Recent Scholarly Literature Across an Array of Publishing Indexes and Disciplines

[HTML] Influence of inflammatory and metabolic factors on keratoconus risk: a causal inference analysis

PG Hysi, AJ Hardcastle, AE Davidson… - Eye, 2026

… Our results confirm a higher risk of keratoconus in patients having any atopic
disease (OR = 1.84, 95%CI = 1.52–2.22), but also other chronic inflammatory
conditions such … Also, higher glucose levels considerably reduced keratoconus …

Early-stage keratoconus in a case of oculodentodigital dysplasia

M Paredes-Hernández, J Ghiringhelli, N Ruiz-Quintero - Archivos de la Sociedad …, 2026

… Alteration of Cx43 has been associated with an increased risk of developing
keratoconus. Keratoconus is a bilateral multifactorial corneal … Several systemic
conditions associated with connective tissue hyperlaxity and collagen abnormalities …

Novel insights into the efficacy of Itone Vs. Hylo eye drops in tear film instability of keratoconus

KA Kullachi, HUE Ammara, MH Jamil, K Rafique… - Rawal Medical Journal, 2026

… herbal eye drops compared to Hylo eye drops in increasing the tear film stability
of patients with mild to moderate cases of Keratoconus. … mild to moderate severity
of keratoconus (K readings: 48–54 D) aged 15–35 years. Patients with severe …

Clinical Translation of Dynamic OCE for Corneal Biomechanical Assessment

SSC Duvvuri - 2025

… anisotropy in astigmatism and 2) mapping biomechanical heterogeneity in
keratoconus. Results: Air-pulse generated broadband, high-… In keratoconus, aRLW-speeds
were lowest in the steeper-cone region (8.55±1.51 m/s) compared with the apex (10.83±1.34 …

[HTML] Ophthalmic screening in down syndrome: A DSMIG UK Best practice recommendation (Revised 2025)

G Riding, G Croft, S Jain - Eye, 2026

… Keratoconus onset is often in adolescence or early adulthood and there are wide-ranging
prevalence estimates, although most studies suggest rates around 20–30%[9, 10].
Most of these disorders are a significant cause of preventable secondary disability at …

[HTML] Sectoral and Layer-Specific Corneal Thinning in Thyroid Eye Disease: A Cross-Sectional Study

YM Chang, TH Weng, SI Pao, TY Lin, MC Tai… - Translational Vision Science …, 2026

Purpose: Corneal thickness in patients with thyroid eye disease (TED) and the layer
or specific region of the cornea primarily affected by corneal thickness changes
remain unclear. This study aimed to examine and compare the differences in …

Scleral Collagen Cross Linkage

ZHAQ YASIR - 2026

For decades, corneal cross-linking has successfully stabilized keratoconus, but the
next frontier of ocular structural stability lies deeper. As diseases linked with scleral
biomechanical properties are surging worldwide, the need for a therapy to …

Same-day complete suture removal after deep anterior lamellar keratoplasty for keratoconus: a comparative retrospective study

SH Alenezi, A Alfarhan, S Alshahrani - Expert Review of Ophthalmology, 2026

Background Despite good graft integrity, post-keratoplasty astigmatism can
significantly limit visual acuity and quality of vision. Standard practice typically
removes only one to two sutures per visit, prolonging visual rehabilitation and …

OCT Radiomics and Machine Learning Enable Accurate Detection of Forme Fruste Keratoconus

S Luo, X Li, K Lin, F Bao, S Chen, F Lu, J Wang - American Journal of Ophthalmology, 2026

… of corneal OCT images combined with machine learning enables accurate FFKC
detection using a single imaging device, providing diagnostic information beyond
conventional morphological assessment and suggesting a potential imaging …

Comparison of epithelium-off versus iontophoresis-assisted transepithelial corneal collagen cross-linking in keratoconus: a systematic review and meta-analysis

TS Alajmi, FF Alasmari, TF Alasmari, A Bamusa… - International Ophthalmology, 2026

… Keratoconus is a progressive corneal ectasia characterized by stromal thinning
and protrusion, leading to irregular astigmatism and visual impairment. To mitigate
these issues, iontophoresis-assisted transepithelial corneal collagen cross-linking (I-CXL) …

Predicting Early Keratoconus Progression Using Biomechanics via Multi-Machine Learning: A Multicenter 2-Year Prospective Cohort Study

Y Huo, R Xie, Z Qu, Y Li, S Wang, J Li, J Hou, H Zou… - Clinical & experimental …

Background This study aimed to develop and validate a biomechanical early
progression index (BEPI) based on machine learning algorithms, intended to predict
early keratoconus progression at the first visit. Methods This multicenter prospective …

[PDF] Long-Term Effects of Gas Permeable Contact Lens Wear on Corneal Endothelium in Kera-toconus: A Comparative Cross-Sectional Study

M Kashif, KH Sam - EC Ophthalmology, 2026

… Results The study included 50 keratoconus patients with contact lens wear and
50 keratoconus controls without contact lens wear, with comparable demographic
characteristics between the two groups. The mean age of contact lens wearers was …

[HTML] Two-to-three-year effectiveness and safety of nurse-led accelerated corneal crosslinking for progressive keratoconus: The Birmingham and Midland Eye Centre Study

M Khan, R Sahota, J Hanson, Y Cabdi, M Bourlaki… - Eye Open, 2026

… in addressing the increased service demand for keratoconus management and
preserving the vision of patients with keratoconus. … For example, several nurse-led
and optometrist-led keratoconus services have been established to assess and …

[HTML] When stress meets keratoconus: Bilateral central serous chorioretinopathy

C Bardi, G Halfi, Y Akannour, E Abdallah - Journal of Clinical Ophthalmology and …, 2026

… of bilateral keratoconus likely triggered CSC. While no direct pathophysiological
relationship exists between keratoconus and CSC, their coexistence complicates
visual assessment, highlighting the need to carefully evaluate the macula in …

[HTML] Multimodal imaging of isotretinoin-induced retinal pigment epithelium atrophy and keratoconus

P Sankhe, AS Nene, S Shah, OH Pirdankar - Journal of Clinical Ophthalmology and …, 2026

Isotretinoin is a US Food and Drug Administration-approved drug for the
management of acne vulgaris. However, it is associated with various ophthalmic
side effects. Herein, we report a case of a 31-year-old female presenting with …

Preliminary digital twin model for predicting big bubble formation in deep anterior lamellar keratoplasty

G Visioli - 2026

… Methods A retrospective analysis was performed on a dataset of patients with
keratoconus who underwent DALK. Preoperative tomographic, topographic, and AS-OCT
parameters were analyzed using logistic regression and a Random Forest (RF) …

[PDF] Changing Strategies in Keratoplasty After Corneal Hydrops: From Penetrating to Lamellar Approaches–A Narrative Review

R Fairaq, O Kirat, M AlMutlak, MA Ahad, O Khan… - Clinical Ophthalmology, 2026

The hallmark of acute corneal hydrops (CH) is Descemet membrane (DM) rupture
that leads to the influx of fluid into the cornea causing corneal edema. Multiple risk
factors have been related to an increased incidence of CH in keratoconus (KC) …

[HTML] AI-Based Personalized Correction for Refractive Errors through Integration with Refractive Surgery

X Li - Proceedings of the 2025 2nd International Conference …, 2025

… OCT, and Scheimpflug photography to detect early changes related to
keratoconus, uneven corneal thickness, and other risk factors for … In keratoconus
diagnoses, algorithms using topography and tomography, including devices such as …

Modern lifestyles, new ocular diseases: The evolving agenda of clinical ophthalmology in 2026

RS Joshi - Journal of Clinical Ophthalmology and Research, 2026

As we enter 2026, ophthalmology stands at a pivotal moment in its evolution. While
surgical techniques, imaging modalities, and diagnostic precision continue to
advance, the most profound changes in eye health are being shaped not inside …

Vertical Tarsal Plate Buckling Following Conjunctival Mullerectomy: An Unusual Complication

M Cale, CT Brian, TT David - Ophthalmic Plastic & Reconstructive Surgery, 2026

DISCUSSION We describe bilateral upper eyelid vertical tarsal kinking following
CMMR—a complication that has not previously been reported. We believe that the
patient's unrecognized floppy eyelids and lateral canthal tendon disinsertion …

[HTML] ABCC6 Heterozygosity as Genetic Predisposition to Cerebrovascular Disease Across Ages

G Amico, M Severino, M Bertamino, R Pascarella… - Genes, 2026

Background: Heterozygosity for pathogenic variants in the ABCC6 gene has been
associated with an increased incidence of cerebrovascular diseases. This study
aims to characterize the prevalence and clinical and neuroradiological phenotypes …

[HTML] Outcome of keratoplasty in India over the last decade: A systematic review and meta-analysis

NI Tamboli, RS Joshi - Journal of Clinical Ophthalmology and Research, 2026

Corneal blindness remains a major cause of visual impairment in India, and
keratoplasty is the definitive treatment for many corneal pathologies, though
outcomes vary by indication and surgical technique. This systematic review and meta-analysis …

Texture-based Analysis of Corneal Dynamics for the Detection of Forme Fruste Keratoconus

S Luo, K Lin, X Li, X Zhang, L He, A Elsheikh, F Bao… - Journal of Refractive …, 2026

