography
T Naujokaitis, R Khoramnia, M Friedrich, HS Son… - Eye, 2024
… In conclusion, we found the inter-zonal ET differences to correlate with the
tomographical changes in keratoconus and to be increased not only in
tomographically significant keratoconus, but also in tomographically normal …
tomographical changes in keratoconus and to be increased not only in
tomographically significant keratoconus, but also in tomographically normal …
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[PDF] Clinical profile and outcomes of rejection after deep anterior lamellar keratoplasty in keratoconus
P Sudaboina, S Chaurasia, S Murthy - Indian Journal of Ophthalmology, 2024
… In this study, all six eyes with rejection had DALK performed for keratoconus. The
potential risk factors that were identified were vernal keratoconjunctivitis in four eyes
(Patient 1, 2, 3, and 4), lid margin disease in one eye (Patient 5), eccentric graft in …
potential risk factors that were identified were vernal keratoconjunctivitis in four eyes
(Patient 1, 2, 3, and 4), lid margin disease in one eye (Patient 5), eccentric graft in …
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[HTML] MEAN CHANGE IN ENDOTHELIAL CELL DENSITY AFTER COLLAGEN CROSS-LINKING IN PROGRESSIVE KERATOCONUS: A QUASI EXPERIMENTAL STUDY
S Khan, A Maqbool, A Gohar, U Arshad, R Sharif, S Zia - Gomal Journal of Medical …, 2024
Background: Corneal collagen cross-linking (CXL) is a minimally invasive technique
that halts the advancement of keratoconus. The objective of our study was to
determine mean change in endothelial cell density in patients with advancing …
that halts the advancement of keratoconus. The objective of our study was to
determine mean change in endothelial cell density in patients with advancing …
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[HTML] Smart decision support system for keratoconus severity staging using corneal curvature and thinnest pachymetry indices
ZJ Muhsin, R Qahwaji, M AlShawabkeh, SA AlRyalat… - Eye and Vision, 2024
This study proposes a decision support system created in collaboration with
machine learning experts and ophthalmologists for detecting keratoconus (KC)
severity. The system employs an ensemble machine model and minimal corneal …
machine learning experts and ophthalmologists for detecting keratoconus (KC)
severity. The system employs an ensemble machine model and minimal corneal …
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[PDF] Early findings in a randomised controlled trial on crosslinking protocols using isoosmolar and hypoosmolar riboflavin for the treatment of progressive keratoconus
I Gustafsson, T Olafsdotttir, O Neumann, P Johansson… - Acta Ophthalmologica, 2024
Purpose To present baseline characteristics and to present the perioperative
corneal thickness during corneal crosslinking (CXL) treatment for progressive
keratoconus and to describe how the addition of sterile water (SW) efficaciously can …
corneal thickness during corneal crosslinking (CXL) treatment for progressive
keratoconus and to describe how the addition of sterile water (SW) efficaciously can …
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Elevating keratoconus management.
KG Spear - Optometry Times, 2024
The article discusses the importance of professional practice guidelines in optometry,
specifically focusing on the diagnosis and management of keratoconus (KC). While
there are currently no professional society guidelines for KC in optometry, the …
specifically focusing on the diagnosis and management of keratoconus (KC). While
there are currently no professional society guidelines for KC in optometry, the …
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Changes in the precorneal tear film at various stages of keratoconus
VV Averich, IA Bubnova - Vestnik oftalmologii, 2024
The combination of keratoconus (KC) with signs of dry eye disease (DES) has been
described in numerous scientific publications. At the same time, there is a
relationship between KC stage and an increase in the severity of DES symptoms …
described in numerous scientific publications. At the same time, there is a
relationship between KC stage and an increase in the severity of DES symptoms …
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Changes in the precorneal tear film at various stages of keratoconus
VV Averich, IA Bubnova - Vestnik oftalmologii, 2024
The combination of keratoconus (KC) with signs of dry eye disease (DES) has been
described in numerous scientific publications. At the same time, there is a
relationship between KC stage and an increase in the severity of DES symptoms …
described in numerous scientific publications. At the same time, there is a
relationship between KC stage and an increase in the severity of DES symptoms …
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[HTML] IOL Power Calculation in Keratoconus
JX Kane - Intraocular Lens Calculations, 2024
… The challenges with keratoconus are the corneal power measurement issues, the
IOL formula calculation errors, and the difficulty in refraction. The different formulas
used in keratoconus cases are compared. The Kane keratoconus formula utilises …
IOL formula calculation errors, and the difficulty in refraction. The different formulas
used in keratoconus cases are compared. The Kane keratoconus formula utilises …
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[PDF] Strengthening keratoconus management systems in South African public sector facilities
PMW Nkoana, KP Mashige, VR Moodley - African Vision and Eye Health, 2024
Background: Provision of comprehensive eye care remains a challenge in low to
medium income countries including South Africa. The recent surge of keratoconus (KC)
is exacerbating this challenge especially in terms of the need for specialised …
medium income countries including South Africa. The recent surge of keratoconus (KC)
is exacerbating this challenge especially in terms of the need for specialised …
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Keratoconus Detection Using Machine Learning
R Sandhiya, NM Chakkravthi, DN Vignesh… - 2024 3rd International …, 2024
… keratoconus promptly and accurately to take the necessary action and stop the
condition from progressing. The goal of this study is to use artificial intelligence
principles and cuttingedge technologies to diagnose keratoconus … whether a …
condition from progressing. The goal of this study is to use artificial intelligence
principles and cuttingedge technologies to diagnose keratoconus … whether a …
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[PDF] A Retrospective Study on keratoconus patients living in the central division, Fiji, 2015–2019.
V Kumar
Purpose: To understand the severity of keratoconus patients living in the central
division of Fiji. Methods: A total of sixty patients who attended to private clinic in
Suva (Fiji) were reviewed. The severity of KCN was graded into three (3) groups …
division of Fiji. Methods: A total of sixty patients who attended to private clinic in
Suva (Fiji) were reviewed. The severity of KCN was graded into three (3) groups …
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[PDF] KeratoEL: Detection of keratoconus using corneal parameters with ensemble learning
PK Paul, A Hossan, SMA Ullah - Health Science Reports, 2024
… between 0 and 4, forme fruste keratoconus (or keratoconus-suspect) for values
between 5 and 29, and keratoconus for values of 30 or higher. This data set, which
used CASIA labels, includes 390 keratoconus cases, 796 forme-fruste keratoconus …
between 5 and 29, and keratoconus for values of 30 or higher. This data set, which
used CASIA labels, includes 390 keratoconus cases, 796 forme-fruste keratoconus …
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Keratoconus: imaging modalities and management
N Alqudah - Medical hypothesis discovery and innovation in …, 2024
… for the online search: keratoconus, diagnosis of keratoconus, advances in the
diagnosis of keratoconus, topography or tomography, … keratoconus, advances in
the treatment of keratoconus, collagen crosslinking, intrastromal ring, keratoplasty …
diagnosis of keratoconus, topography or tomography, … keratoconus, advances in
the treatment of keratoconus, collagen crosslinking, intrastromal ring, keratoplasty …
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Keratoconus and Inflammatory bowel disease: Mendelian randomization
Y Jin, Y Wang, X Qiu, J Liu, S Qu - Frontiers in Genetics
… Studies have shown that inflammation may play a role in keratoconus.
Inflammatory enteritis (IBD), including ulcerative colitis(UC), is a … and keratoconus.
Methods The instrumental variable of IBD and UC was selected, the information of …
Inflammatory enteritis (IBD), including ulcerative colitis(UC), is a … and keratoconus.
