Pachymetric Thresholds for Keratoconus Progression Based on MS-39 Measurement Precision
R Ning, Y Wang, X Yang, X Huang, J Li, G Savini… - … and Physiological Optics, 2026
… keratoconus progression are redefined in this study using a hybrid tomographic
device. ● This study sought to establish measurement thresholds for different
grades of keratoconus, … adaptive thresholds further improved the precision of …
device. ● This study sought to establish measurement thresholds for different
grades of keratoconus, … adaptive thresholds further improved the precision of …
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[PDF] Socioeconomic and Clinical Factors Associated a Tertiary Referral Cohort with Keratoconus Severity and Follow-Up in a Tertiary Referral Cohort
T Wang - Clinical Ophthalmology, 2026
I read with great interest the article by Alrefai and colleagues entitled “Socioeconomic
and Clinical Factors Associated with Keratoconus Severity and Follow-Up in a
Tertiary Referral Cohort”, recently published in Clinical Ophthalmology. 1 The …
and Clinical Factors Associated with Keratoconus Severity and Follow-Up in a
Tertiary Referral Cohort”, recently published in Clinical Ophthalmology. 1 The …
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[PDF] Eyelid laxity characteristics in Japanese patients with keratoconus: Implications for the evaluation of floppy eyelid syndrome
M Ikeda, H Namba, Y Chida, T Usui - 2026
… Floppy eyelid syndrome (FES), characterized by eyelid laxity, has been
increasingly recognized in association with keratoconus. This study aimed to
investigate the characteristics of eyelid laxity in Japanese patients with keratoconus …
increasingly recognized in association with keratoconus. This study aimed to
investigate the characteristics of eyelid laxity in Japanese patients with keratoconus …
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Rizzuti's sign in advanced keratoconus
RK Jha, S Seth - Arquivos Brasileiros de Oftalmologia, 2026
A 24-year-old male presented with progressive, painless visual decline in the right
eye, with a best-corrected visual acuity of 20/80. Slit-lamp photographs obtained
with temporal illumination demonstrated a sharply demarcated conical light reflex on …
eye, with a best-corrected visual acuity of 20/80. Slit-lamp photographs obtained
with temporal illumination demonstrated a sharply demarcated conical light reflex on …
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212 Pediatric keratoconus diagnosis by corneal tomography: a large-scale validation study
A Romanelli - Journal of American Association for Pediatric …, 2026
… Of these, 1,738 were normal corneas and 831 had a diagnosis of keratoconus.
Multiple tomographic variables obtained from Pentacam (… K2 and Kmax are the
most robust and clinically valuable Pentacam parameters for diagnosing pediatric …
Multiple tomographic variables obtained from Pentacam (… K2 and Kmax are the
most robust and clinically valuable Pentacam parameters for diagnosing pediatric …
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[HTML] Serum thrombospondin-1, growth differentiation factor-15, and resolvin D1 and E1 levels in the pathogenesis of keratoconus
R Kılıç, ŞG Konuk, M Katar, G Bektur - Arquivos Brasileiros de Oftalmologia, 2026
… -15, resolvin D1, and resolvin E1 in patients with keratoconus. Methods: Thirty-five
patients with keratoconus and 35 control subjects of similar age and sex were
evaluated. The keratoconus group was divided into four stages according to the …
patients with keratoconus and 35 control subjects of similar age and sex were
evaluated. The keratoconus group was divided into four stages according to the …
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Obesity and Eye Diseases
P Kamila, B Anna, M Małgorzata - Nutrients, 2026
… BMI on keratoconus [34], while a large population-based study among
adolescents also found an association between BMI and keratoconus [… oxidative
stress and altered antioxidant responses are characteristic features of keratoconus [39] …
adolescents also found an association between BMI and keratoconus [… oxidative
stress and altered antioxidant responses are characteristic features of keratoconus [39] …
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[HTML] Non-Invasive Longitudinal Imaging of the Cornea in Pathophysiological Conditions Across Mice and Humans Using Self-Referenced Optical Coherence Microscopy
HF Pattan - 2026
… Although the etiology of keratoconus remains unknown, recent studies have
reported damage to corneal nerves associated with the rupture of the Bowman’s
layer within the keratoconus area, leading to a direct interaction between epithelial …
reported damage to corneal nerves associated with the rupture of the Bowman’s
layer within the keratoconus area, leading to a direct interaction between epithelial …
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Photorefractive Keratectomy in Keratoconus: Long-Term Outcomes from a Pre-Cross-Linking Era Cohort
GE Tamayo, N Moros, EJ Polania-Baron, C Castell… - Journal of Cataract & …, 2026
… The purpose of this study was to describe long-term visual, refractive, and
topographic outcomes of a small cohort of patients with keratoconus who underwent
PRK prior to CXL availability, with follow-up exceeding 20 years. Given the …
topographic outcomes of a small cohort of patients with keratoconus who underwent
PRK prior to CXL availability, with follow-up exceeding 20 years. Given the …
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305 Comparative analysis of anterior and posterior corneal tomographic parameters in normal and keratoconus pediatric eyes using Scheimpflug imaging
A Katz, C Anderson, N Morales-Mancillas, L Perilloux… - Journal of American …, 2026
Methods This retrospective chart review included patients< 19 with keratoconus and
controls who underwent Scheimpflug tomography. Diagnosis of keratoconus
followed established criteria. Data collected included visual acuity, manifest …
controls who underwent Scheimpflug tomography. Diagnosis of keratoconus
followed established criteria. Data collected included visual acuity, manifest …
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025 Corneal crosslinking in children with keratoconus ages 3 to 16 years: topographic diagnostic criteria and surgical outcomes
N Pereyra-Munoz, F Bautista-Mendoza, S Brizuela… - Journal of American …, 2026
Methods Between August of 2022 and September of 2025, a PentacamHR was
obtained from 540 children ages 3-16 years with an astigmatism≥+ 3.0 D. Twenty-seven
children (54 eyes) were diagnosed with KC and ACXL was performed in 14 children …
obtained from 540 children ages 3-16 years with an astigmatism≥+ 3.0 D. Twenty-seven
children (54 eyes) were diagnosed with KC and ACXL was performed in 14 children …
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320 Association of Down syndrome with keratoconus in pediatric population: a retrospective cohort analysis
R Shahrokni, I Abboud, A Elhusseiny, H Saeed - Journal of American Association for …, 2026
Methods We performed a retrospective cohort study using TriNetX database.
Children≤ 18 years with≥ 5 ophthalmology encounters and a diagnosis of Down
syndrome (ICD-10: Q90) were compared with a control cohort without the diagnosis …
Children≤ 18 years with≥ 5 ophthalmology encounters and a diagnosis of Down
syndrome (ICD-10: Q90) were compared with a control cohort without the diagnosis …
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027 Noninvasive epithelium-on oxygen-enriched corneal collagen crosslinking for the treatment of pediatric patients with keratoconus
M Raizman - Journal of American Association for Pediatric …, 2026
Methods 30 eyes of pediatric patients aged 12 to 17 years were randomized 2: 1 to
CXL treatment (n= 19) or Sham procedure (n= 11). The primary efficacy endpoint
evaluated the mean change in maximum corneal curvature (Kmax) from baseline to …
CXL treatment (n= 19) or Sham procedure (n= 11). The primary efficacy endpoint
evaluated the mean change in maximum corneal curvature (Kmax) from baseline to …
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[HTML] Management of Double Anterior Chamber After Deep Anterior Lamellar Keratoplasty Using Descemetopexy with Corneal Patch: A Case Report
MDD Icaza, MDJC Cadavid, MDGR Vera-Duarte - American Journal of …, 2026
… Observations A 45-year-old man with advanced keratoconus underwent DALK
using the type 2 big-bubble technique. A small peripheral Descemet membrane (DM)
rupture occurred intraoperatively without evident aqueous leakage, and surgery was …
using the type 2 big-bubble technique. A small peripheral Descemet membrane (DM)
rupture occurred intraoperatively without evident aqueous leakage, and surgery was …
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335 Increased vitreous chamber depth associated with high myopia in children
B Devine, N Shaikh, M Stec, L Nichols, SWJ Shin… - Journal of the American …, 2026
Methods Retrospective review of pediatric patients (3-17 years) with myopia< 0.00 D.
Baseline axial length and keratometry were stratified by cycloplegic refraction,
myopia control treatment, race, and ethnicity for analysis. Patients with pseudophakia …
Baseline axial length and keratometry were stratified by cycloplegic refraction,
myopia control treatment, race, and ethnicity for analysis. Patients with pseudophakia …
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072 Phenotypic and genotypic characterization of posterior polymorphous corneal dystrophy in children: a 13 year clinical review
M Gagrani, E Franco, A Abuseif, K Tripi, H Scanga… - Journal of American …, 2026
Methods We retrospectively reviewed patients with PPCD from 2012 to 2025.
Clinical data included demographics, presenting symptoms, visual acuity, refraction,
slit-lamp findings, intraocular pressure, comorbidities, family history, and …
Clinical data included demographics, presenting symptoms, visual acuity, refraction,
slit-lamp findings, intraocular pressure, comorbidities, family history, and …
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077 Socioeconomic and racial disparities in pediatric ophthalmology referrals: insights from the UCSD EyeMobile program
L Hennein, N Ramesh, A Legala, R Lee, S Borooah… - Journal of American …, 2026
… Leading referral reasons included strabismus (18.4%), high refractive error (17.1%),
and suspicion for keratoconus (14.3%). Referral rates declined from 0.69% in very
low COI areas to 0.34% in very high COI areas (P= 0.008). Higher COI was …
and suspicion for keratoconus (14.3%). Referral rates declined from 0.69% in very
low COI areas to 0.34% in very high COI areas (P= 0.008). Higher COI was …
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[HTML] Prediction of Maximum Keratometry Progression With Stratified Progression Criteria in Keratoconus Patients Using Machine Learning
A Schlatter, L Pomberger, A Honeder, J Zeilinger… - Translational Vision Science …, 2026
Purpose: The aim of this study was to use machine learning to predict 12-months
progression of maximum keratometry (K max) within stratified repeatability limits
based on a baseline topography/optical coherence tomography measurement in …
progression of maximum keratometry (K max) within stratified repeatability limits
based on a baseline topography/optical coherence tomography measurement in …
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[PDF] Keratoconus severity detection using LSTM and machine learning techniques
ST Ozyer - 2026
… Keratoconus(KC) is a common degenerative condition of the cornea delineated
by corneal steeping caused by corneal protrusion and … the advancement of
keratoconus. In this study, machine learning (ML) algorithms were employed to …
by corneal steeping caused by corneal protrusion and … the advancement of
keratoconus. In this study, machine learning (ML) algorithms were employed to …
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36 CAIRS–a biological game-changer in keratoconus management? Early clinical outcomes of cor-neal allogenic intrastromal ring segments
J Kahlert, T Berger, B Seitz, L Daas - 2026
Purpose To evaluate short-term visual and topographic outcomes of Corneal
Allogenic Intrastromal Ring Segments (CAIRS) in patients with keratoconus after 3
months.Methods This prospective case series included 5 eyes of 5 patients with …
Allogenic Intrastromal Ring Segments (CAIRS) in patients with keratoconus after 3
months.Methods This prospective case series included 5 eyes of 5 patients with …
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Changing trends in keratoplasty: a 20-year analysis from a tertiary referral center in Türkiye
AS Balci, A Kirgiz, B Altindis, S Liman Uzun… - International Ophthalmology, 2026
… The proportion of keratoplasty performed for keratoconus decreased over time,
whereas pseudophakic bullous keratopathy and regraft … The proportion of
keratoplasty performed for keratoconus declined, while pseudophakic bullous …
whereas pseudophakic bullous keratopathy and regraft … The proportion of
keratoplasty performed for keratoconus declined, while pseudophakic bullous …
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[HTML] Penetran Keratoplastinin Orta-Dönem Sonuçlarının Değerlendirilmesi
M YILDIRIM, FTY ÖZTÜRK - Fırat Tıp Dergisi, 2026
… Conclusion: In this study, the most common indication for PK over a 5-year period
was keratoconus and representing the initial experiences of … Keratoconus is a
leading indication with a frequency ranging from 7-31% in many studies (14, 2628) …
was keratoconus and representing the initial experiences of … Keratoconus is a
leading indication with a frequency ranging from 7-31% in many studies (14, 2628) …
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28 Evaluation of electron-beamed, pre-cut corneal allogenic intrastromal ring segments (e-CAIRS) in a rabbit model: implications for biocompatibility and standardized …
RC Shoufani, E Han, TLQ Ying, F Giuliano, AK Riau… - 2026
Purpose Keratoconus management using CAIRS offers a biologically compatible
alternative to synthetic ring seg-ments. However, current … reliable and efficient
alternative to freshly cut CAIRS, and thereby broadening access to therapeutic …
alternative to synthetic ring seg-ments. However, current … reliable and efficient
alternative to freshly cut CAIRS, and thereby broadening access to therapeutic …
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[PDF] Uncertainty-Aware Artificial Intelligence for Automatic Detection of Ophthalmic Diseases from Medical Images
D Furman
… Diego Ponzin) at the Venice Eye Bank Foundation and the University of Brescia
contributed directly to the keratoconus part of this dissertation, especially to Chapter
4, which presents an uncertainty-aware pipeline for keratoconus support …
contributed directly to the keratoconus part of this dissertation, especially to Chapter
4, which presents an uncertainty-aware pipeline for keratoconus support …
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31 Diverging global trends in anterior lamellar keratoplasty: a comparative analysis of eye bank tissue distribution and implications for increasing tissue availability …
V Jünger, A Margarella, G Visioli, C Nucci, F Scarinci… - 2026
… Ectatic disorders such as keratoconus are optimally treated with ALK, whereas
endothelial dysfunction is treated with EK. Despite these advances, global access to
corneal tissues remains limited by persistent donor shorta-ges and regional …
endothelial dysfunction is treated with EK. Despite these advances, global access to
corneal tissues remains limited by persistent donor shorta-ges and regional …
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Short-term retinal microvascular and structural changes after epi-on and epi-off corneal cross-linking assessed by SD-OCTA
S Yorukoglu Kayabas, IE Ay, T Horozoglu Ceran… - International Ophthalmology, 2026
… with more advanced keratoconus, whereas epi-on CXL was selected for eyes
with better visual acuity and milder disease. This clinical allocation resulted in
baseline differences, particularly worse BCVA and thinner CCT in the epi-off group …
with better visual acuity and milder disease. This clinical allocation resulted in
baseline differences, particularly worse BCVA and thinner CCT in the epi-off group …
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15 A 100-year-old donor saves 2 cases of fungal sclerokeratitis associated with panendophthalmitis
T Garcin, S Essadiq, S Begnaud, B Birebent, L Merabet… - 2026
… The woman’s background was bilateral keratoconus 6 previous penetra-ting
keratoplasty (PK) in the infected right eye including 5 during the last 9 months due to
Paecilomy-ces lilacinus keratitis. Last PK was done 1 month and half ago with …
keratoplasty (PK) in the infected right eye including 5 during the last 9 months due to
Paecilomy-ces lilacinus keratitis. Last PK was done 1 month and half ago with …
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[HTML] Prevalence and determinants of keratoconus in Kilimanjaro region: a population-based evaluation
FP Maro, VR Moodley - BMC Ophthalmology, 2026
Purpose of the study The study aimed to determine the distribution and determinants
of keratoconus (KC) among individuals aged 12–45 years in the Kilimanjaro region,
where epidemiological data are currently lacking. Materials and methods A cross-sectional …
of keratoconus (KC) among individuals aged 12–45 years in the Kilimanjaro region,
where epidemiological data are currently lacking. Materials and methods A cross-sectional …
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[HTML] Longitudinal biomechanical changes and progression-associated parameters in subclinical keratoconus: a prospective study
Y Han, X Chen, S Li, J Li, S Zuo, Y Wang - BMC Ophthalmology, 2026
Purpose In this longitudinal study, we assessed biomechanical changes in eyes with
subclinical keratoconus (SKC) and explored features associated with progression.
Methods A total of 283 patients were included. The mean follow-up was 24.8 ± 13.7 …
subclinical keratoconus (SKC) and explored features associated with progression.
Methods A total of 283 patients were included. The mean follow-up was 24.8 ± 13.7 …
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Interobserver Variability in the Identification of Keratoconus Suspects Among Teenagers and Young Adults: Comparison With Scheimpflug Tomographic Indices
S Georgiadou, A Zisimopoulos, CH Karabatsas… - Cornea, 2026
… of keratoconus (KCN) and keratoconus-suspect (KCN-S), but primarily addresses
the normal-versus-suspect KC boundary. The demonstrated variability between the
2 experienced corneal experts (CHK and AJK) in their assessment of such eyes …
the normal-versus-suspect KC boundary. The demonstrated variability between the
2 experienced corneal experts (CHK and AJK) in their assessment of such eyes …
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[PDF] Corneal transplantation in the Amazon: a 10-year retrospective study
MJ Cohen, SVA Cohen, LMP da Silva, APL Anders… - Arq Bras Oftalmol, 2026
… , keratoconus is consistently reported as the leading indication for corneal
transplantation(8,10,12). In contrast, Carvalho et al.(13) identified leucoma as the
most common indication in Amazonas in 1996, followed by keratoconus …
transplantation(8,10,12). In contrast, Carvalho et al.(13) identified leucoma as the
most common indication in Amazonas in 1996, followed by keratoconus …
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Effect of Green Light-Mediated Corneal Cross-Linking on the Delivery of Rose Bengal and Vancomycin in Staphylococcus aureus-Infected Eyes
SE George, A Roy, PK Sharma, S Upadhyay… - ACS Applied Bio Materials
Rose Bengal (RB)-green light (GL) cross-linking (RGX), a phototherapy used to treat
infectious keratitis, activates RB to generate reactive oxygen species (ROS),
promoting bacterial killing and corneal strengthening through collagen cross-linking …
infectious keratitis, activates RB to generate reactive oxygen species (ROS),
promoting bacterial killing and corneal strengthening through collagen cross-linking …
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[HTML] Repeatability and Agreement between novel SS-OCT VG2 and CASIA2 in Anterior Segment Parameters
Z Qu, Y Huo, R Xie, Y Jiang, Y Li, H Lu, Y Wu, G Zhao… - … and Photodynamic Therapy, 2026
… The samples we included did not involve populations with diseases or
postoperative populations, such as those with keratoconus or individuals
undergoing follow-up after refractive surgery. Therefore, the repeatability and …
postoperative populations, such as those with keratoconus or individuals
undergoing follow-up after refractive surgery. Therefore, the repeatability and …
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[HTML] Safety and Efficacy of Optimal Keratoplasty in Reduction of Hyperopia and Hyperopic Presbyopia: A Retrospective Observational Study
KJ Rodgers, HG Glen, MJ Berry - Clinical Ophthalmology, 2026
… Exclusion criteria included nystagmus; uncontrolled uveitis, severe blepharitis,
lagophthalmos; moderate to severe dry eye disease; corneal pathology and/or
shape disorders such as keratoconus; previous ocular surgery; autoimmune disease; …
lagophthalmos; moderate to severe dry eye disease; corneal pathology and/or
shape disorders such as keratoconus; previous ocular surgery; autoimmune disease; …
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[HTML] Defocus Spectacle Lenses: How Special Glasses Help Slow Childhood Myopia
VP July
Defocus Spectacle Lenses: How Special Glasses Help Slow Childhood Myopia - Dr.