Purpose: To propose CVS-omics, a radiomics framework using Corvis ST (CVS) (Oculus
Optikgeräte GmbH) imaging and machine learning, for precise identification of forme
fruste keratoconus (FFKC), a subtle corneal condition often undetected by …

[PDF] Advancing subclinical keratoconus detection using polarization-sensitive optical coherence tomography and artificial intelligence

RP Patil, R Narasimhan, A Pisharody, R Shetty… - Biophotonics Discovery, 2026

Significance Early detection of keratoconus (KC), a progressive corneal disorder,
remains a major clinical challenge. Polarization-sensitive optical coherence
tomography (PS-OCT) is an advanced imaging technique that can quantify corneal …

Corneal collagen cross-linking at diagnosis in pediatric keratoconus: A prospective study from the Indian Subcontinent

R Arora, P Jain, T Garg - Indian Journal of Ophthalmology

… Performing CXL at diagnosis is safe and effective in halting pediatric keratoconus
progression while improving visual and refractive outcomes. Early treatment is
particularly relevant for high-risk ethnic groups such as Indian children, where …

Evaluation of a comatic aberration-based nomogram for symmetrical intracorneal ring segment implantation in keratoconus

N Mechleb, C Panthier, F Fabro, S Elahi, S Stephan… - Canadian Journal of …

Objective The aim of this study was to evaluate the short-term results of a comatic
aberration-based nomogram of intrastromal corneal ring segments in different
keratoconus patterns and stages. Setting Hospital Foundation Adolphe de …

Early Biocompatibility Following Xenogeneic Intrastromal Implantation of Excimer Laser–Reshaped Micro-concave Lenticules Derived From Human KLEx

S Liang, S Cheng, B Mei, Z Meng, C Zhou - Journal of Refractive Surgery, 2026

… contribute to the growing body of evidence supporting the feasibility of using
reshaped stromal lenticules for potential human applications in correcting low
myopia when corneal thickness or irregular morphology limits conventional …

Association of Big Five Inventory Personality Traits With Postoperative Satisfaction and Visual Quality Following Corneal Refractive Surgery

S Chandran, M Kaur, JS Titiyal, N Kumar, R Sinha - Journal of Refractive Surgery, 2026

… Corneal tomography was performed to rule out forme fruste keratoconus. Ray-tracing
aberrometry (iTRACE; Tracey Technologies) was used to assess Strehl ratio,
modulation transfer function (MTF), and higher order aberrations (HOAs). Dry eye …

[HTML] Therapeutic Outcomes of Three Surgical Approaches for Acute Corneal Hydrops

J Bai, S Li, C Liu, L Li, L Zhao, Z Dou - Journal of Investigative Surgery, 2026

… The longest follow-up time after CSAI in this study was two years, during which no
recurrence of progression or keratoconus was observed. … after edema resolution,
decline further surgical intervention, and show no evidence of rapid keratoconus …

Decreased Corneal Biomechanical Stability and Structural Integrity in PPAR-α Knockout Mice

C Zhu, H He, H Yan, A Liu, M Liang, R Zong, B Liu… - Experimental Eye Research, 2026

Recent evidence indicates that inflammatory cytokines and proteolytic enzymes play
a vital role in the development of biomechanical failure in the cornea. Previous
studies have shown that inflammatory cascades could be inhibited by peroxisome …

Illusions

L Skorin, Z Dwyer - Charles Bonnet Syndrome and Other Visual …

… Corneal structural diseases such as keratoconus which may induce irregular
astigmatism and Fuchs' corneal endothelial dystrophy which … Corneal cross-linking
can be performed to slow or halt the progression of keratoconus.Cataracts can be …

Enhancing eye care training: a comprehensive rubric for retinoscopy

VK Yelagondula, S Dutta, M Rizwan, S Madhukuri… - Clinical and Experimental …, 2026

… These include the application of rubrics in specific teaching environments, the
need for certain amendments, allowances when using model eyes, and complex
cases such as irregular reflex in keratoconus, paediatric refraction and cycloplegic …

[HTML] Visual outcomes of scleral lenses in different stages and cone locations of keratoconus: A retrospective observational study

S Kaya, A Sağlik - Medicine, 2026

… keratoconus based on disease stage and cone localization and provide data to
inform clinical practice. This retrospective study included 95 eyes from 61
keratoconus … Patients were categorized according to keratoconus stage (mild …

Comparing outcomes of penetrating keratoplasty versus deep anterior lamellar keratoplasty for keratoconus: a systematic review and meta-analysis

FS Al-Ghamdi, SS Taishan, RO Alanazi, FS Alsalem… - International Journal of …, 2026

Keratoconus is a progressive corneal ectasia that can lead to visual impairment.
Penetrating keratoplasty (PK) has traditionally been the standard surgical
intervention. However, deep anterior lamellar keratoplasty (DALK) has emerged as …

[HTML] Hormonal Modulation of Keratoconus: A Systematic Review and Screening Strategy for at-risk Populations

M Ashraf, E Shoraka, S Shahabi, S Ghalibafan… - Ophthalmology Science, 2026

Topic Keratoconus (KCN) is a progressive corneal ectasia with poorly understood
etiology and risk factors leading to inadequate screening methods for at-risk
populations. One potentially vulnerable population includes individuals …

[PDF] Uncovering pleiotropic loci linking keratoconus and allergic diseases through integrative genomic analyses

G Li, Y Wang, Y Xiao, S Li - Scientific Reports, 2026

Keratoconus (KC) is a progressive corneal disease increasingly linked to immune
dysregulation. Epidemiological studies have suggested comorbidity between KC
and allergic diseases such as atopic dermatitis (AD), allergic conjunctivitis (AC) …

[PDF] … , Visual, and Refractive Outcomes of Total Corneal Wavefront-Guided Transepithelial PRK With Accelerated CXL in Keratoconus Using Objective Stability Markers

L Haro-Morlett, S Arba-Mosquera, A Hernandez-Solis… - Journal of Refractive …, 2026

… This prospective, interventional, single-center study included patients with mild to
moderate keratoconus. All underwent TCWG-TransPRK (… keratoconus care.
These findings support the procedure as a safe and effective option for non-progressive …

[HTML] Staging of keratoconus indices based on localized corneal biomechanics Stress-Strain Index Map

R Ning, Y Ren, J Xiahou, S Xu, K Li, Y Wang, X Yang… - Ophthalmology Science

… 78 keratoconus (KC) patients were included in this study. All subjects had corneal
tomography (Pentacam HR, Oculus, Wetzlar, Germany) and … Cohen κ statistics
and Contingency tables were used to compare CBBS and Topographic keratoconus …

[HTML] Corneal Cross-Linking in Keratoconus: Comparative Analysis of Standard, Accelerated and Transepithelial Protocols

R Jaruseviciene, R Tamuleviciute, S Galgauskas - Journal of Clinical Medicine, 2026

Keratoconus is a progressive, non-inflammatory corneal ectasia characterized by
stromal thinning and conical protrusion. Corneal collagen cross-linking (CXL)
remains the only proven treatment to halt its progression. This review compares the …

[HTML] Corneoscleral Morphology in Keratoconus and Its Association With Corneal Tomography and Biomechanics

W Ruan, X Zhu, M Li, Z Xu, M Lin, F Lu, L Hu - Translational Vision Science & …, 2026

… The inclusion criteria for the keratoconus group were based on the global
consensus on keratoconus 1 , 2 , 11 : at least one clinical sign of keratoconus
observed via slit-lamp examination (eg, stromal thinning, Fleischer ring, Vogt's striae …

[HTML] Prevalence of Meibomian Gland Dysfunction in Patients with Keratoconus in an Optometry Clinic in the Palestinian Authority

R Ifrah, T Darwish - Biomedicines, 2026

Background/Objectives: Meibomian gland dysfunction (MGD) has been shown to be
more prevalent in patients with keratoconus (KC) in Turkey, Egypt, and Israel but has
not been examined in the Palestinian Authority (PA). Therefore, this study compared …

[HTML] Decoding Cone Morphology in Keratoconus: A Retrospective Study on Contact Lens Selection in Turkish Patients

G Varan, S Güler, SD Güler, BN Tabakçi, Y Yildirim - Journal of Current …, 2026

… keratoconus, such as globus keratoconus and Grade 4 disease. Hybrid and rigid
gas permeable (RGP) lenses were commonly prescribed for moderate keratoconus…
optimizing visual rehabilitation in patients with keratoconus. Scleral lenses are the …

[PDF] Comparison of tear film quantity parameters between keratoconus and normal eyes

F Narooie-Noori, M Khorrami-Nejad, N Ayad… - International Journal of …, 2026

… Therefore, future studies are recommended to investigate the quality and quantity
of tear film across different stages of keratoconus. Finally, KCN severity was not
stratified in correlational analyses. … and inflammatory molecules in the tears of …

Modeling Biomechanics of the Corneal Column with Keratoconus During Implantation of Intrastromal Segments

IN Zakharov, EG Solodkova, SV Balalin, VH Le… - Mechanics of Solids, 2026

… At the same time, patient-oriented FEM models of keratoconus treatment using
ISS installation, based on individualized parameters of … This study develops a
personalized finite element (FE) model of a cornea with keratoconus for intrastromal …