Methods The instrumental variable of IBD and UC was selected, the information of …
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Exploring the Causal Relationship between BMI and Keratoconus: A Mendelian Randomization Study
J Wang, F Liu, J Mo, F Zheng, D Gong, J Su, S Ding… - Frontiers in Medicine
Background: Despite reports suggesting a link between obesity and keratoconus,
the causal relationship is not fully understood.We used genome-wide association
study (GWAS) data from public databases for a two-sample Mendelian …
the causal relationship is not fully understood.We used genome-wide association
study (GWAS) data from public databases for a two-sample Mendelian …
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Corneal densitometry changes after femtosecond laser-assisted intracorneal ring segments implantation in keratoconus
A Mounir, EM Mostafa, I Amer, AA Abdelgbar… - … hypothesis discovery and …, 2024
Background: Intrastromal corneal ring segments are commonly implanted in the
corneas of eyes with mild-to-moderate keratoconus; however, changes in corneal
densitometry (CD) after implantation are a matter of debate in the current literature …
corneas of eyes with mild-to-moderate keratoconus; however, changes in corneal
densitometry (CD) after implantation are a matter of debate in the current literature …
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[PDF] … pain and epithelial healing time after corneal collagen cross-linking following Conventional versus laser Epithelial removal in females with progressive keratoconus
I Fathy
Background: Keratoconus (KC) is a non-inflammatory, bilateral condition
characterized by increasing corneal thinning & bulging due to its biomechanical
instability, it is one of the most common disorders that affect corneal transparency …
characterized by increasing corneal thinning & bulging due to its biomechanical
instability, it is one of the most common disorders that affect corneal transparency …
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Clinical outcomes of femtosecond laser-assisted corneal allogenic intrastromal ring segment (CAIRS) in the treatment of keratoconus
A Kirgiz, BK Atik, M Emul, M Taskapili - Clinical & experimental ophthalmology
Background To evaluate the results of corneal allogenic intrastromal ring segment (CAIRS)
implantation in keratoconus. Methods The medical records of patients with
keratoconus who underwent CAIRS implantation were reviewed. The CAIRS …
implantation in keratoconus. Methods The medical records of patients with
keratoconus who underwent CAIRS implantation were reviewed. The CAIRS …
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[HTML] Systemic and ocular associations of Keratoconus
BS Hefley, AA Ali, P Bhattacharya, J Hjortdal… - Expert Review of …, 2024
Introduction Keratoconus (KC) is the most prevalent corneal ectasia in the world and
its pathogenesis is influenced by both ocular and systemic factors. This review
explores the multifaceted associations between keratoconus and systemic health …
its pathogenesis is influenced by both ocular and systemic factors. This review
explores the multifaceted associations between keratoconus and systemic health …
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Efficacy and safety of corneal cross-linking in Keratoconus patients with corneal thickness less than 400 μm: A systematic review
F Mohammadi, M Daniell, M Mcguinness, MZ Mustafa… - … Ophthalmology & Visual …, 2024
Purpose: A minimum corneal thickness of 400 μm after epithelium removal has been
recommended for keratoconus (KC) patients undergoing conventional corneal
collagen cross-linking (CXL) to avoid endothelial cell damage, excluding patients …
recommended for keratoconus (KC) patients undergoing conventional corneal
collagen cross-linking (CXL) to avoid endothelial cell damage, excluding patients …
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[HTML] Safety of refractive surgery in patients diagnosed with keratoconus through biomechanical and tomographic properties by an artificial intelligence algorithm
JLD Hickman, GP Hernandez, F Velazquez-Valenzuela… - … Ophthalmology & Visual …, 2024
… Patients with keratoconus diagnosed solely by tomographic data were not
considered candidates for LASIK. Patients were followed for a … This study
suggests that although an increased TBI is diagnostic for keratoconus, it is not …
considered candidates for LASIK. Patients were followed for a … This study
suggests that although an increased TBI is diagnostic for keratoconus, it is not …
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Worldwide analysis of climate-related determinants of keratoconus
H Shabani, J De Ridder, A Asaad, MA Meester… - … Ophthalmology & Visual …, 2024
… -related variables on keratoconus prevalence. Methods : We systematically
reviewed studies about keratoconus prevalence and incidence in the … Finally, the
potential impact of these climate variables on keratoconus prevalence was …
reviewed studies about keratoconus prevalence and incidence in the … Finally, the
potential impact of these climate variables on keratoconus prevalence was …
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[HTML] The comparative efficacy and safety of hypotonic vs isotonic riboflavin for corneal cross-linking in'thick'keratoconic corneas: a Save Sight Keratoconus Registry study
SL Watson, A Gupta, RA Mills, JY Chen, L Sullivan… - … Ophthalmology & Visual …, 2024
… corneal thickness> 400 µm who had undergone epithelium-off CXL for
keratoconus and had follow-up data at 1-year met the inclusion … Hypotonic
riboflavin compared to isotonic riboflavin produced a greater change in visual acuity …
keratoconus and had follow-up data at 1-year met the inclusion … Hypotonic
riboflavin compared to isotonic riboflavin produced a greater change in visual acuity …
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The association between keratoconus and mental health: a Save Sight Keratoconus Registry study
H Kandel, E Durakovic, SJ Sitaula, SL Watson - Investigative Ophthalmology & Visual …, 2024
… keratoconus and mental health. The primary objective was to understand the
prevalence of mental health symptoms among individuals with keratoconus … the
prospective, web-based, international Save Sight Keratoconus Registry data …
prevalence of mental health symptoms among individuals with keratoconus … the
prospective, web-based, international Save Sight Keratoconus Registry data …
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Can we model keratoconus' growth?
B Fantaci, B Calvo, JFR Matas - Investigative Ophthalmology & Visual Science, 2024
Purpose: Keratoconus is a bilateral disease, characterized by steepening and
thinning of corneal tissue, which alters its mechanical properties. Etiology and
development of this pathology are still not clear, even if its histopathology has been …
thinning of corneal tissue, which alters its mechanical properties. Etiology and
development of this pathology are still not clear, even if its histopathology has been …
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Social Determinants of Health as Risk Factors for Keratoconus in the All of Us Database
C Tan, A Puran, R Talebi, F Yu, V Tseng, A Coleman - Investigative Ophthalmology & …, 2024
… factors for keratoconus have been established, the impact of social determinants
of health on the epidemiology and pathophysiology of keratoconus are not well
understood. This study investigated associations between education and annual …
of health on the epidemiology and pathophysiology of keratoconus are not well
understood. This study investigated associations between education and annual …
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Risk of Keratoconus in Patients with ADHD: A TriNetX Analysis
ZS Hussain, J Muayad, A Loya, T Siddiqui, A Lee - Investigative Ophthalmology & …, 2024
Purpose: Recent research has pointed to a possible connection between attention-deficit/hyperactivity
disorder (ADHD) and keratoconus. This study seeks to examine the presence of this
association within an international database. Methods: We performed a …
disorder (ADHD) and keratoconus. This study seeks to examine the presence of this
association within an international database. Methods: We performed a …
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Changing landscape of keratoconus management
L Charters - 2024
… stage 3 keratoconus in the 8-mm zone and stages 3 and 4 keratoconus in the 6-mm
zone. "Our study provides a large normative database of aberrations seen in
keratoconus," … "We also provide a reference range for corneal wavefront in …
zone. "Our study provides a large normative database of aberrations seen in
keratoconus," … "We also provide a reference range for corneal wavefront in …
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[HTML] Combined DSAEK With Cataract Surgery in a Patient With Fuchs Endothelial Corneal Dystrophy and Keratoconus After Corneal Crosslinking
DG Vakalopoulos, VF Diakonis, L Lalou, M Katsimpras… - Cornea Open, 2024
Purpose: To report a combined Descemet stripping automated endothelial
keratoplasty (DSAEK) with cataract surgery in a case of Fuchs endothelial corneal
dystrophy (FECD) and keratoconus after corneal crosslinking combined with …
keratoplasty (DSAEK) with cataract surgery in a case of Fuchs endothelial corneal
dystrophy (FECD) and keratoconus after corneal crosslinking combined with …
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Long-Term Results of Sterile Corneal Allograft Ring Segments Implantation in Keratoconus Treatment.