Val Phua Skip to main content Hit enter to search or ESC to close Search Close
Search Dr. Val Phua Dr. Val Phua Menu About Dr Val Phua Technology Procedures …
Val Phua Skip to main content Hit enter to search or ESC to close Search Close
Search Dr. Val Phua Dr. Val Phua Menu About Dr Val Phua Technology Procedures …
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Empirical Evaluation of Virtual Fonts With Enhanced Out-of-Focus Legibility in the Presence of Inaccurate or Incomplete Eye Accommodation Demand
J Kim - 2026
One of the key challenges in optical see-through (OST) augmented reality (AR)
environments is accommodation mismatch caused by the fixed focal plane of
commercial head-mounted displays (HMDs). Devices such as the Microsoft …
environments is accommodation mismatch caused by the fixed focal plane of
commercial head-mounted displays (HMDs). Devices such as the Microsoft …
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Vibration Event Identification Technology in Φ-OTDR Based on a Gated Residual Fusion and Frequency Encoding Dual-Path Backbone Neural Network
C Ying, B Feng, S Wan, J Yu - IEEE Sensors Journal, 2026
This paper studies the vibration event recognition task for Φ-OTDR systems and
proposes a dual-path backbone network named GRF-FEDPBNet (Gated Residual
Fusion-Frequency Encoding Dual Path Backbone Network). The core novelty of this …
proposes a dual-path backbone network named GRF-FEDPBNet (Gated Residual
Fusion-Frequency Encoding Dual Path Backbone Network). The core novelty of this …
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Adipose-Derived Stem Cells in Ophthalmic Regenerative Medicine: From Cell Replacement to Precision Engineering
B Li, L Ling, R Liu, X Zhang, Y Kang, J Guo - Stem Cell Reviews and Reports, 2026
… Preliminary trials of intrastromal implantation of autologous ASCs for advanced
keratoconus and corneal scars demonstrated … Assessment of the effects of
intrastromal injection of adipose-derived stem cells in keratoconus patients. Int J …
keratoconus and corneal scars demonstrated … Assessment of the effects of
intrastromal injection of adipose-derived stem cells in keratoconus patients. Int J …
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[HTML] A large language models-assisted and expert-corrected workflow for preoperative anesthesia assessment drafts: A single-centre exploratory feasibility study
S Gu, J Ping, H Lin, H Xu, F Fang, D Su, X Kang - Medicina Clínica, 2026
Background Large language models (LLMs) may help organize clinical information,
but their use in perioperative settings requires careful evaluation because errors
may have immediate safety implications. This study aimed to describe the feasibility …
but their use in perioperative settings requires careful evaluation because errors
may have immediate safety implications. This study aimed to describe the feasibility …
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A Syed - Eye, 2026
… inflammatory and metabolic factors in keratoconus risk [1]. Their findings confirm
a substantially higher risk of keratoconus in patients with atopic … A plausible
mechanistic bridge links the atopy, rheumatoid arthritis, and Crohn’s disease findings …
a substantially higher risk of keratoconus in patients with atopic … A plausible
mechanistic bridge links the atopy, rheumatoid arthritis, and Crohn’s disease findings …
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Relationship between Atopy and Keratoconus: Study of Contributing Factors and Involved Mechanisms
AN Sari Yanez, M Rodriguez, S Maria - Opuntia Brava, 2026
El queratocono es una ectasia corneal progresiva cuya fisiopatología, previamente
considerada no inflamatoria, ha sido reevaluada debido a la evidencia que vincula
los procesos inflamatorios y los fenómenos atópicos con su desarrollo y progresión …
considerada no inflamatoria, ha sido reevaluada debido a la evidencia que vincula
los procesos inflamatorios y los fenómenos atópicos con su desarrollo y progresión …
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[PDF] Rapid Growth and Persistent Geographic Concentration of Recorded Outpatient Corneal Cross-Linking Production in Brazil's Unified Health System, 2017-2025
MG Maués, V Amin, M Rezende, L Rodrigues - Cureus, 2026
… Corneal cross-linking (CXL) is the principal intervention used to stabilize
progressive keratoconus. The procedure was incorporated into Brazil's Unified
Health System (Sistema Único de Saúde (SUS)) in 2016 and became operational in …
progressive keratoconus. The procedure was incorporated into Brazil's Unified
Health System (Sistema Único de Saúde (SUS)) in 2016 and became operational in …
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Outcomes of wavefront-guided scleral lenses in keratoconus patients
OH Masoud, CY Chang, BB Meghpara, ZA Syed - Optometry and vision science …, 2026
Purpose This study investigated the change in higher order aberrations (HOAs) and
visual acuity with wavefront-guided scleral lenses (WFGSLs) in the management of
patients with keratoconus. Methods A total of 22 eyes from 13 patients with …
visual acuity with wavefront-guided scleral lenses (WFGSLs) in the management of
patients with keratoconus. Methods A total of 22 eyes from 13 patients with …
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[HTML] Nfe2l2-knockout mouse model exhibits oxidative stress-associated stromal degeneration and inflammatory activation resembling keratoconus pathology
X Li, J Gu, X Sun, Y Liang, S Mao, Y Chen, X Wang… - PeerJ, 2026
Oxidative stress is central to keratoconus (KC) pathogenesis, and NRF2 is a key
antioxidant regulator. However, an in vivo model linking NRF2 loss to KC has been
lacking. We generated CRISPR/Cas9 Nfe2l2-knockout (KO) mice and assessed 4-month-old …
antioxidant regulator. However, an in vivo model linking NRF2 loss to KC has been
lacking. We generated CRISPR/Cas9 Nfe2l2-knockout (KO) mice and assessed 4-month-old …
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Epithelial Thickness and Stromal Changes in Keratoconus Patients after Intra Corneal Ring Implantation
OMH Sayed, AAE Nassar, MS Ibrahim - Al-Azhar International Medical Journal, 2026
Background: The most common kind of primary corneal ectasia is keratoconus (KC),
which is marked by bilateral and asymmetric corneal … ), we aimed to examine
stromal alterations and epithelial thickness maps in keratoconus patients both …
which is marked by bilateral and asymmetric corneal … ), we aimed to examine
stromal alterations and epithelial thickness maps in keratoconus patients both …
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[PDF] Refractive prediction errors of Barrett KCN, Kane KCN, SRK/T, and a customized approach in moderate-to-severe keratoconus after cataract surgery
SD Saad, K Jadidi, M Khodaparast, S Pirhadi, F Nejat… - Scientific Reports, 2026
… These challenges are especially pronounced in moderate and severe
keratoconus, where … Several approaches have been introduced to improve IOL
power calculation in keratoconus… recently, keratoconus-specific formulas such as …
keratoconus, where … Several approaches have been introduced to improve IOL
power calculation in keratoconus… recently, keratoconus-specific formulas such as …
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Management of astigmatism in keratoconus with therapeutic refractive surgery
H Zhang, JL Alió del Barrio, Q Bao, MD Alio… - Frontiers in Medicine
Astigmatism is a major determinant of visual impairment in keratoconus (KC), yet in
this setting it cannot be understood as a simple cylindrical refractive error. Instead, it
reflects a complex optical phenotype generated by anterior and posterior corneal …
this setting it cannot be understood as a simple cylindrical refractive error. Instead, it
reflects a complex optical phenotype generated by anterior and posterior corneal …
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[PDF] Bridging inflammation, metabolism, and mechanics in keratoconus: a mechanistic perspective
A Syed - Eye (London, England)
… inflammatory and metabolic factors in keratoconus risk [1]. Their findings confirm
a substantially higher risk of keratoconus in patients with atopic … A plausible
mechanistic bridge links the atopy, rheumatoid arthritis, and Crohn’s disease findings …
a substantially higher risk of keratoconus in patients with atopic … A plausible
mechanistic bridge links the atopy, rheumatoid arthritis, and Crohn’s disease findings …
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Long-term outcome of collagen cross-linking (CXL) for progressive keratoconus with coexistent Fuchs endothelial corneal dystrophy
N Balakrishnan, R Deshmukh - BMJ case reports, 2026
Corneal endothelial toxicity leading to corneal oedema or endothelial
decompensation is a potential concern after corneal collagen cross-linking,
especially in patients with susceptible corneas, such as in cases of Fuchs …
decompensation is a potential concern after corneal collagen cross-linking,
especially in patients with susceptible corneas, such as in cases of Fuchs …
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[PDF] Vision-Related Quality of Life and Work Productivity in Patients With Keratoconus and Glaucoma: A Comparative Cross-Sectional Study
M Dionysopoulou, N Kotsopoulos, E Karampli… - Cureus, 2026
… , they differ in pathophysiology, with keratoconus affecting corneal optics and
POAG causing … This study compared patient-reported outcomes between
individuals with keratoconus and … 102 with keratoconus and 51 with POAG) …
POAG causing … This study compared patient-reported outcomes between
individuals with keratoconus and … 102 with keratoconus and 51 with POAG) …
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Automated Detection and Classification of Keratoconus Using Deep Learning with ResNet-50
P Nasra, GR Kiran, P Negi, PK Mishra, T Sharma - 2026 5th OPJU International …, 2026
Keratoconus is a progressive eye disorder causing thinning and … Keratoconus
with a 96.8-percent accuracy. The suggested model is trained on a variety of data
comprising of cornea topography images that belong to three categories, including …
with a 96.8-percent accuracy. The suggested model is trained on a variety of data
comprising of cornea topography images that belong to three categories, including …
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[PDF] Polarimetric interferometry-derived isogyre parameters correlate with keratoconus severity: a retrospective observational study
G Beschi, I Pezzagno, S Vaccaro, M Rovati, L Grezzi… - Scientific Reports, 2026
… Keratoconus involves progressive corneal thinning and stromal collagen
disorganization … We conducted a retrospective observational study of 95
keratoconus patients and 21 healthy … arm (AUC 0.87) differentiated keratoconus …
disorganization … We conducted a retrospective observational study of 95
keratoconus patients and 21 healthy … arm (AUC 0.87) differentiated keratoconus …
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[PDF] Keratoconus false-positive screening rates in eyes with pterygium: tomographic and biomechanical artifacts
PF Rodrigues, FAC dos Santos, BK Moscovici… - Arq Bras Oftalmol, 2026
… We hypothesized that pterygium-related abnormalities in keratoconus screening
indices are … early keratoconus, including elevated BAD-D and increased
keratoconus screening indices (particularly TBI). However, no participant met the …
indices are … early keratoconus, including elevated BAD-D and increased
keratoconus screening indices (particularly TBI). However, no participant met the …
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[PDF] Novel Treatments for Keratoconus
C Paik - inSIGHT, 2026
… Keratoconus is a progressive condition … The management of keratoconus has
evolved significantly over the past two decades, with novel therapeutic approaches …
This review examines the latest advances in keratoconus treatment, focusing on …
evolved significantly over the past two decades, with novel therapeutic approaches …
This review examines the latest advances in keratoconus treatment, focusing on …
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[HTML] OCT Eye Scans: What They Show, How They Work and What the Results Mean
VP July
The scan must therefore be interpreted together with the patient’s symptoms, visual
acuity, clinical examination and other investigations. OCT artefacts are common
enough to cause both false diagnoses and missed progression if the underlying …
acuity, clinical examination and other investigations. OCT artefacts are common
enough to cause both false diagnoses and missed progression if the underlying …
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Global Prevalence of Keratoconus in the Adult Population: A Systematic Review
K Cenková, M Šín, J Tesař, I Němcová, V Fridman… - Bratislava Medical Journal, 2026
Purpose To synthesize contemporary estimates of adult keratoconus prevalence
worldwide and determine how geography, demographics, and study methodology
shape reported rates. Methods We systematically reviewed original studies (2019–2024) …
worldwide and determine how geography, demographics, and study methodology
shape reported rates. Methods We systematically reviewed original studies (2019–2024) …
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Clinical Profile, Risk factors and Topographic Characteristics of Keratoconus at a Tertiary Eye Hospital: An Observational Study.
P Shrestha, B Thapa, L Singh, S Paudel - Journal of the Nepal Medical Association, 2026
… of cases had unilateral keratoconus, while 43.9% had bilateral keratoconus,
whereas a study conducted in Malaysia showed that around 77% of cases had
bilateral keratoconus.Population-based studies have reported a higher percentage …
whereas a study conducted in Malaysia showed that around 77% of cases had
bilateral keratoconus.Population-based studies have reported a higher percentage …
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Targeting Higher Order Aberrations Alone in Keratoconus: A Tissue-Saving Alternative to Established Protocols
ST Awwad, KE Asfar, S Arba-Mosquera, N Wahoud… - Journal of Refractive …, 2026
Purpose: To evaluate cone stromal ablation depth with varying optical zones using
different customized ablation strategies in keratoconus. Methods: This retrospective
computational analysis assessed 59 eyes from 59 patients with mild to moderate …
different customized ablation strategies in keratoconus. Methods: This retrospective
computational analysis assessed 59 eyes from 59 patients with mild to moderate …
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[PDF] One‐Year Results of Accelerated Transepithelial Corneal Cross‐Linking for Progressive Keratoconus: A Prospective Interventional Study
RA Fayyadh, OS Mahmood, AB Abdulelah… - Eye & ENT Research, 2026
… Method: This prospective interventional study included 126 eyes from 63 patients
with documented progressive keratoconus. Both eyes of … parameters in this
prospective cohort of eyes with progressive keratoconus. These findings should be …
with documented progressive keratoconus. Both eyes of … parameters in this
prospective cohort of eyes with progressive keratoconus. These findings should be …
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Corneal Allograft Intrastromal Ring Segment (CAIRS) in Modern Practice for Management of Keratoconus
MA Sallam, MM Macky, RA Albairmani, BM Basheer… - Korean journal of ophthalmology …
This review discusses the role of Corneal Allograft Intrastromal Ring Segments (CAIRSs)
in the treatment of keratoconus and ectatic corneal disease, covering their
mechanisms, techniques, outcomes, and prospects. The technique was developed …
in the treatment of keratoconus and ectatic corneal disease, covering their
mechanisms, techniques, outcomes, and prospects. The technique was developed …
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Edge-Deployed Vision Transformer
MM Daud, WMDW Zaki, FM Ali, HA Mutalib - … of the Third International Conference on …, 2026
… In this paper, we present an edgecomputing mobile application for the automatic
classification of keratoconus using a Vision Transformer (ViT) … The presented
method provides a workflow that can sort input images into two classes, keratoconus …
classification of keratoconus using a Vision Transformer (ViT) … The presented
method provides a workflow that can sort input images into two classes, keratoconus …
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Stromal Lenticule Addition Keratoplasty (SLAK) for the Management of Severe Corneal Flattening After Corneal Cross-linking
GD Kymionis, VA Tsagkogiannis, DG Vakalopoulos… - Journal of Refractive …, 2026
… Nubile et al7 evaluated 15 eyes with advanced keratoconus treated with SLAK
and reported a significant increase in corneal thickness, … Although previous
studies have primarily demonstrated reduction of excessive steepening in …
and reported a significant increase in corneal thickness, … Although previous
studies have primarily demonstrated reduction of excessive steepening in …
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Oral Riboflavin for Sunlight-Induced Corneal Cross-linking: Efficacy Assessment in a Rabbit Model In Vivo Using Extensometry and OCT Elastography
EA Torres-Netto, ME Aydemir, NJ Lu, S Kling, N Hafezi… - Journal of Refractive …, 2026
… of keratoconus,7 eye rubbing can certainly exacerbate its progression.Corneal
cross-linking (CXL)9 is the current standard of care for halting keratoconus …
riboflavin combined with daily sunlight exposure might stabilize keratoconus without …
cross-linking (CXL)9 is the current standard of care for halting keratoconus …
riboflavin combined with daily sunlight exposure might stabilize keratoconus without …
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OPTICAL IMAGING AND CHARACTERIZATION OF OPHTHALMIC TISSUE AND DEVICES
PL Sawyers - 2026
The work presented in this dissertation spans the full range of the eye, with projects
relating to three elements of the eye: the cornea, the crystalline lens, and the retina.
The majority of the cornea’s biomechanical properties are defined by the stroma, the …
relating to three elements of the eye: the cornea, the crystalline lens, and the retina.
The majority of the cornea’s biomechanical properties are defined by the stroma, the …
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[HTML] The Matricellular Protein CCN1 Induces Corneal Stromal Cells Senescence and Inflammation to Trigger Extracellular Matrix Remodeling in Keratoconus
L Zhang, C Wei, Y Li, J Shi, Y Chi, Y Zhang, Q Bao… - … Ophthalmology & Visual …, 2026
Purpose: Keratoconus (KC) is a multifactorial corneal degenerative disorder
characterized by reduced extracellular matrix (ECM) and cellular content. This study
investigates the role and mechanism of cellular communication network factor 1 (CCN1) …
characterized by reduced extracellular matrix (ECM) and cellular content. This study
investigates the role and mechanism of cellular communication network factor 1 (CCN1) …
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A Hybrid Deep Learning and Machine Learning Approach for Keratoconus Detection Using
SR Bakall, NS Bansod, SR Sankaye¹, AD Kadam¹… - Proceedings of International …
Accurate and early diagnosis of Keratoconus, a moderate corneal thin-ning disorder,
is important to prevent serious vision loss. This research paper presents a composite
proposal that utilizes the ability of deep learning to extract the features and uses …
is important to prevent serious vision loss. This research paper presents a composite
proposal that utilizes the ability of deep learning to extract the features and uses …
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[PDF] Clinical Evolution and Multimodal Imaging of Late Onset Severe Focal Stromal Degeneration After Corneal Collagen Cross-Linking for Keratoconus
A Mularoni, L Rania, E Fabbri, K Mularoni, G Mussoni… - Cornea Open, 2026
… She had previously undergone bilateral corneal CXL using standard Dresden
protocol for progressive keratoconus performed in an external clinic 9 years earlier
by one of the authors (AM). Prior corneal CXL, K1 amounted 53.42 D and K2 50.32 D …
protocol for progressive keratoconus performed in an external clinic 9 years earlier
by one of the authors (AM). Prior corneal CXL, K1 amounted 53.42 D and K2 50.32 D …
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[PDF] Imagining the future: Imaging for surgical planning
Y Feng
… This is particularly crucial for cases involving keratoconus (KC) or post-refractive
surgery … underlying stromal changes, as seen in keratoconus and other ectatic
disorders. Our findings … For instance, for Keratoconus Management, ETM reveals …
surgery … underlying stromal changes, as seen in keratoconus and other ectatic
disorders. Our findings … For instance, for Keratoconus Management, ETM reveals …
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Risk factors for keratoconus: a systematic review and meta-analysis
R Chen, X Ou, Q Zeng - BMC Ophthalmology, 2026
Purpose Keratoconus (KC) is a sight-threatening disease with unclear etiology.
Understanding its risk factors is essential for prevention and mechanistic insight.
This study presents a comprehensive systematic review and meta-analysis to …
Understanding its risk factors is essential for prevention and mechanistic insight.
This study presents a comprehensive systematic review and meta-analysis to …
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[PDF] Prevalence and Risk Factors of Keratoconus Among Refractive Surgery Candidates in Iraq: Findings from a Multicenter Cross-Sectional Study
YS Yasin, RA Fayyadh, OS Mahmood, AB Abdulelah… - Benha Medical Journal, 2026
Objective: The goal of this study is to determine the prevalence of keratoconus (KC)
among candidates for refractive surgery in Iraq, the prevalence of demographic and
clinical risk factors of relevance, and the effectiveness of current screening methods …
among candidates for refractive surgery in Iraq, the prevalence of demographic and
clinical risk factors of relevance, and the effectiveness of current screening methods …
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[HTML] Still Seeing Poorly After Cataract Surgery: It Was Undiagnosed Keratoconus
JFB Logroño
… When we studied the cornea with tomography, the real cause appeared: bilateral
keratoconus that had never been diagnosed. Keratoconus is not a rare disease. The
classic figure places it at around 1 in 2,000 people, although more recent …
keratoconus that had never been diagnosed. Keratoconus is not a rare disease. The
classic figure places it at around 1 in 2,000 people, although more recent …
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E Bonacci, C Pagnacco, A Fasolo, F Barzaghi… - International Ophthalmology, 2026
… In this small prospective pilot study, bilateral implantation of a non-diffractive
EDOF IOL was associated with favourable short-term visual outcomes in highly
selected patients with stable early keratoconus. These preliminary findings suggest …
EDOF IOL was associated with favourable short-term visual outcomes in highly
selected patients with stable early keratoconus. These preliminary findings suggest …
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[HTML] Early Ocular and Systemic Markers of Keratoconus: A Mini-Review
FU Khan, S Ullah, M Shahzadi, M Noor - CME Journal Geriatric Medicine, 2026
… Keratoconus (KC) is a progressive corneal ectatic disorder characterized by
stromal thinning… This review consolidates current evidence on the earliest markers
of keratoconus, encompassing … Emerging data suggest that keratoconus should …
stromal thinning… This review consolidates current evidence on the earliest markers
of keratoconus, encompassing … Emerging data suggest that keratoconus should …
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Research progress on intraocular lens power calculation in cataract patients with keratoconus
YX Zhu, XH Xie, JQ Zhang, LX Luo - [Zhonghua yan ke za zhi] Chinese journal of …, 2026
Keratoconus (KCN) is a progressive corneal ectasia disorder characterized by
thinning and steepening of the cornea. Intraocular lens (IOL) power calculation in
cataract patients with KCN often leads to a significant hyperopic prediction error …
thinning and steepening of the cornea. Intraocular lens (IOL) power calculation in
cataract patients with KCN often leads to a significant hyperopic prediction error …
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[PDF] Clinical outcomes after implantation of a combination of intrastromal corneal ring segments in different optical zones in advanced keratoconus
JSB Soares, ML Dos Santos, LT Costa, EM Almodin… - Indian Journal of …, 2026
… Purpose: To evaluate the efficacy and safety of combined intrastromal corneal ring
segment (ICRS) implantation in different optical zones for advanced keratoconus.
Methods: This retrospective study analyzed 32 eyes from 30 patients who underwent …
segment (ICRS) implantation in different optical zones for advanced keratoconus.
Methods: This retrospective study analyzed 32 eyes from 30 patients who underwent …
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A Novel Chaos-inspired Artificial Intelligence-based Model for Keratoconus Prediction
S Adib-Moghaddam, N Nassiri, M Bahman, M Mohebbi… - Journal of Ophthalmic and …, 2026
… discrimination between keratoconus and normal eyes. Conclusion: Given the
complex and nonlinear behavior of keratoconus progression, … Model) capable of
accurately detecting keratoconus. Although the findings are promising, further …
complex and nonlinear behavior of keratoconus progression, … Model) capable of
accurately detecting keratoconus. Although the findings are promising, further …
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Chinese expert consensus on the early screening and diagnosis of keratoconus (2026)
Refractive Surgery Group of Chinese Ophthalmologist … - … ke za zhi] Chinese journal of …, 2026
Keratoconus is a common blinding corneal disease among young adults. A large
number of … accurate screening and diagnostic system for keratoconus has
important clinical significance for … on confusing concepts and terms related to …
number of … accurate screening and diagnostic system for keratoconus has
important clinical significance for … on confusing concepts and terms related to …
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Evaluation of keratoconus patients with or without surgery by both sub-scales of “Keratoconus End-Points Assessment Questionnaire”
B Akbulut Yagci, O Ozkan, Z Ozbek, CA Utine - EUROPEAN EYE RESEARCH
… was to evaluate the results of Keratoconus End-Points Assessment Questionnaire
(KEPAQ) in patients who did or did not have any surgery for keratoconus. METHODS:
This cross-sectional, single-center, observational study included 127 patients with …
(KEPAQ) in patients who did or did not have any surgery for keratoconus. METHODS:
This cross-sectional, single-center, observational study included 127 patients with …
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The declining need for keratoplasty in keratoconus: Are we entering the era of corneal preservation?