[PDF] One-Year Impact of Scleral Lens Wear on Corneal Morphology in Keratoconus with and Without Intracorneal Ring Segment

M Serramito Blanco, A Privado Aroco… - 2026

… lens wear in keratoconus eyes and to determine their impact on visual
performance. Methods: Sixty-five keratoconus subjects were divided … vision
correction in keratoconus. The findings highlight the importance of personalized …

[HTML] Guide to Pentacam Interpretation for Keratoconus and Corneal Ectasia

A Chen, D Srikumaran, ZA Syed, M Belin - Cornea Open, 2025

Purpose: The Pentacam, a Scheimpflug-based tomographic device, is an invaluable
tool for identifying corneal diseases. The purpose of this review was to explain the
data and images available on the 4 Maps Refractive, Belin/Ambrósio Enhanced …

[HTML] From Corneal Tomography, Biomechanics to Visual Function: Diagnostic Advances in Early Keratoconus

Y Huo, Y Wang - 2025

… keratoconus, and subclinical keratoconus. As the aim of this chapter is to
elucidate the diagnostic advances in early keratoconus, unifying the criteria for early
keratoconus … Table 1 shows the typical definitions of each early keratoconus term …

Sociodemographic and clinical characteristics of keratoconus: multi-centric study from India

S Chatterjee, N Kapur, S Sawant, N Jain, VS Sangwan - Eye, 2025

… This study aimed to determine if the sociodemographic and clinical characteristics
of patients with keratoconus had changed in recent … screened for keratoconus with
corneal tomography, leading to a greater number of keratoconus detections [5, 6] …

[HTML] Celastrol nanomedicine eye drops restore redox homeostasis and prevents keratoconus progression via PI3K/AKT/AP-1 signaling

R Liu, R Ma, N Zhang, X Geng, J Li, L Zhu, Z Li - Redox Biology, 2025

Keratoconus (KC) is a progressive corneal disorder primarily driven by oxidative
stress, though its precise molecular mechanisms remain incompletely understood,
and effective pharmacological treatments are currently lacking. Our proteomic …

Role of hypoxia-related differentially expressed genes in pathogenesis of keratoconus and construction of diagnostic models

M Wu, M He, Y Du - Experimental Eye Research, 2025

… high accuracy (AUC > 0.9) for the early detection of keratoconus. Furthermore, the
immune cell infiltration analysis revealed a positive … keratoconus. The results of
our study lay the groundwork for subsequent investigations into the molecular …

Comparison of conventional corneal crosslinking with the accelerated procedure in progressive keratoconus

L Ramm, DT Trojan, D Wittig, F Raiskup, R Khoramnia… - International Ophthalmology, 2025

Purpose To evaluate the long-term efficacy of corneal crosslinking using the
standard protocol (S-CXL) and the accelerated protocol (A-CXL) over a period of 8
years. Methods This retrospective cohort study included 61 eyes from 61 patients …

[HTML] Evaluation of systemic inflammatory biomarkers associated with high-density lipoprotein in keratoconus patients: a retrospective case-control study

B Çakır, MM Osmanoğlu, BG Sönmezoğlu - BMC ophthalmology, 2025

Background To evaluate systemic inflammatory markers including the monocyte to
high density lipoprotein cholesterol (HDL) ratio (MHR), neutrophil to HDL ratio (NHR),
lymphocyte to HDL ratio (LHR), neutrophil to lymphocyte ratio (NLR), platelet to HDL …

Comparative evaluation of tonometry methods in keratoconus

SE Avetisov, VV Averich, AV Volzhanin, AA Antonov… - Vestnik oftalmologii, 2025

The chronic course of keratoconus (KC) and the associated structural and functional
changes in the cornea complicate the interpretation of intraocular pressure (IOP)
measurements. A promising approach is to analyze tonometric data with …

[PDF] Bilateral Keratoconus: a Cataract Preoperative Assessment Incidental Finding. Role of Tomography in Biometry and Multifocality of Cone Effect

E KARMIRIS, EE CHRISTOU, M SPYROPOULOU… - Maedica A Journal of …, 2025

Background: Implantation of intraocular lenses (IOLs) for full refractive correction at
all distances is the ideal goal for cataract surgery. A comprehensive examination is
pivotal to identify corneal pathology such as keratoconus, in order to achieve optimal …

Tear Film Inflammatory Biomarkers in Keratoconus: Insights into Disease Severity and Diagnostic Potential

SL Pallamreddy, CS Sandhya, MK Damdamraju… - Korean journal of ophthalmology …

Background Keratoconus (KC) involves a progressive corneal deformation,
recognized as having an inflammatory component, despite traditionally being
considered non-inflammatory. This study investigates the notable tear film cytokines …

[HTML] The Relationship Between Corneal Stiffness Distribution and Tomography in Keratoconus Patients

NJ Lu, M Jiménez-García, A Elsheikh, A Makarem… - American Journal of …, 2025

… Keratoconus (KC) is a bilateral corneal ectatic disease characterized by
progressive thinning and localized biomechanical weakening of the corneal tissue.
These structural changes can lead to increased myopia, irregular astigmatism …

[HTML] The causal effect of oxidative stress on the risk of keratoconus: A bidirectional two-sample Mendelian randomization study

J Wang, J Zhang, Q Sun - Medicine, 2025

Keratoconus (KC) is an intricate disease involving multiple factors. It is widely
accepted that the pathogenesis of KC is linked to oxidative stress (OS). Nevertheless,
the precise causal relationship between OS and KC remains uncertain due to the …

[HTML] Simultaneous Implantation of Intracapsular Fixed-Aperture Intraocular Lens and Toric Sulcus Intraocular Lens to Treat Cataract in Patients With Keratoconus

SS Zhang, W Henein, L Brien, M Green - Cornea Open, 2025

… The aim of this study was to evaluate the treatment of patients with keratoconus
and cataract with cataract extraction and insertion of dual … ), 14 patients with
keratoconus do not enjoy the same benefit from toric lens insertion and those with …

[PDF] Photorefractive Keratectomy in Keratoconus Suspect Eyes with Borderline Topographies: One-Year Longitudinal Assessment of Visual, Refractive, and Topographic …

HM Rabie, P Nourizadeh, N Karrabi

… suspected of keratoconus (KCS) who consented to refractive surgery were
enrolled. Inclusion criteria were: age >30 years, best-corrected visual acuity (BCVA)
of 10/10, stable refractive error for at least two years, and at least two topographic …

Sterile Corneal Infiltrates After Combined Riboflavin-UVA Corneal Collagen Cross-Linking for Keratoconus

A Pelit, Z Kunt - 2025

… progression of keratoconus [2–5]. Standard CXL is a safe and approved
procedure that was shown to stabilize the progressive keratoconus. … Patients with
moderate and advanced keratoconus were included in our study. A placido disk …

Performance of new Corvis ST parameters in differentiating between healthy corneas and different stages of keratoconus in a North African population

B Omari, C Khodriss, C El Ouazzani, F Bousgheiri… - Journal Français d' …, 2026

… in differentiating between keratoconus severities (AUC = 0.861 and 0.850,
respectively). CBiF and cCBI showed excellent ability to diagnose keratoconus (AUC
= 0.937 and 0.933, respectively). SSIv2 demonstrated good potential (AUC = 0.796) …

Evaluation of fluid reservoir turbidity with different reservoir compositions and its effect on visual acuity in keratoconus patients wearing scleral lenses

M Subramanian, A Baniya, R Dutta - Contact Lens and Anterior Eye, 2025

Purpose: This study aims to evaluate and compare the Scleral Lens Fluid Reservoir
turbidity when using unpreserved normal saline and with addition of lubricating eye
drops and to compare its effect on visual quality during 6h lens wear in keratoconus …

Clinical outcomes with a higher order aberration (HOA) correcting scleral lens for keratoconus

J Jedlicka - Contact Lens and Anterior Eye, 2025

Purpose: The purpose of this paper was to evaluate the visual outcomes of 17 eyes
of 11 keratoconic patients wearing scleral lenses with standard lens optics versus
scleral lenses with a higher order aberration (HOA) correcting added. Methods: All …

Correction: Prediction of the ectasia screening index from raw Casia2 volume data for keratoconus identification by using convolutional neural networks

M Mirsalehi, B Fassbind, A Streich, A Langenbucher - PloS one, 2025

Correction: Prediction of the ectasia screening index from raw Casia2 volume data
for keratoconus identification by using convol … Correction: Prediction of the ectasia
screening index from raw Casia2 volume data for keratoconus identification by using …

Macromolecular Differences in the Extracellular Matrix Between Normal and Keratoconus Human Corneas: An Ex Vivo Study

MB Peres, JL Covre, LR da Rosa, PC Cristovam… - Current Eye Research, 2025

… cross-links, stopping the progression of keratoconus.Citation 31 The protocol
initially described (… PGs and other ECM macromolecules from normal and
keratoconus human corneas. … between the normal and keratoconus groups, and …

[HTML] Comparison of corneal pachymetry evolution after accelerated corneal crosslinking in keratoconus eyes using anterior segment optical coherence tomography and …

A Lang, B Seitz, C Munteanu, E Flockerzi - International Ophthalmology, 2025

Purpose This retrospective clinical study compared longitudinal corneal pachymetry
measurement evolution after accelerated corneal crosslinking (A-CXL, 9 mW/cm 2 ,
10 min) in keratoconus (KC) eyes as measured by Pentacam HR Scheimpflug …