KP FFN, C Tanriverdi, ZY Karaca, KD Tran, A Kilic - Cornea, 2024
… This prospective study included 62 eyes of 49 patients with keratoconus who
underwent corneal allograft ring segments implantation at … This study
demonstrated that sterile corneal allograft ring segments implantation is a safe and …
underwent corneal allograft ring segments implantation at … This study
demonstrated that sterile corneal allograft ring segments implantation is a safe and …
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Whole-exome Sequencing Screening for Candidate Genes and Variants Associated with Primary Sporadic Keratoconus in Chinese Patients
C Song, L Li, C Liu, L Hu, J Bai, W Liang, L Zhao… - Experimental Eye Research, 2024
The pathogenesis of keratoconus (KC) is complex, and genetic factors play an
important role. The purpose of this study was to screen and analyse candidate
genes and variants in Chinese patients with primary sporadic KC. Whole-exome …
important role. The purpose of this study was to screen and analyse candidate
genes and variants in Chinese patients with primary sporadic KC. Whole-exome …
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Identification of hub genes and molecular pathways in keratoconus by integrating bioinformatics and literature mining at the RNA level
F Meng, S Ren - International Ophthalmology, 2024
Objective Keratoconus (KC) is a condition characterized by progressive corneal
steepening and thinning. However, its pathophysiological mechanism remains
vague. We mainly performed literature mining to extract bioinformatic and related …
steepening and thinning. However, its pathophysiological mechanism remains
vague. We mainly performed literature mining to extract bioinformatic and related …
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[HTML] Late-onset corneal edema after customized crosslinking for progressive keratoconus
MMS Vandevenne, TTJM Berendschot, N Visser… - American Journal of …, 2024
… We describe a patient after customized crosslinking (CXL) for progressive
keratoconus who developed corneal edema with spontaneous … A 24-year-old
male was referred to our clinic with forme fruste keratoconus in his right eye and …
keratoconus who developed corneal edema with spontaneous … A 24-year-old
male was referred to our clinic with forme fruste keratoconus in his right eye and …
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Evaluation and Diagnosis of Keratoconus and Pellucid Marginal Degeneration
MR Santhiago, YS Rabinowitz, JB Randleman - Corneal Cross-Linking, 2024
Keratoconus (KC) is a bilateral, progressive, ectatic disorder associated with
different degrees of corneal stroma impairment characterized by biomechanical
weakening of multifactorial etiology. 1 The presentation and progression is based on …
different degrees of corneal stroma impairment characterized by biomechanical
weakening of multifactorial etiology. 1 The presentation and progression is based on …
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[PDF] Feature Selection and Detection of Keratoconus Using Random Forest and Bagging
Z Muhsin, R Qahwaji, SA AlRyalat, M Al Bdour…
Development of an effective machine learning method for detecting keratoconus (KC)
from dozens of corneal topography data remains a challenge. This paper proposes
a machine learning model based on an ensemble Bagging technique and a …
from dozens of corneal topography data remains a challenge. This paper proposes
a machine learning model based on an ensemble Bagging technique and a …
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[HTML] Biomechanical changes following corneal crosslinking in keratoconus patients
E Felter, R Khoramnia, M Friedrich, HS Son… - Graefe's Archive for Clinical …, 2024
Purpose To evaluate the biomechanical and tomographic outcomes of keratoconus
patients up to four years after corneal crosslinking (CXL). Methods In this
longitudinal retrospective-prospective single-center case series, the preoperative …
patients up to four years after corneal crosslinking (CXL). Methods In this
longitudinal retrospective-prospective single-center case series, the preoperative …
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Coexisting Keratoconus
DD Koch - What I Say, 2024
… As you know, in addition to your cataract, you have a condition called keratoconus.
Keratoconus is a thinning of the cornea that causes the cornea to take on an
irregular shape. This irregular shape ranges from mild (having only minimal effect on …
Keratoconus is a thinning of the cornea that causes the cornea to take on an
irregular shape. This irregular shape ranges from mild (having only minimal effect on …
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[PDF] Cost-effectiveness of corneal collagen cross-linking for keratoconus in district general hospital settings in the United Kingdom
P Dervenis, N Dervenis, FC Lam - 2024
Purpose Keratoconus is a bilateral corneal ectasia occurring in adolescence or early
adulthood. Collagen crosslinking is being used as an option to halt disease
progression. However, still many district general hospitals lack the equipment of …
adulthood. Collagen crosslinking is being used as an option to halt disease
progression. However, still many district general hospitals lack the equipment of …
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[HTML] Evaluation of allied health professional-led keratoconus management service in the United Kingdom: the Birmingham and Midland Eye Centre (BMEC) study
M Bourlaki, M Khan, S Bandyopadhyay, R Sahota… - Eye, 2024
… keratoconus clinics and CXL services led by nurses and optometrists [collectively
known as allied health professionals (AHPs)] [4, 5]. This cross-sectional study aimed
to examine the effectiveness and safety of AHP-led keratoconus … keratoconus from …
known as allied health professionals (AHPs)] [4, 5]. This cross-sectional study aimed
to examine the effectiveness and safety of AHP-led keratoconus … keratoconus from …
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[HTML] Identification of Keratoconus-Related Phenotypes in Three Ppip5k2 Mouse Models
T Akoto, R Hadvina, S Jones, J Cai, H Yu, H McCord… - … Ophthalmology & Visual …, 2024
Purpose: It is necessary to establish a mouse model of keratoconus (KC) for
research and therapy. We aimed to determine corneal phenotypes in 3 Ppip5k2
mouse models. Methods: Central corneal thickness (CCT) was determined using …
research and therapy. We aimed to determine corneal phenotypes in 3 Ppip5k2
mouse models. Methods: Central corneal thickness (CCT) was determined using …
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[HTML] The Association of a Single Nucleotide Variant in COL5A1 to Early Onset Keratoconus and Pectus Excavatum—Convergence of Extracellular Matrix Pathologies
G Bryant, P Moore, M Sathyamoorthy - Medicina, 2024
… Decreased central corneal thickness is a hallmark of the condition, and numerous
genes have played a role in altering corneal thickness and the subsequent development
of keratoconus. Variants in the structural and regulatory genes of the extracellular matrix …
genes have played a role in altering corneal thickness and the subsequent development
of keratoconus. Variants in the structural and regulatory genes of the extracellular matrix …
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[HTML] Hunting Keratoconus
H Goyal, S CARRUBBA
Global detection of keratoconus in its earliest stages remains a challenge to our field.
However, increased adoption of corneal topography and, more recently, tomography
has improved detection rates at incipient stages, even when overt clinical findings …
However, increased adoption of corneal topography and, more recently, tomography
has improved detection rates at incipient stages, even when overt clinical findings …
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Effect of corneoscleral lenses on visual acuity and corneal parameters in patients with keratoconus
A ALI, K HALEH, R SAEED, MT SEYYED - International Eye Science, 2024
… In this prospective study, 43 cases(83 eyes)with keratoconus were included and
examined. A corneoscleral contact lens was fitted, and … , since there were no
clinical noticeable changes in the corneal parameters, this lenses can be used …
examined. A corneoscleral contact lens was fitted, and … , since there were no
clinical noticeable changes in the corneal parameters, this lenses can be used …
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Effect of Corneal Allogenic Intrastromal Ring Segment (CAIRS) Implantation Surgery in Patients With Keratoconus According to Prior Corneal Cross-linking Status
B Yucekul, C Tanriverdi, S Taneri, FFN Keskin Perk… - Journal of Refractive …, 2024
… RESULTS This study included 67 eyes of 47 patients with advanced keratoconus.