PR Srivatsa - Journal of Clinical Ophthalmology and Research, 2026
… , keratoconus patients progressed through spectacles and rigid contact lenses,
ultimately to corneal transplantation, which is regarded as the definitive treatment for
advanced keratoconus… Genetic therapy in keratoconus holds the potential to …
ultimately to corneal transplantation, which is regarded as the definitive treatment for
advanced keratoconus… Genetic therapy in keratoconus holds the potential to …
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[HTML] Interventional Keratoconus: A New Era of Early Action and Advanced Treatment
V Thompson, W Trattler, OD Elise Kramer, F FSLS…
… “We all know that keratoconus leads to irreversible corneal damage, and it's our
job to recognize it early. In my opinion, we don't want to just wait and observe.” …
Keratoconus is a progressive corneal ectatic disorder, not a dystrophy, meaning the …
job to recognize it early. In my opinion, we don't want to just wait and observe.” …
Keratoconus is a progressive corneal ectatic disorder, not a dystrophy, meaning the …
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[PDF] Evaluation of keratoconus patients with or without surgery by both sub-scales of “Keratoconus End-Points Assessment Questionnaire”
BA Yagci, O Ozkan, Z Ozbek, CA Utine - Vol. 6/No 2/August 2026
… results of Keratoconus End-Points Assessment Questionnaire (KEPAQ) in
patients who did or did not have any surgery for keratoconus. … Herein, we aimed to
evaluate the results of KEPAQ in patients who did or did not have any keratoconus …
patients who did or did not have any surgery for keratoconus. … Herein, we aimed to
evaluate the results of KEPAQ in patients who did or did not have any keratoconus …
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K Ekemiri, C Ekemiri, D Singh, R Seemongal-Dass… - Vision, 2026
Purpose: Keratoconus is a progressive corneal ectatic disorder that causes visual
impairment, particularly in adolescents and young adults. Evidence on its
epidemiology in Latin America and the Caribbean remains limited. This study aimed …
impairment, particularly in adolescents and young adults. Evidence on its
epidemiology in Latin America and the Caribbean remains limited. This study aimed …
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[HTML] Anterior Segment and Corneal Disorders
SE Acar - 2026
… across infectious keratitis, keratoplasty, keratoconus, refractive surgery, phakic
intraocular lens … DL models achieve diagnostic accuracies exceeding 95% in
keratoconus and fungal keratitis … Furthermore, AI-driven models identify …
intraocular lens … DL models achieve diagnostic accuracies exceeding 95% in
keratoconus and fungal keratitis … Furthermore, AI-driven models identify …
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[HTML] Evaluating the rationale and outcomes of crosslinking corneal stromal lenticules: a systematic review with exploratory pooled analysis
RB Radulescu, S Ferrari, AE Ranetti, HT Stanca… - Graefe's Archive for Clinical …, 2026
… Preliminary clinical data suggest possible benefit in selected advanced
keratoconus cases. However, current evidence remains insufficient to establish
efficacy. Controlled trials are warranted to standardize protocols and validate long-term …
keratoconus cases. However, current evidence remains insufficient to establish
efficacy. Controlled trials are warranted to standardize protocols and validate long-term …
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[HTML] Corneal Cross-Linking: Suitability, Procedure, Risks and Recovery By drvaladmin July 29, 2026 No Comments
V Phua
… High-quality randomised trials and an American Academy of Ophthalmology
evidence review support epithelium-off CXL as an effective treatment for progressive
keratoconus and post-refractive-surgery ectasia. Long-term studies show that …
evidence review support epithelium-off CXL as an effective treatment for progressive
keratoconus and post-refractive-surgery ectasia. Long-term studies show that …
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[HTML] Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care
L Buzzonetti, C Mazzotta, M Iester, M Pauklin… - Ophthalmology and Therapy, 2026
… the diagnosis, monitoring and management of paediatric keratoconus. Paediatric
keratoconus is a corneal ectasia that typically presents … diagnostic criteria, risk
factors and classification systems of paediatric keratoconus. It outlines strategies for …
keratoconus is a corneal ectasia that typically presents … diagnostic criteria, risk
factors and classification systems of paediatric keratoconus. It outlines strategies for …
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Factors Associated with Pediatric Keratoconus–A Population-Based Nested Case–Control Study
O Ben-Shaul, S Schwartz, A Segal, N Stein, M Hyams… - Ophthalmic Epidemiology, 2026
… the factors associated with the development of keratoconus. Results: Overall,
1953 pediatric keratoconus patients with a mean age of 14.2 … consistent predictors
of keratoconus severity and the frequency of corneal transplantation in the adult …
1953 pediatric keratoconus patients with a mean age of 14.2 … consistent predictors
of keratoconus severity and the frequency of corneal transplantation in the adult …
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[PDF] Corneal allogenic intrastromal ring segments for the treatment of keratoconus
R Barbara, G De Salvo, R Hanna, A Sepetis… - Scientific Reports, 2026
To assess the clinical outcomes of Corneal Allogenic Intrastromal Ring Segments (CAIRS)
as a therapeutic approach for keratoconus (KC), with a focus on visual acuity,
refractive status, and corneal topographic parameters. In this retrospective analysis …
as a therapeutic approach for keratoconus (KC), with a focus on visual acuity,
refractive status, and corneal topographic parameters. In this retrospective analysis …
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Stage-dependent alterations in corneal epithelium, stromal keratocyte density, and subbasal nerve plexus in keratoconus: an in vivo confocal microscopy study
T Kucukbalci, BS Uysal, D Balaban, MC Ozmen… - Graefe's Archive for Clinical …, 2026
… Therefore, IVCM plays an important role in improving our understanding of
keratoconus … the keratoconus group were age between 18 and 65 years with a
diagnosis of keratoconus and … Patients with keratoconus who wore rigid contact …
keratoconus … the keratoconus group were age between 18 and 65 years with a
diagnosis of keratoconus and … Patients with keratoconus who wore rigid contact …
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Challenges to the Access and Utilization of Corneal Cross-Linking in Keratoconus Patients in the United States
ABJJ Jo, MDY Bian, MWD Chamberlain, MDM Chen… - American Journal of …, 2026
… This essay reflects on experiences from all authors in their care for keratoconus
patients, a historical summary of CXL in the United States, … shortcomings in
effectively screening keratoconus in at-risk patients in the United States. Although …
patients, a historical summary of CXL in the United States, … shortcomings in
effectively screening keratoconus in at-risk patients in the United States. Although …
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Aberration-guided Intraocular Lens Power Calculation in Keratoconus: Ray Tracing Optimization
MMS Vandevenne, J Aramberri, T Berendschot… - Journal of Cataract & …, 2026
… adjusted for these cases: Kane keratoconus,20 Holladay 2 with keratoconus
adjustment21 and the Barrett True K formula for keratoconus.The Kane keratoconus
formula minimizes the influence of corneal power in estimating the effective lens position …
adjustment21 and the Barrett True K formula for keratoconus.The Kane keratoconus
formula minimizes the influence of corneal power in estimating the effective lens position …
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[PDF] Keratoconus
S Papadopoulos - 2026
Keratoconus is a noninflammatory corneal ectatic disease that leads to a conical,
bulgingshaped cornea by way of corneal thinning. In the early stages, it is usually
asymptomatic but as the disease progresses, irregular astigmatism, haze and …
bulgingshaped cornea by way of corneal thinning. In the early stages, it is usually
asymptomatic but as the disease progresses, irregular astigmatism, haze and …
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[PDF] Visual Rehabilitation of Bilateral Keratoconus With Customized Scleral Lenses: A Case Report
NY Al-Tamimi, M Amer, FNE Graini, R Gore - Cureus, 2026
… of a 24-year-old female with bilateral keratoconus (OD > OS) successfully fitted
with scleral … Scleral lenses provided effective visual rehabilitation in advanced
keratoconus, restoring 6/6 … and scleral lens fitting in a patient with keratoconus …
with scleral … Scleral lenses provided effective visual rehabilitation in advanced
keratoconus, restoring 6/6 … and scleral lens fitting in a patient with keratoconus …
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[PDF] Prevalence and risk factors of Keratoconus among school children in Oman: A Population Based Study
Z Mohamed, GS Vankudre, J Ayyappan, A Alkaabi - 2026
… Keratoconus prevalence in this study aligns with regional reports, confirming a
higher burden than in Western populations. Consanguinity as a significant predictor
underscores the need for genetic counseling and risk awareness, and the strong …
higher burden than in Western populations. Consanguinity as a significant predictor
underscores the need for genetic counseling and risk awareness, and the strong …
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[PDF] Acute Corneal Hydrops as the Initial Manifestation of Keratoconus: A Case Report and Systematic Review with Pooled Descriptive Analysis
A Barbara, R Barbara - 2026
Purpose: To report a case of acute corneal hydrops (ACH) as the initial presenting
manifestation of keratoconus (KC) and to systematically review the published
literature on this presentation. Methods: A new case is reported: a 16-year-old …
manifestation of keratoconus (KC) and to systematically review the published
literature on this presentation. Methods: A new case is reported: a 16-year-old …
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[PDF] Posterior segment alterations in keratoconus patients: an updated comprehensive review
MH Mohmmed, R Ambrósio Jr, K Jadidi, H Hashemian… - Therapeutic Advances in …, 2026
Keratoconus (KC) has traditionally been classified as a progressive anterior
segment disorder, primarily affecting the cornea. However, emerging evidence from
advanced imaging modalities—such as optical coherence tomography (OCT), OCT …
segment disorder, primarily affecting the cornea. However, emerging evidence from
advanced imaging modalities—such as optical coherence tomography (OCT), OCT …
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[HTML] A Computational Framework Integrating Biomechanics and Microstructural Tissue Modeling for Keratoconus Severity Assessment
C Gómez, J González-Cabrero, D Piñero, JL Alió… - Results in Engineering, 2026
Accurate biomechanical characterization of the cornea is essential for early
detection and progression assessment of keratoconus, particularly in subclinical
stages where conventional metrics lack sensitivity. This study presents a novel …
detection and progression assessment of keratoconus, particularly in subclinical
stages where conventional metrics lack sensitivity. This study presents a novel …
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[PDF] Socioeconomic and Clinical Factors Associated with Keratoconus Severity and Follow-Up in a Tertiary Referral Cohort
F Alrefai, KS Multani, LD Redden, J Hsueh, K Ding… - Clinical Ophthalmology, 2026
… Keratoconus (KCN) is the most common type of corneal ectasia and is a bilateral,
typically asymmetric disorder characterized by progressive thinning and steepening
of the cornea, resulting in irregular astigmatism and vision impairment.The …
typically asymmetric disorder characterized by progressive thinning and steepening
of the cornea, resulting in irregular astigmatism and vision impairment.The …
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[HTML] The rationale for designating keratoconus as a systemic disease
S Mabry, D Karamichos - Expert Review of Ophthalmology, 2026
Keratoconus (KC) is a heterogenous progressive corneal ectasia characterized by
corneal deformation, irregular astigmatism and impaired visual acuity. Our capacity
to diagnosis KC depends on the corneal phenotype of this disease. However …
corneal deformation, irregular astigmatism and impaired visual acuity. Our capacity
to diagnosis KC depends on the corneal phenotype of this disease. However …
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Repeatability of Epithelial Thickness Mapping in Normal and Keratoconus Eyes Using a Novel Hybrid Scheimpflug—Optical Coherence Tomography Device
VA Augustin, M Friedrich, J Keim, L Finken, E Felter… - Cornea, 2026
… The aim of this study was to analyze the epithelial thickness measurement
repeatability in healthy and keratoconus eyes and define severity-dependent
thresholds. Methods: This prospective, cross-sectional, observational, monocentric …
repeatability in healthy and keratoconus eyes and define severity-dependent
thresholds. Methods: This prospective, cross-sectional, observational, monocentric …
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Introduction to Keratoconus and the Need for Doughnut Refractive Lenticule Transplantation
Z Shah - … Transplantation Technique for Advanced Keratoconus, 2026
Keratoconus is a progressive, noninflammatory ectatic disorder of the cornea
marked by localized stromal thinning, biomechanical weakening, and anterior/posterior
ectasia of the corneal surface. This conical deformation leads to significant optical …
marked by localized stromal thinning, biomechanical weakening, and anterior/posterior
ectasia of the corneal surface. This conical deformation leads to significant optical …
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[HTML] Addressing the Gap in Keratoconus Diagnosis
OD Tiffany Andrzejewski, PA Majmudar - Optometric Management, 2026
In a busy cornea practice, keratoconus (KC) certainly doesn’t feel like a rare disease,
but that’s how it is classified under the Orphan Drug Act—a law that helps incentivize
treatments for rare diseases with faster Food and Drug Administration (FDA) review …
but that’s how it is classified under the Orphan Drug Act—a law that helps incentivize
treatments for rare diseases with faster Food and Drug Administration (FDA) review …
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Assessment of accommodation amplitude and binocular vision in patients with keratoconus
AF Marzouk, ALA Al Dorghamy, WA El Hady Allam… - Tanta Medical Journal, 2026
… Corneal topography is currently the main diagnostic tool for early keratoconus
detection. Anisometropia is a hallmark of keratoconus because of the bilateral asymmetry
of the cornea. A complete assessment of binocular vision and accommodation …
detection. Anisometropia is a hallmark of keratoconus because of the bilateral asymmetry
of the cornea. A complete assessment of binocular vision and accommodation …
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[PDF] Corneal endothelial cells change in different stages of keratoconus
RS Bhatti, S Khan, H Mansoor, A Maqbool, R Zafar… - ÐÎÑÑÈÉÑÊÈÉ …, 2026
Purpose. To evaluate the changes in morphology and total endothelial count in
patients with different stages of keratoconus (KC). Material and methods. A cross-sectional
study included 564 eyes of KC patients (57.8% males and 42.2% females) aged 19.9±6.5 …
patients with different stages of keratoconus (KC). Material and methods. A cross-sectional
study included 564 eyes of KC patients (57.8% males and 42.2% females) aged 19.9±6.5 …
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Comparing Scleral Lenses with Different Oxygen Permeabilities in a Keratoconus Population
A Le - 2026
Keratoconus (KC) causes corneal thinning and ectasia, resulting in irregular
astigmatism and visual distortion. Scleral lenses (SL) correct vision by vaulting the
cornea with a thick lens (~ 300 μm) and fluid reservoir (FR, 100–200 μm). These …
astigmatism and visual distortion. Scleral lenses (SL) correct vision by vaulting the
cornea with a thick lens (~ 300 μm) and fluid reservoir (FR, 100–200 μm). These …
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[PDF] Multimodal learning for clinically consistent RGP fitting in keratoconus
H Xie, Y Zhao, P Xu, J Ye, G Jia, L An - Scientific Reports, 2026
… Keratoconus (KC) is a progressive corneal degenerative disease characterized
by localized corneal thinning and conical protrusion, often … to-severe keratoconus
due to their superior optical correction capabilities1. However, the high …
by localized corneal thinning and conical protrusion, often … to-severe keratoconus
due to their superior optical correction capabilities1. However, the high …
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[HTML] Anterior segment optical coherence tomography evaluation of early corneal changes following corneal collagen cross-linking for progressive keratoconus
ASS Hassanein, EM Ghoneim, RSAEA ElGendy - Medical hypothesis, discovery & …, 2026
… Background: Keratoconus is a progressive corneal ectatic disorder characterized
by stromal … -off CXL in eyes with progressive keratoconus using anterior segment
optical coherence tomography (… Methods: In this prospective study, eyes with …
by stromal … -off CXL in eyes with progressive keratoconus using anterior segment
optical coherence tomography (… Methods: In this prospective study, eyes with …
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[HTML] Corneal Sensitivity Across Keratoconus Stages: A Pilot Study
B Gaspar, N Cruz, C Tavares, A Fonte, JQ Gil, E Costa… - … Sociedade Portuguesa de …, 2026
… Keratoconus stages were distributed as follows: stage I – 50%, stage II – …
keratoconus severity, as classified by the Amsler–Krumeich system, and corneal
sensitivity. Nonetheless, these results contribute to the ongoing investigation of …
keratoconus severity, as classified by the Amsler–Krumeich system, and corneal
sensitivity. Nonetheless, these results contribute to the ongoing investigation of …
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[PDF] Corneal Sensitivity Across Keratoconus Stages: A Pilot Study Sensibilidade Corneana Nos Diferentes Estadios De Queratocone: Um Estudo Piloto
B Gaspar, N Cruz, A Fonte, JQ Gil, E Costa, C Tavares - 2026
… Keratoconus stages were distributed as follows: stage I – 50%, stage II – …
keratoconus severity, as classified by the Amsler–Krumeich system, and corneal
sensitivity. Nonetheless, these results contribute to the ongoing investigation of …
keratoconus severity, as classified by the Amsler–Krumeich system, and corneal
sensitivity. Nonetheless, these results contribute to the ongoing investigation of …
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Doughnut Refractive Lenticule Transplantation (DRLT): A Novel Sutureless Corneal Transplantation Technique for Advanced Keratoconus
Z Shah
Keratoconus continues to challenge corneal surgeons worldwide, particularly in
advanced stages where visual rehabilitation and biomechanical stabilization remain
difficult despite the evolution of modern corneal surgery. Conventional treatment …
advanced stages where visual rehabilitation and biomechanical stabilization remain
difficult despite the evolution of modern corneal surgery. Conventional treatment …
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[PDF] “Aye, there's the rub”–ocular allergy and keratoconus
ZLBBM MD, EWTCPD FRANZCO
… had keratoconus) in quantitative meta-analyses; and 7 studies (6 cross-sectional,
1 basic science) with 899 participants (709 of which had keratoconus) in descriptive
analyses. Three meta-analyses were performed to synthesise the associations …
1 basic science) with 899 participants (709 of which had keratoconus) in descriptive
analyses. Three meta-analyses were performed to synthesise the associations …
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[TXT] Research Paper/Araştırma Makalesi
İ Toprak, C Yıldırım, V Yaylalı
… Materials and Methods: This retrospective study included 133 patients with
keratoconus and … measurements appear to be altered by aging in both
keratoconus and control groups, … whereas eyes with keratoconus in all age …
keratoconus and … measurements appear to be altered by aging in both
keratoconus and control groups, … whereas eyes with keratoconus in all age …
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[HTML] Vitamins and ocular health: a perspective on nutritional influence in vision disorders
P Garg, S Shrinkhal, R Shukla, A Shukla, SP Singh… - … hypothesis, discovery & …, 2026
Background: Vitamins are essential for ocular health, and their deficiencies are
associated with xerophthalmia, age-related macular degeneration (AMD), cataracts,
glaucoma, diabetic retinopathy (DR), dry eye disease (DED), keratoconus, and optic …
associated with xerophthalmia, age-related macular degeneration (AMD), cataracts,
glaucoma, diabetic retinopathy (DR), dry eye disease (DED), keratoconus, and optic …
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[HTML] Tomographic assessment of the thinnest corneal point following customized epithelium-off cross-linking for progressive ectasia
AM Reda, WA Mohamed - Medical hypothesis, discovery & innovation in …, 2026
Background: Customized corneal cross-linking (CXL) enables spatially
individualized ultraviolet-A (UVA) irradiation of ectatic corneas. However, changes in
the thickness and spatial location of the thinnest corneal point remain insufficiently …
individualized ultraviolet-A (UVA) irradiation of ectatic corneas. However, changes in
the thickness and spatial location of the thinnest corneal point remain insufficiently …
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Conventional Lasik Vs Flapless Smile and Silk with Ai Intervention: A Comprehensive Analysis
K Malviya, S Qausain, M Basheeruddin - 2026 IEEE 1st International Conference on …, 2026
… Another prevalent corneal ectatic illness that, if untreated, can deteriorate over
time and cause visual impairment is keratoconus. Although … Another prevalent
corneal ectatic illness that, if untreated, can deteriorate over time and cause visual …
time and cause visual impairment is keratoconus. Although … Another prevalent
corneal ectatic illness that, if untreated, can deteriorate over time and cause visual …
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Evolution and Concept of Doughnut Refractive Lenticule Transplantation
Z Shah - … Transplantation Technique for Advanced Keratoconus, 2026
Keratoconus, particularly in its advanced stages, presents a formidable clinical
challenge [1]. Patients with extremely thin corneas, stromal opacity, and decentered
cones often fall outside the safe parameters for tissue preserving interventions such …
challenge [1]. Patients with extremely thin corneas, stromal opacity, and decentered
cones often fall outside the safe parameters for tissue preserving interventions such …
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Beyond the Cornea: Early Changes in Scleral, Iris, and Corneal Parameters After Corneal Collagen Cross-Linking
ES Un, T Akyol, O Parca, G Pekel, I Toprak - 2026
… parameters following corneal collagen cross-linking (CXL) in eyes with
progressive keratoconus. Methods: This retrospective study included 94 eyes of 94
patients with progressive keratoconus who underwent standard epithelium-off CXL …
progressive keratoconus. Methods: This retrospective study included 94 eyes of 94
patients with progressive keratoconus who underwent standard epithelium-off CXL …
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Instrumentation and Technical Considerations in Doughnut Refractive Lenticule Transplantation
Z Shah - … Transplantation Technique for Advanced Keratoconus, 2026
The evolution of DRLT as a novel surgical approach for advanced keratoconus has
brought forward the need for a precise, reproducible, and anatomically respectful
technique. Unlike full-thickness grafting procedures, DRLT achieves structural and …
brought forward the need for a precise, reproducible, and anatomically respectful
technique. Unlike full-thickness grafting procedures, DRLT achieves structural and …
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Corneal Parameter Analysis Following Globe-Derived Doughnut Refractive Lenticule Transplantation
Z Shah - … Transplantation Technique for Advanced Keratoconus, 2026
… the predictable behavior of the doughnut lenticule within the corneal stroma and
underscore its value in managing advanced keratoconus. … the predictable
behavior of the doughnut lenticule within the corneal stroma and underscore its …
underscore its value in managing advanced keratoconus. … the predictable
behavior of the doughnut lenticule within the corneal stroma and underscore its …
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Surgical Techniques of Doughnut Refractive Lenticule Transplantation (DRLT)
Z Shah - … Transplantation Technique for Advanced Keratoconus, 2026
This chapter presents the complete surgical evolution and operative techniques of
DRLT, tracing its development from the earliest SMILE/globe-derived lenticules to
highly advanced AI-guided hybrid collagen and dual-level constructs. It outlines how …
DRLT, tracing its development from the earliest SMILE/globe-derived lenticules to
highly advanced AI-guided hybrid collagen and dual-level constructs. It outlines how …
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Postoperative Care and Complication Management in Doughnut Refractive Lenticule Transplantation
Z Shah - … Transplantation Technique for Advanced Keratoconus, 2026
The postoperative phase is a critical determinant of long-term success in DRLT.
Although the sutureless, intrastromal pocket approach inherently promotes faster
rehabilitation and minimizes the risks associated with open-sky techniques, the …
Although the sutureless, intrastromal pocket approach inherently promotes faster
rehabilitation and minimizes the risks associated with open-sky techniques, the …
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Pseudokeratoconus in geleophysic dysplasia: a diagnostic pitfall
P Gupta, G Chattannavar, M Pushpwan, R Kekunnaya… - BMJ Case Reports, 2026
… Keratoconus (KC) is a corneal ectasia associated with stromal thinning and
biomechanical weakness which induces irregular astigmatism, … Case Report:
Novel ADAMTSL2 compound heterozygous mutations in geleophysic dysplasia with …
biomechanical weakness which induces irregular astigmatism, … Case Report:
Novel ADAMTSL2 compound heterozygous mutations in geleophysic dysplasia with …
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Corneal Parameter Analysis Following SMILE-Derived Doughnut Refractive Lenticule Transplantation
Z Shah - … Transplantation Technique for Advanced Keratoconus, 2026
Accurate and reproducible imaging plays a central role in understanding the
structural, refractive, and biomechanical changes that occur following DRLT. As an
anterior to mid-stromal additive procedure designed to normalize corneal geometry …
structural, refractive, and biomechanical changes that occur following DRLT. As an
anterior to mid-stromal additive procedure designed to normalize corneal geometry …
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DRLT 197
Z Shah - Doughnut Refractive Lenticule Transplantation (DRLT)
… the predictable behavior of the doughnut lenticule within the corneal stroma and
underscore its value in managing advanced keratoconus. … This marked visual
recovery highlights the dual role of DRLT in both stabilizing keratoconus and …
underscore its value in managing advanced keratoconus. … This marked visual
recovery highlights the dual role of DRLT in both stabilizing keratoconus and …
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8.14 The Global Adoption and Future Dominance of DRLT
Z Shah - Doughnut Refractive Lenticule Transplantation (DRLT)
Long-term stability is the hallmark of any successful corneal intervention particularly
in progressive ectatic diseases like keratoconus. DRLT, as a biologically integrated,
minimally invasive, and refractively neutral stromal reinforcement technique, has …
in progressive ectatic diseases like keratoconus. DRLT, as a biologically integrated,
minimally invasive, and refractively neutral stromal reinforcement technique, has …
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RV Merola, S Cronemberger - Int J Ophthalmol, 2026
● Accurate measurement of intraocular pressure (IOP) is essential for the diagnosis
and treatment of glaucoma. Keratoconus (KC) is an ectatic corneal disease, which
evolves with progressive non-inflammatory thinning and is characterized by irregular …
and treatment of glaucoma. Keratoconus (KC) is an ectatic corneal disease, which
evolves with progressive non-inflammatory thinning and is characterized by irregular …
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[PDF] A Review of Artificial Intelligence in Ophthalmology: Key Aspects, Challenges, and Future Directions
PP Ray - Eye & ENT Research, 2026
Artificial intelligence (AI) is increasingly reshaping ophthalmology because the
specialty depends heavily on structured imaging, quantitative measurements, and
repeatable diagnostic workflows. This review provides a clinically grounded and …
specialty depends heavily on structured imaging, quantitative measurements, and
repeatable diagnostic workflows. This review provides a clinically grounded and …
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[TXT] http://researchspace. auckland. ac. nz
CA Jordan
… Keratoconus occurs due to a combination of genetic and environmental factors. …
These inter-related studies provide new data on keratoconus in New Zealand, on the
… Figure 1-10: The Zernike polynomial analysis map in a patient with keratoconus, …
These inter-related studies provide new data on keratoconus in New Zealand, on the
… Figure 1-10: The Zernike polynomial analysis map in a patient with keratoconus, …
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Complications of Epithelium-Off Crosslinking for Keratoconus: A Single Institution Historical Experience
WV Lin, CY Chang, D Monteleone-Haught, BD Ayres… - Journal of Cataract & …, 2026
… Exclusion criteria included follow-up period less than 3 months and indication for
CXL other than keratoconus. Data extracted from electronic medical records included
sociodemographic characteristics and clinical factors (including preoperative …
CXL other than keratoconus. Data extracted from electronic medical records included
sociodemographic characteristics and clinical factors (including preoperative …
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[HTML] Integrated Tear Vitamin D–IL-6–NRF2 Signature Associated with Keratoconus Severity: An Exploratory Cross-Sectional Study
RGC Leça, FLA Fonseca, GRL da Veiga, BCA Alves… - The Ocular Surface, 2026
STRUCTURED ABSTRACT Purpose Tear-based biomarkers with consistent,
severity-graded associations remain lacking in keratoconus. We examined, in an
exploratory cross-sectional design, the association between tear vitamin D …
severity-graded associations remain lacking in keratoconus. We examined, in an
exploratory cross-sectional design, the association between tear vitamin D …
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[HTML] Corneal tomography in children and adolescents with systemic allergy
K Mahida
… or forme fruste keratoconus and only three as having clinical keratoconus. These
findings … both subclinical/forme fruste keratoconus and clinical keratoconus, these
phenotypes were … subtle alterations in corneal architecture before the …
findings … both subclinical/forme fruste keratoconus and clinical keratoconus, these
phenotypes were … subtle alterations in corneal architecture before the …
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[PDF] Toward Patient-Specific Mapping of Early Corneal Alterations
J Casado-Moreno, A Consejo - Jornada de Jóvenes Investigadores del I3A, 2026
… in conventional tomographic maps, particularly in subclinical keratoconus,
enabling earlier spatial characterization of ectatic changes. … Corneal ectatic
diseases, such as keratoconus (KC), are characterized by a progressive localized …
enabling earlier spatial characterization of ectatic changes. … Corneal ectatic
diseases, such as keratoconus (KC), are characterized by a progressive localized …
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[HTML] Multifactorial analysis of corneal biomechanical stability after deep anterior lamellar keratoplasty: integration of anterior segment imaging indices and ocular response …
Y Zhao, J Guo, Y Wang, M Xie, W Wei - American Journal of Translational Research, 2026
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Immune cells and cytokines in the scleral lens fluid reservoir in keratoconus
M Keyzer, E Guerra, P Bhattacharyya, MK Walker - Contact Lens and Anterior Eye, 2026
… keratoconus group and 16 in the normal group. All immune cell counts within the
FR were greater in keratoconus compared to normal (p = 0.02), and keratoconus …
Several additional mediators (eg, IL-6, IL-8, MCP-1) trended higher in keratoconus …
FR were greater in keratoconus compared to normal (p = 0.02), and keratoconus …
Several additional mediators (eg, IL-6, IL-8, MCP-1) trended higher in keratoconus …
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Increased genotoxicity in human corneal epithelial cells associated with keratoconus
ME Yiğit, S Çetinkaya, G Özge, O Erdem, Ö Ayyıldız - International Ophthalmology, 2026
… has been implicated in corneal disease, direct experimental evidence of
genotoxic alterations in corneal epithelial cells in keratoconus remains limited. We
evaluated genotoxicity in human corneal epithelial cells associated with …
genotoxic alterations in corneal epithelial cells in keratoconus remains limited. We
evaluated genotoxicity in human corneal epithelial cells associated with …
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Development and Physicochemical Characterization of a 1.4% Riboflavin-5-Phosphate Ophthalmic Solution for Corneal Cross-Linking.