[HTML] Knowledge of Early Keratoconus Diagnosis and Management in Nyanza and Western Kenya: Practitioners' Perspective

MM Njeru, IS Soler, SN Maina, HA Golicha - The Open Ophthalmology Journal, 2025

… A substantial number of practitioners demonstrated limited knowledge of early
keratoconus, possibly due to the low rates of keratoconus … of early keratoconus.
Practitioners' qualifications were significantly associated with knowledge in early …

[PDF] Hierarchical Attention for Sparse Volumetric Anomaly Detection in Subclinical Keratoconus

L Kandakji, W Woof, N Pontikos - arXiv preprint arXiv:2512.03346, 2025

… cross-sections illustrating the subtle morphological progression with increasing
keratoconus probability (𝑝𝐾𝐶). (A) Region of interest for … from normal to severe
keratoconus, with corresponding keratoconus probability ranges pKC. Keratoconus …

[PDF] Keratometric Evaluation of the Anterior and Posterior Corneal Surface Before and After Corneal Cross-linking for Pediatric Keratoconus

B Wójcik-Niklewska, M Janik - Journal of Pediatric Ophthalmology & Strabismus, 2025

… of keratoconus is between 0.2 and 4.79 per 100.000 and 1.5 and 25 cases per
100.00 persons/year. The highest prevalence has been reported in those 20 to 30
years old and in the Middle East and Asia.Patients with keratoconus … before and …

[PDF] DOES TRANSPLANTATION OF THE BOWMAN LAYER REDUCE THE PROGRESSION OF KERATOCONUS? A SYSTEMATIC REVIEW

MA ISMAIL, BM ALHASHIDI, BK ALSHAHRI… - … , Methodology in Applied …, 2025

Background: Keratoconus is a progressive corneal ectatic disorder that can severely
impair vision. Bowman layer transplantation (BLT) has been proposed as a
minimally invasive surgical option to stabilize ectasia and preserve vision in …

[HTML] Corneal cross-linking for keratoconus: a global economic and clinical perspective

B Gurnani, K Kaur - Journal of Medical Economics, 2025

… Keratoconus typically presents during adolescence or early adulthood critical
years for education, productivity, and workforce participationCitation 4 . Preventing
vision loss through timely CXL not only reduces direct medical expenditures but also …

Exploring biomarkers for keratoconus: current insights and future directions

D Nautiyal, S Gaba, U Jain - Molecular Biology Reports, 2026

… profile of keratoconus may help to focus on better diagnosis. The present review
will increase our insights into keratoconus pathophysiology … Bowman was the first
to observe keratoconus using an ophthalmoscope [2, 3]. A Swiss physician named …

Biomechanical and Inflammatory Pathways Underlying the Genetic Architecture of Keratoconus: A Genomic SEM Study

T Shuijing, W Jiakang, Y Tingting, J Ma - Experimental Eye Research, 2025

Background The genetic architecture of keratoconus (KC) is complex, and the
interplay between its biomechanical and inflammatory etiological components
remains poorly defined. We aimed to quantitatively resolve these distinct genetic …

[HTML] Results of contralateral Athens and decentered individualized sphero-cylindrical (DISC) protocols for keratoconus management

I Knezović, N Jovanović, S Djurić - 2025

… Keratoconus (KC) is characterized by corneal thinning and bulging, typically
beginning in … ) technique to stop the progression of keratoconus by increasing the
covalent connections … Thirty-four years old male, Caucasian patient was …

[PDF] COEXISTENCE OF KERATOCONUS AND AGE-RELATED MACULAR DEGENERATION: AN UNUSUAL CASE REPORT

AM Januškevičiūtė, R Vaičiulienė, D Žaliūnienė

… Keratoconus is a progressive corneal ectasia, usually diagnosed in younger
patients that can … presenting with the coexistence of keratoconus and macular
choroidal neovascularization. … The objective of the article is to present a rare …

Exploring biomarkers for keratoconus: current insights and future directions

D Nautiyal, S Gaba, U Jain - Molecular Biology Reports, 2026

… profile of keratoconus may help to focus on better diagnosis. The present review
will increase our insights into keratoconus pathophysiology … Bowman was the first
to observe keratoconus using an ophthalmoscope [2, 3]. A Swiss physician named …

Biomechanical and Inflammatory Pathways Underlying the Genetic Architecture of Keratoconus: A Genomic SEM Study

T Shuijing, W Jiakang, Y Tingting, J Ma - Experimental Eye Research, 2025

Background The genetic architecture of keratoconus (KC) is complex, and the
interplay between its biomechanical and inflammatory etiological components
remains poorly defined. We aimed to quantitatively resolve these distinct genetic …

[HTML] Results of contralateral Athens and decentered individualized sphero-cylindrical (DISC) protocols for keratoconus management

I Knezović, N Jovanović, S Djurić - 2025

… Keratoconus (KC) is characterized by corneal thinning and bulging, typically
beginning in … ) technique to stop the progression of keratoconus by increasing the
covalent connections … Thirty-four years old male, Caucasian patient was …

[PDF] COEXISTENCE OF KERATOCONUS AND AGE-RELATED MACULAR DEGENERATION: AN UNUSUAL CASE REPORT

AM Januškevičiūtė, R Vaičiulienė, D Žaliūnienė

… Keratoconus is a progressive corneal ectasia, usually diagnosed in younger
patients that can … presenting with the coexistence of keratoconus and macular
choroidal neovascularization. … The objective of the article is to present a rare …

Reveal a Risk and Potential Mechanism for Keratoconus Progression with Isotretinoin: Toxicogenomic, Transcriptomics and Real-World Evidence Insights

T Tao, Y Peng, M Zhao, K Yan, Q Zhang, X Zheng… - Experimental Eye Research, 2025

Purpose Limited clinical data and unstable animal models hinder understanding
isotretinoin-induced keratoconus. We addressed this by integrating
pharmacovigilance with computational approaches. Methods Isotretinoin-associated …

[HTML] Structural and microvascular retinal changes in keratoconus: an OCT and OCT angiography study

O Ozkan, CA Utine, R Piscopo, LD Andrea - Medical hypothesis, discovery & …, 2025

Background: Keratoconus is increasingly recognized as a condition that may affect
not only corneal structure but also posterior segment parameters. This study aimed
to evaluate alterations in central macular, choroidal, and peripapillary retinal nerve …

[HTML] Six-month longitudinal analysis of visual, tomographic, and densitometric changes after corneal collagen cross-linking in keratoconus

E Karatas, S Koksaldi, CA Utine - Medical hypothesis, discovery & innovation in …, 2025

Background: Keratoconus is a progressive corneal ectasia commonly treated with
corneal collagen cross-linking (CXL) to halt further progression. Although transient
anterior stromal haze frequently develops after CXL, its impact on visual recovery …

Efficacy of Variable-thickness Sinusoidal Intracorneal Ring Segments in Management of Keratoconus: A Multicenter Retrospective Study

M Hosny, S Kwitko, J Ruiz, M Harouch, H Kamoun… - … Journal of Keratoconus and …, 2025

Purpose: To evaluate the outcomes of implanting variable thickness intracorneal
ring segments (Vt-ICRS) in the treatment of keratoconus. Patients and methods: A
retrospective multicenter study from seven centers in five different countries …

[PDF] Outcomes of Scleral Lens in Different Stages and Cone Locations of Keratoconus

S KAYA, A SAĞLIK

… moderate-stage keratoconus and paracentral cone localization compared with
other groups (p< 0.05). In advanced keratoconus, the gain … Conclusion: SCLs
signi cantly enhance visual acuity in keratoconus patients, with the most substantial …

A Standardized Protocol of Simultaneous Transepithelial Phototherapeutic Keratectomy Followed by Corneal Collagen Crosslinking for Keratoconus.

R Angunawela, M Bizrah, J Kabbani, RP Patel - 2025

… keratoconus who underwent a standardized protocol of transepithelial
phototherapeutic keratectomy (t-PTK) laser followed by accelerated corneal
collagen crosslinking (CXL). METHODS: All patients with progressive keratoconus …

[PDF] The Arrangement of a Framework, Scheimpflug Imaging and the Modern Treatment of the Ectatic Corneal Disorder: Keratoconus

M Chandra, J Singh, IA Ansari, A Jha

Objective: To review recent advancements in the understanding, diagnosis, and
management of keratoconus, emphasizing the role of Scheimpflug imaging and the
Belin ABCD classification in early detection and treatment planning. Design …

[HTML] Comparison of visual acuity outcomes and topographic differences: Rigid gas-permeable lens versus mini-scleral lenses for moderate-to-severe keratoconus

EC Chang, CJ Kuo, SH Lee, YC Hou - Taiwan Journal of Ophthalmology

PURPOSE: The purpose of the study was to compare the visual outcomes of small-diameter
rigid gas-permeable (RGP) lenses and mini-scleral lenses (MScL) in patients with
moderate-to-severe keratoconus (KC) and to evaluate the utility of corneal …

… Corneal Pocket Implantation of 360-Degree MyoRing® Versus Corneal Tunnel Implantation of 340-Degree Keraring® for the Management of Central Keratoconus

M Abdel-Radi, M Anwar, MM Mostafa - Current Eye Research, 2025

Purpose To report the intraoperative and postoperative complications and to
evaluate the outcomes of femtosecond laser-assisted pocket implantation of 360-degree
MyoRing ® versus tunnel implantation of 340-degree Keraring ® for the …

Incidence of keratoconus following allergic conjunctivitis: a multicenter retrospective cohort study using a US healthcare network database

N Lishinsky-Fischer, N Erdinest, O Buhbut, Z Gur - Contact Lens and Anterior Eye, 2026

… a relationship between atopic conditions and keratoconus, many were limited by
sample size, … between allergic conjunctivitis and incident keratoconus in a large
pediatric and young … Forest plots summarizing the hazard ratios for keratoconus …

CUTTING-EDGE DIAGNOSTIC INNOVATIONS: A META-ANALYSIS OF EARLY KERATOCONUS DETECTION

MURR PARREY, HN ALENEZI, RS ALANAZI… - … , Methodology in Applied …, 2025

Background: Keratoconus (KC) is a progressive corneal ectasia that can remain
undetected in its early or subclinical stages, delaying sight-preserving interventions
such as corneal cross-linking (CXL). Accurate and timely diagnosis is essential to …

Tear levels of apoptotic, matrix-degrading and antioxidant biomarkers in patients with and without keratoconus: A cross sectional study.