The median age was 27 years (range: 20 to 52 years) and 34 (72%) of the patients
were men. There were 30 eyes in the CXL group and 37 eyes in the non-CXL group. …
The median age was 27 years (range: 20 to 52 years) and 34 (72%) of the patients
were men. There were 30 eyes in the CXL group and 37 eyes in the non-CXL group. …
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Allergic rhinitis and keratoconus: a systematic review and meta-analysis
JE Lo, YH Huang, N Bhattacharyya, EA Moulton… - The Journal of Allergy and …, 2024
… AR and 144 keratoconus, (2) provided the number of patients with or without
keratoconus and the 145 number of patients with keratoconus diagnosed with or
without AR, and (3) provided 146 information on how patients were diagnosed with …
keratoconus and the 145 number of patients with keratoconus diagnosed with or
without AR, and (3) provided 146 information on how patients were diagnosed with …
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[HTML] New data reveals startingly high prevalence of keratoconus in pediatric patients
J Harthan - 2024
Keratoconus (KC) is a progressive, bilateral, asymmetric corneal ectasia that results
in central or paracentral corneal thinning and steepening. 1, 2 The loss of corneal
biomechanical strength along with progressive thinning and steepening leads to …
in central or paracentral corneal thinning and steepening. 1, 2 The loss of corneal
biomechanical strength along with progressive thinning and steepening leads to …
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[PDF] Structural Outcomes of Corneal Cross-Linking for Keratoconus
Y Statsenko, D Smetanina, R Voitetskii, GL Simiyu… - 2024
Background: Studies have tried to identify predictors of functional markers of
keratoconus progression, whereas structural outcomes of collagen cross-linking
have not been properly investigated. Objective: find and set up a combination of …
keratoconus progression, whereas structural outcomes of collagen cross-linking
have not been properly investigated. Objective: find and set up a combination of …
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[HTML] Keratoconus and Corneal Ectasia with Relatively Low Keratometry
LPG Esporcatte, MQ Salomão, BT Lopes, N Sena… - Ophthalmology and Therapy, 2024
… Cases with maximum mean zone 3 mm keratometry (Kmax zone mean 3 mm)
lower than 47.6 diopters (D) were considered as low-keratometry keratoconus, and
cases with Kmax zone mean 3 mm higher than 47.6 D were regarded as high-keratometry …
lower than 47.6 diopters (D) were considered as low-keratometry keratoconus, and
cases with Kmax zone mean 3 mm higher than 47.6 D were regarded as high-keratometry …
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[PDF] Corneal Surface Elevation and Thickness in Relation to the Fit of Rigid Contact Lenses in Keratoconus and After Corneal Cross-Linking
A Biscevic, M Ahmedbegovic-Pjano, S Grisevic… - Clinical Ophthalmology, 2024
… and patients' comfort ratings in keratoconus. Citation34 The current study found
this occurred in keratoconus and post-CXL cases. … with more advanced and
severe keratoconus, and required slightly smaller lenses compared with the non-CXL …
this occurred in keratoconus and post-CXL cases. … with more advanced and
severe keratoconus, and required slightly smaller lenses compared with the non-CXL …
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Bioinformatics analysis of signature genes related to cell death in keratoconus
J Liu, J Gao, S Xing, Y Yan, X Yan, Y Jing, X Li - Scientific reports, 2024
… However, the etiology mechanism of keratoconus is still unclear. This study aims
to identify the signature genes related to cell death in keratoconus and examine the
function of these genes. A dataset of keratoconus from the GEO database was …
to identify the signature genes related to cell death in keratoconus and examine the
function of these genes. A dataset of keratoconus from the GEO database was …
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Corneal Cross-linking for Progressive Keratoconus
T Koller, S Seiler, T Seiler - Corneal Cross-Linking. Farhad Hafezi, 2024
… reported about cross-linking for keratoconus at several meetings. Wollensak et
al3 presented the first prospective study on CXL in 23 eyes with a follow-up of one
year or longer. He reported stabilization and even regression of the keratoconus as …
al3 presented the first prospective study on CXL in 23 eyes with a follow-up of one
year or longer. He reported stabilization and even regression of the keratoconus as …
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[PDF] Symposium: Keratoconus Long-term results of cornea collagen cross-linking with riboflavin for keratoconus
V Agrawal - Indian Journal of Ophthalmology
… In the light of currently available data, we can thus say that CXL is a safe
procedure that is successful in arresting keratoconus. It is advisable to perform this
procedure in patients with progressive keratoconus. Younger patients tend to have a …
procedure that is successful in arresting keratoconus. It is advisable to perform this
procedure in patients with progressive keratoconus. Younger patients tend to have a …
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Crosslinking with UV-A and riboflavin in progressive keratoconus: From laboratory to clinical practice–developments over 25 years
F Raiskup, R Herber, J Lenk, LE Pillunat, E Spoerl - Progress in Retinal and Eye …, 2024
Abstract Changes in the biomechanical and biochemical properties of the human
cornea play an important role in the pathogenesis of ectatic diseases. A number of
conditions in primarily acquired (keratoconus or pellucid marginal degeneration) or …
cornea play an important role in the pathogenesis of ectatic diseases. A number of
conditions in primarily acquired (keratoconus or pellucid marginal degeneration) or …
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[PDF] Effect of Collagen Crosslinking on Quality of Life in Patients with Keratoconus
M Dickey, R Phadke, J Baca, J Thomas, C Pepper…
Although keratoconus is fairly prevalent, the underlying mechanisms for its cause
are still unknown. At the same time, it is still the leading cause for a corneal
transplant in the United States. One treatment, collagen cross-linking, is relatively …
are still unknown. At the same time, it is still the leading cause for a corneal
transplant in the United States. One treatment, collagen cross-linking, is relatively …
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Clinical study on the difference of binoculus biological parameters of the anterior segment in early keratoconus diagnosis
叶凡， 薛劲松 - qwer
… biological parameters of the anterior segment in subclinical keratoconus. Methods:
A retrospective case-control study. A total of 183 patients who visited our hospital
from March 2022 to November 2023 were included, including 107 cases in the …
A retrospective case-control study. A total of 183 patients who visited our hospital
from March 2022 to November 2023 were included, including 107 cases in the …
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[HTML] Correlation between Corneal Volume and Corneal Biomechanics and Corneal Volume Significance in Staging and Diagnosing Keratoconus
Z Wu, Y Zhang, Y Li, F Yang, X Su, Y Gao, S Wei, J Li - Journal of Ophthalmology, 2024
Purpose. To investigate the relationship between corneal volume (CV) at different
zones and corneal biomechanics in keratoconus (KC) along with the significance of
CV in diagnosing and staging KC. Methods. This prospective clinical study included …
zones and corneal biomechanics in keratoconus (KC) along with the significance of
CV in diagnosing and staging KC. Methods. This prospective clinical study included …
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New data reveals high prevalence of keratoconus in pediatric patients.
J Harthan - Optometry Times, 2024
A recent study conducted by the Illinois College of Optometry and the International
Keratoconus Academy of Eye Care Professionals found a higher prevalence of
keratoconus (KC) in pediatric patients than previously reported. The study used …
Keratoconus Academy of Eye Care Professionals found a higher prevalence of
keratoconus (KC) in pediatric patients than previously reported. The study used …
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[PDF] Ten-year incidence of keratoconus in relation to sex, age, and thyroid gland dysfunction: a nationwide population-based cohort study (2009–2018)
IK Chung, BS Kim, KD Han, YS Yoo, H Kim, C Jeong - Annals of Translational …, 2024
… predominance in keratoconus incidence and suggests a possible connection
between hyperthyroidism and keratoconus. Furthermore, it … differences in the
development of keratoconus and determined the incidence of clinically diagnosed …
between hyperthyroidism and keratoconus. Furthermore, it … differences in the
development of keratoconus and determined the incidence of clinically diagnosed …
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Assessment of large-diameter and small-diameter SoftK specialty contact lenses for early-stage keratoconus
E Gal, J Gispets, M Zyroff, E Netanya, L Gantz - … & physiological optics: the journal of the …
Introduction Soft contact lenses may be a good alternative for early-stage
keratoconus (KC) patients who do not tolerate rigid gas permeable (RGP) lenses
due to ocular discomfort or complications. This prospective study compared …
keratoconus (KC) patients who do not tolerate rigid gas permeable (RGP) lenses
due to ocular discomfort or complications. This prospective study compared …
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[HTML] Association of Novel Loci With Keratoconus Susceptibility in a Chinese Genome-Wide Association Study
L Xu, X Zheng, S Yin, K Yang, Q Fan, Y Gu, Y Yuan… - … Ophthalmology & Visual …, 2024
Purpose: Keratoconus (KC) is a progressive corneal disease that can lead to
corneal blindness if not properly managed. The purpose of this study was to identify
genetic associations with KC in China and to investigate whether these genetic …
corneal blindness if not properly managed. The purpose of this study was to identify
genetic associations with KC in China and to investigate whether these genetic …
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[HTML] Keratoconus presentation with respect to age, gender, and severity in Western India
ZA Shah, DM Purohit, PM Danayak, JD Patel… - Journal of Clinical …, 2024
Purpose: To study the demographic profile of keratoconus (KC) patients visiting a
tertiary eye care hospital in Western India. Materials and Methods: This cross-sectional,
observational study included newly diagnosed KC patients visiting our hospital …
tertiary eye care hospital in Western India. Materials and Methods: This cross-sectional,
observational study included newly diagnosed KC patients visiting our hospital …
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[PDF] Keratoconus in the West Region of Cameroon: Stakeholder knowledge and management
EN Ayukotang, VR Moodley, KP Mashige - African Vision and Eye Health, 2024
… Keratoconus is a multifaceted eye abnormality linked to both congenital and
ecological determinants. … 'We don't have machines to detect cases of keratoconus.