PP Chinchole, AA Kedar, YB Zambare, YA Meshram… - Bol Sustavy Pozvonochnik, 2026
… The finding of this study indicated that Riboflavin-5-Phosphate ophthalmic
solution for the Keratoconus treatment by KXL was good, … a thorough analysis of
keratoconus, which has since grown to be the journal's most-cited article[1]. The …
solution for the Keratoconus treatment by KXL was good, … a thorough analysis of
keratoconus, which has since grown to be the journal's most-cited article[1]. The …
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Bridging the gap: socioeconomic disparities in pediatric vision referrals from the UCSD EyeMobile Program
N Ramesh, AR Legala, R Lee, L Hennein, S Borooah… - Journal of the American …, 2026
… Notably, our findings show a higher relative frequency of suspected keratoconus
than other pediatric mobile eye clinics; this may be related to concerns for
keratoconus on the part of referring providers when encountering high astigmatism …
than other pediatric mobile eye clinics; this may be related to concerns for
keratoconus on the part of referring providers when encountering high astigmatism …
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Enhancing Patient Comfort in Epi-Off Crosslinking: The Potential of High-O2 Chambers
A Mohammadi, S Dehghani, H Abbas, D Savage… - Journal of Cataract & …, 2026
… , presence of progressive keratoconus, and thinnest corneal pachymetry greater
than 450 µm. Keratoconus progression was defined as a >… active ocular surface
disease, coexistence of ocular pathologies other than keratoconus, history of …
than 450 µm. Keratoconus progression was defined as a >… active ocular surface
disease, coexistence of ocular pathologies other than keratoconus, history of …
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L Thom, VVR Moodley - International Ophthalmology, 2026
… This study provides the first multicentre assessment of keratoconus within Malawi’s
tertiary eye-care system and demonstrates that keratoconus constitutes a substantial
clinical burden among patients attending referral refraction services. The disease …
tertiary eye-care system and demonstrates that keratoconus constitutes a substantial
clinical burden among patients attending referral refraction services. The disease …
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[PDF] Corneal Tomography and Biomechanical Characteristics in Siblings of Patients with Keratoconus: A Cross-Sectional Study
SI Machlovi, A Fawad, AA Shah, A Sohail, A Shabbir… - Life and Science, 2026
Objective: To assess and compare corneal tomographic and biomechanical
characteristics between siblings ofpatients with keratoconus and healthy siblings of
individuals without ocular pathology, aiming to detect earlysubclinical changes …
characteristics between siblings ofpatients with keratoconus and healthy siblings of
individuals without ocular pathology, aiming to detect earlysubclinical changes …
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[HTML] Neural Network Detection of Subclinical Keratoconus Enhanced by Radial Distortion Augmentation of Posterior Corneal Tomography
RM Hazarbassanov, L Weinketz, LA dos Santos… - … Ophthalmology & Visual …, 2026
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Assessment of corneal epithelial thickness map for the early detection of keratoconus
MA Ghonaim, DAELT EL-Mowafy, HSED El Nahass… - Journal of the Egyptian …, 2026
… Corneal epithelial thickness map for early detection of keratoconus M. Ghonaim et
al. 267 … ROC curve for corneal epithelium in maximum back elevation to discriminate
subclinical from early keratoconus. … Epithelial thickness map of early keratoconus …
al. 267 … ROC curve for corneal epithelium in maximum back elevation to discriminate
subclinical from early keratoconus. … Epithelial thickness map of early keratoconus …
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A Modular Smartphone-Based Multimodal Imaging Platform for Anterior Segment Imaging, Corneal Topography, and AI-Assisted Cataract and Keratoconus Screening
KC Kiroshka - Investigative Ophthalmology & Visual Science, 2026
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An Engineered Fish Scale-Based Composite Corneal Ring for Sustained Platelet-Rich Growth Factor Delivery: Material Characterization, Optimization, and In-vitro …
R Jarchizadeh, R Imani, SH Keshel, M Khani - Journal of Drug Delivery Science and …, 2026
… Keratoconus is a common corneal disease that can lead to serious vision
problems. Keratoconus is a corneal disorder that typically arises … This surgery is
vital for individuals with severe corneal damage, such as advanced keratoconus …
problems. Keratoconus is a corneal disorder that typically arises … This surgery is
vital for individuals with severe corneal damage, such as advanced keratoconus …
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MS Anwar, E Özbilge - IEEE Access, 2026
… ABSTRACT Keratoconus is an eye disease that can cause significant vision loss
if not … To detect the keratoconus stage using 2D RGB colour images and
overcome the limitations … modifying the Xception architecture for automatic …
if not … To detect the keratoconus stage using 2D RGB colour images and
overcome the limitations … modifying the Xception architecture for automatic …
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[PDF] Corneal Tomography Changes After Simultaneous Topical Application of Cyclosporine and Trehalose in Keratoconus Evaluated with an Artificial Intelligence Model
R Shetty, P Khamar, G Kundu, P Shetty, D Honniganur… - Clinical Ophthalmology, 2026
… keratoconus. In this study, we evaluated the effect of a topical trehalose 3% eye
drop (administered four times daily) in combination with cyclosporine 0.05% (twice
daily) in patients with early to moderate keratoconus … and keratoconus based on …
drop (administered four times daily) in combination with cyclosporine 0.05% (twice
daily) in patients with early to moderate keratoconus … and keratoconus based on …
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[PDF] Comparative Outcomes of Same-Size versus Different-Size Grafts in Deep Anterior Lamellar Keratoplasty for Keratoconus: A Focus on Postoperative Astigmatism
MM Daloub, RA Alkhoja
… Methods: In this prospective comparative study, 70 patients with keratoconus
undergoing DALK … DALK is an effective procedure for managing advanced
keratoconus. The use of a same-size … technique to enhance the refractive …
undergoing DALK … DALK is an effective procedure for managing advanced
keratoconus. The use of a same-size … technique to enhance the refractive …
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[PDF] Corneal tomography in children and adolescents with systemic allergy
K Mahida, SR Jagtap - Arq Bras Oftalmol, 2026
… or forme fruste keratoconus and only three as having clinical keratoconus. These
findings … both subclinical/forme fruste keratoconus and clinical keratoconus, these
phenotypes were … in corneal architecture before the development of overt …
findings … both subclinical/forme fruste keratoconus and clinical keratoconus, these
phenotypes were … in corneal architecture before the development of overt …
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[PDF] Precise Epithelium Removal for Ectatic Corneas Technique in Corneal Collagen Crosslinking (PERFECT-CXL): Technique Description and Clinical Outcomes
J Desilets, K Agarwal, KM Hatch - Clinical Ophthalmology, 2026
… and effective technique in halting progression of KCN and can be utilized in
various stages of keratoconus. Keywords: corneal ectasia, … procedure that halts or
slows progression of corneal ectatic disorders, including keratoconus (KCN) and …
various stages of keratoconus. Keywords: corneal ectasia, … procedure that halts or
slows progression of corneal ectatic disorders, including keratoconus (KCN) and …
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Corneal tomography detection of elevated ectasia risk in atopic dermatitis patients with no prior ophthalmologic diagnosis
J Lenk, R Herber, E Sporl, LE Pillunat, KR Pillunat… - … papers of the Medical Faculty of …
Background To investigate the association between atopic dermatitis (AD) and
keratoconus (KC) in atopic dermatitis patients with no prior ophthalmologic diagnosis.
Methods Thirty eyes of 30 patients with moderate to severe AD were included in this …
keratoconus (KC) in atopic dermatitis patients with no prior ophthalmologic diagnosis.
Methods Thirty eyes of 30 patients with moderate to severe AD were included in this …
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[PDF] Indications, Surgical Procedures, and Vision Outcomes of Keratoplasty at Tripoli Eye Hospital, Libya
M Eljabri, FK Said, A Alshareef, A Ehnaidy - AlQalam Journal of Medical and Applied …, 2026
… The most common indication in our study was keratoconus. The second most
common cause for PK in this study was decompensated cornea, caused by most
commonly caused by conditions such as Fuchs endothelial dystrophy or surgical …
common cause for PK in this study was decompensated cornea, caused by most
commonly caused by conditions such as Fuchs endothelial dystrophy or surgical …
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Bridging the diagnostic gap in keratoconus: lessons from South Asia for UK primary care
A Syed - Eye, 2026
We read with interest the multicentre study by Chatterjee et al. characterising the
sociodemographic and clinical profile of 421 newly diagnosed keratoconus patients
across four tertiary centres in India [1]. The finding that diagnosis continues to occur …
sociodemographic and clinical profile of 421 newly diagnosed keratoconus patients
across four tertiary centres in India [1]. The finding that diagnosis continues to occur …
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[PDF] Contact Lenses and Vision-Related Quality of Life: Evidence and Clinical Insights
EA Osae, KA Osei, NC Edwards, E Wygonik… - Clinical Optometry, 2026
… In keratoconus, RGP and scleral lenses dramatically improve NEI-VFQ-25
composite scores, even in cases of advanced disease. Barriers … in VR-QoL among
adult and pediatric patients with refractive error, keratoconus, ocular surface disease …
composite scores, even in cases of advanced disease. Barriers … in VR-QoL among
adult and pediatric patients with refractive error, keratoconus, ocular surface disease …
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JB Randleman - Journal of Refractive Surgery, 2026
… in their 1990 study of asymptomatic family members of patients with keratoconus.
The authors found that 14 of 28 (50%) of … keratoconus represent an incomplete
expression of the keratoconus gene, and it is therefore possible that these patterns …
The authors found that 14 of 28 (50%) of … keratoconus represent an incomplete
expression of the keratoconus gene, and it is therefore possible that these patterns …
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Severity-Graded Repeatability of AS-OCT Including Epithelial and Stromal Metrics in Patients With Keratoconus Versus Healthy Individuals
R Khoramnia, T Naujokaitis, M Friedrich, HS Son… - Journal of Refractive …, 2026
… with keratoconus and healthy individuals and in different keratoconus severity
groups using intra-subject variance. … keratoconus, the repeatability of most
evaluated parameters was slightly lower in patients with keratoconus and tended to …
groups using intra-subject variance. … keratoconus, the repeatability of most
evaluated parameters was slightly lower in patients with keratoconus and tended to …
| | | |
Analysis of the inner and outer retinal layer thicknesses of patients with keratoconus
M Karahan, Ö Baskurt, Z Ceylan, L Hazar - Clinical and Experimental Optometry, 2026
… higher for patients with moderate and advanced keratoconus than for those in the
control group and those with early keratoconus. Some previous studies have
reported no changes in RNFL thickness in patients with keratoconus, while others …
control group and those with early keratoconus. Some previous studies have
reported no changes in RNFL thickness in patients with keratoconus, while others …
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Distinct corneal morphometric remodeling in early keratoconus: Insights from sirius scheimpflug-placido tomography and quantitative epithelial pattern assessment-a …
HH Telek, H Sabur, TH Ceran, YA Özdemir, S Akkaya - Medicine, 2026
This study aimed to investigate the diagnostic performance of Sirius Scheimpflug-Placido
tomography parameters in distinguishing early-stage keratoconus (KC) from normal
eyes and to determine whether quantitative epithelial pattern assessment adds …
tomography parameters in distinguishing early-stage keratoconus (KC) from normal
eyes and to determine whether quantitative epithelial pattern assessment adds …
| | | |
The Science and Clinical Evolution of Corneal Cross-Linking: Mechanism of Action, Ultra-Structural Changes, Clinical Indications, and Emerging Treatment Strategies
C Mazzotta, M Lombardo, A Avitabile, G Alessio… - Ophthalmology and therapy, 2026
Keratoconus is the most common corneal ectatic disorder worldwide. Typically
manifesting in adolescence, it imposes a substantial burden on quality of life and, if
untreated, may progress to advanced stages requiring corneal transplantation …
manifesting in adolescence, it imposes a substantial burden on quality of life and, if
untreated, may progress to advanced stages requiring corneal transplantation …
| | | |
[PDF] Toward a More Rigorous Definition of Customized Corneal Cross-Linking
C Caruso, G Barbaro - Journal of Refractive Surgery, 2026
We read with great interest the recent systematic review and meta-analysis by Hsu
et al1 evaluating customized corneal cross-linking (CXL) for keratoconus. The
authors should be congratulated for addressing an increasingly important topic in …
et al1 evaluating customized corneal cross-linking (CXL) for keratoconus. The
authors should be congratulated for addressing an increasingly important topic in …
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[PDF] Reply: Toward a More Rigorous Definition of Customized Corneal Cross-Linking
JH Hsu, TH Tsai, TW Lin - Journal of Refractive Surgery, 2026
We read with great interest the recent systematic review and meta-analysis by Hsu
et al1 evaluating customized corneal cross-linking (CXL) for keratoconus. The
authors should be congratulated for addressing an increasingly important topic in …
et al1 evaluating customized corneal cross-linking (CXL) for keratoconus. The
authors should be congratulated for addressing an increasingly important topic in …
| | | |
[PDF] Conservative Management of Intrastromal Corneal Ring Segment Extrusion Using Suture-Assisted Repositioning: A Case Series
J Warrak, Y Tlaiss, A Tarchichi, E Warrak - International Medical Case Reports …, 2026
… This retrospective case series of two eyes (two patients) included eyes with
keratoconus that developed recurrent ICRS extrusion despite exhaustive
conservative management, including bandage contact lens use, topical antibiotic …
keratoconus that developed recurrent ICRS extrusion despite exhaustive
conservative management, including bandage contact lens use, topical antibiotic …
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[HTML] Fighting Back Against HOAs
OD Jamie Kuzniar, OD Trevor Fosso…
| | | |
H Zhang, JLA Del Barrio, AE Rodriguez, RI Barraquer… - Clinical & experimental …
Background To report the 1-year clinical outcomes of decellularised human corneal
stromal lamina implantation, with or without autologous adipose-derived adult stem
cells (ADASCs), for advanced keratoconus in a European cohort. Methods In this …
stromal lamina implantation, with or without autologous adipose-derived adult stem
cells (ADASCs), for advanced keratoconus in a European cohort. Methods In this …
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Pathogenesis, Early Detection, and Treatment ofKeratoconus: An Updated Narrative Review
T Juran, IA Maluli, J Shaw, L Patel, M Sathyamoorthy - Annals of Eye Science, 2026
… review of the pathophysiology of keratoconus, to allow continued optimization of …
of keratoconus, diagnostics, and management options. Key Content and Findings:
Recent literature highlights significant progress in understanding the molecular and …
of keratoconus, diagnostics, and management options. Key Content and Findings:
Recent literature highlights significant progress in understanding the molecular and …
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[PDF] Goniosynechialysis Combined with iStent Implantation for Refractory Angle Closure Following Tectonic Penetrating Keratoplasty: A Case Report
U Kanj, AA Mohite, L Jiang, B Ilango - Journal of Current Glaucoma Practice, 2026
… surgery (MIGS) approach successfully prevented irreversible sight loss from acute
secondary angle closure following tectonic penetrating keratoplasty (PKP) in an eye
with a prior porcine-derived corneal stromal implant (Xenia®) as treatment for …
secondary angle closure following tectonic penetrating keratoplasty (PKP) in an eye
with a prior porcine-derived corneal stromal implant (Xenia®) as treatment for …
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RN Pop, P Nicula, C Nicula, D Nicula, B Pop - Vision, 2026
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Pulsed accelerated corneal cross-linking for pediatric keratoconus: a prospective study from the Indian subcontinent
P Jain, A Mehta, R Arora, I Gupta, P Dutta, V Agrrawal… - International Ophthalmology, 2026
… (PACXL) in children with progressive keratoconus and to determine its safety and
efficacy in an Indian pediatric cohort. Methods This was a prospective interventional
study including 40 eyes of 31 children (< 18 years) with progressive keratoconus …
efficacy in an Indian pediatric cohort. Methods This was a prospective interventional
study including 40 eyes of 31 children (< 18 years) with progressive keratoconus …
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[PDF] Sectorial customized corneal crosslinking for keratoconus: an inverse biomechanical design study with an anisotropic reduced shell finite-element surrogate
J Sumaya-Martinez, A Altamirano-Torres - arXiv preprint arXiv:2607.06385, 2026
We propose an inverse biomechanical design framework for sectorial customized
corneal crosslinking in keratoconus. The cornea is modeled as an anisotropic
reduced shell with spatially varying crosslinking-induced stiffening, enabling the …
corneal crosslinking in keratoconus. The cornea is modeled as an anisotropic
reduced shell with spatially varying crosslinking-induced stiffening, enabling the …
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Behavioral and Sociodemographic Factors Associated with Vision-Related Quality of Life in Keratoconus: A Cross-Sectional Study in Riyadh, Saudi Arabia
S Alsalamah, Y Abosabaah, G Alhabs, L Marghlani… - Vision, 2026
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Epithelial thickness ratio: a quantitative OCT-based metric for characterizing epithelial remodelling in keratoconus
KA Hutchinson, L Breslin, M Holdsworth, D Johnson - Canadian journal of ophthalmology …
… keratoconus from 18 patients were included. Normal eyes were selected from a
refractive surgery practice, whereas eyes with keratoconus … ETR values were
compared between normal eyes and those with keratoconus, and diagnostic …
refractive surgery practice, whereas eyes with keratoconus … ETR values were
compared between normal eyes and those with keratoconus, and diagnostic …
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[HTML] Role of AI in the diagnosis and disease progression of keratoconus
A Ilyas
… segment conditions such as keratoconus, becoming the focal point of its
expansion(1,3). … Keratoconus is a bilateral, asymmetrical corneal ectatic disorder
characterized by progressive … have been used to detect the early signs of …
expansion(1,3). … Keratoconus is a bilateral, asymmetrical corneal ectatic disorder
characterized by progressive … have been used to detect the early signs of …
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[HTML] Navigating the Irregular Road
LA Sicks
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[PDF] Ocular Surface, Tear Film, and Corneal Biomechanics in Pregnancy: A Systematic Review of Hormonal–immunological Modulation with a Translational Case …
A Suryawan, W Andonotopo, RA Putra, TM Rahardjo… - Journal of Ophthalmological …, 2026
… [8] Still, clinically oriented reports continue to describe transient topographic
fluctuations in keratoconus during pregnancy, reinforcing the notion that corneal
shape may be more labile than previously assumed.[9] Investigations into tear film …
fluctuations in keratoconus during pregnancy, reinforcing the notion that corneal
shape may be more labile than previously assumed.[9] Investigations into tear film …
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[HTML] Agreement in the classification of keratoconus severity: a comparative study based on anterior corneal surface topographic parameters
C Villa-Collar, J Santodomingo-Rubido… - Contact Lens and Anterior …, 2026
… In research settings, classification enables the comparison of outcomes among
patients with similar stages of keratoconus. In summary, staging the degree of
keratoconus development once the disease has been diagnosed offers substantial …
patients with similar stages of keratoconus. In summary, staging the degree of
keratoconus development once the disease has been diagnosed offers substantial …
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[PDF] Multifactorial analysis of corneal biomechanical stability after deep anterior lamellar keratoplasty: integration of anterior segment imaging indices and ocular response …
Y Zhao, J Guo, Y Wang, M Xie, W Wei - Am J Transl Res, 2026
… We did a multifactorial analysis of corneal biomechanical stability after DALK for
keratoconus. We took numbers from advanced anterior segment imaging and
combined them with direct biomechanical data from ORA. The importance of …
keratoconus. We took numbers from advanced anterior segment imaging and
combined them with direct biomechanical data from ORA. The importance of …
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[HTML] Ocular and Systemic Phenotyping of Bardet–Biedel Syndrome Type 7 (BBS7) in a Palestinian Male: Case Report and Literature Review
I Taha, L Abusamra, SF Shalabi, K Huraibat… - Case Reports in …, 2026
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[HTML] … and Topographic Changes after Transepithelial vs. Epithelium-off Continuous Accelerated Corneal Cross-linking in Keratoconus: Updated Stress-Strain Index as a …
BX Mao, CC He, Q Ye, WJ Liu, YQ Li, D Oehring… - Ophthalmology Science, 2026
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[PDF] … Parameters Stability after Corneal Ring Segment Surgery in Keratoconus: Topographic Parameters Stability after Corneal Ring Segment Surgery in Keratoconus
SZ Khan, AA Khan, A Rasheed, R Saeed, A Saeed… - Pakistan Journal of Health …, 2026
… Keratoconus is a bilateral, non-inflammatory disease that leads to the bulging
outward of a … cohort, which included all eligible keratoconus subjects visting Out
Patient Department, Fatima … of ICRS, resulting in an overall improvement in the …
outward of a … cohort, which included all eligible keratoconus subjects visting Out
Patient Department, Fatima … of ICRS, resulting in an overall improvement in the …
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Repeated DMEK after Long-Standing DALK Failure in Keratoconus: Case Report of a Complex Staged Corneal Transplantation.
EA Ortiz - Medical Research Archives, 2026
… ) is the preferred surgical treatment for advanced keratoconus with preserved
endothelial function, … Case Presentation: A 57-year-old Afro-Caribbean woman
with keratoconus diagnosed at 40 … While DALK effectively treats anterior stromal …
endothelial function, … Case Presentation: A 57-year-old Afro-Caribbean woman
with keratoconus diagnosed at 40 … While DALK effectively treats anterior stromal …
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Efficacy and safety of progressive fluence pulsed light epithelium-on accelerated corneal cross-linking for progressive keratoconus: 18-month prospective results
M Ferrise, C Gagliano, F D'Esposito, F Cappellani… - International journal of …, 2026
Aim To report the 18-month clinical outcomes of the progressively higher fluence
pulsed light (7.2 to 10 J/cm 2 ) epithelium-on accelerated corneal crosslinking (PFPL
M Epi-On ACXL) protocol for progressive keratoconus. Methods This was a …
pulsed light (7.2 to 10 J/cm 2 ) epithelium-on accelerated corneal crosslinking (PFPL
M Epi-On ACXL) protocol for progressive keratoconus. Methods This was a …
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Artificial intelligence for diagnosis of keratoconus using Scheimpflug based corneal tomography
S Qayyum, M Arshad, H Saeed - International journal of ophthalmology, 2026
Aim To develop and evaluate the diagnostic accuracy of deep learning (DL) models
in differentiating keratoconus (KC) from normal eyes with regular astigmatism.
Methods A comparative cross-sectional study was conducted at the Cornea and …
in differentiating keratoconus (KC) from normal eyes with regular astigmatism.