D Alunni-Fegatelli, U Camellin, F Franchina… - 2025

… be associated with clinically manifest keratoconus. ROC curve analysis …
keratoconus and 33 were age-matched healthy subjects. The linear combination of
the three tear biomarkers levels (AUC = 0.811; CI 95 %: 0.712-0.911) accurately …

The application of artificial intelligence-based algorithms in predicting the progression of keratoconus: a systematic review

H Hashemi, A Jamali, P Nabovati, F Babapour Mofrad… - International Ophthalmology, 2025

Purpose To conduct a systematic review of studies examining the use of artificial
intelligence (AI) algorithms in predicting the progression of keratoconus (KCN).
Methods A comprehensive review was conducted using PubMed, Google Scholar …

Comparison of t-PTK+ CXL and CXL with mechanical debridement for keratoconus: fellow eye study

B Kepez Yildiz, O Yucel, YB Akbas, AS Balci… - International Ophthalmology, 2025

… This retrospective, comparative, fellow-eye study included 52 eyes of 26
keratoconus patients, each with a thinnest corneal thickness greater than 450 µm
before the … Accelerated CXL following t-PTK may offer enhanced therapeutic …

[HTML] Prevalence and factors associated with keratoconus among high school students in Trinidad and Tobago: A cross-sectional population-based study

NE Ezinne, MA Kwarteng, S Phagoo… - Contact Lens and Anterior …, 2026

Background This study aimed to determine the prevalence of keratoconus (KC)
among high school students in Trinidad and Tobago (T&T) and identify associated
factors. Methods This cross-sectional study was conducted using multi-stratified …

[HTML] Evaluation of the Accuracy of Intraocular Lens Power Calculation Formulas for Cataract Surgery in Patients with Keratoconus

F Hatami, SK Mirzaei, MA Javadi, S Feizi, S Safi… - Journal of Ophthalmic & …, 2025

Purpose To compare the refractive accuracy of different intraocular lens (IOL) power
calculation formulas in eyes with keratoconus (KCN) undergoing cataract surgery.
Methods This retrospective case series included the medical records of patients with …

[HTML] Comparative Analysis of Corneal Biomechanical Properties in Keratoconus and Post-Refractive Surgery Ectasia Using Scheimpflug-Based Imaging

K Bansal, T Gupta, A Akhlaq - European Journal of Cardiovascular Medicine, 2025

Purpose: To compare corneal biomechanical parameters in eyes with keratoconus
and post-refractive surgery ectasia using Scheimpflug-based imaging and to
evaluate whether distinct biomechanical signatures can aid in differentiating the two …

[HTML] Data-driven detection of subclinical keratoconus via semi-supervised clustering of multi-dimensional corneal biomarkers

L Kandakji, S Balal, A Stupnicki, S Liu, M Leucci… - Ophthalmology Science

… Most progression occurred from subclinical keratoconus to keratoconus, while
direct transitions from healthy to keratoconus were rare. … curves estimating the
probability of remaining keratoconus-free over time for eyes classified at baseline as …

[PDF] Toxic Anterior Segment Syndrome Following Implantable Collamer Lens Implantation in a Patient With Keratoconus and Nystagmus: A Case Report

AK Alharbi, M Dabi, A Almuzaini, A Almalki… - Cureus, 2025

… for keratoconus) was evaluated for refractive surgery. Pre-crosslinking, corneal
topography had confirmed bilateral keratoconus associated … To our knowledge,
there are no prior reports in the literature involving the use of toric ICLs in patients …

[PDF] Corneal Allogenic Intrastromal Ring Segments For The Treatment Of Keraroconus CAIRS in Keratoconus

R Barbara, G Salvo, R Hanna, A Sepetis, NL Espinoza… - 2025

… This retrospective study included 24 eyes from 22 patients with keratoconus who
experienced suboptimal visual acuity with spectacles and were intolerant to contact
lenses. All patients underwent femtosecond laser-assisted CAIRS implantation …

Vision-Related Quality of Life in Iraqi Keratoconus Patients: A Comparative Analysis of Surgical and Non-Surgical Interventions

HA Aljaberi, S Rahmani, A Mohammad, MO Almuttairi - Korean journal of ophthalmology …

Purpose To compare vision-related quality of life (QoL) between surgical and non-surgical
interventions in Iraqi patients with unilateral keratoconus (KC) and to identify
independent clinical predictors of QoL outcomes. Methods This multicenter cross-sectional …

[HTML] Dynamic ocular surface secretome analysis in keratoconus patients under scleral lens intervention

L Zeng, C Lu, X Zhou, Z Chen, Q Le, F Zhou - Eye Discovery, 2025

Objective To characterize the temporal dynamics of the ocular surface secretome in
response to scleral lens (SL) wear in keratoconus and to explore potential molecular
mechanisms. Methods Ocular surface secretions were collected from four patients …

[HTML] A proteomic window into the stressed ocular surface—Comments on "dynamic ocular surface secretome analysis in keratoconus patients under scleral lens …

T Wang, W Shi - Eye Discovery, 2025

The ocular surface secretome provides a dynamic molecular readout of ocular health.
A longitudinal proteomic study of keratoconus patients wearing scleral lenses
reveals rapid immune activation and metabolic adaptation, offering insights into the …

Cataract surgery in keratoconus: current challenges and future directions

C Sarnicola, E Sarnicola, V Sarnicola - Current Opinion in Ophthalmology

Despite significant progress, outcomes in keratoconus remain less predictable than
in normal eyes. Careful patient selection, keratoconus-adjusted formulas, and
staged surgical strategies are essential. Future priorities include prospective …

[HTML] Changes in corneal symmetry and tear film stability after laser asymmetric keratectomy in patients with keratoconus suspect: A retrospective study

JS Min, BM Min - Medicine, 2025

Keratoconus suspect (KCS) has been a contraindication of laser refractive surgery (LRS)
due to postoperative corneal ectasia, but is well indicated with LRS combined with
corneal remodeling using laser asymmetric keratectomy (LAK). This study compared …

[PDF] Incidence and Clinical Characteristics of Keratoconus Patients in a University-based Eye Clinic

FS Barodawala, KK Leong - International Journal of Keratoconus and Ectatic …, 2025

Aim and background: Keratoconus (KC) is a bilateral, asymmetrical,
noninflammatory corneal ectasia that causes blurred vision from the irregular
astigmatism by corneal protrusion, thinning, and steepening. This study aims to …

[PDF] Asthma and Keratoconus: A Vision at Risk and the Urgency of Early Screening

Z Junaid, N Babar - Pakistan Journal of Medical Sciences, 2025

… Keratoconus or KC is a progressive eye disease where the cornea thins and
bulges outward… For instance, Lema and Durán documented that patients with
keratoconus had elevated … collagen cross-linking1 to reduce or prevent …

[HTML] Integration of tear fluid biomarkers and machine learning for the early detection of keratoconus

Y Lin, Y Yao, X Miao, S Tang, L Huang - BMC ophthalmology, 2025

Background Keratoconus (KC) is a progressive corneal disorder that leads to visual
impairment owing to corneal thinning and deformation. While current diagnostic
methods are effective in the later stages, early detection of KC remains challenging …

[HTML] Beyond Vision: Unveiling the Psychiatric Dimensions of Keratoconus

TG Nuță, MC Manea, CI Varlam, G Nuță, AM Mareș… - Medicina, 2025

… to find the possible connection between keratoconus and specific mental illnesses. …
This study takes a broader look at the relationship between keratoconus and
psychiatric disorders. … Most small, cross-sectional studies reported significant …

Impact of contact lens correction on wavefront aberrations and vision quality in keratoconus

G Swartz, K Alam, A Gentle, LE Downie - Ophthalmic & physiological optics: the journal of the …

… in keratoconus, with a focus on residual ocular wavefront error and its impact on
vision performance. Findings: Corneal rigid gas permeable (RGP) contact lenses,
commonly used in keratoconus … the optical characteristics of the cornea in …

[HTML] Inter-Eye Molecular Discrepancies in the Corneal Epithelium Point to TFRC in the Keratoconus Severity Signature and Mechanism of Cone Formation