Not only that, I am the only one in this centre who is knowledgeable about …
ecological determinants. … 'We don't have machines to detect cases of keratoconus.
Not only that, I am the only one in this centre who is knowledgeable about …
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[HTML] Deep anterior lamellar keratoplasty in advanced keratoconus in children: A 4-year study
B Preethi, KK Kumar, N Malepati - Journal of Clinical Ophthalmology and Research, 2024
… anterior lamellar keratoplasty (DALK) in children and adolescents with advanced
keratoconus (KC) at a tertiary eye care center in India. … Deep anterior lamellar
keratoplasty (DALK) for advanced keratoconus (KC) in pediatric age group has seen …
keratoconus (KC) at a tertiary eye care center in India. … Deep anterior lamellar
keratoplasty (DALK) for advanced keratoconus (KC) in pediatric age group has seen …
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[HTML] Modulation transfer function and higher order aberrations with and without corneo scleral lens in an eye with keratoconus
S Shah, OH Pirdankar, LD Patil, S Sheth, P Jain… - Journal of Clinical …, 2024
… revealed right eye keratoconus and left eye was Forme fruste keratoconus. There
was a … irregularities arising from ectatic disorders such as keratoconus. Scleral
lenses are lenses to … ), Strehl ratio in addition to HOA with corneo-scleral contact …
was a … irregularities arising from ectatic disorders such as keratoconus. Scleral
lenses are lenses to … ), Strehl ratio in addition to HOA with corneo-scleral contact …
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[HTML] Quality and Readability of Online Information on Keratoconus in Portugal
C Costa, R Souza-Oliveira, J Gil, E Costa, C Tavares… - … Sociedade Portuguesa de …, 2024
INTRODUÇÃO: O queratocone é a ectasia corneana primária mais comum.
Atualmente, os doentes procuram na Internet respostas às suas expectativas em
termos de diagnóstico, tratamento e prognóstico. Porém, os sites não são filtrados …
Atualmente, os doentes procuram na Internet respostas às suas expectativas em
termos de diagnóstico, tratamento e prognóstico. Porém, os sites não são filtrados …
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[HTML] Controversies in the Management of Keratoconus
C Carriazo, MM Sinjab, C Liu, J Chhablani…
This book presents new technologies which are available now for the rehabilitation
of visual acuity in patients suffering from keratoconusand for arresting the
progression of this frustrating disease. All these current treatment options in differing …
of visual acuity in patients suffering from keratoconusand for arresting the
progression of this frustrating disease. All these current treatment options in differing …
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[PDF] Transcriptome RNA-Seq Analysis of Normal and Keratoconus Corneal Epithelium
FH Boshahma, MSM Solyman, M Ali, EA McDonnel… - 2024… plots were used to identify how characteristics impact development of keratoconus. …
and keratoconus development. Overexpression of peroxisome genes increases
phytanic acid levels, and causes Zellweger spectrum, affecting the cornea and …
and keratoconus development. Overexpression of peroxisome genes increases
phytanic acid levels, and causes Zellweger spectrum, affecting the cornea and …
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[PDF] Prospective study on the efficacy of RoseK2 contact lenses in the treatment of keratoconus: 59 patients
K Amine, L Robbana, S Hassina, N Tebbay… - J Clin Images Med Case …, 2024… We adapted corneal RPGCL (RoseK2 type) on 113 eyes of 59 patients with
keratoconus. The sex ratio was … Keratoconus geometry was closely correlated
with disease progression. This study confirms that RoseK2 RPGCLs are an effective …
keratoconus. The sex ratio was … Keratoconus geometry was closely correlated
with disease progression. This study confirms that RoseK2 RPGCLs are an effective …
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[PDF] Factors associated with keratoconus in Israel—A cross‐sectional population‐based study
O Ben‐Shaul, A Segal, S Schwartz, N Stein, M Hyams… - Acta Ophthalmologica, 2024
… keratoconus and fibromyalgia implied in a few case reports, we also investigated
the association between this chronic condition and keratoconus (… Further, the
study explored ethnicity as a risk factor for keratoconus and compared the prevalence …
the association between this chronic condition and keratoconus (… Further, the
study explored ethnicity as a risk factor for keratoconus and compared the prevalence …
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Alternative methods of surgical treatment of keratoconus
AV Tereshchenko, IG Trifanenkova, SK Demianchenko… - Vestnik oftalmologii, 2024
The introduction of early diagnostic methods for keratoconus into clinical practice
has become the basis for the development of surgical treatment techniques for this
pathology, such as corneal collagen crosslinking and interlamellar keratoplasty with …
has become the basis for the development of surgical treatment techniques for this
pathology, such as corneal collagen crosslinking and interlamellar keratoplasty with …
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Comparative analysis of clinical and functional parameters in patients with stable stage II-III keratoconus after implantation of corneal segments and fitting of scleral …
AT Khanjian, AV Ivanova, AS Sklyarova… - Vestnik oftalmologii, 2024
The modern treatment strategy for keratoconus (KC) involves sequential application
of medical technologies aimed at stabilizing pathological changes in the cornea and
restoring visual acuity. Purpose This study compares the effect of implantation of …
of medical technologies aimed at stabilizing pathological changes in the cornea and
restoring visual acuity. Purpose This study compares the effect of implantation of …
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[PDF] Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions: theoretical basis
C Caruso, L D'Andrea, M Troisi, M Rinaldi, R Piscopo… - Int J Ophthalmol, 2024
● Keratoconus is an ectatic condition characterized by gradual corneal thinning,
corneal protrusion, progressive irregular astigmatism, corneal fibrosis, and visual
impairment. The therapeutic options regarding improvement of visual function …
corneal protrusion, progressive irregular astigmatism, corneal fibrosis, and visual
impairment. The therapeutic options regarding improvement of visual function …
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[HTML] Polygenic prediction of keratoconus and its measures: cross-sectional and longitudinal analyses in community-based young adults
SSY Lee, S Diaz-Torres, W He, S Yazar, E Chan… - American Journal of …, 2024
… Previous studies have validated a PRS for keratoconus in cross-sectional
analyses of older individuals. However, keratoconus typically affects younger adults.
This study thus explored the associations between keratoconus and its measures …
analyses of older individuals. However, keratoconus typically affects younger adults.