Methods A comparative cross-sectional study was conducted at the Cornea and …
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One-Year Visual, Refractive, Tomographic, and Aberrometric Outcomes of Repeat Corneal Collagen Crosslinking in Eyes with Progressive Keratoconus
T Celik Buyuktepe, B Kılıç, OO Ucakhan-Gunduz - Beyoglu Eye Journal
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Enhancing the diagnostic precision of subclinical keratoconus by combining indices from Scheimpflug tomography, corneal biomechanics, and anterior segment …
N Razak, B Mohd-Ali, WHWA Halim - International journal of ophthalmology, 2026
Aim To determine the diagnostic precision of combined Scheimpflug tomography
and biomechanical analysis with optical coherence tomography (OCT) for detection
of subclinical keratoconus (SCKC). Methods All subjects in this prospective, cross-sectional …
and biomechanical analysis with optical coherence tomography (OCT) for detection
of subclinical keratoconus (SCKC). Methods All subjects in this prospective, cross-sectional …
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[PDF] One-Year Visual, Refractive, Tomographic, and Aberrometric Outcomes of Repeat Corneal Collagen Crosslinking in Eyes with Progressive Keratoconus
TC Buyuktepe, B Kılıç, OO Ucakhan-Gunduz - BEYOGLU EYE
… in the management of keratoconus progression at 1-year follow-up. Methods:
Charts of consecutive progressive keratoconus patients who … , refractive, topographic
and aberrometric outcomes of repeat CXL in the management of keratoconus …
Charts of consecutive progressive keratoconus patients who … , refractive, topographic
and aberrometric outcomes of repeat CXL in the management of keratoconus …
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[HTML] ADVANCED DIAGNOSTIC TECHNOLOGIES IN OPTOMETRY
M Aamir - Advanced Developments in Allied Healthcare: A …, 2026
… These technologies assist in the early diagnosis of glaucoma, diabetic retinopathy,
macular disorders, keratoconus, and refractive abnormalities, thereby improving
visual outcomes and reducing the risk of preventable blindness. Furthermore, the …
macular disorders, keratoconus, and refractive abnormalities, thereby improving
visual outcomes and reducing the risk of preventable blindness. Furthermore, the …
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[HTML] CONTACT LENS TECHNOLOGY AND PRACTICE
U Salma, N Ali - Advanced Developments in Allied Healthcare: A …, 2026
… The chapter also highlights the role of contact lenses in orthokeratology,
keratoconus management, and pediatric myopia control. Proper patient education,
hygiene practices, regular follow-up, and individualized lens selection remain …
keratoconus management, and pediatric myopia control. Proper patient education,
hygiene practices, regular follow-up, and individualized lens selection remain …
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[HTML] Obesity and Keratoconus: A Mediation Study Based on the Chinese Keratoconus Cohort
K Yang, A Chang, R Tu, L Xu, Y Gu, Q Fan, S Yin… - Translational Vision Science …, 2026
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Changes in tomographic parameters across different wearing and cessation periods of apical clearance-fitted rigid gas-permeable contact lenses in keratoconus
FC Hsiao, YN Chen, JW Chen, TH Tsai, EYC Kang… - Graefe's Archive for Clinical …, 2026
… gas-permeable (RGP) lens cessation in keratoconus and define a clinically
feasible and sufficient period for reliable baseline morphology. Methods This
retrospective longitudinal study included 42 eyes of 23 patients with keratoconus …
feasible and sufficient period for reliable baseline morphology. Methods This
retrospective longitudinal study included 42 eyes of 23 patients with keratoconus …
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Cataract Surgery in Keratoconus: Pre-operative Assessment, Intra-operative Challenges and Post-operative Considerations
AA Balamoun, A Matsou, M Rechichi, T Giobellina - Cataract Surgery: Practice …, 2026
… The Amsler-Krumeich classification system is widely employed to grade and
stage keratoconus [8]. The severity of keratoconus influences the choice of surgical
techniques, intraocular lens selection, and the management of astigmatism. In cases …
stage keratoconus [8]. The severity of keratoconus influences the choice of surgical
techniques, intraocular lens selection, and the management of astigmatism. In cases …
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IOL Calculations in Keratoconus
C Mazzotta, D Borroni, F D'Oria, M Ferrise - Cataract Surgery: Practice, Technique …, 2026
… In conclusion, monofocal IOLs remain the most suitable lens option for most
keratoconus patients. However, toric IOLs may be considered in very select cases of
mild keratoconus with regular central symmetric astigmatism, provided that the …
keratoconus patients. However, toric IOLs may be considered in very select cases of
mild keratoconus with regular central symmetric astigmatism, provided that the …
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[PDF] Late-Onset Infectious Keratitis Over 10 Years After Intracorneal Ring Segment Implantation Treated with Deep Anterior Lamellar Keratoplasty: A Case Report
Y Akasaki, T Funaki, T Inomata, S Nakatani… - Case Reports in …, 2026
… Introduction: Intracorneal ring segments (ICRS) are employed to manage
keratoconus but carry the risk of late-onset complications such … Case presentation:
A 56-year-old woman with atopic dermatitis and keratoconus presented with severe …
keratoconus but carry the risk of late-onset complications such … Case presentation:
A 56-year-old woman with atopic dermatitis and keratoconus presented with severe …
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Urrets-Zavalia Syndrome (UZS) After Cataract Surgery
DS Anwar - Cataract Surgery: Practice, Technique and Innovation, 2026
… penetrating keratoplasty (PKP) for keratoconus patients who received atropine
eye drops. In 1963, Alberto Urrets-Zavalia, an ophthalmologist from Argentina, first
described six cases of fixed dilated pupils after penetrating keratoplasty for …
eye drops. In 1963, Alberto Urrets-Zavalia, an ophthalmologist from Argentina, first
described six cases of fixed dilated pupils after penetrating keratoplasty for …
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[HTML] Inflammatory Mediators Involved in Conjunctival and Corneal Remodeling of Vernal Keratoconjunctivitis
NJ Karbach, F Tariq - Life, 2026
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[HTML] Short-Term Impact of Scleral Lens Wear on Intraocular Pressure and Retinal Nerve Fiber Layer Thickness
P Dhungel, MK Alanazi, P Caroline, L Yudcovitch… - Life, 2026
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Second-Generation ELZA-sub400 Protocol: Individualized High-Fluence Cross-Linking for Ultra-Thin Keratoconus Corneas
F Hafezi, RE Akcan, S Kling, L Kollros, M Depczyńska… - American Journal of …, 2026
PURPOSE To evaluate the safety and efficacy of a second-generation individualized
corneal cross-linking (CXL) protocol (ELZA-sub400) using high-fluence UV-A
irradiation in ultrathin ectatic corneas. DESIGN Retrospective, single-centre …
corneal cross-linking (CXL) protocol (ELZA-sub400) using high-fluence UV-A
irradiation in ultrathin ectatic corneas. DESIGN Retrospective, single-centre …
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[HTML] Comparison of the Ratio Between Anterior and Posterior Curvature Centered on the Thinnest Point (A/B Ratio) in Normal and Keratoconus Eyes
E Szalai, R Ambrosio, E Flockerzi, B Seitz… - Translational Vision Science …, 2026
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[HTML] Reduced Image Quality Impairs Monocular Blur-Driven Accommodation in Keratoconus
T Bhakta, K Jain, P Sudanabonia, S Sager, A Gambin… - … Ophthalmology & Visual …, 2026
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[HTML] Topography-Assisted Refraction in Keratoconus: a Clinical Comparative Study
R Albertazzi, C Rocha-de-Lossada, DP Piñero - Oftalmología Clínica y Experimental, 2026
Purpose: Refraction in patients with keratoconus is challenging because irregular
corneal morphology often limits the accuracy of conventional methods. This study
aimed to develop and evaluate a corneal topography-assisted refraction (TAR) …
corneal morphology often limits the accuracy of conventional methods. This study
aimed to develop and evaluate a corneal topography-assisted refraction (TAR) …
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Determinants of Rapidly Progressive Keratoconus: A Pentecam-Based Clinical Analysis of 405 Eyes
FB Özdemir, C Doğan, E Atalay - Investigative Ophthalmology & Visual Science, 2026
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Evaluation of microcirculation in the optic nerve head of keratoconus eyes
S Ichinohasama, H Namba, T Shiba, T Kobayashi… - … Ophthalmology & Visual …, 2026
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Unsupervised phenotyping of suspect keratoconus based on posterior tomography and epithelial remodeling
A Salman - BMC Ophthalmology, 2026
Purpose To characterize structural heterogeneity within suspect keratoconus (SKC)
using an unsupervised phenotyping strategy integrating posterior tomographic and
epithelial remodeling parameters. Methods In this cross-sectional study, 55 eyes …
using an unsupervised phenotyping strategy integrating posterior tomographic and
epithelial remodeling parameters. Methods In this cross-sectional study, 55 eyes …
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Corneal transplant and intraocular lens exchange outcomes after cataract surgery in keratoconus
K Shah, AF Omar - Investigative Ophthalmology & Visual Science, 2026
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Quantifying Keratoconus Morphology with Cone Region Metrics for Progression Monitoring
K Hsu, H Shirazi, R Grytz, WJ Dupps - Investigative Ophthalmology & Visual Science, 2026
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Comprehensive Gene Expression Analysis of the Corneal Stroma in Keratoconus Patients
K Kitazawa, Y Yamashita, T Yuasa, N Ueda, Y Yuma… - … Ophthalmology & Visual …, 2026
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[HTML] Nanomaterial-Enhanced Corneal Cross-Linking: Engineering Strategies for Transforming Keratoconus Management
L Huang, Y Fu, F Li - Pharmaceutics, 2026
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[PDF] The repeatability and comparison between swept-source optical coherence tomography and Scheimpflug imaging in healthy eyes and various grades of keratoconus
MMS Vandevenne, A Boonstra, RMMA Nuijts… - Scientific Reports, 2026
… of keratoconus. In this prospective, cross-sectional study, 117 eyes (86
keratoconus and 31 healthy controls) with various grades of keratoconus … In
keratoconus eyes, SS-OCT demonstrated better repeatability in posterior …
keratoconus and 31 healthy controls) with various grades of keratoconus … In
keratoconus eyes, SS-OCT demonstrated better repeatability in posterior …
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[HTML] Characteristics influencing visual outcomes of corneal topography-guided excimer laser keratectomy combined with corneal cross-linking for keratoconus
Z Liu, Z Dai, H Zhang, Y Chen - Photodiagnosis and Photodynamic Therapy, 2026
Purpose To identify preoperative predictive factors for visual outcomes of corneal
topography-guided excimer laser keratectomy (TG-PRK) combined with corneal
collagen cross-linking (CXL) in keratoconic eyes, and to explore potential thresholds …
topography-guided excimer laser keratectomy (TG-PRK) combined with corneal
collagen cross-linking (CXL) in keratoconic eyes, and to explore potential thresholds …
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KeraSwin: Swin Transformer based Keratoconus Screening from Corneal Topography
MH Jafar, J Archpaul, A Taurshia, TM Thiyagu - 2026 4th International Conference …, 2026
… One of the main problems is that subclinical keratoconus may have subtle
changes that are … These techniques are effective for manifest keratoconus but
tend to be less sensitive to early-… -based approach for screening keratoconus from …
changes that are … These techniques are effective for manifest keratoconus but
tend to be less sensitive to early-… -based approach for screening keratoconus from …
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Autoencoder-Based Transfer Learning for Multi-Stage Keratoconus Classification Using Corneal Biomechanical Parameters
SR Bakal, SR Sankaye, NS Bansod, AD Kadam… - … International Conference on …, 2026
… Abstract: Keratoconus is the non-inflammatory and a progressive corneal disease
where early keratoconus stage detection and staging are … There are limited
number of works exists on numerical corneal parameter based multistage …
where early keratoconus stage detection and staging are … There are limited
number of works exists on numerical corneal parameter based multistage …
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One-Year Comparative Outcomes of Conventional Versus Accelerated Corneal Cross-Linking in Progressive Keratoconus
I Bešlić, S Vidas Pauk, M Tomić, M Kalauz, T Kuzman… - Medicina, 2026
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[PDF] Diagnostic Accuracy of Corneal and Epithelial Thickness Map Parameters in Detecting Keratoconus, Subclinical Keratoconus, and Suspect Keratoconus
Z Jiang, Y Feng, M Qu, Y Gao - 2026
… In this study, the inclusion criteria for subclinical keratoconus encompassed the
contralateral eye of patients with unilateral keratoconus. For suspected keratoconus,
the inclusion criteria were based on the posterior elevation map from Pentacam …
contralateral eye of patients with unilateral keratoconus. For suspected keratoconus,
the inclusion criteria were based on the posterior elevation map from Pentacam …
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Clinicopathological Features of Keratoconus in Down Syndrome Patients
D Toameh, M Mazza, S Grandmaison, A Fajardo… - … Ophthalmology & Visual …, 2026
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Validating an automated algorithm to evaluate Cup/disc ratio from fundus images of keratoconus population wearing scleral lenses
P Simard, L Michaud, T Papanikolaou, MM Maghezzi… - … Ophthalmology & Visual …, 2026
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Who gets cross-linked? Insights from over 4500 patients with keratoconus
SL Watson, A Gupta, JY Chen, A Watson, V Daien… - … Ophthalmology & Visual …, 2026
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CPD: The real world of keratoconus
SW OAM, H Kandel
… Patients with keratoconus want to improve their vision, limit progression and
maintain their quality of life. Notably, the impact on quality of life of … This article
synthesises evidence from clinical trials, the Save Sight Keratoconus Registry and …
maintain their quality of life. Notably, the impact on quality of life of … This article
synthesises evidence from clinical trials, the Save Sight Keratoconus Registry and …
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[PDF] QUANTITATIVE ASSESSMENT OF CORNEAL BIOMECHANICS FOLLOWINGUVACROSSLINKING: INTEGRATIONOFOPTICAL …
R Lohmüller, E Center - Buch der Abstracts
Keratoconus is a degenerative corneal disorder that leads to progressive thinning
and deformation, causing significant visual impairment in young patients. Riboflavin-UVA
corneal crosslinking (CXL) is widely applied to enhance corneal biomechanical …
and deformation, causing significant visual impairment in young patients. Riboflavin-UVA
corneal crosslinking (CXL) is widely applied to enhance corneal biomechanical …
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Influence of corneal endothelial cell density after penetrating keratoplasty on contact lens induced corneal swelling
L Szczotka-Flynn, M Schornack, BA Benetz, Z Chen… - Optometry and Vision …, 2026
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[HTML] The prevalence of refractive errors among patients with keratoconus attending Damascus hospital, Syria: a cross-sectional study
R Akwan, AN Alhouri, HN Alhouri, R Aljaramani… - BMC ophthalmology, 2026
Background Keratoconus (KC) is a progressive ectatic corneal disease
characterized by corneal thinning and cone-like protrusion, leading to significant
refractive errors. Despite its global impact, local data for the Syrian population …
characterized by corneal thinning and cone-like protrusion, leading to significant
refractive errors. Despite its global impact, local data for the Syrian population …
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[PDF] CORNEAL COLLAGEN CROSS-LINKING (CXL) IN THE TREATMENT OF KERATOCONUS: MODERN MODIFICATIONS, CLINICAL EFFECTIVENESS AND FUTURE …
NJ Kattahodjaeva - AXBOROTNOMASI
… analyzed, focusing on surgical treatment of keratoconus and the specifics of its
progression. … keratoconus, which is important for selecting therapy individually [4].
The aim of this review is to present modern literature data on surgical management …
progression. … keratoconus, which is important for selecting therapy individually [4].
The aim of this review is to present modern literature data on surgical management …
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Identification of a novel homozygous CHST3 variant in an Iranian patient with Spondyloepiphyseal dysplasia and congenital joint dislocations
P Nejati, E Alimoradi, F Molavi, M Kamari… - Human Gene, 2026
… Our patient exhibited classical skeletal features alongside uncommon
extraskeletal manifestations—keratoconus and significant cardiac anomalies—which
might broaden the known phenotype of CHST3-related disorders. The presence of …
extraskeletal manifestations—keratoconus and significant cardiac anomalies—which
might broaden the known phenotype of CHST3-related disorders. The presence of …
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Cutting-Edge Cross-Linking Biomaterials Advancing Ophthalmic Therapeutics
R Ning, X Fu, L Chen, X Huang, Z Chen, Y Shao… - Progress in Retinal and Eye …, 2026
Corneal cross-linking (CXL) has emerged as an important therapeutic strategy for
enhancing the biomechanical stability of corneal tissues. Originally introduced to
slow or halt the progression of keratoconus (KC), its indications have expanded to …
enhancing the biomechanical stability of corneal tissues. Originally introduced to
slow or halt the progression of keratoconus (KC), its indications have expanded to …
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Early Detection of Keratoconus Using Corneal Tomography Image Analysis by GPT-5.4
N Kapelushnik, D Kamar, J Megreli, O Reitblat, R Sella… - Cornea
Purpose To evaluate the diagnostic performance and limitations of a general-purpose
multimodal large language model (GPT-5.4) in detecting early keratoconus (KC)
using corneal tomography images. Methods This retrospective study included 66 …
multimodal large language model (GPT-5.4) in detecting early keratoconus (KC)
using corneal tomography images. Methods This retrospective study included 66 …
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[HTML] Study of the ocular changes after stromal Ferrara ring implantation in patients with keratoconus
PF de Almeida Cunha, EAF Alves, FBD da Silva…
PURPOSE: To compare the changes in corneal curvature, visual acuity and
spherical equivalent before and after the implantation of the intrastromal corneal
Ferrara ring in contact lens intolerant keratoconus patients. METHODS: The first 400 …
spherical equivalent before and after the implantation of the intrastromal corneal
Ferrara ring in contact lens intolerant keratoconus patients. METHODS: The first 400 …
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[PDF] Insights into the clinical presentation, imaging, and management of infiltrative keratitis following accelerated corneal collagen cross-linking
A Bari, N Sushma, T Agarwal, C Shakkarwal… - Indian Journal of …, 2026
… Purpose: To analyze the risk factors, clinical features, visual outcomes, and in‑vivo
imaging characteristics in cases of keratoconus developing keratitis following
accelerated collagen cross‑linking (CXL). Methods: A retrospective observational …
imaging characteristics in cases of keratoconus developing keratitis following
accelerated collagen cross‑linking (CXL). Methods: A retrospective observational …
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Comparison of corneoscleral topographic consistency in eyes with low-to-moderate and high astigmatism
Z Xiang, D Han, D Gu, Y Qian, Z Chen - Contact Lens and Anterior Eye, 2026
… In keratoconus, the steepest corneal and scleral regions share spatial
consistency [7]. Therefore, it may be speculated that corneoscleral … It was reported
that a patient with keratoconus exhibited a significant change in the scleral elevation …
consistency [7]. Therefore, it may be speculated that corneoscleral … It was reported
that a patient with keratoconus exhibited a significant change in the scleral elevation …
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[PDF] Correlation of Rubbing of Eyes with Keratoconus
A Bibi, M Affan, MI Sadiq, W Ali, MU Sadiq, A Zahid - Journal of Ophthalmology, 2026
… Despite this, there is disagreement over how much rubbing the eyes can
contribute to the development and progression of keratoconus. The goal of the
research is to ascertain whether excessive eye rubbing is linked to keratoconus and …
contribute to the development and progression of keratoconus. The goal of the
research is to ascertain whether excessive eye rubbing is linked to keratoconus and …
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[HTML] Vision-Related Quality of Life in Keratoconus: Cross-Sectional Evaluation and Changes After Corneal Cross-Linking
JQ Gil, P Gil, M Francisco, M Portela, E Garcês… - AJO International, 2026
Purpose To evaluate vision-related quality of life (VR-QoL) in keratoconus using the
Portuguese-validated Keratoconus Outcomes Research Questionnaire (KORQ),
explore its association with clinical and tomographic parameters, and assess short-term …
Portuguese-validated Keratoconus Outcomes Research Questionnaire (KORQ),
explore its association with clinical and tomographic parameters, and assess short-term …
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Validation of a questionnaire on repeated eye-rubbing and ocular microtrauma in patients with keratoconus
D Touboul, V Budnikova, V Saunier, N Thierry… - Journal Français d' …, 2026
… risk factors for the onset and progression of keratoconus. A questionnaire was
developed and … first time to a National Reference Center for Keratoconus (CRNK).
This questionnaire was … inhibition of F&MOR in patients with keratoconus …
developed and … first time to a National Reference Center for Keratoconus (CRNK).
This questionnaire was … inhibition of F&MOR in patients with keratoconus …
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[PDF] … -Linking on Corneal Thickness in Children with Progressive Keratoconus: Collagen Cross-Linking on Corneal Thickness in Children with Progressive Keratoconus
N Kumar, A Fatima, S Tahir, A Sattar, I Ali, MS Farrukh - Pakistan Journal of Health …, 2026
… having progressive Keratoconus [5]. Even the ability to halt progression of
Keratoconus amongst adults has been established well in the published literature.
Treating pediatric Keratoconus using CXL is an area of research that is limited [6, 7] …
Keratoconus amongst adults has been established well in the published literature.
Treating pediatric Keratoconus using CXL is an area of research that is limited [6, 7] …
| | | |
Three-year outcomes of customized transepithelial corneal cross-linking with oxygen supplementation in keratoconus
T Kojima, Y Lin, A Hishida, T Nakamura - BMC Ophthalmology, 2026
… This descriptive, non-comparative analysis showed that custom TE-CXL with
oxygen supplementation may be associated with stabilization of keratoconus over a
3-year period without observed adverse events. Further randomized controlled …
oxygen supplementation may be associated with stabilization of keratoconus over a
3-year period without observed adverse events. Further randomized controlled …
| | | |
[PDF] Validation of Belin ABCD Staging in Clinical and Subclinical Keratoconus: A Pilot Study
MA Abd Elrahman El-Sebaey, AIMR Zaky… - The Egyptian Journal of Hospital …
… ABCD keratoconus (KC) staging in normal, subclinical and clinical keratoconus …
keratoconus patient, whether clinical or subclinical. It may be beneficial in
differentiating between clinical and subclinical keratoconus and keratoconus …
keratoconus patient, whether clinical or subclinical. It may be beneficial in
differentiating between clinical and subclinical keratoconus and keratoconus …
| | | |
Machine Learning in Corneal Ectasia Screening: Performance and Interpretability
D Sá, M Passos, T Peller, I Mendes, A Abreu… - International Conference on …, 2027
… This section describes the ML methodology adopted for the development and
evaluation of models to support the detection of keratoconus. … This analysis
identified the topographic and pachymetric parameters with the greatest influence …
evaluation of models to support the detection of keratoconus. … This analysis
identified the topographic and pachymetric parameters with the greatest influence …
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[HTML] Comparative Diagnostic Efficacy of Swept-Source OCT and Scheimpflug Imaging in Clinically Unaffected Eyes of Very Asymmetric Ectasia
R Herber, T Naujokaitis, R Ambrósio Jr, L Ramm… - Ophthalmology Science, 2026
Purpose To determine the diagnostic ability of corneal tomography indices for
detecting corneal ectasia using a swept-source optical coherence tomography
system (SS-OCT; ANTERION), a rotating Scheimpflug camera system (Pentacam HR) …
detecting corneal ectasia using a swept-source optical coherence tomography
system (SS-OCT; ANTERION), a rotating Scheimpflug camera system (Pentacam HR) …
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Deciphering the Astigmatic Code in Libyan Keratoconus: From Epidemiological Trends to Clinical Precision
W Saadeddin, A Alshareef - AlQalam Journal of Medical and Applied Sciences, 2026
Keratoconus is a progressive corneal ectasia that typically begins in adolescence,
causing irregular astigmatism and visual impairment; in Libya, high consanguinity
rates and intense ultraviolet exposure amplify its prevalence and severity, yet local …
causing irregular astigmatism and visual impairment; in Libya, high consanguinity
rates and intense ultraviolet exposure amplify its prevalence and severity, yet local …
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[HTML] Missed type 2 big bubble as an under-recognized cause of post-deep anterior lamellar keratoplasty double anterior chamber: A case report
P Jain, K Bansal, A Pradhan, P Rangari - Latin American Journal of Ophthalmology, 2026
Deep anterior lamellar keratoplasty (DALK) is commonly performed for stromal
corneal pathology with healthy endothelium. Double anterior chamber is a
recognized early postoperative complication, usually attributed to microperforation of …
corneal pathology with healthy endothelium. Double anterior chamber is a
recognized early postoperative complication, usually attributed to microperforation of …
| | | |
OCT masterclass 9: Anterior OCT
J Higginbotham - Optician, 2026
… Another sign of keratoconus is from the topography curvature maps. With standard,
‘with the rule’ astigmatism as seen on a typical axial curvature map, we have what
we call a classic ‘bow tie’ pattern. Figure 10a shows an example of a classic normal …
‘with the rule’ astigmatism as seen on a typical axial curvature map, we have what
we call a classic ‘bow tie’ pattern. Figure 10a shows an example of a classic normal …
| | | |
Impact of rigid contact lens use on visual acuity and vision-related quality of life in keratoconus
G Şahin Vural, S Sav Ertürk - International Ophthalmology, 2026
… This is consistent with recent evidence demonstrating that keratoconus
significantly affects multiple dimensions of … keratoconus. In the light of these
information, this study aimed to assess visual acuity improvement alongside vision-related …
significantly affects multiple dimensions of … keratoconus. In the light of these
information, this study aimed to assess visual acuity improvement alongside vision-related …
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Corneal allogenic intrastromal ring segment implantation in post crosslinked keratoconus: one-year outcomes from a UK tertiary centre
C Way, A Matsou, H Naveed, M Elalfy - 2026
… Keratoconus is a bilateral corneal ectasia characterised by progressive stromal
thinning and … (CXL) is used to arrest progression in progressive keratoconus,
whereas spectacles, contact lenses, … in coma, which is known to be a more …
thinning and … (CXL) is used to arrest progression in progressive keratoconus,
whereas spectacles, contact lenses, … in coma, which is known to be a more …
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[HTML] Sex Hormone Imbalance in Keratoconus: Estrogen-Mediated Collagen Remodeling and Biomechanical Weakening
M Zhang, Y Liu, N Gao, Y Ma, F Li, X Li, M Cui, S Zhao… - … Ophthalmology & Visual …, 2026
Purpose: To investigate the role of sex hormone imbalance in keratoconus (KC)
pathogenesis and its effects on corneal collagen metabolism and biomechanics.