K Jaskiewicz-Rajewicz, A Wysocka… - … Ophthalmology & Visual …, 2025

Purpose: There is no molecular evidence available confirming or contradicting inter-eye
molecular variability in keratoconus (KTCN). The key question is whether the use of
a model of more and less affected eyes of the same pair facilitates the identification …

Wavefront changes after local cross-linking for keratoconus

SI Anisimov, SM Micovic, NS Anisimova, NA Gavrilova - Vestnik oftalmologii, 2025

Objective This study aimed to analyze the dynamics of corneal wavefront aberration
changes after local corneal cross-linking and assess their impact on visual acuity in
patients with keratoconus. Material and methods The study group included 22 …

… to Data Standards: A Translational Evidence Framework for Corneal Crosslinking: Systematic Review and Meta-Analysis: Corneal Crosslinking in Keratoconus

D Oehring, T Kim, H Lee, D Sung-Yong, T Terletskyi… - 7th International Conference …, 2025

Introduction: Corneal crosslinking (CXL) is the only treatment capable of halting the
progression of keratoconus, a progressive corneal thinning disease that causes
distorted vision. Despite its widespread clinical adoption and a rapidly expanding …

RNN-PSO: a tuned neural network with optimisation algorithm for keratoconus classification

GP Ramesh, P Subramanian, BR Reddy - International Journal of Computer …, 2025

… which improves the keratoconus classification performance. … keratoconus and
advanced keratoconus in terms of accuracy, sensitivity and specificity. The method
attains an accuracy of 0.80 on normal, 0.81 on sub-clinical, 0.85 on keratoconus and …

[PDF] Use of Ultraviolet Cross-Linking for the Treatment of Thin Corneas in Keratoconus

MM Bikbov, AR Khalimov, AE Babushkin, EL Usubov - Kazan medical journal, 2025

Ultraviolet cross-linking of corneal collagen is an innovative technique designed to
increase corneal strength in keratoconus by creating additional cross-links within the
macromolecules of the extracellular matrix. The method is based on exposing the …

[HTML] Evaluating the Predictive Accuracy of the Kane and SRK/T Formulas in Keratoconus Patients Undergoing Cataract Surgery

YB Akbaş, H Davarcı, BK Yıldız, A Ceylan, FO Aydın… - Turkish Journal of …, 2025

… in the multicenter studies that dominate the literature on IOL calculations for
patients with keratoconus. In addition, due to the limited number of patients with
either stage 2 or stage 3 keratoconus, these cases were assessed collectively in this …

The The Development of Criteria for Identifying Keratoconus Risk Group During the Initial Ophthalmic Examination

M Solomatina, G Laganovska, J Gertnere - Baltic Journal of Clinical Medicine and …, 2025

Objectives: There has been an increase in the number of patients diagnosed with
keratoconus … and analytical study included 100 patients with keratoconus
diagnose and a control group of … to find out if there is an association between …

Excimer laser-assisted ex vivo model for eccentric keratoconus in human donor corneas

M El Zarif, M Nubile, S Kluge, M Totta, J Kunstmann… - Experimental Eye Research, 2025

Purpose To develop a reproducible ex vivo model of eccentric keratoconus (KC)
using a customized excimer laser ablation profile based on patient data, replicating
the corneal morphology of ectatic disease. Methods Human donor corneas were re-profiled …

Evaluation of 60 months long-term results of accelerated corneal cross-linking treatment in pediatric keratoconus patients with new progression indices: TH Ceran et al …

T Horozoglu Ceran, P Kosekahya, M Koc - Japanese Journal of Ophthalmology, 2025

… , pediatric keratoconus patients were reviewed individually and 40 eyes of 40
patients with progressive pediatric keratoconus who underwent … Keratoconus
diagnosis was based on the characteristic keratoconus signs in the anterior sagittal …

[HTML] Transcriptomic profiling reveals neural–immune–stromal dysregulation and risk-associated gene signatures in advanced keratoconus

K Du, R Peng, G Xiao, Y Qu, L Han, J Hong - Scientific Reports, 2025

This study aimed to characterize transcriptomic alterations and the effects of
demographic and behavioral risk factors on disease-associated gene expression
patterns in late-stage keratoconus (KC). Corneal stromal tissues from 31 KC patients …

Early Detection of Keratoconus Through Astigmatism Monitoring

B SOUMIA, L DOUNIA - 2025

… one of the earliest warning signs of developing keratoconus but only the
monitoring of specific … the accuracy of these parameters in detecting early
keratoconus. Results: Myopic astigmatism was … Conclusion: Changes in …

[HTML] What is the quality-of-life status of patients with keratoconus who have not had a surgical intervention? A systematic review

D Sari, H Kandel, R Kha, SL Watson - Eye, 2025

… with keratoconus who have not had a surgical intervention to manage their
keratoconus. Data … Studies had sample sizes ranging from 25 to 1209 participants
with keratoconus. The NEI … Patients with keratoconus who have not undergone …

[HTML] Prevalence of Keratoconus and Associated Risk Factors Among High School Students in Couva, Trinidad: A Cross-Sectional Study

NE Ezinne, S Phagoo, A Roopnarinesingh… - Vision, 2025

Purpose: This study aimed to determine the prevalence and associated risk factors
of keratoconus (KC) among high school students in Couva, Trinidad and Tobago.
Method: A cross-sectional, school-based approach was used, involving a simple …

[PDF] Enhancing Keratoconus care in a public healthcare system in KwaZulu-Natal, South Africa

NM Gcabashe, VR Moodley, S Buthelezi, R Hansraj - … of Primary Health Care & Family …, 2025

Background: Keratoconus (KC) is a self-limiting corneal ectasia with an unknown
definitive aetiology. It presents as a corneal thinning disorder that results in myopia
and irregular astigmatism and, if left untreated, leads to visual impairment. Aim: This …

[PDF] Keratoconus in Northern Tanzania: A hospital-based prevalence and clinical profile study

FP Maro, VR Moodley - African Vision and Eye Health, 2025

Background: Keratoconus (KC), a progressive, corneal, ectatic disease varies in
prevalence globally. Differences and similarities in KC prevalence have been
observed, and despite clinicians anecdotally reporting many KC cases, no empirical …

AI Helps Doctors Treat Keratoconus Before Vision Damage Occurs

A It's - The Indian Practitioner, 2025

… (AI) system that can accurately predict which patients with keratoconus require
treatment to stabilize their corneas and prevent vision loss. The findings were
presented at the 43rd Congress of the European Society of Cataract and Refractive …

Long-term outcomes after high-energy accelerated pulsed corneal cross-linking (15 mW/cm2; 7.2 J/cm2) for keratoconus: a 6 years retrospective analysis

S Luca, F Romina, C Mattia, M Luigi, G Laura… - International ophthalmology, 2025

… Long-term outcomes after high-energy accelerated pulsed corneal cross-linking (15
mW/cm 2 ; 7.2 J/cm 2 ) for keratoconus: a 6 years … Conclusion: High-energy pl-ACXL
appears to be an effective procedure for halting the progression of keratoconus and …

[HTML] Advanced Diagnostic Imaging in Keratoconus

PK Gupta, S Greenstein

… Consider how optical coherence tomography (OCT) and epithelial thickness
maps can be used as diagnostic tools for patients with keratoconus. … Peter Hersh
with a focus on crosslinking for keratoconus. Dr. Greenstein did his ophthalmology …

[HTML] Reducing astigmatism following accelerated transepithelial corneal collagen cross-linking for keratoconus: A prospective study

R Setyowati, R Widyaningrum, S Supanji, K Zai… - Medicine, 2025

… in the young population of keratoconus before and after accelerated …
Keratoconus population when exposed to UVA radiation for 10 minutes at an
intensity of 9 mW/cm 2 . The purpose of this study is to demonstrate the safety and …

CORNEAL CROSS-LINKING AS A THERAPEUTIC APPROACH IN PEDIATRIC KERATOCONUS

BF Aguiar, LMS de Oliveira, LFE de Queiroz… - CIPEEX, 2025

… Traditionally, management includes glasses or contact lenses, but these methods
do not prevent the progression of keratoconus, which … and helps prevent
keratoconus progression. OBJECTIVE: To evaluate the effectiveness of CXL in …

[PDF] Correlation Study Between Corneal Topographic and Biomechanical Parameters with Tear Inflammatory Mediator Levels in Keratoconus

J Du, H Liu, Y Lu, Z Qiuyan, D Wen, Z Deng - 2025

Objective: To analyze the correlations among tear inflammatory mediator
concentration, corneal topographic and biomechanical parameters in keratoconus (KC)
patients. To assess the potential of tear inflammatory mediators as supplementary …

[PDF] Genetic Perspective and Clinical Characteristic of First-Degree Relatives of Keratoconus: A Review

N Razak, WHWA Halim, B Mohd-Ali

… family history of keratoconus in patients with keratoconus is prominent…
keratoconus suggested that there is a potential predisposition to keratoconus (42).
Research has also indicated that approximately 13.3% of immediate family …

[PDF] Genetic Perspective and Clinical Characteristic of First-Degree Relatives of Keratoconus: A Review