This study thus explored the associations between keratoconus and its measures …
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[HTML] Multi-modal imaging for the detection of early keratoconus: a narrative review
M Al Bdour, HM Sabbagh, HM Jammal - Eye and Vision, 2024
… Keratoconus is a common progressive corneal disorder that can be associated
with significant … disease, which include subclinical keratoconus and forme fruste
keratoconus, detection of such … for the detection of early cases of keratoconus …
with significant … disease, which include subclinical keratoconus and forme fruste
keratoconus, detection of such … for the detection of early cases of keratoconus …
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[HTML] Dual benefits of scleral lenses in collateral cases of Stevens-Johnson syndrome and Keratoconus-A case series
K Subramanian - Latin American Journal of Ophthalmology, 2024
Scleral lenses (SL) are larger diameter lenses that rest over the scleral, unlike the
corneal lenses. These lenses are fitted to not touch the cornea by creating a space
that will be filled with sterile isotonic fluid. Indications of SL include corneal ectatic …
corneal lenses. These lenses are fitted to not touch the cornea by creating a space
that will be filled with sterile isotonic fluid. Indications of SL include corneal ectatic …
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[HTML] Keratoconus Progression Determined at the First Visit: A Deep Learning Approach With Fusion of Imaging and Numerical Clinical Data
LM Hartmann, DS Langhans, V Eggarter, TJ Freisenich… - Translational Vision Science …, 2024
Purpose: Multiple clinical visits are necessary to determine progression of
keratoconus before offering corneal cross-linking. The purpose of this study was to
develop a neural network that can potentially predict progression during the initial …
keratoconus before offering corneal cross-linking. The purpose of this study was to
develop a neural network that can potentially predict progression during the initial …
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[PDF] AvaGen Genetic Testing versus Ocular Screening Assessments Including the Keratoconus Severity Score (KSS) and Randleman Ectasia Risk Score System (ERSS) …
M Moshirfar, S Pandya, S Zhang, IM Stoakes, A Ayesha… - Clinical Ophthalmology, 2024
Purpose To determine whether the AvaGen (AG) Genetic Eye Test provided
additional information for screening for the presence of keratoconus (KC) and
assessing KC risk in refractive surgery candidates, as compared to the Keratoconus …
additional information for screening for the presence of keratoconus (KC) and
assessing KC risk in refractive surgery candidates, as compared to the Keratoconus …
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The Chinese keratoconus (CKC) cohort study
K Yang, X Liu, L Xu, Y Gu, Q Fan, S Yin, Y Wang… - European Journal of …, 2024
… Keratoconus (KC) is a corneal disorder characterized by corneal thinning, blurred
vision, and irregular astigmatism, and KC eventually progresses to corneal
blindness if effective measures are not applied [1,2,3]. It affects both males and …
vision, and irregular astigmatism, and KC eventually progresses to corneal
blindness if effective measures are not applied [1,2,3]. It affects both males and …
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Refractive surgical approaches to keratoconus: A systematic review and network meta-analysis
S Niazi, F Doroodgar, SH Nazari, Y Rahimi… - Survey of Ophthalmology
Advancements in diagnostic methods and surgical techniques for keratoconus (KC)
have increased non-invasive treatment options. Successful surgical planning for KC
involves a combination of clinical science, empirical evidence, and surgical expertise …
have increased non-invasive treatment options. Successful surgical planning for KC
involves a combination of clinical science, empirical evidence, and surgical expertise …
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[HTML] Does collagen cross linking have any effect on retinal circulation in patients with keratoconus? An optical coherence tomography angiography (OCTA) study
S Bamdad, A Attar, M Fallahzadeh, F Ebrahimi… - BMC ophthalmology, 2024
Background We aimed to employ Optical Coherence Tomography Angiography (OCTA)
to comprehensively assess changes in the optic nerve head (ONH) and macular
perfusion before and after the Corneal Collagen Cross-Linking (CCL) procedure in …
to comprehensively assess changes in the optic nerve head (ONH) and macular
perfusion before and after the Corneal Collagen Cross-Linking (CCL) procedure in …
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Update on corneal crosslinking for keratoconus and corneal ectasia
SA Greenstein, PS Hersh - Current Opinion in Ophthalmology
… Performing CXL early to prevent progression and visual loss for our patients with
keratoconus is critical. This is especially important in the pediatric population when
progression of keratoconus can be rapid and severe. A recent study performed in a …
keratoconus is critical. This is especially important in the pediatric population when
progression of keratoconus can be rapid and severe. A recent study performed in a …
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[PDF] Artificial intelligence–can technology help predict the progression of keratoconus? A systematic review
S Watson, I Jiang, E Durakovic, H Kandel - 2024
… Studies were included if they were published in peer-reviewed journals, reported
at least one accuracy measure, and investigated keratoconus progression rather
than diagnosis or treatment efficacy. The outcome measures included accuracy in …
at least one accuracy measure, and investigated keratoconus progression rather
than diagnosis or treatment efficacy. The outcome measures included accuracy in …
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Image-and impression-based technology for scleral lens fitting for keratoconus: Efficiency of the fitting process
E Shorter, J Fogt, C Nau, J Harthan, A Nau… - Contact Lens and Anterior …, 2024
… keratoconus could streamline the fitting process by creating an initial lens based
upon the actual ocular surface shape rather than a standard diagnostic lens. This
study describes practitioner-reported efficiency of the SL fitting process of patients …
upon the actual ocular surface shape rather than a standard diagnostic lens. This
study describes practitioner-reported efficiency of the SL fitting process of patients …
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[HTML] A rare case of bilateral keratoconus and granular corneal dystrophy managed with contact lens
R Dutta, M Agarwal, M Subramanian, K Subramanian - Indian Journal of …, 2024
Keratoconus (KC) is a bilateral, non-inflammatory, progressive thinning disorder of
the cornea that results in high irregular astigmatism, distortion, and poor vision.
Granular corneal dystrophy (GCD) is an autosomal dominant stromal dystrophy with …
the cornea that results in high irregular astigmatism, distortion, and poor vision.
Granular corneal dystrophy (GCD) is an autosomal dominant stromal dystrophy with …
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Association of Vernal Keratoconjunctivitis (VKC) with Keratoconus in Patients Presenting to Ophthalmology Clinics of Rawal Institute of Health Sciences, Pakistan
M Zehra, MS Anwar, E Yousafzai, W Akhter, AM Rana - Pakistan Armed Forces …, 2024
… The disease severity, periodicity, and eye rubbing lead to the development of
keratoconus. Conclusion: Pediatric keratoconus deteriorates … early diagnosis,
recognition of progression, and appropriate intervention to prevent vision-threatening …
keratoconus. Conclusion: Pediatric keratoconus deteriorates … early diagnosis,
recognition of progression, and appropriate intervention to prevent vision-threatening …
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[HTML] Comparing the clinical applicability of wavefront phase imaging in keratoconus versus normal eyes
C Belda-Para, G Velarde-Rodríguez, M Velasco-Ocaña… - Scientific Reports, 2024
The aim of this work is to quantitatively assess the wavefront phase of keratoconic
eyes measured by the ocular aberrometer t· eyede (based on WaveFront Phase
Imaging Sensor), characterized by a lateral resolution of 8.6 µm without requiring …
eyes measured by the ocular aberrometer t· eyede (based on WaveFront Phase
Imaging Sensor), characterized by a lateral resolution of 8.6 µm without requiring …
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[PDF] Successful Collagen Crosslinking in Patients With Keratoconus and Systemic Scleroderma
A Alghamdi, EA Alghamdi, A Alghamdi, MM Abusayf… - Cureus, 2024
Scleroderma is an autoimmune disease that affects connective tissue. Keratoconus (KC)
is a rare ocular condition that may appear alongside scleroderma. Contact lenses
are an essential visual aid for KC patients, especially in advanced cases. However …
is a rare ocular condition that may appear alongside scleroderma. Contact lenses
are an essential visual aid for KC patients, especially in advanced cases. However …
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International Keratoconus Academy of Eye Care Professionals: A historical perspective: The collective enhances education, research, and quality of life.