Methods: Fifteen newly diagnosed, treatment-naïve KC patients and 12 age-and sex-matched …
pathogenesis and its effects on corneal collagen metabolism and biomechanics.
Methods: Fifteen newly diagnosed, treatment-naïve KC patients and 12 age-and sex-matched …
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[HTML] Diagnostic Yield of Keratoconus Among Patients Presenting with Astigmatism≥ 1D at A Tertiary Eye Hospital in Uganda
J Otiti-Sengeri, D Mugisha, J Sengeri, R Ssekitoleko… - AJO International, 2026
Abstract Purpose To determine the diagnostic yield of keratoconus and associated
factors among patients with astigmatism attending a … Keratoconus diagnosis was
confirmed using Scheimpflug imaging reviewed by 2 corneal specialists. The …
factors among patients with astigmatism attending a … Keratoconus diagnosis was
confirmed using Scheimpflug imaging reviewed by 2 corneal specialists. The …
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[HTML] Subclinical corneal endothelial alterations in Familial Mediterranean Fever patients during clinical remission
F Sumer, O Cure, B Kizilkaya, S Subasi - Graefe's Archive for Clinical and …, 2026
… For each eye, the system's built-in keratoconus screening indices (SCORE and
KVf) were reviewed, and any case flagged as keratoconus or keratoconus-suspect
was … Accordingly, no participant in either group carried a diagnosis of keratoconus …
KVf) were reviewed, and any case flagged as keratoconus or keratoconus-suspect
was … Accordingly, no participant in either group carried a diagnosis of keratoconus …
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[HTML] Use of Corneal Allogenic Intrastromal Ring Segments (CAIRS) in High Astigmatism, a Case Report.
B Khayat, OM Alabbasi, G Aljohani - American Journal of Ophthalmology Case …, 2026
Background Corneal allogenic intrastromal ring segments (CAIRS) were developed
as a biologic alternative to synthetic intracorneal ring segments and are primarily
reported in the management of keratoconus and corneal ectasia. Its role in high …
as a biologic alternative to synthetic intracorneal ring segments and are primarily
reported in the management of keratoconus and corneal ectasia. Its role in high …
| | | |
Comparative effectiveness of accelerated and standard corneal cross-linking in pediatrics: a systematic review and meta-analysis
YM Al-Shammari, F Aljassar, SM Al-Shammari… - Graefe's Archive for Clinical …, 2026
… This systematic review is designed to assess the efficacy and safety of the CXL
procedure in pediatric keratoconus compared to that of the standard CXL procedure.
It seeks to clarify whether accelerated treatment provides equivalent disease …
procedure in pediatric keratoconus compared to that of the standard CXL procedure.
It seeks to clarify whether accelerated treatment provides equivalent disease …
| | | |
Correlation Analysis Between Tomographic, Biomechanical, and Chorioretinal Changes in Patients With Keratoconus
MK Pandl, HS Son, M Friedrich, LJ Kessler, MK Köppe… - Journal of Refractive …, 2026
… This comprised 184 eyes of 128 patients diagnosed as having keratoconus, 12
eyes with forme fruste keratoconus (FFK), and 100 eyes of 53 … Therefore, our
results mainly pertain to early-stage keratoconus and may not be generalized for the …
eyes with forme fruste keratoconus (FFK), and 100 eyes of 53 … Therefore, our
results mainly pertain to early-stage keratoconus and may not be generalized for the …
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Keratoconus molecular alterations revealed by Fourier-transform infrared spectroscopy
P Oszczędłowski, A Dróżdż, R Rejdak, K Rękas… - Experimental Eye Research, 2026
Purpose In this study, we aimed to identify infrared spectral markers specific to
keratoconic corneas obtained during penetrating keratoplasty, based on
characteristic molecular alterations associated with the disease. Methods Corneal …
keratoconic corneas obtained during penetrating keratoplasty, based on
characteristic molecular alterations associated with the disease. Methods Corneal …
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[HTML] NEDD8 Promotes the Progression and Inflammation of Keratoconus by Increasing the Expression of YAP1
J Qu, X Zhang, C Wei, H Yu, S Dou, H Gao - Investigative Ophthalmology & Visual …, 2026
Purpose: Keratoconus (KC) is an adolescent-onset vision-impairing corneal disorder
with incompletely elucidated pathogenesis. This study aims to elucidate the
regulatory role of NEDD8 in the Hippo-YAP signaling pathway and its influence on …
with incompletely elucidated pathogenesis. This study aims to elucidate the
regulatory role of NEDD8 in the Hippo-YAP signaling pathway and its influence on …
| | | |
Toll-like receptors in corneal ectasia: linking innate immunity to keratoconus
M Tobeiha, A Peyman, E Foroughi, PV Esfahani… - Molecular biology reports, 2026
Clinical manifestations of keratoconus (KC) are well described; however, its exact
pathophysiology remains unknown. While KC is typically known as a primarily
degenerative disease which progression is accelerated by mechanical trauma, Toll-like …
pathophysiology remains unknown. While KC is typically known as a primarily
degenerative disease which progression is accelerated by mechanical trauma, Toll-like …
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Public knowledge about keratoconus: a cross-sectional online survey in Brazil
ABC Neto, DC Amaral, AMP Silva, ALP Souza… - Rev. bras. oftalmol., 2026
… Global Consensus on Keratoconus, was distributed via social media and an
ophthalmology bulletin. Adults (≥ 18 years) participated anonymously after
providing informed consent. The questionnaire assessed demographics, ocular …
ophthalmology bulletin. Adults (≥ 18 years) participated anonymously after
providing informed consent. The questionnaire assessed demographics, ocular …
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Baseline Demographics and Topographic Features in Keratoconic Eyes With Hydrops After Ipsilateral Prior Corneal Cross-linking
P Sudanaboina, S Misra, MH Ali, M Fernandes… - Journal of Refractive …, 2026
… Several studies have reported the efficacy of CXL in preventing the progression of
keratoconus.… Acute hydrops is a complication that occurs in severe and
progressive keratoconus, arising … 2 keratoconus, two eyes had stage 3 …
keratoconus.… Acute hydrops is a complication that occurs in severe and
progressive keratoconus, arising … 2 keratoconus, two eyes had stage 3 …
| | | |
An Eye Rubbing Detection Using Smartwatch and Machine Learning
J Wu, P Han - IETE Journal of Research, 2026
Frequent eye rubbing (ER) is associated with progressive ocular conditions such as
keratoconus and dry eye disease. Continuous and objective ER monitoring is
therefore clinically important, yet remains challenging due to class imbalance and …
keratoconus and dry eye disease. Continuous and objective ER monitoring is
therefore clinically important, yet remains challenging due to class imbalance and …
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[HTML] Non-antibiotic management of bacterial keratitis
M Akbar, C Phung, A Monical, ML Armstrong… - Saudi Journal of …, 2026
… developed and have been tested largely in keratoconus treatment. A next step
will be testing … -linking, which has shown some promise in keratoconus treatment
but has no current data on … in keratoconus, although it is an important area for …
will be testing … -linking, which has shown some promise in keratoconus treatment
but has no current data on … in keratoconus, although it is an important area for …
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[HTML] Clinical outcomes of Chinese eyes with irregular corneas managed with a scleral lens
Q Tan, J Jiang, P Cho, SJ Vincent - Eye Discovery, 2026
Purpose To evaluate the clinical outcomes of a four-zone scleral lens in the
management of Chinese eyes with irregular corneas from primary or secondary
corneal ectasias, corneal transplants, and corneal scarring. Methods This was a …
management of Chinese eyes with irregular corneas from primary or secondary
corneal ectasias, corneal transplants, and corneal scarring. Methods This was a …
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[PDF] Factors influencing clinical research participation in ophthalmology: a mixed-methods study in keratoconus
N Boychev, K Shakya, J Kopel, N Venkateswaran… - Scientific Reports, 2026
Keratoconus (KC) disproportionately affects young and underserved populations,
yet clinical research participation remains unevenly distributed. To inform equitable
recruitment strategies, we investigated demographic, behavioral, and perceptual …
yet clinical research participation remains unevenly distributed. To inform equitable
recruitment strategies, we investigated demographic, behavioral, and perceptual …
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[HTML] Multimodal Classification of Keratoconus Progression Using Corneal Surface Geometry and Refractive Data: The Role of Peripheral Regions and Missing-Data …
C Cano-Espinosa, J González, C Gómez, JM Bolarín… - Knowledge-Based Systems, 2026
… Keratoconus is a progressive corneal disorder characterized by thinning and
irregular deformation of the cornea, which … of keratoconus progression are
therefore essential for effective clinical management. This study presents a …
irregular deformation of the cornea, which … of keratoconus progression are
therefore essential for effective clinical management. This study presents a …
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[HTML] Bilateral lens subluxation in a patient with homocystinuria: a case report
Z Zhan, J Cai, J Wang, X Liu, D Nie, D Ma - American Journal of Ophthalmology Case …, 2026
Purpose To report a case of bilateral lens subluxation associated with
homocystinuria that had been previously misdiagnosed with high myopia, amblyopia,
and keratoconus. Observations A 19-year-old Asian female presented with …
homocystinuria that had been previously misdiagnosed with high myopia, amblyopia,
and keratoconus. Observations A 19-year-old Asian female presented with …
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[HTML] Cataract surgery in corneal disease
S Anand
… Where available, disease specific formulas should be used (such as for post-refractive
surgery eyes or keratoconus). In keratoconus, the keratoconus-specific formulae (Barrett
True-K, Kane Keratoconus) have been shown to perform better than generic …
surgery eyes or keratoconus). In keratoconus, the keratoconus-specific formulae (Barrett
True-K, Kane Keratoconus) have been shown to perform better than generic …
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Development and Validation of a Non-Invasive RT-qPCR Protocol for Nrf2 mRNA Quantification in Human Tear Fluid: A Platform for Ocular Surface Redox Biomarker …
RGC Leça, FLA Fonseca, GL da Veiga, B Alves… - Experimental eye research
Nuclear factor erythroid 2-related factor 2 (Nrf2) is the master transcriptional
regulator of cellular antioxidant responses and has been implicated in ocular
surface diseases including keratoconus and dry eye. However, validated methods …
regulator of cellular antioxidant responses and has been implicated in ocular
surface diseases including keratoconus and dry eye. However, validated methods …
| | | |
[PDF] The Future of Interventional Keratoconus Management: Perspectives on Integrating Epithelium-on Oxygen-Enriched Cross-Linking into Comprehensive Care …
KA Beckman, ZA Syed, SJ Gromacki - Therapeutics and Clinical Risk Management, 2026
… and quality of life for patients with keratoconus; it also may reduce the economic
burden of keratoconus for health systems and society by … -centered, interventional
keratoconus care pathway will likely require expanded awareness and education …
burden of keratoconus for health systems and society by … -centered, interventional
keratoconus care pathway will likely require expanded awareness and education …
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[HTML] Corneal tissue addition keratoplasty for the treatment of keratoconus
M Diamandi, BH Feldman - 2026
Methods: We conducted a single center, prospective, open label clinical trial where
CTAK was performed on 11 patients, 12 eyes. Patients were selected based on any
of the following indications: contact lens intolerance, unsatisfactory level of visual …
CTAK was performed on 11 patients, 12 eyes. Patients were selected based on any
of the following indications: contact lens intolerance, unsatisfactory level of visual …
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Role of an optimized tomographic biomechanical index for keratoconus screening in laser vision correction candidates in Thailand.
N Teeyapant, P Phrueksaudomchai - 2026
… in differentiating between normal populations and subclinical keratoconus or
keratoconus populations, although the difference was not … early keratoconus and
at-risk patients. The cTBI could help reduce the false positive rate of diagnosing …
keratoconus populations, although the difference was not … early keratoconus and
at-risk patients. The cTBI could help reduce the false positive rate of diagnosing …
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Corneal Sub-basal Nerve Fiber Plexus Tortuosity in Eyes with Ectasia Susceptibility and Keratoconus: A Cross-sectional In Vivo Confocal Microscopy Study
M Aghi, E Spoerl, R Khoramnia, F Raiskup, R Herber - The ocular surface
Purpose This study used in vivo confocal microscopy (IVCM) to examine changes in
the sub-basal corneal nerve plexus (SBNP) in susceptibility to ectasia and clinical
keratoconus (KC). Methods Eighty-one eyes of 81 participants with no previous …
the sub-basal corneal nerve plexus (SBNP) in susceptibility to ectasia and clinical
keratoconus (KC). Methods Eighty-one eyes of 81 participants with no previous …
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[HTML] Case Report: Effective management of acute corneal hydrops with concurrent nystagmus and retinitis pigmentosa: combination of deep lamellar corneal suturing and …
Y Zhou, A Aishan, YC Yang, X Li - Frontiers in Medicine, 2026
… Diagnosed with bilateral keratoconus concurrently with retinitis pigmentosa and
nystagmus … Three patients presented with acute corneal edema due to rapid
progression of keratoconus. … the tears with keratoconus patients and the relation …
nystagmus … Three patients presented with acute corneal edema due to rapid
progression of keratoconus. … the tears with keratoconus patients and the relation …
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Stromal Transplantation and corneal-sparing techniques in ectatic diseases
T Hayashi, A Igarashi, K Fujiwara, H Kobashi, HS Son… - Progress in retinal and eye …
… In this review, we summarise the structural basis of corneal biomechanics, the
pathological mechanisms of stromal failure in keratoconus and related disorders,
and the biological responses that follow stromal interventions. We then evaluate …
pathological mechanisms of stromal failure in keratoconus and related disorders,
and the biological responses that follow stromal interventions. We then evaluate …
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[PDF] Finite element simulation for finding shear wave velocity on the Feline cornea and Comparison with shear wave velocity on human cornea, canine, and keratoconus
P Mazinani - Comptes Rendus. Mécanique, 2026
This study presents a finite element (FE) simulation framework for determining the
shear wave velocity of the feline cornea and comparing it with human, canine, and
keratoconic corneas. A hyperviscoelastic material model was implemented in …
shear wave velocity of the feline cornea and comparing it with human, canine, and
keratoconic corneas. A hyperviscoelastic material model was implemented in …
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[TXT] Research Paper/Araştırma Makalesi
İ Toprak, C Yıldırım, V Yaylalı
… Materials and Methods: This retrospective study included 133 patients with
keratoconus and … measurements appear to be altered by aging in both
keratoconus and control groups, … whereas eyes with keratoconus in all age …
keratoconus and … measurements appear to be altered by aging in both
keratoconus and control groups, … whereas eyes with keratoconus in all age …
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[HTML] Anterior Segment Eye Diseases and Quality of Life: An Updated Comprehensive Narrative Review
M Khorrami-Nejad, F Narooie-Noori, Q Al-khafaji… - Journal of Ophthalmic and …, 2026
Anterior segment eye diseases significantly affect patients’ quality of life (QoL) by
impairing physical health, psychological well-being, social interactions, and
economic stability. Conditions such as dry eye disease, blepharitis, conjunctivitis …
impairing physical health, psychological well-being, social interactions, and
economic stability. Conditions such as dry eye disease, blepharitis, conjunctivitis …
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[PDF] A deep learning approach for keratoconus detection using spatio-temporal features from corneal imaging
A Syta, T Chorągiewicz, J Gęca, R Karpiński… - Scientific Reports, 2026
Keratoconus is a progressive corneal disease that requires early and accurate
detection to prevent severe visual impairment. This study presents a deep learning-based
classification model for distinguishing between healthy and keratoconic eyes using …
detection to prevent severe visual impairment. This study presents a deep learning-based
classification model for distinguishing between healthy and keratoconic eyes using …
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[HTML] Genetic and biomechanical factors in keratoconus: a review of pathogenic mechanisms, diagnostic strategies, and risk stratification
W Pielak, J Koszewski, A Janiszewska, W Kołkowski… - Quality in Sport, 2026
Background. Keratoconus (KC) is a progressive, asymmetric corneal ectasia driven
by inherited extracellular matrix variation that establishes a baseline biomechanical
phenotype on which eye rubbing and atopy precipitate disease. Aim. To synthesize …
by inherited extracellular matrix variation that establishes a baseline biomechanical
phenotype on which eye rubbing and atopy precipitate disease. Aim. To synthesize …
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[HTML] Regional Biomechanical and Topographic Changes following Epi-on vs Epi-off Continuous ACXL in Keratoconus: SSIv2 as a Superior Biomarker
BX Mao, CC He, Q Ye, WJ Liu, YQ Li, D Oehring… - Ophthalmology Science, 2026
AbstractPurposeTo compare regional biomechanical and topographic outcomes
between transepithelial (Epi-on) and epithelium-off (Epi-off) continuous accelerated
corneal cross-linking (ACXL) in keratoconus.DesignRetrospective cohort study.Subjects77 …
between transepithelial (Epi-on) and epithelium-off (Epi-off) continuous accelerated
corneal cross-linking (ACXL) in keratoconus.DesignRetrospective cohort study.Subjects77 …
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Causal associations between sex hormones and keratoconus: a two-sample Mendelian randomization study
W Zhao, J Feng, X Chen, H Zhang, Z Dong - Ophthalmic Genetics, 2026
Introduction This Mendelian randomization (MR) study evaluated potential causal
associations between sex hormones and keratoconus (KC) using large-scale GWAS
summary data. Methods The primary analysis utilized the inverse-variance weighted …
associations between sex hormones and keratoconus (KC) using large-scale GWAS
summary data. Methods The primary analysis utilized the inverse-variance weighted …
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Evaluation of epithelial, stromal, and corneal thickness maps in the distinction between pellucid marginal degeneration and inferior keratoconus (pellucid-like)
BDY Erdal, B Kazancı - BMC ophthalmology
Background To distinguish between these two ectasias, which can be confused with
each other, using epithelial, stromal, and total corneal thickness maps in patients
with pellucid marginal degeneration (PMD) and inferior keratoconus (I-KC) that have …
each other, using epithelial, stromal, and total corneal thickness maps in patients
with pellucid marginal degeneration (PMD) and inferior keratoconus (I-KC) that have …
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[HTML] MD, FACS 1✉, 3 Phone+ 905326025879 Email aypelit@ yahoo. com Zeynep Kunt MD 1 Email zynp. kunt@ gmail. com
A Pelit
… progression of keratoconus [2–5]. Standard CXL is a safe and approved
procedure that was shown to stabilize the progressive keratoconus. … Patients with
moderate and advanced keratoconus were included in our study. A placido disk …
procedure that was shown to stabilize the progressive keratoconus. … Patients with
moderate and advanced keratoconus were included in our study. A placido disk …
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[HTML] ORCID ID: 0009-0004-2800-6612 Co-Corresponding author: Prof QinMei Wang, MD No. 270 Xueyuan West Road, WenZhou City, ZheJiang Prov, 325027, China e …
FJ Bao
… In summary, both transPTK ACXL and transEpi ACXL are effective in halting the
progression of keratoconus and improving corneal biomechanical properties.
However, transPTK ACXL appears to offer superior biomechanical improvements …
progression of keratoconus and improving corneal biomechanical properties.
However, transPTK ACXL appears to offer superior biomechanical improvements …
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[HTML] Eye Repair Lab, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy 2 Cornea and Ocular Surface Disease Service, Ophthalmology …
M Pederzolli, A Rocchetti, G Ferrari, P Torreri…
… Because not all patients with a KC diagnosis may attend referral centers, we used
the term “average yearly report rate” rather than “incidence” to express the number
of keratoconus diagnoses registered on average in a year based on the total …
the term “average yearly report rate” rather than “incidence” to express the number
of keratoconus diagnoses registered on average in a year based on the total …
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Contact Lens usage in pediatric patients: Experiences from a tertiary eyecare center in Turkey
AS Balci, B Altindis, K Sen, GG Akgun, F Ozcelik - Contact Lens and Anterior Eye, 2026
… Five patients were wearing contact lenses for ametropia and two for keratoconus;
ametropic patients used soft contact lenses, whereas those with keratoconus wore
rigid corneal lenses. Contact lens wear was discontinued in all cases following the …
ametropic patients used soft contact lenses, whereas those with keratoconus wore
rigid corneal lenses. Contact lens wear was discontinued in all cases following the …
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A practical and efficient technique for corneal allogenic ring segment implantation: prolene suture-guided insertion
Y Koçluk, MT Albayrak, B Kasım, B Özkan - Cell and Tissue Banking, 2026
… Medical records and surgical videos of patients who underwent CAIRS for
keratoconus were retrospectively reviewed. All procedures were performed by the
same surgeon using standardized femtosecond laser parameters. Donor stromal …
keratoconus were retrospectively reviewed. All procedures were performed by the
same surgeon using standardized femtosecond laser parameters. Donor stromal …
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[PDF] Pattern and Prevalence of Ocular Morbidity in School Children: A Cross-Sectional Statistical Study in District Haripur, Pakistan
N Ullah, O Chohan, MM Khan, JF Wazir, I Ahmad…
… Some other ocular conditions such as Ptosis were 0.3% and Nystagmus,
Keratoconus and Chalazion were found 0.4% collectively. The … conditions such as
ptosis 0.3% and other conditions as nystagmus, keratoconus and chalazion was …
Keratoconus and Chalazion were found 0.4% collectively. The … conditions such as
ptosis 0.3% and other conditions as nystagmus, keratoconus and chalazion was …
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Updates on Refractive Surgery: Benefits, Risks, and Costs of Modern Treatment Options
D Bandaru, IS Zhou, D Zhu - Current Opinion in Ophthalmology
… This study demonstrates a significant niche role for PRK in patients with
suspected keratoconus, indicating that simultaneous PRK and CXL can enhance
visual acuity and refractive outcomes without evidence of ectasia over a 12-month …
suspected keratoconus, indicating that simultaneous PRK and CXL can enhance
visual acuity and refractive outcomes without evidence of ectasia over a 12-month …
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[HTML] Eye Center at Medical Center, University of Freiburg, Killianstraße 5, 79106 Freiburg im Breisgau, Germany 2 Eye Hospital, University Hospital of Basel, Switzerland …
S Nuessle, M Glegola, T Schulz, T Reinhard
… Following the initial diagnosis of keratoconus in 1960 (n = 1, 27%), there was a
continuous yet … for keratoconus exhibits a right-skewed asymmetry, with
diagnoses occurring from age 13 onwards and a modal value of 28 years (n = 34) …
continuous yet … for keratoconus exhibits a right-skewed asymmetry, with
diagnoses occurring from age 13 onwards and a modal value of 28 years (n = 34) …
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[HTML] Simone Nuessle1, Mateusz Glegola1, Tabea Schulz1, Thomas Reinhard1
J Haedrich, C Auw-Haedrich
… The age distribution for keratoconus exhibits a right-skewed asymmetry, with
diagnoses occurring from age 13 onwards and a modal value of 28 years (n = 34).
The highest age at surgery for keratoconus was 92 years (n = 1). In contrast, the age …
diagnoses occurring from age 13 onwards and a modal value of 28 years (n = 34).