N Razak, WHWA Halim, B Mohd-Ali

… family history of keratoconus in patients with keratoconus is prominent…
keratoconus suggested that there is a potential predisposition to keratoconus (42).
Research has also indicated that approximately 13.3% of immediate family …

[HTML] A rare co-occurrence of keratoconus and tuberous sclerosis complex in a young female: A case report and literature review

SC Sugali, SK Kodavoor, R Dandapani - Indian Journal of Ophthalmology-Case …, 2025

… keratoconus is extremely uncommon. An 18-year-old female presented with
uncorrected visual acuity of counting fingers at 4 meters. Examination revealed high
myopia with corneal signs of keratoconus, … The rare coexistence of keratoconus …

Nitrosative Stress, Mitochondrial Peptides, and Ferroptosis Markers in Corneal Epithelial Cells from Keratoconus Patients

C Demirkiran, A Mete, AT Demiryürek, A Saracaloglu… - Current Eye Research, 2025

… The Amsler–Krumeich classification is one of the extensively utilized systems for
identification of keratoconus and evaluation of disease progression, and we have
used this classification in clinical examination of keratoconus. This severity staging …

[PDF] PREDICTING EARLY STAGE KERATOCONUS USING TREE-BASED ENSEMBLE MODELS

P CHERNOV

Early Stage Keratoconus (ESKC) am eye that is challenging to diagnose as its
symptoms are evident using simple eye test. This creates the problem of late
diagnosis and means that patients receive treatment when the disease progresses …

[HTML] Evaluating Changes in Pro-and Anti-Inflammatory Mediators in Keratoconus Following Corneal Collagen Cross-linking: A Systematic Review: Pro-and Anti …

RS Huang, A Mihalache, MM Popovic, CC Chan - AJO International, 2025

Purpose To investigate the changes in pro- and anti-inflammatory mediators
following corneal collagen cross-linking (CXL) in patients with keratoconus (KC).
Design Systematic review. Methods A comprehensive literature search was …

Experimental Use of Ozone in Cross-Linking: Transforming Keratoconus Management

AS Dogan, C Gurdal, S Caliskan, E Onder, A Isgoren… - Current Eye Research, 2025

Purpose Keratoconus is a progressive corneal disorder characterized by thinning of
the stromal layer. Corneal cross-linking (CXL), a widely used treatment, focuses on
improving corneal strength by enhancing collagen cross-links. Alternative methods …

[PDF] Keratoconus–Impact on Mental Health and Quality of Life Before and After Specific Therapeutic Interventions: A Review

A Manasar, A Matuszek, E Siedy-Florek, K Szlachetka…

… This review aims to present an impact of keratoconus on mental health and
quality of life before and after specific therapeutic interventions.… patients with
keratoconus and treatment methods for keratoconus were used, and the most …

[PDF] Clinician-Assisted Exploratory Data Analysis Framework for Early Keratoconus Detection

ZJ Muhsin, R Qahwaji, I Ghafir, M AlShawabkeh…

Advances in corneal imaging have generated vast datasets, making it challenging to
extract clinically relevant insights. Machine Learning (ML) provides ophthalmologists
with essential tools for keratoconus (KC) detection and clinical decision-making …

[PDF] Update of Keratoconus Correct Microsurgical Resolution: Mini Selective ARK J Sur & Surgic Proce., 3 (4): 1-4

M Lombardi - Center of Ophthalmologic Regenerative Medicine, Italy, 2025

… Using these simple instrumentation and Principle it is possible to apply to the
Keratoconus affected corneas the same and obtain (if correctly applied and using a good
experience in corneal Diamond incisional microsurgery) the Result that the modified …

[PDF] KERATOCONUS MANAGEMENT WITH CORNEAL COLLAGEN CROSSLINKING (Epi-on): A CASE REPORT

I Ismaili, S Gazepov - KNOWLEDGE-International Journal, 2025

… The prevalence of keratoconus is estimated at approximately 1 in 2000 individuals,
with a male … On the slit-lamp examination, keratoconus presents with a range of
characteristic findings depending … The aim of this study is to present a case of …

Variants and Perturbed Pathways Associated with Keratoconus and a Novel Stromal Corneal Dystrophy

FL Braddock - 2025

Keratoconus (KC) is a progressive corneal ectasia typically presenting in early
adulthood, with a prevalence of 1.2-3.3%. It is a complex condition and both
environmental and genetic factors contribute to KC risk. Family history is a major risk …

An efficient technique for keratoconus disease prediction by utilizing extensive feature extraction and AI method

A Vijjapu, VSSV Alluri, K Kalyani, DV Kumar… - Information Sciences, 2025

… The effective management of Keratoconus, an advanced eye condition
characterized by a … predicts and classifies them into normal, Keratoconus, and
suspect Keratoconus. The CSA-FS-… reliable way to diagnose keratoconus …

[HTML] Keratoconus diagnosis based on macro-micro corneal characteristics via optical coherence tomography

C Chen, F Zhang, Y Tang, H Cao, L Chen, S Qian… - Biomedical Optics Express, 2025

… new insight for keratoconus, we developed … keratoconus potential index (KPI)
as a quantitative measure for diagnosing keratoconus and mapping disease risks of
104 participants, which showed excellent diagnostic power (with an area under the …

[HTML] A rare case of Blepharophimosis-Ptosis-Epicanthus inversus syndrome (BPES) associated with keratoconus: a multidisciplinary approach to diagnosis and …

A Al Khathami, AH Al Ghamdi - BMC Ophthalmology, 2025

… keratoconus, a progressive corneal ectasia characterized by thinning, steepening,
and irregular astigmatism, has not been previously reported in the literature [5].
Keratoconus … Here, we report the first known case of BPES associated with …

Long-term Results of Corneal Cross-linking for Recurrence of Keratoconus After Keratoplasty

E Bonacci, A Fasolo, MC Ventura, V Romano… - Journal of Refractive …, 2025

Purpose: To evaluate the long-term efficacy of accelerated corneal cross-linking (A-CXL)
in halting the progression of recurrence of keratoconus in the graft. Methods: This
was a retrospective chart review of patients who underwent A-CXL for recurrence of …

[PDF] Repeatability of the ABC Parameters of the ABCD Keratoconus Grading System With Varying Zonal Averaging Diameters as Evaluated on Dual Scheimpflug/Placido …

KE Asfar, P Ibrahim, JF Assaf, CJ Roberts, A Salloum… - Journal of Refractive …, 2025

… Given the lack of a previous study of the ABC parameters' repeatability in eyes
with keratoconus using the Galilei or the MS-39, we aimed to achieve a 15%
confidence estimate and therefore at least 43 independent sample eyes would be …

Repeatability of the Pentacam HR and IOLMaster 700 in Patients With Keratoconus and Intracorneal Ring Segments

E Fernández López, E Arias-García, C Martínez-Gil… - Journal of Refractive …, 2025

… To explore the effect of keratoconus severity on measurement repeatability, we
initially considered classifying keratoconus severity according to the Amsler-Krumeich
grading system. However, this was not feasible in our dataset due to the highly …

[PDF] Evidence of the Influence of Intra-stromal Ring Implant on Slowing the Progression of Keratoconus

DF Mota, FBD da Silva, ND Daher - Ophthalmology, 2025

… Keratoconus is a progressive ectatic corneal disease that usually begins in the
second decade of life and is characterized by … keratoconus should be aimed not
only at visual rehabilitation, but also at stopping or slowing down its progression. In …

[HTML] Halo sign in keratoconus: a case report

H He, L Qu - BMC ophthalmology, 2025

… There are several clinical signs that may contribute to the diagnosis of
keratoconus. Their appearance is associated with the evolution of keratoconus. In
this case, the formation of a halo on the iris in a patient with stage IV keratoconus …

Prevalence and Corneal Morphometry of Pediatric Keratoconus: A Two-Year Cross-Sectional Study in Ukraine

T Viktoriya - London Journal of Medical and Health Research, 2025

This study aimed to assess the prevalence and corneal morphometric characteristics
of pediatric keratoconus in children aged 6� 16 years in Ukraine, using data
collected over a two-year period. Participants were stratified by age group (6� 10 …

The effect of altitude on the incidence of keratoconus in Israel–a population-based study

O Ben-Shaul, A Segal, M Hyams, N Stein… - Eye, 2025

… Keratoconus patients were identified using ICD-9 codes. Annual keratoconus
incidence was calculated for three residential altitude groups: below 0 m, 0–500 m,
and above 500 m. To address ethnic confounding, keratoconus prevalence rates in …

[HTML] Early treatment of allergic conjunctivitis in preventing keratoconus

NJY Tay, JY Yap, YW Lim - Australian journal of general practice, 2025

A man, aged 24 years, with a history of allergic rhinitis presented with a two-day
history of sudden onset right eye redness, pain and blurred vision. Upon further
enquiry, he revealed that since his teenage years, he had experienced intermittent …

[PDF] Theranostic-guided Corneal Phototherapy for Precise and Predictive Treatment of Keratoconus and Ectatic Corneal Disorders: A Case Series

M Lombardo, S Serrao, M Fruschelli, G Lombardo - … Keratoconus and Ectatic Corneal …, 2025

… for keratoconus and corneal ectasia. Materials and methods: The clinical
outcomes of three representative patients affected by keratoconus … Results:
Patients underwent theranostic-guided transepithelial corneal phototherapy for …