SB Eiden, AS Morgenstern - Optometry Times, 2024
… of keratoconus management. The mission of IKA is to promote and develop
knowledge about the diagnosis and management of keratoconus and … IKA
focuses on education, research, and improving the quality of life for patients with …
knowledge about the diagnosis and management of keratoconus and … IKA
focuses on education, research, and improving the quality of life for patients with …
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Targeted next-generation sequencing analysis in Italian patients with keratoconus
M Lombardo, U Camellin, R Gioia, S Serrao, V Scorcia… - Eye, 2024
… Targeted NGS research provided new insights into the causative effect of candidate
genes in the clinical phenotype of keratoconus. Filaggrin mutations were found to
represent a genetic risk factor for development of progressive disease in Italy. … In a …
genes in the clinical phenotype of keratoconus. Filaggrin mutations were found to
represent a genetic risk factor for development of progressive disease in Italy. … In a …
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Implantable Collamer Lenses (ICL) for treating keratoconus
MA Al-Dabaat, R ِAbu Nassar, H Mesmar, S Amireh… - 2024
Purpose: Implantable Collamer Lens (ICL) implantation is a promising solution for
correcting refractive errors, particularly in advanced Keratoconus (KC). Despite its
increasing use, comprehensive data on its efficacy and complications remain limited …
correcting refractive errors, particularly in advanced Keratoconus (KC). Despite its
increasing use, comprehensive data on its efficacy and complications remain limited …
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[PDF] Diagnosis of Forme Fruste Keratoconus Using Corvis ST Sequences with Digital Image Correlation and Machine Learning
L Yang, K Qi, P Zhang, J Cheng, H Soha, Y Jin, H Ci… - Bioengineering, 2024
Purpose: This study aimed to employ the incremental digital image correlation (DIC)
method to obtain displacement and strain field data of the cornea from Corvis ST (CVS)
sequences and access the performance of embedding these biomechanical data …
method to obtain displacement and strain field data of the cornea from Corvis ST (CVS)
sequences and access the performance of embedding these biomechanical data …
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A pilot study on Langerhans cells in keratoconus patients by in vivo confocal microscopy before and after corneal cross-linking and correlation with eye rubbing
E Ferrini, C Posarelli, M Figus, D Lisi, G Gabbriellini - Contact Lens and Anterior Eye, 2024
Purpose The aim of this study was to investigate the corneal microstructure and
Langerhans cells using in vivo confocal microscopy in keratoconus patients before
and after cross-linking, and to correlate the morphologic findings with clinical and …
Langerhans cells using in vivo confocal microscopy in keratoconus patients before
and after cross-linking, and to correlate the morphologic findings with clinical and …
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Comparison between Anterior Segment Optical Coherence Tomography and pentacam in The Diagnosis of Keratoconus
AR Youssef, A Sharawy, AA Shebl - Benha Medical Journal, 2024
… keratoconus. This study aimed to compare the efficacy of Anterior Segment
Optical Coherence Tomography (AS-OCT) in detection of subclinical keratoconus …
the efficacy of AS-OCT in detection of subclinical keratoconus with the efficacy of the …
Optical Coherence Tomography (AS-OCT) in detection of subclinical keratoconus …
the efficacy of AS-OCT in detection of subclinical keratoconus with the efficacy of the …
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[HTML] Longitudinal Analysis of Corneal Biomechanics of Suspect Keratoconus: A Prospective Case-Control Study
Y Huo, X Chen, R Xie, J Li, Y Wang - Bioengineering, 2024
… indicator for the diagnosis of early keratoconus and suggested as a diagnostic
point for keratoconus by the global consensus on keratoconus; a PTE of >… The
SKC group included clinical keratoconus contralateral eye, having at least one …
point for keratoconus by the global consensus on keratoconus; a PTE of >… The
SKC group included clinical keratoconus contralateral eye, having at least one …
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Research progress of clinical application and complication of contact lens in keratoconus
REN Shengwei, FAN Qi, Y Kaili, LYU Tianbin - International Eye Science, 2024
… of early keratoconus can be corrected by spectacles. For the irregular astigmatism
of moderate to severe keratoconus, spectacles are no … contact lenses, the
application of contact lenses in different types of keratoconus, the complications of …
of moderate to severe keratoconus, spectacles are no … contact lenses, the
application of contact lenses in different types of keratoconus, the complications of …
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Keratoconus disease classification with multimodel fusion and vision transformer: a pretrained model approach
S Yaraghi, T Khatibi - BMJ open ophthalmology, 2024
… keratoconus image classification system that leverages multiple pretrained
models and a transformer architecture to achieve state-of-the-art performance in
detecting keratoconus… the accuracy of image classification models for keratoconus …
models and a transformer architecture to achieve state-of-the-art performance in
detecting keratoconus… the accuracy of image classification models for keratoconus …
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[PDF] New Developments in Corneal Cross-Linking for Keratoconus–Enhancing the Shape of the Cornea
R Herber, F Raiskup - 2024
Purpose. Corneal cross-linking (CXL) is an established treatment for corneal ectasia,
particularly keratoconus. The goal of the treatment is to stabilize the biomechanically
weakened cornea, thereby halting further progression of the disease and preventing …
particularly keratoconus. The goal of the treatment is to stabilize the biomechanically
weakened cornea, thereby halting further progression of the disease and preventing …
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Utility of Artificial Intelligence in the Diagnosis & Management of Keratoconus: A Systematic Review
D Goodman, AY Zhu - Frontiers in Ophthalmology
Introduction: The application of artificial intelligence (AI) systems in ophthalmology is
rapidly expanding. Early detection and management of keratoconus is important for
preventing disease progression and the need for corneal transplant. We review …
rapidly expanding. Early detection and management of keratoconus is important for
preventing disease progression and the need for corneal transplant. We review …
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1162 Keratoconus in an Adolescent with Obstructive Sleep Apnea
J Purewal, A Jayakumar, I Perez - Sleep, 2024
… that occur during sleep and may contribute to the development of keratoconus.
Based on the IRIS Registry, the prevalence of keratoconus in adults is 2.9%
compared to 0.27% in pediatrics. We describe a pediatric patient with keratoconus …
Based on the IRIS Registry, the prevalence of keratoconus in adults is 2.9%
compared to 0.27% in pediatrics. We describe a pediatric patient with keratoconus …
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[HTML] Evaluation of dynamic corneal response parameters and the biomechanical E-staging after Intacs® SK implantation in keratoconus
E Flockerzi, T Berger, B Seitz, L Hamon, L Daas - Indian Journal of Ophthalmology, 2024
Purpose: This retrospective longitudinal study evaluated the biomechanical E-staging
in KC corneas before and after intracorneal ring segment (ICRS) implantation (Intacs®
SK, Addition Technology, Illinois, United States). Methods: Biomechanical E-staging …
in KC corneas before and after intracorneal ring segment (ICRS) implantation (Intacs®
SK, Addition Technology, Illinois, United States). Methods: Biomechanical E-staging …
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[HTML] The HUC progression score: A new method for determining KERATOCONUS progression
BL Eguileor, BS Zorrozúa, JE Ecenarro - European Journal of Ophthalmology, 2024
… Regarding the stage of keratoconus that progresses the most, our results suggest
that the mildest keratoconus is most likely to progress. This contrasts with other
studies which conclude that the greater the severity of keratoconus, the greater the …
that the mildest keratoconus is most likely to progress. This contrasts with other
studies which conclude that the greater the severity of keratoconus, the greater the …
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[PDF] Clinical profile of keratoconus in central India
R Gupta
… All Patients of Keratoconus without any previous interventions were included in
this study. Results: 129 eyes of 68 patients diagnosed with … Keratoconus causes
irregular astigmatism, leading to various degree of visual impairment.[5] Existing …
this study. Results: 129 eyes of 68 patients diagnosed with … Keratoconus causes
irregular astigmatism, leading to various degree of visual impairment.[5] Existing …
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Comparative analysis of the Agreement of Keratometry Readings across three devices in varying stages of Keratoconus: A Cross-Sectional Study
ΚΝ Παπαδόπουλος - 2024
The aim of the present thesis was to evaluate the agreement of keratometry (K)
readings obtained from three different devices-Pentacam HR, MS-39 and IOL-Master
700-across various grades of keratoconus. A cross-sectional analysis was …
readings obtained from three different devices-Pentacam HR, MS-39 and IOL-Master
700-across various grades of keratoconus. A cross-sectional analysis was …
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Immediate postoperative keratitis caused by Rhizopus species following standard CXL for keratoconus: A case report and literature review
A Venugopal, M Ravindran - European Journal of Ophthalmology, 2024
… He was diagnosed with progressive keratoconus in the right eye more than left
eye. After … to improve the biomechanical strength of the cornea in keratoconus.