The highest age at surgery for keratoconus was 92 years (n = 1). In contrast, the age …
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[PDF] Long-term results of excimer laser interventions in the combined treatment of keratoconus: 2 years of follow-up
SY Mogilevskyy, IV Afanasiev, LI Denysiuk - Archive of Ukrainian Ophthalmology, 2026
… Keratoconus is a common progressive corneal disorder that leads to a decline in
visual … excimer laser techniques as part of combined treatment for keratoconus
over a 2-year follow-up … Keratoconus progression was observed only in the first …
visual … excimer laser techniques as part of combined treatment for keratoconus
over a 2-year follow-up … Keratoconus progression was observed only in the first …
| | | |
[PDF] Bilateral inverse Keratoconus with Descemet's membrane folds: A rare case report
C Deepthi, T Mandadi, GV Prabhakar, T Islam
… However, rare variants such as inverse keratoconus exhibit predominant superior
corneal … We report a rare case of bilateral inverse keratoconus with Descemet’s
membrane folds, in … atypical for classical keratoconus and hence supports the …
corneal … We report a rare case of bilateral inverse keratoconus with Descemet’s
membrane folds, in … atypical for classical keratoconus and hence supports the …
| | | |
Evaluation of epithelial, stromal, and corneal thickness maps in the distinction between pellucid marginal degeneration and inferior keratoconus (pellucid-like)
BD Yıldırım Erdal, B Kazancı - BMC Ophthalmology, 2026
Background To distinguish between these two ectasias, which can be confused with
each other, using epithelial, stromal, and total corneal thickness maps in patients
with pellucid marginal degeneration (PMD) and inferior keratoconus (I-KC) that have …
each other, using epithelial, stromal, and total corneal thickness maps in patients
with pellucid marginal degeneration (PMD) and inferior keratoconus (I-KC) that have …
| | | |
[PDF] Eyelid Elevation and Ocular Surface Rehabilitation Using Quadrant-Asymmetric Scleral Contact Lenses in Facial Nerve Palsy with Keratoconus: A 2-Case Series
N Erdinest, Z Gur, M Tabi, N Blum, N Shemesh… - Case Reports in …, 2026
Introduction: Facial nerve palsy (FNP) with associated ptosis and keratoconus (KC)
presents a combined challenge of visual dysfunction, ocular surface disease, and
cosmetic impairment. While surgical procedures are frequently performed, scleral …
presents a combined challenge of visual dysfunction, ocular surface disease, and
cosmetic impairment. While surgical procedures are frequently performed, scleral …
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[PDF] Predictive Accuracy of Intraocular Lens Power Calculation Formulas for Cataract Surgery in Keratoconus: A Systematic Review and Network Meta-Analysis
FF Aljahdali, M Albadri, RK Sharif, BJ Alharbi… - Clinical Ophthalmology, 2026
… In addition, the severity of keratoconus plays an important role in refractive
predictability. As the disease progresses, increasing corneal … More recently,
keratoconus-specific formulas such as the Kane Keratoconus and Barrett True-K …
predictability. As the disease progresses, increasing corneal … More recently,
keratoconus-specific formulas such as the Kane Keratoconus and Barrett True-K …
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[HTML] Combination of tissue-derived and shape-based parameters for subclinical keratoconus detection
J Casado-Moreno, AR Arizcuren, JJ Rozema… - Biomedical Optics Express, 2026
This study investigates whether combining clinically conventional shape-based
tomographic parameters and image-derived descriptors extracted from raw
Scheimpflug corneal images improves the detection of subclinical keratoconus (SKC) …
tomographic parameters and image-derived descriptors extracted from raw
Scheimpflug corneal images improves the detection of subclinical keratoconus (SKC) …
| | | |
Identification of Candidate Genes for Keratoconus by Trio-Based Whole-Exome Sequencing in 81 Families from Northwestern China
Z Lin, J Zhang, B Cai, R Li, W Li, B Li, Z Wang, K Liu… - Experimental Eye Research, 2026
AbstractKeratoconus (KC) is a progressive corneal ectatic disorder with genetic
heterogeneity, yet the genetic variants underlying familial cases remain poorly
characterized. We performed Trio-based whole-exome sequencing (Trio-WES) on …
heterogeneity, yet the genetic variants underlying familial cases remain poorly
characterized. We performed Trio-based whole-exome sequencing (Trio-WES) on …
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[HTML] The macular microvasculature evaluated by OCTA in various stages of keratoconus compared to healthy controls: A cross-sectional study
R Sorkhabi, A Mostafaie, MH Ahoor, A Teymoorpoor… - … and Photodynamic Therapy, 2026
AbstractObjectiveTo investigate the macular microvasculature and thickness in
keratoconus (KCN) cases with various stagings and compare them with healthy
controls.DesignCross-sectionalMethods110 eyes of 57 KCN cases (35 males and …
keratoconus (KCN) cases with various stagings and compare them with healthy
controls.DesignCross-sectionalMethods110 eyes of 57 KCN cases (35 males and …
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A78-14 Spontaneous Pneumothorax as the Initial Manifestation of Birt-Hogg-Dubé Syndrome: A Case Report
H Alshabatat, A Tempowski - American Journal of Respiratory and Critical Care …, 2026
… A 48-year-old male with asthma and keratoconus presented with sudden left
apical chest pain and dyspnea in January 2023. He denied trauma, hemoptysis,
fever, or travel. Examination showed hemodynamic stability with mild left …
apical chest pain and dyspnea in January 2023. He denied trauma, hemoptysis,
fever, or travel. Examination showed hemodynamic stability with mild left …
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[PDF] Interventional Keratoconus Management: The Critical Imperative for Early Detection and Treatment
KM Hatch, E Donnenfeld, AS Morgenstern, MJ Ibach - Clinical Ophthalmology, 2026
… Citation20 If misdiagnosed as simple myopia, patients with subclinical
keratoconus undergoing corneal refractive surgery are at high risk … and preserve
quality of life in patients with keratoconus. Screening for keratoconus will have …
keratoconus undergoing corneal refractive surgery are at high risk … and preserve
quality of life in patients with keratoconus. Screening for keratoconus will have …
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CornOrb: A Multimodal Dataset of Orbscan Corneal Topography and Clinical Annotations for Keratoconus Detection
M El Amine Lazouni, L Ryma Lazouni… - arXiv e-prints, 2026
In this paper, we present CornOrb, a publicly accessible multimodal dataset of
Orbscan corneal topography images and clinical annotations collected from patients
in Algeria. The dataset comprises 1,454 eyes from 744 patients, including 889 …
Orbscan corneal topography images and clinical annotations collected from patients
in Algeria. The dataset comprises 1,454 eyes from 744 patients, including 889 …
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Corneal allogenic intrastromal ring segments improve visual and topographic outcomes in advanced keratoconus: Short Title: CAIRS in Advanced Keratoconus
N YEŞİLIRMAK, N Kara, B Aksoy, D Ulusoy - Scientific Reports, 2026
… patients with advanced keratoconus. This retrospective observational study
included 25 eyes of 20 patients with advanced keratoconus (defined … In conclusion,
CAIRS provided substantial visual, refractive, and topographic improvements in …
included 25 eyes of 20 patients with advanced keratoconus (defined … In conclusion,
CAIRS provided substantial visual, refractive, and topographic improvements in …
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[PDF] Keratoconus and Its Effects on Visual Acuity: Early Diagnosis: Ali Saeed Mahdi and Salam Tareq Jawad
AS Mahdi, ST Jawad - Dijlah Journal of Medical Sciences P-ISSN: 3078-3178 …, 2026
… by the loss of quality of life associated with keratoconus. Research in the scientific
community still … morphologic characteristics of patients with keratoconus based on
the advanced diagnostic … knowledge and the process of diagnostic and treatment …
community still … morphologic characteristics of patients with keratoconus based on
the advanced diagnostic … knowledge and the process of diagnostic and treatment …
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[PDF] Effectiveness and Safety of Contact Lens-Assisted Collagen Cross-Linking in Thin Corneas with Progressive Keratoconus: A Prospective Interventional Study
J Singh, P Chahar, P Sharma - International Journal of Pharmacy Research & …, 2026
… keratoconus. Contact lens-assisted collagen cross-linking (CACXL) has emerged
as a potential alternative for thin corneas. … keratoconus with thin corneas. Methods:
This hospital-based interventional study included 75 eyes of 48 adult patients with …
as a potential alternative for thin corneas. … keratoconus with thin corneas. Methods:
This hospital-based interventional study included 75 eyes of 48 adult patients with …
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Outcomes of high-fluence (7.2 J/cm2) accelerated collagen cross-linking in advanced keratoconus
E Can - Taiwan Journal of Ophthalmology, 2026
… MATERIALS AND METHODS: This retrospective cohort study included 109 eyes from
96 patients with advanced keratoconus (preoperative maximum keratometry, Kmax ≥58
D). All patients underwent an accelerated epi‑off CXL protocol (12 mW/cm2 for 10 min; …
96 patients with advanced keratoconus (preoperative maximum keratometry, Kmax ≥58
D). All patients underwent an accelerated epi‑off CXL protocol (12 mW/cm2 for 10 min; …
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Advances in Corneal Biomechanical Characterization via Corvis ST: Review and Prospects
SJ Wu, PJ Shih - Multiscale Science and Engineering, 2026
The Corvis ST (Oculus, Germany) has emerged as a leading non-contact device for
in vivo assessment of corneal biomechanics, combining ultra-high-speed
Scheimpflug imaging with a precisely controlled air-puff to capture dynamic corneal …
in vivo assessment of corneal biomechanics, combining ultra-high-speed
Scheimpflug imaging with a precisely controlled air-puff to capture dynamic corneal …
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Corneal Allogeneic Intrastromal Ring Segments for keratoconus–recent evidence and the move to customized and custom shaped CAIRS
S Jacob, ST Awwad, A Agarwal - Current Opinion in Ophthalmology
… This review focuses on the use in patients with keratoconus, of corneal allogeneic
intrastromal ring segments (CAIRS) as well as customized and custom shaped
CAIRS for corneal reshaping, stabilization and individualized, tissue-based corneal …
intrastromal ring segments (CAIRS) as well as customized and custom shaped
CAIRS for corneal reshaping, stabilization and individualized, tissue-based corneal …
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Comment on “Optical Coherence Tomography Radiomics and Machine Learning Enable Accurate Detection of Forme Fruste Keratoconus”
R Shanthi, K Kavitha - American Journal of Ophthalmology
… [1], who applied radiomics-based machine learning to optical coherence
tomography (OCT) images for the detection of forme fruste keratoconus. This
approach addresses a clinically consequential diagnostic gap for forme fruste …
tomography (OCT) images for the detection of forme fruste keratoconus. This
approach addresses a clinically consequential diagnostic gap for forme fruste …
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Corneal epithelial mapping after accelerated corneal cross-linking: early remodeling patterns
SA Rattan, AA Jawad - International ophthalmology, 2026
Purpose To evaluate early regional corneal epithelial thickness changes following
accelerated epithelium-off corneal cross-linking (CXL) in progressive keratoconus
using anterior segment optical coherence tomography (AS-OCT), and to explore …
accelerated epithelium-off corneal cross-linking (CXL) in progressive keratoconus
using anterior segment optical coherence tomography (AS-OCT), and to explore …
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Data-Driven Modelling of Corneal Diseases Using Machine Learning
H Jomaa - 2026
… The thesis presented here addresses this problem through interpretable data-driven
modelling across two related corneal ectatic conditions: keratoconus and post–laser
vision correction ectasia. For keratoconus, classification was first studied using …
modelling across two related corneal ectatic conditions: keratoconus and post–laser
vision correction ectasia. For keratoconus, classification was first studied using …
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[TXT] SPIEDigitalLibrary. org/conference-proceedings-of-spie
H Bouazizi, I Brunette, J Meunier - Proc. of SPIE Vol
… have tested 10 cornea with keratoconus and 30 corneas with Fuchs’ dystrophy.
Keratoconus is a disorder of the eye which … Corneas that were diagnosed as
keratoconus were more distorted than normal corneas, so, RMS errors were always more …
Keratoconus is a disorder of the eye which … Corneas that were diagnosed as
keratoconus were more distorted than normal corneas, so, RMS errors were always more …
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Clinical Outcomes and Safety of Customized Corneal Cross-linking for Keratoconus: A Systematic Review and Meta-analysis
JH Hsu, TH Tsai, TW Lin - Journal of Refractive Surgery, 2026
… -linking (CXL) has been the cornerstone treatment for halting keratoconus
progression by biomechanically stiffening the cornea.Long-term studies … Moreover,
because keratoconus is focal rather than diffuse,6 uniformly stiffening the entire …
progression by biomechanically stiffening the cornea.Long-term studies … Moreover,
because keratoconus is focal rather than diffuse,6 uniformly stiffening the entire …
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[HTML] The impact of contact lenses on binocular vision in patients with Keratoconus
ZD Rahmatabadi, SA Naroo, F Hatami, S Abdi… - Journal of Optometry, 2026
AbstractBackgroundTo compare the effect of corneal rigid and scleral contact lenses
(CRCL & SCL) on binocular vision and accommodative function in keratoconus (KCN)
patients.MethodsIn this prospective non- randomized comparative interventional …
(CRCL & SCL) on binocular vision and accommodative function in keratoconus (KCN)
patients.MethodsIn this prospective non- randomized comparative interventional …
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[HTML] Len opacification following corneal cross-linking for keratoconus in a young woman
A Chingan, Y Louanchi, L Beral - Indian Journal of Ophthalmology-Case Reports, 2026
… keratoconus to strengthen the corneal stroma by formation of covalent cross-link
by exposing the cornea to UVA radiation. We report the case of 14-year-old girl who
was followed for evolving bilateral keratoconus. … that developed after CXL for …
by exposing the cornea to UVA radiation. We report the case of 14-year-old girl who
was followed for evolving bilateral keratoconus. … that developed after CXL for …
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[HTML] Epithelial ingrowth following Bowman layer anterior stromal transplantation managed with Nd: YAG laser: A case report
P Kher, SKV Satyamurthy, AN Shastri, SS Male - Indian Journal of Ophthalmology …, 2026
… A 20-year-old female underwent Bowman layer anterior stromal transplantation (BLAST)
for advanced keratoconus in her right eye. … layer anterior stromal transplantation (BLAST)
for advanced keratoconus (KC) and its successful management with YAG laser …
for advanced keratoconus in her right eye. … layer anterior stromal transplantation (BLAST)
for advanced keratoconus (KC) and its successful management with YAG laser …
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Imaging in anterior segment disorders
N Kapur, A Gour, V Sangwan - Current Opinion in Ophthalmology
… Differentiating Pellucid marginal degeneration (PMD) from other ectatic disorders
like keratoconus is challenging due to multiple overlapping clinical features. High
against-the-rule astigmatism with inferior peripheral steepening extending into the …
like keratoconus is challenging due to multiple overlapping clinical features. High
against-the-rule astigmatism with inferior peripheral steepening extending into the …
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[HTML] Prosthetic Corneal Surgery: A Narrative Review of Current Keratoprostheses and the Future Prospects of New Biomaterials
Ł Drzyzga, D Śpiewak, M Dorecka… - Bioengineering, 2026
… The progression of keratoconus in young populations (10–25 years of age) is as
high as 88% [3], with pediatric keratoconus showing a significantly higher
progression rate than keratoconus in adult populations. Advanced stages may be …
high as 88% [3], with pediatric keratoconus showing a significantly higher
progression rate than keratoconus in adult populations. Advanced stages may be …
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[HTML] Diagnostic Value of Sirius Scheimpflug–Placido Corneal Tomography in Keratoconus and Subclinical Keratoconus
A Dal, SA Postacı, T Akikol, B Kutluksaman - Photodiagnosis and Photodynamic …, 2026
AbstractPurpose: To determine the diagnostic accuracy and optimal threshold
values of anterior and posterior corneal parameters obtained with the Sirius+
Scheimpflug–Placido tomography system in detecting clinical keratoconus (KCN) …
values of anterior and posterior corneal parameters obtained with the Sirius+
Scheimpflug–Placido tomography system in detecting clinical keratoconus (KCN) …
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Keratoconus Profile in the Elderly: Prevalence and Clinical Indices
M Khabazkhoob - Cornea, 2026
… To assess the prevalence and associated characteristics of keratoconus (KCN)
among individuals aged 60 years and older. … Keratoconus (KCN) is a significant
progressive ectasia characterized by corneal thinning and irregular astigmatism …
among individuals aged 60 years and older. … Keratoconus (KCN) is a significant
progressive ectasia characterized by corneal thinning and irregular astigmatism …
| | | |
Imaging in anterior segment disorders
N Kapur, A Gour, V Sangwan - Current Opinion in Ophthalmology
… Differentiating Pellucid marginal degeneration (PMD) from other ectatic disorders
like keratoconus is challenging due to multiple overlapping clinical features. High
against-the-rule astigmatism with inferior peripheral steepening extending into the …
like keratoconus is challenging due to multiple overlapping clinical features. High
against-the-rule astigmatism with inferior peripheral steepening extending into the …
| | | |
Advances in in vivo Measurement Methods for Ocular Biomechanical Material Properties
Q Li, J Wang, K Wang, G Lan, K Qiu, D Wang, X Wang - Yiyong Shengwu Lixue …, 2026
The cornea, sclera, and optic nerve head (ONH) are critical tissues for maintaining
ocular structural integrity and visual function. In recent years, glaucoma, keratoconus,
and high myopia have been confirmed to be closely associated with biomechanical …
ocular structural integrity and visual function. In recent years, glaucoma, keratoconus,
and high myopia have been confirmed to be closely associated with biomechanical …
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Machine learning–based transcriptomic analysis of differentially expressed genes in the epithelium and stroma of keratoconus
K Du, R Peng, G Xiao, Y Qu, L Han, J Hong - Human Genomics, 2026
Background This study was conducted to delineate layer-specific transcriptomic
alterations in the keratoconus (KC) epithelium and stroma and to identify potential
biomarkers using machine learning (ML)-based analysis. Methods Two publicly …
alterations in the keratoconus (KC) epithelium and stroma and to identify potential
biomarkers using machine learning (ML)-based analysis. Methods Two publicly …
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Update on topography and tomography for refractive surgery
VM Fernandes, C McGlone, KB Fernandez, KM Rocha - Current Opinion in Ophthalmology
… Recent innovations in corneal topography and tomography have greatly
improved the ability to detect subclinical keratoconus, evaluate corneal
biomechanics, and develop personalized surgical plans. The integration of 3D …
improved the ability to detect subclinical keratoconus, evaluate corneal
biomechanics, and develop personalized surgical plans. The integration of 3D …
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Advances in anterior segment imaging
D Henick, J Chow - Current Opinion in Ophthalmology
… and monitoring of keratoconus, there is a continued effort to diagnose
keratoconus in its … of keratoconus, with an overall area under the curve of 0.68 in
their prediction model [20▪] . In this investigation, no differences were found between …
keratoconus in its … of keratoconus, with an overall area under the curve of 0.68 in
their prediction model [20▪] . In this investigation, no differences were found between …
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[HTML] Evaluation of an allied health professionals-led keratoconus service in a tertiary UK centre
LE Boddy, SY Woo, P Murch, D Said, HS Dua - Eye, 2026
… This paper evaluates the outcomes of an AHP-led keratoconus service reviewing
both untreated keratoconus patients and patients treated with CXL. Ophthalmology
referrals comprise 10% of all outpatient referrals in the UK, the largest of any …
both untreated keratoconus patients and patients treated with CXL. Ophthalmology
referrals comprise 10% of all outpatient referrals in the UK, the largest of any …
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[PDF] N, S Co-Doped Carbon Quantum Dots-Riboflavin Composite Photosensitizers for Enhanced Iontophoresis-Assisted Corneal Cross-Linking
T Xu, Y Liu, W Zhang, Q Jiang, Y Jin, L Lin, L Wang… - Advanced Science
… Iontophoresis-assisted corneal cross-linking (I-CXL) is an emerging
transepithelial technique for treating keratoconus. I-CXL employs a small … the
superiority of the NS-CQDs-RF composite photosensitizers in I-CXL, offering a novel …
transepithelial technique for treating keratoconus. I-CXL employs a small … the
superiority of the NS-CQDs-RF composite photosensitizers in I-CXL, offering a novel …
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[TXT] Applications and advantages of
N Soeters, JJM van Delden, R Koole, R Nuijts…
… Keratoconus is a degenerative corneal disorder in which the cornea becomes
cone- … one third of unilateral cases eventually develops into bilateral keratoconus.4 …
regularly confused with keratoconus, and can only be distinguished from keratoconus …
cone- … one third of unilateral cases eventually develops into bilateral keratoconus.4 …
regularly confused with keratoconus, and can only be distinguished from keratoconus …
| | | |
Current approaches to the diagnosis and treatment of keratoconus in children: a review
EY Markova, NA Gavrilova, AA Postolnik… - Russian Pediatric …, 2026
Keratoconus is a progressive degenerative corneal condition, characterized by
disrupted and disorganized structure of the collagen matrix, which leads to corneal
thinning and ectasia. The combined impact of genetic, hormonal, and environmental …
disrupted and disorganized structure of the collagen matrix, which leads to corneal
thinning and ectasia. The combined impact of genetic, hormonal, and environmental …
| | | |
15 The cornea
M Collins, S Vincent, S Read - Handbook of Visual Optics, Volume One …, 2026
… such as diseases affecting the cornea (eg keratoconus and pellucid marginal
degeneration), … Keratoconus causes a significant increase in the total higher-order
aberrations of the cornea … The major higher-order aberrations produced by …
degeneration), … Keratoconus causes a significant increase in the total higher-order
aberrations of the cornea … The major higher-order aberrations produced by …
|
[PDF] From Algorithms to the Ocular Surface: AI Current Applications and Future Directions
ANB Othmani, ULHNHS FY, MD Baker, RWNHS ST - Standing on the Shoulders of Giants: A …
… AI’s utility is well illustrated in keratoconus (KC) diagnosis. KC is a progressive
corneal disorder leading to myopia and irregular astigmatism… New artificial
intelligence index based on Scheimpflug corneal tomography to distinguish …
corneal disorder leading to myopia and irregular astigmatism… New artificial
intelligence index based on Scheimpflug corneal tomography to distinguish …
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[PDF] A NOVEL APPROACH TO DENTAL X-RAY ANALYSIS: USING VISION TRANSFORMERS FOR DETECTING CARIES
NA Khudhair
… On the other hand, CNN has been applied to predict the existence of Keratoconus.
Inference in the CNN model trained with the GoogleNet … “Detection of keratoconus
disease depending on corneal topography using deep learning”. Kufa Journal of …
Inference in the CNN model trained with the GoogleNet … “Detection of keratoconus
disease depending on corneal topography using deep learning”. Kufa Journal of …
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Fabrication and Surgical Application of Enriched Photo-crosslinked Gelatin–Riboflavin Hydrogels for Corneal Wound Repair in Rabbits
C Romo-Valera, J Etxebarria, M Rodriguez-Astigarraga… - Journal of Visualized …, 2026
This article presents a step‑by‑step protocol to fabricate, supplement, and surgically
apply an in situ blue‑light–crosslinkable gelatin hydrogel for corneal stromal wound
repair in rabbits. The hydrogel precursor comprises gelatin at 5% (w/v) and riboflavin …
apply an in situ blue‑light–crosslinkable gelatin hydrogel for corneal stromal wound
repair in rabbits. The hydrogel precursor comprises gelatin at 5% (w/v) and riboflavin …
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Óptica y Fotónica en México
A Martínez-García, JA Rayas-Alvarez…
Este artículo presenta una panorámica del desarrollo histórico, institucional y
temático de la óptica y la fotónica en México, en el marco del número especial de
Óptica Pura y Aplicada. Se revisan los antecedentes desde las culturas …
temático de la óptica y la fotónica en México, en el marco del número especial de
Óptica Pura y Aplicada. Se revisan los antecedentes desde las culturas …
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[PDF] TRANSFER LEARNING-DRIVEN DEEP NEURAL NETWORK FRAMEWORK FOR EARLY AND ACCURATE BREAST CANCER DETECTION
DB Shanmugam, S Athinarayanan, AJ Christilda…
Breast cancer continues to be one of the world’s leading causes of death for women
and early detection is essential to increasing survival rates and simplifying treatment.
Even though they work well traditional diagnostic methods frequently require a lot of …
and early detection is essential to increasing survival rates and simplifying treatment.