[PDF] Awareness of Keratoconus Among the Diagnosed Cases of Keratoconus in Patients Visiting Al Shifa Trust Eye Hospital: Awareness of Keratoconus in Patients

T Ahmed, F Akhtar, MA Moqeet, HG Shah, SF Bukhari… - Pakistan Journal of Health …, 2025

… % participants with advanced keratoconus gave a history of eye rubbing due to a
lack of awareness [13]. A Study regarding the association of keratoconus with other …
This study aims to determine the level of awareness of keratoconus among …

Long-term effects of corneal collagen cross-linking (CXL) in patients with keratoconus

J Lelas, S Ramić, D Šarić, B Kuzmanović Elabjer… - . 20. Kongres Hrvatskog …

Aim: To evaluate the long-term effects of corneal cross- linking in patients with
progressive keratoconus Patients and methods: 38 eyes of 38 patients with
progressive keratoconus were treated with CXL and were included in the study …

Keratoconus progression during pregnancy after corneal cross-linking

S Ramić, I Pavlović, T Topalović, D Šarić… - 23. kongres Hrvatskog …

Aim: To report a case series of six patients who had a pregnancy during follow-up
after corneal cross-linking. Patients and methods: Retrospective chart review. We
included 6 female patients (12 eyes), with an average age of 30.45+/-2.24 years …

Scheimpflug Tomography Changes In Patients With Keratoconus After Collagen Cross-Linking–One-Year Follow-Up

I Ćubela, D Miletić, S Ramić, I Pavlović, D Šarić… - 43rd Congress of the European …

Purpose: To evaluate Scheimpflug tomography changes in patients with
keratoconus before and one year after collagen cross-linking (CXL). Setting: A
retrospective study was conducted on 46 patients of both genders who underwent …

Long-Term Outcomes of Corneal Cross-Linking in Patients with Keratoconus

S Ramić, I Pavlović, I Ćubela, D Šarić… - … I OPTOMETRIJSKOG DRUŠTVA

Objective: To analyze the effects of corneal cross-linking in patients with a minimum
follow-up of 5 years after the procedure. Patients and Methods: This retrospective
study included 22 patients (mean age 33.52±5.23 years; 11 women; 40 eyes; 19 …

ABCD grading system in patients with keratoconus after collagen cross-linking–one-year follow-up

I Ćubela, D Miletić, S Ramić, I Pavlović, D Šarić… - … I OPTOMETRIJSKOG DRUŠTVA

Aim: To evaluate ABCD grading system changes in patients with keratoconus before
and oneyear after collagen cross-linking (CXL). Patients and methods: A
retrospective study was conducted on 45 patients of both genders who underwent …

Re:'validity of keratoconus screening tests'

N Erdinest, N Aharoni - Clinical and Experimental Optometry, 2025

… "Validity of keratoconus screening tests" was read with great interest. 1 This work
underscores the imperative for enhanced keratoconus … acuity, refractive error, and
astigmatism can facilitate early detection of keratoconus. However, the authors aptly …

Ocular Comorbidities in Psoriasis: A Retrospective Study on Dry Eye Syndrome, Keratoconus, and Cataract Development

SY Iritaş, İ Iritaş - The Journal of Dermatology, 2025

… of keratoconus in female patients with psoriasis (p = 0.0159). These findings
suggest that psoriasis may be associated with an increased likelihood of specific
ocular conditions, particularly keratoconus and DES. The sex‐related disparity …

[PDF] Stromal Curvature, Power and Corneal‐Stromal Curvature Ratios From a Hybrid AS‐OCT in Eyes With Keratoconus

JA Wendelstein, A Ostermaier, K Freller, A Grendele… - Clinical & Experimental …, 2025

… Background: To characterise stromal curvature and curvature ratios in
keratoconus (KCN) using … Conclusion: In advanced keratoconus, three- surface
modelling yields different corneal power … of keratoconus and refine our …

Metaheuristic-optimized swin transformer with SHAP explainability for keratoconus classification from corneal topography maps

SMS Sujitha, S Subiramoniyan, J Mahil, T Jarin - International Ophthalmology, 2025

Keratoconus (KCN) is an uncommon corneal disorder where the central cornea
undergoes advanced thinning and causes non-uniform astigmatism. This results in
metamorphopsia and potential vision loss if it is left untreated. Early detection of …

Study on the role of sex hormones and prolactin induced proteins in keratoconus

Z CHEN, W ZHANG, L GAO, N ZHANG, J LI - International Eye Science, 2025

Keratoconus (KC) is a blinding eye disease caused by a variety of factors, with its
pathogenesis still not well understood. In recent years, it has been discovered that
sex hormones and prolactin-induced protein (PIP) have a profound impact on the …

[HTML] Comprehensive evaluation of oculus pentacam in subclinical keratoconus and clinical keratoconus patients at different stages

N Razak, BM Ali, WHWA Halim - Saudi Journal of Ophthalmology

… Pentacam parameters to distinguish subclinical keratoconus (SCKC) and clinical
keratoconus (CKC) at different stages in normal eyes. … Pairwise comparison of
corneal topography and tomography in subclinical keratoconus, different stages of …

[HTML] Macular safety and outcomes of accelerated cross-linking with a 7.2 J/cm² energy dose in keratoconus: A prospective case series

M Subasi, A Özdemir, V Yeter, E Can - Saudi Journal of Ophthalmology

PURPOSE: The purpose of this study was to evaluate the macular safety and clinical
outcomes of an accelerated Corneal collagen crosslinking (CXL) protocol using 12
mW/cm² ultraviolet-A (UV-A) irradiation for 10 min (total energy dose: 7.2 J/cm²) with …

[HTML] Genetics of Keratoconus: A Comprehensive Review

RH Barcelo-Canton, DSJ Ting, JS Mehta - Genes, 2025

Keratoconus (KC) is a progressive, multifactorial corneal ectatic disorder
characterized by localized stromal thinning and irregular astigmatism, with incidence
and prevalence varying markedly among populations. These differences are …

Effectiveness and safety of cross-linking in keratoconus patients with corneal thickness< 400μm: A systematic review and meta-analysis

F Mohammadi, MB McGuinness, MZ Mustafa… - American Journal of …, 2025

Topic In this systematic review and meta-analysis, we aimed to investigate the
effectiveness and safety of corneal cross-linking (CXL) in patients with keratoconus
and thin corneas (corneal thickness <400μm). Clinical relevance Guidelines for the …

Single-cell RNA sequencing reveals LGALS9+ epithelial and COMP+ stromal cell crosstalk driving keratoconus pathogenesis

T Han, Y Yu, Y Wang, X Peng, Z Chen, Q Lin, X Zhou - International Journal of …, 2025

Objectives Keratoconus is an ophthalmic disease that seriously endangers patients'
vision and quality of life. This study aimed to investigate the cellular landscape of
keratoconus and uncover key pathological cell populations and signaling pathways …

Corneal Cross-Linking in Keratoconus: A Scoping Review of Clinical Evidence and Public Health Implications

R Ojeda-Salamanca, B Villagra, NF Vargas… - 2025

… Keratoconus is a progressive corneal disease of high clinical and social relevance,
where early detection and timely treatment are essential to preserve vision and
avoid major surgical interventions (1). Traditionally, therapeutic management of …

[PDF] Vision Transformer Embedded Feature Fusion Model with Pre-Trained Transformers for Keratoconus Disease Classification

MF Ishrak, MM Rahman, MIK Joy, A Tamuly, S Akter… - 2025

Keratoconus is a progressive eye disorder that, if undetected, can lead to severe
visual impairment or blindness, necessitating early and accurate diagnosis. The
primary objective of this research is to develop a feature fusion hybrid deep learning …

Correlation of Tear Cortisol Levels with Morphological and Biomechanical Parameters of Keratoconus

X Zhao, T Sun, Y Yuan, Y Zhang, Y Chen - Frontiers in Medicine

Introduction: Keratoconus (KC) is a vision-threatening corneal disorder
predominantly affecting young males, significantly impairing their quality of life. We
aim to evaluate tear cortisol levels in KC and compare with controls, and to …

[HTML] The microenvironment of ocular surface in keratoconus: a systematic review

S Niazi, F Doroodgar, S Pflugfelder, K Bayat… - Eye and Vision, 2025

… and progression of keratoconus. This comprehensive review aims to investigate
the complex relationship between keratoconus and ocular surface diseases by
examining the microenvironmental changes that occur on the ocular surface …

[PDF] Economics of corneal cross-linking for keratoconus treatment

CJ Rapuano, RL Lindstrom, E Donnenfeld, JP Berdahl… - Journal of Medical …, 2025

… The simulation of keratoconus progression, which is a key driver of model
outcomes, was … We simulated 4,000 eyes of 2,000 patients diagnosed with
keratoconus to compare the … Keratoconus is an eye condition that affects the …

[HTML] Persistent Proinflammatory Cytokine Profile in the Tear Fluid of Stable Keratoconus: Rethinking Clinical Quiescence

P Gil, JQ Gil, N Cruz, C Costa, P Rodrigues-Santos… - Translational Vision Science …, 2025

… This study evaluates whether patients with stable keratoconus exhibit persistent
inflammatory activity in tear fluid compared to healthy … stable keratoconus is
associated with a distinct proinflammatory tear fluid cytokine profile, challenging the …

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