The long-term safety and … edema, endothelial damage, and progression of …
eye. After … to improve the biomechanical strength of the cornea in keratoconus.
The long-term safety and … edema, endothelial damage, and progression of …
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Repeatability of epithelium thickness measured by an AS-OCT in different grades keratoconus and compared to AS-OCT/Placido topography
Y Wang, R Ning, K Li, H Xu, Y Li, Y Yang, I Gustafsson… - American Journal of …, 2024
… Considering the role of epithelial thickness in the diagnosis of keratoconus and
the fact that epithelium changes with the severity of KC, we believe that it is
necessary to investigate the accuracy of different devices in measuring ET. As far as …
the fact that epithelium changes with the severity of KC, we believe that it is
necessary to investigate the accuracy of different devices in measuring ET. As far as …
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Long-term results of accelerated corneal collagen crosslinking in paediatric patients with progressive keratoconus: 10-year follow-up
S Ahmet, G Yayla Akincilar, A Kirgiz… - Eye, 2024
… The Global Consensus on Keratoconus and Ectatic Diseases states that CCL is
extremely important in the treatment of keratoconus with … In our clinical practice,
we recommend ACCL in paediatric keratoconus patients as soon as the diagnosis is …
extremely important in the treatment of keratoconus with … In our clinical practice,
we recommend ACCL in paediatric keratoconus patients as soon as the diagnosis is …
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[PDF] OP-2 Bowman's layer in health, keratoconus and other corneal conditions
A Borgia, S Lawman, C Hart, M Posarelli, M Ahmed… - 2024
Purpose To investigate the central thickness of Bowman's layer in patients with
keratoconus, healthy cornea and other corneal conditions in relation to corneal
curvature and, epithelial and total corneal thickness in health, keratoconus (KC) and …
keratoconus, healthy cornea and other corneal conditions in relation to corneal
curvature and, epithelial and total corneal thickness in health, keratoconus (KC) and …
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OP-7 A comparison of keratoconus progression following collagen cross-linkage using standard or personalised keratometry thresholds
JPO Li, H Maile, C Bunce, M Leucci, B Allan, S Tuft… - 2024
… definitions of keratoconus progression … keratoconus eyes, with a variation of
Bland-Altman to determine the 95% regression-based limits of agreement (LoA). We
created Kaplan-Meier survival plots for standard and adaptive thresholds. The …
Bland-Altman to determine the 95% regression-based limits of agreement (LoA). We
created Kaplan-Meier survival plots for standard and adaptive thresholds. The …
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P-16 How to assess the effectiveness of corneal cross-linking for keratoconus: need of a shared protocol
M Ventura, M Airaldi, L Pagano, K Gadhvi, S Kaye… - 2024
Objective Comparing definitions of progression in keratoconus (KC) patients after
corneal cross-linking (CXL). Methods Retrospective case series of KC eyes
underwent CXL. Keratoconus progression after CXL treatment was defined based …
corneal cross-linking (CXL). Methods Retrospective case series of KC eyes
underwent CXL. Keratoconus progression after CXL treatment was defined based …
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[PDF] OP-6 The involvement of corneal nerves in the pathogenesis of keratoconus
M Al-Aqaba, H Dua - 2024
… of the involvement of corneal nerves in keratoconus and suggests further that they
may play … Objective To define if keratoconus progression estimates following
collagen cross-linkage (… We compared standard definitions of keratoconus progression …
may play … Objective To define if keratoconus progression estimates following
collagen cross-linkage (… We compared standard definitions of keratoconus progression …
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P-18 DMEK in ICE syndrome and keratoconus
Z Ashena, C Thaung - 2024
Case A 60-year-old male presented with gradual, painless deterioration of vision in
his left eye over four years. His past ophthalmic history was clear with no record of
trauma, surgery, infection or inflammation. His left eye's best corrected visual acuity (BCVA) …
his left eye over four years. His past ophthalmic history was clear with no record of
trauma, surgery, infection or inflammation. His left eye's best corrected visual acuity (BCVA) …
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Higher order aberrations in keratoconus
N Erdinest, N London, D Landau, R Barbara, A Barbara… - International Ophthalmology, 2024
… keratoconus has been described as a noninflammatory disease, reports of
associations with alterations in inflammatory mediators indicate that keratoconus
often … With the acceleration of refractive surgery, it is important to identify patients …
associations with alterations in inflammatory mediators indicate that keratoconus
often … With the acceleration of refractive surgery, it is important to identify patients …
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Functional Approach to IOL Selection in Eyes With Combined Cataract and Keratoconus With an Option for Refractive Lens Exchange
GJ Goebel, DA Price, MO Price, FW Price Jr - Journal of Refractive Surgery, 2024
… Although all of the eyes in this study had previously stable keratoconus and the
follow-up duration in our study was longer than in many prior reports (Table 3), it is
possible keratoconus could progress over a longer time period. The Holladay II …
follow-up duration in our study was longer than in many prior reports (Table 3), it is
possible keratoconus could progress over a longer time period. The Holladay II …
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[HTML] Artificial Neural Network for Automated Keratoconus Detection Using a Combined Placido Disc and Anterior Segment Optical Coherence Tomography Topographer
JLA Del Barrio, AM Eldanasoury, J Arbelaez, S Faini… - Translational Vision Science …, 2024
… versus keratoconus subjects class, and normal subjects versus keratoconus
suspect subjects class. For the sake of simplicity, we decided to omit abnormal and
myopic postoperative classes because the main aim of the study was the detection …
suspect subjects class. For the sake of simplicity, we decided to omit abnormal and
myopic postoperative classes because the main aim of the study was the detection …
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Differences Between Simulated Keratometry and Total Corneal Power in Eyes With Keratoconus and a Formula to Improve IOL Power Calculation Results
CP Coutinho, D Schiano-Lomoriello, C Mazzotta… - Journal of Refractive …, 2024
… calculation in eyes with keratoconus. Recent studies have shown that the results
are acceptable in eyes with stage I keratoconus (ie, those … proper formula is
chosen.9,10 On the other hand, in stage III keratoconus (ie, with keratometry > 53.00 …
are acceptable in eyes with stage I keratoconus (ie, those … proper formula is
chosen.9,10 On the other hand, in stage III keratoconus (ie, with keratometry > 53.00 …
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RiTe conjugate mediated corneal collagen crosslinking, a novel therapeutic intervention for keratoconus–In vitro and in vivo study
H Rohira, S Shankar, S Yadav, PP Srivastava… - International Journal of …, 2024
Corneal collagen crosslinking (CXL) is an effective method to halt the disease
progression of keratoconus, a progressive corneal dystrophy leading to cone
shaped cornea. Despite the efficacy of standard protocol, the concerning step of this …
progression of keratoconus, a progressive corneal dystrophy leading to cone
shaped cornea. Despite the efficacy of standard protocol, the concerning step of this …
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[PDF] Comparison of keratoplasty outcomes at the scar versus edema stages of keratoconus
Y Chen, Z You, C Wang, R Gao, K Zhang - Arq Bras Oftalmol, 2024
… Keratoconus is a dilated corneal disorder in which the local corneal stroma
becomes thinner, … Acute corneal edema is a keratoconus condition that results
from the Descemet membrane … This study examined the outcomes of two …
becomes thinner, … Acute corneal edema is a keratoconus condition that results
from the Descemet membrane … This study examined the outcomes of two …
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