Even though they work well traditional diagnostic methods frequently require a lot of …
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[PDF] ENHANCED BREAST TOMOSYNTHESIS RECONSTRUCTION USING DISTANCE-DRIVEN MAXIMUM LIKELIHOOD EXPECTATION MAXIMIZATION TECHNIQUE
NA Malalla, AA Al-azza, SA Malalla, SM Dawood…
Early detection of breast cancer significantly improves patient outcomes through
timely and accurate diagnosis. This study proposes a hybrid image reconstruction
method combining the Maximum Likelihood Expectation Maximization (MLEM) …
timely and accurate diagnosis. This study proposes a hybrid image reconstruction
method combining the Maximum Likelihood Expectation Maximization (MLEM) …
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[PDF] ESTIMATION OF RADAR JAMMING WAVEFORMS WITH CFAR ALGORITHMS FOR DIFFERENT TARGET SITUATIONS
BK Ammar
This paper focuses on target detection, emphasizing its significance and exploring
the implementation of Constant False Alarm Rate (CFAR) detection algorithms.
Explores the performance of CA (Cell Average), GO (Greatest of), and SO (Smallest …
the implementation of Constant False Alarm Rate (CFAR) detection algorithms.
Explores the performance of CA (Cell Average), GO (Greatest of), and SO (Smallest …
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[PDF] A DEEP LEARNING FRAMEWORK FOR REAL-TIME STRESS DETECTION USING FACIAL EXPRESSIONS
N Nithya, AA Ali, S Parvathi, PM Sajid
Given its direct effects on human health productivity at work and general well-being
stress detection has emerged as a crucial area of affective computing research. Self-reports
and physiological sensors which are either subjective invasive or expensive to …
stress detection has emerged as a crucial area of affective computing research. Self-reports
and physiological sensors which are either subjective invasive or expensive to …
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[PDF] OPTIMIZING SENTIMENT ANALYSIS WITH BERT ENHANCED BY BILSTM AND BIGRU LAYERS
V Uma, V Ganesh
As mobile technology develops rapidly, social media becomes a rich source of
platform for people to voice for his or her opinions and point of views. In order to
support business decision making and policy making, we need to quantify public …
platform for people to voice for his or her opinions and point of views. In order to
support business decision making and policy making, we need to quantify public …
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[PDF] OPTIMIZED DEEP LEARNING TECHNIQUES TO PREDICT LEARNERS'ONLINE PERFORMANCE
SRA Abdullah
Existing models for predicting students’ academic performance show limitations
which result in their inability to make accurate predictions. The system achieved
operational efficiency together with precise predictions, which created problems for …
which result in their inability to make accurate predictions. The system achieved
operational efficiency together with precise predictions, which created problems for …
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Keratoconus Profile in the Elderly: Prevalence and Clinical Indices
EJ Holland - Cornea, 2026
Keratoconus Profile in the Elderly: Prevalence... : Cornea … Keratoconus Profile in
the Elderly: Prevalence and Clinical Indices …
the Elderly: Prevalence and Clinical Indices …
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[HTML] Oxidative Stress in Keratoconus Is Evident in Tear Fluid and Stromal Cells and Alleviated in Cell Culture by Sulforaphane
MA Koduri, M Charter, R Sonar, R Deshmukh… - … Ophthalmology & Visual …, 2026
Purpose: Keratoconus (KC) is a common eye disease characterized by progressive
corneal thinning and steepening. Despite multiple treatment options, there is no
definitive cure for KC. Previously we identified loss and dysregulation of nuclear …
corneal thinning and steepening. Despite multiple treatment options, there is no
definitive cure for KC. Previously we identified loss and dysregulation of nuclear …
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[HTML] Progressive Corneal Flattening after Corneal Collagen Crosslinking in a Case of Early Keratoconus
P Jain, I Gupta, A Hariani, GR Annadevula - tnoa Journal of Ophthalmic Science and …, 2026
To report a case of progressive corneal flattening after corneal collagen cross-linking
(CXL) in early keratoconus. A 29-year-old female with bilateral early keratoconus
underwent uneventful CXL in 2018 in the right eye using the standard Dresden …
(CXL) in early keratoconus. A 29-year-old female with bilateral early keratoconus
underwent uneventful CXL in 2018 in the right eye using the standard Dresden …
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OP11 Corneal crosslinking in thin corneas following the sub400 protocol
S Teodor, A Spyros, D Knight, F Figueiredo - BMJ Open Ophthalmology, 2026
… We conducted a prospective audit of patients with progressive keratoconus and
thin corneas (<400 µm) referred to Cornea Service at Royal Victoria Infirmary,
Newcastle upon Tyne. Consecutive cases treated between March 2022 and June …
thin corneas (<400 µm) referred to Cornea Service at Royal Victoria Infirmary,
Newcastle upon Tyne. Consecutive cases treated between March 2022 and June …
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[HTML] Automated triage for new keratoconus referrals using multimodal deep learning
S Balal, ML Kandakji, MM Leucci, PA Keane, MD Gore… - Ophthalmology Science, 2026
… To develop and validate deep learning models for predicting keratoconus
progression risk using multimodal imaging and clinical data, … AI models can be
used to develop risk-stratified pathways for monitoring keratoconus, reducing …
progression risk using multimodal imaging and clinical data, … AI models can be
used to develop risk-stratified pathways for monitoring keratoconus, reducing …
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[HTML] Epithelial thickness gradients as a diagnostic biomarker for early-stage keratoconus
Z Jansone-Langina, J Gertnere, V Kezika… - International Ophthalmology, 2026
… steeper in keratoconus than in regular astigmatism—even in Stage I—and
correlates with steep keratometry and TCT. With areas under the curves (AUCs) up
to 0.976, ΔET provides a rapid, non-invasive epithelial-based biomarker for early …
correlates with steep keratometry and TCT. With areas under the curves (AUCs) up
to 0.976, ΔET provides a rapid, non-invasive epithelial-based biomarker for early …
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Structural retinal and choroidal changes in keratoconus: A cross-sectional OCT study stratified by ABCD grading
MH Mohammed, H Hashemian, K Jadidi, SA Naroo… - Graefe's Archive for Clinical …, 2026
Purpose To evaluate posterior segment structural changes in patients with
keratoconus (KC), and to assess their association with anterior segment parameters
across disease severity stages using the ABCD classification system. Methods This …
keratoconus (KC), and to assess their association with anterior segment parameters
across disease severity stages using the ABCD classification system. Methods This …
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OP4 Impact of delayed treatment on disease progression of patients with keratoconus listed for collagen cross-linking–CXL
M Naseer, M Hegab, T Patel - 2026
… linked to noticeable progression of keratoconus, especially concerning the
anterior corneal curvature parameters.Background Keratoconus is a … Methods We
conducted a retrospective audit of 77 eyes from 60 patients with keratoconus who …
anterior corneal curvature parameters.Background Keratoconus is a … Methods We
conducted a retrospective audit of 77 eyes from 60 patients with keratoconus who …
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Analysis of tear meniscus and anterior segment alterations in keratoconus patients after scleral contact lens
C Erkan Pota, YS Atlıhan - EUROPEAN EYE RESEARCH
PURPOSE: The objective of the study is to evaluate the effects of scleral contact
lenses (ScL) wear on tear meniscus parameters and anterior segment changes in
patients with keratoconus (KC). METHODS: This prospective study included 37 eyes …
lenses (ScL) wear on tear meniscus parameters and anterior segment changes in
patients with keratoconus (KC). METHODS: This prospective study included 37 eyes …
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OP11 Corneal crosslinking in thin corneas following the sub400 protocol
T Stefanache, S Atzamoglou, D Knight, F Figueiredo - 2026
… Purpose To report clinical outcomes of keratoconus patients undergoing the sub-400
protocol in a UK tertiary referral centre. Methods We conducted a prospective audit
of patients with progressive keratoconus and thin corneas (<400 µm) referred to …
protocol in a UK tertiary referral centre. Methods We conducted a prospective audit
of patients with progressive keratoconus and thin corneas (<400 µm) referred to …
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OP5 Partial thickness compression sutures without intracameral air tamponade for acute hydrops in corneal ectasia: a case series
S Myers - 2026
… Five eyes had keratoconus and two had pellucid marginal degeneration. Median
time to corneal oedema resolution was one month (range one week to three months),
significantly shorter than expected with conservative management. Mean CCT …
time to corneal oedema resolution was one month (range one week to three months),
significantly shorter than expected with conservative management. Mean CCT …
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OP2 Clinical and topographic comparison between CAIRS and TG-PRK combined with CXL in the management of keratoconic patients
F Macario, F Edozie, C Cristian, H Mukherjee - 2026
… Conclusions Both CAIRS and TG-PRK + CXL are effective treatments for
keratoconus. CAIRS offers meaningful topographic improvement and may be
preferable in thin corneas or when tissue preservation is required. TG-PRK + CXL …
keratoconus. CAIRS offers meaningful topographic improvement and may be
preferable in thin corneas or when tissue preservation is required. TG-PRK + CXL …
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[HTML] Scheimpflug Photography-Based Evaluation of Structural Iris Changes Across Keratoconus Stages in Comparison with Healthy Eyes
O Özalp, OB Gür, SM İçer, HNN Yılmaz, E Atalay - Ophthalmology and Therapy, 2026
Introduction Keratoconus (KC) is a progressive corneal disorder caused by impaired
biomechanical integrity, leading to geometric deformation. Although corneal
changes are well characterized, iris structural alterations across KC stages remain …
biomechanical integrity, leading to geometric deformation. Although corneal
changes are well characterized, iris structural alterations across KC stages remain …
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STUDY OF INTRA OCULAR LENS POWER CALCULATIONS IN EGYPTIAN PATIENTS WITH KERATOCONUS
HA Helaly, IH Shereen, MS El-Mansy, E Elbanna - ALEXMED ePosters, 2026
Keratoconus is a progressive, non-inflammatory corneal disorder characterized by
thinning and conical protrusion of the cornea, leading to irregular astigmatism,
myopia, and visual impairment. It commonly presents in adolescence or early …
thinning and conical protrusion of the cornea, leading to irregular astigmatism,
myopia, and visual impairment. It commonly presents in adolescence or early …
| | | |
Evaluating corneal topographic patterns in keratoconic eyes and their association with keratoconus changes over time
H Hashemi, A Jamali, P Nabovati, A Hashemi… - International journal of …, 2026
Aim To evaluate various corneal topographic patterns in keratoconus (KCN) and
their association with disease progression. Methods A retrospective cohort study
was conducted on 636 eyes of 335 KCN patients (396 males, 240 females) with a …
their association with disease progression. Methods A retrospective cohort study
was conducted on 636 eyes of 335 KCN patients (396 males, 240 females) with a …
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[HTML] Epithelial-Island Corneal Crosslinking in the Treatment of Progressive Keratoconus Patients with Thin Corneas: 2-Year Visual, Refractive, Keratometric, Tomographic …
TÇ Büyüktepe, B Kılıç, ÖÖ Uçakhan - Turkish Journal of Ophthalmology, 2026
… We retrospectively reviewed the charts of consecutive patients with advanced
keratoconus who had a thinnest corneal thickness (TCT) of< 380 µm as measured
by anterior segment optic coherence tomography and underwent epithelial-island …
keratoconus who had a thinnest corneal thickness (TCT) of< 380 µm as measured
by anterior segment optic coherence tomography and underwent epithelial-island …
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[HTML] Effect of Accelerated Epi-Off Crosslinking on Optical Quality, Corneal Aberrations, and Epithelial Wavefront During Adolescence
BDY Erdal, B Kazancı - Turkish Journal of Ophthalmology, 2026
… The study included adolescent patients who were referred to the cornea and
contact lens unit for keratoconus, were diagnosed with progressive keratoconus
during follow-up, and were subsequently treated with A-CXL. A total of 109 eyes …
contact lens unit for keratoconus, were diagnosed with progressive keratoconus
during follow-up, and were subsequently treated with A-CXL. A total of 109 eyes …
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Advancements in Artificial Intelligence: Transforming the Diagnosis and Treatment of Corneal Diseases and Refractive Surgery
A Espaillat - … Ophthalmology: The Integration of Artificial Intelligence …, 2026
… This review discusses AI applications in corneal imaging techniques, especially
in detecting keratoconus (KC) [6], diagnosing infectious keratitis (IK) [7], and
predicting corneal graft complications [8]. AI can detect subtle changes in corneal …
in detecting keratoconus (KC) [6], diagnosing infectious keratitis (IK) [7], and
predicting corneal graft complications [8]. AI can detect subtle changes in corneal …
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[PDF] Implantation of Small-Aperture IOL in Patients with Cataract and Preexisting Corneal Comorbidities
C Samarawickrama, M Khan - Clinical Ophthalmology, 2026
… Figure 1 shows the corneal tomography (Pentacam) image of a typical
keratoconus case from our study subjects. … Furthermore, we did not assess IOL
power calculators specifically designed for keratoconus, as the patients included …
keratoconus case from our study subjects. … Furthermore, we did not assess IOL
power calculators specifically designed for keratoconus, as the patients included …
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[PDF] A label-free machine learning atlas of corneal aberration clusters from dual-surface Zernike coefficients: a retrospective cross-sectional study of 3,533 eyes
O Karakulak, E Ayıntap, İ Çıkmazkara, AA Demirtaş… - 2026
… in keratoconus, coma and trefoil on the posterior surface progress in the opposite
direction to the anterior surface and partially counterbalance the anterior aberrations
[18]. In the detection of subclinical keratoconus… The severity of keratoconus has …
direction to the anterior surface and partially counterbalance the anterior aberrations
[18]. In the detection of subclinical keratoconus… The severity of keratoconus has …
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Advancing Teleophthalmology and Remote Monitoring Using Artificial Intelligence
A Espaillat - … Ophthalmology: The Integration of Artificial Intelligence …, 2026
… Moreover, AI is advancing for corneal conditions like keratitis and keratoconus, as
well as for planning cataract surgeries and … , anterior segment OCT, or slit lamp
photos to distinguish conditions like keratoconus, pterygium, and keratitis [26] …
well as for planning cataract surgeries and … , anterior segment OCT, or slit lamp
photos to distinguish conditions like keratoconus, pterygium, and keratitis [26] …
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[PDF] Reliability of a Scheimpflug-based tomographer compared with a Placido-based topographer and specular microscopy in healthy eyes
CL Budib, CHP Oliani, G de Oliveira Ferreira… - Arq Bras Oftalmol, 2026
… Corneal imaging is critical for the early detection of ectatic disorders such as
keratoconus, for screening candidates for refractive surgery, and for calculating
intraocular lens (IOL) power in cataract surgery(2,3). Inaccurate measurements may …
keratoconus, for screening candidates for refractive surgery, and for calculating
intraocular lens (IOL) power in cataract surgery(2,3). Inaccurate measurements may …
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[HTML] Using artificial intelligence to detect keratoconus progression based on age and anterior segment optical coherence tomography images
T Miyai, K Kamiya, Y Ayatsuka, Y Kato, H Ishii, N Shoji… - Asia-Pacific Journal of …, 2026
In this study, we aimed to establish and evaluate an index to define keratoconus
progression based on map images obtained from anterior segment optical
coherence tomography (AS-OCT) and age through deep learning. AS-OCT images …
progression based on map images obtained from anterior segment optical
coherence tomography (AS-OCT) and age through deep learning. AS-OCT images …
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[HTML] Comparison of choroidal biomarkers and scleral thickness in keratoconus in relation to corneal cross-linking
N Valsecchi, G Folgaria, S Febbraro, A Lorenzi… - Graefe's Archive for Clinical …, 2026
… Our findings align with previous reports linking keratoconus to PPE. Furthermore,
we observed the exclusive presence of PPE-like … into account, as faster
progression of keratoconus itself could be associated with other ocular or systemic …
we observed the exclusive presence of PPE-like … into account, as faster
progression of keratoconus itself could be associated with other ocular or systemic …
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[HTML] The potential of scleral lenses
S Schwarz
… Keratoconus and other ectatic disorders In keratoconus, the progressive bulging
and thinning of the cornea leads to pronounced irregularity of the anterior surface.
The irregularity of the anterior surface of the cornea is significant because it has a …
and thinning of the cornea leads to pronounced irregularity of the anterior surface.
The irregularity of the anterior surface of the cornea is significant because it has a …
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Single-shot, depth-encoded multiplexed OCT for multi-spot tracking of induced transient corneal dynamics
K Karnowski, J Milkiewicz, O CETINKAYA, A Pachacz… - Biomedical Optics Express, 2026
… Current non-contact methods for assessing corneal biomechanics often rely on
global metrics or single-meridian scanning, potentially missing the focal and
asymmetric stiffness changes characteristic in corneal pathologies like keratoconus …
global metrics or single-meridian scanning, potentially missing the focal and
asymmetric stiffness changes characteristic in corneal pathologies like keratoconus …
| | | |
Disheveled associated activator of morphogenesis 2 variants may produce alport-like changes: a case report
D Yang, H Chen, Z Fan, J Fan - Molecular Cytogenetics, 2026
… Specifically, in addition to IgA nephropathy, this patient also had diffuse thinning
of GBM, reduced segmental expression of type IV collagen α3 in the glomerulus,
and binocular keratoconus which is consistent with features of Alport syndrome …
of GBM, reduced segmental expression of type IV collagen α3 in the glomerulus,
and binocular keratoconus which is consistent with features of Alport syndrome …
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[PDF] An integrated model of care for vision impairment within the public health system of Limpopo province, South Africa
MM LESHABANE, N RAMPERSAD, KP MASHIGE - 2026
… Contact lenses and keratoconus care were available at one tertiary-level hospital.
Medical interventions were co-managed by ophthalmic nurses, optometrists, and
ophthalmologists. Cataract surgery services were offered at three hospitals, while …
Medical interventions were co-managed by ophthalmic nurses, optometrists, and
ophthalmologists. Cataract surgery services were offered at three hospitals, while …
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Revolutionizing Ophthalmology: The Integration of Artificial Intelligence Algorithms
A Espaillat
… Detection of subclinical Keratoconus using a novel combined tomographic and
biomechanical model based on an automated decision tree… Evaluating the
performance of various machine learning algorithms to detect subclinical …
biomechanical model based on an automated decision tree… Evaluating the
performance of various machine learning algorithms to detect subclinical …
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Systematic Meta-Analysis of Impact of Glaucoma, Keratoconus, and Clinical Factors on High-Risk Corneal Transplantation Outcomes
L Li, F Luo, W Wang - Journal of Visualized Experiments (JoVE), 2026
… Among the various high-risk indications, glaucoma and keratoconus were
selected as the … high-risk ocular conditions such as glaucoma and keratoconus,
on the outcomes of high-risk … impact of glaucoma, keratoconus, and related …
selected as the … high-risk ocular conditions such as glaucoma and keratoconus,
on the outcomes of high-risk … impact of glaucoma, keratoconus, and related …
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[PDF] Second Harmonic Generation Imaging of an Animal Model of Keratoconus
H Chuo - 2026
Keratoconus is a type of degenerative ectasia that causes a local reduction of
corneal stiffness due to the degradation of collagen fibers. This leads to abnormal
corneal shape and function. Using second harmonic imaging and order coefficient …
corneal stiffness due to the degradation of collagen fibers. This leads to abnormal
corneal shape and function. Using second harmonic imaging and order coefficient …
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[PDF] Use of Anterior Segment Optical Coherence Tomography to Manage Acute Corneal Hydrops in Keratoconus
MK Man OD - Optometric Clinical Practice, 2026
… Background: Acute corneal hydrops, a rare complication of keratoconus and other
corneal … 40-year-old African American female with keratoconus. AS-OCT images
supported treatment with … Conclusion: Acute corneal hydrops in keratoconus can …
corneal … 40-year-old African American female with keratoconus. AS-OCT images
supported treatment with … Conclusion: Acute corneal hydrops in keratoconus can …
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[HTML] A Datasheet for the INSIGHT Moorfields Cornea Anterior Segment Dataset (CADMUS)
S Balal, Z Alsafi, M Leucci, PA Keane, D Gore… - Ophthalmology Science, 2026
… a keratoconus population to map device-specific precision limits for the MS-39
throughout the range of disease severity and to examine the effect of averaging
repeated measures from a single timepoint. Precise mapping of precision limits for …
throughout the range of disease severity and to examine the effect of averaging
repeated measures from a single timepoint. Precise mapping of precision limits for …
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[HTML] Demographic and clinical presentations of keratoconus in Trinidad and Tobago: a retrospective study
NE Ezinne, MA Kwarteng, S Tagoh, E Bissoon… - BMC ophthalmology, 2026
… Keratoconus is a progressive corneal disorder characterised by thinning and
protrusion of the … This study evaluated the demographic and clinical
characteristics of keratoconus among … This study provides the first comprehensive …
protrusion of the … This study evaluated the demographic and clinical
characteristics of keratoconus among … This study provides the first comprehensive …
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[HTML] Postoperative Pain and Functional Limitations After Corneal Cross-Linking for Keratoconus: A Patient-Reported Outcome Study
R Jaruseviciene, G Kirkickaite, S Galgauskas - Life, 2026
Background: Keratoconus is a progressive corneal condition that leads to visual
impairment and is primarily managed with corneal cross-… (CXL) for keratoconus.
Methods: A structured survey was conducted among 31 patients who underwent …
impairment and is primarily managed with corneal cross-… (CXL) for keratoconus.
Methods: A structured survey was conducted among 31 patients who underwent …
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[HTML] The role of corneal epithelial thickness parameters with different degrees of keratoconus in the diagnosis of keratoconus
T Wang, Q Cao - 2026
… Assuming a power of 80%, a significance level of 0.05, and based on preliminary
data indicating a mean difference in epithelial thickness parameters between
keratoconus and control groups, we estimated that a sample size of 64 eyes with …
data indicating a mean difference in epithelial thickness parameters between
keratoconus and control groups, we estimated that a sample size of 64 eyes with …
| | | |
[PDF] Advancements in contact lens technology: A comprehensive review of current materials and future prospects
W van der Berg, S de Vries, E Bakker
… Rigid gas permeable lenses comprised 9.2% of fittings, predominantly utilized for
keratoconus management, orthokeratology applications, and complex corneal
irregularities where soft lens options provide inadequate visual outcomes. Hybrid …
keratoconus management, orthokeratology applications, and complex corneal
irregularities where soft lens options provide inadequate visual outcomes. Hybrid …
| | | |
SOFTRING-The New CAIRS. To Join the Best of Two Worlds
FBD Silva, FS León, JSB Soares, LI Villavicencio… - Highlights of Ophthalmology, 2026
The case report describes the first “SoftRing” implant. It consists of a segment made
of hydrophilic acrylic, which becomes soft with the natural moisture of the corneal
stroma. The implant treatment was performed on a woman with keratoconus and a …
of hydrophilic acrylic, which becomes soft with the natural moisture of the corneal
stroma. The implant treatment was performed on a woman with keratoconus and a …
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[PDF] Corneal Collagen Crosslinking for Keratoconus: Experience of the Ophthalmology Department at CHU Hassan II in Fez (ABOUT 65 CASES)
M Mouajab, H Moutei, F Chraibi, M Abdellaoui… - Sch J Med Case Rep, 2026
Keratoconus is an idiopathic corneal dystrophy characterized by ectasia and
progressive non-inflammatory thinning of the cornea. It affects young individuals and
has considerable progressive potential, thus constituting a source of visual …
progressive non-inflammatory thinning of the cornea. It affects young individuals and
has considerable progressive potential, thus constituting a source of visual …
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[HTML] LncRNA DANCR Regulates PARP1-Mediated Oxidative Stress Response in Corneas by Encoding a Novel Micropeptide miPEPDR
X Ma, J Hao, HB Hilal, Z Cheng, P Feng, J Song… - … Ophthalmology & Visual …, 2026
… In this study, we uncovered that differentiating antagonistic non-protein-coding
RNA (DANCR) is downregulated in keratoconus and under … Based on corneal
tissues from healthy controls and patients with keratoconus (n = 4 per group), we …
RNA (DANCR) is downregulated in keratoconus and under … Based on corneal
tissues from healthy controls and patients with keratoconus (n = 4 per group), we …
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[PDF] Ayurvedic Kriyakalpa Treatment in Keratoconus-A Case Report
MJ Ashwini, A Kumar, U Nataraj - Int. J. Sci. R. Tech, 2026
… Here in, we report a case of keratoconus which was effectively managed with
Ayurvedic kriyakalpa treatment. … Environmental factors such as Eye rubbing is
being considered an important factor and accounts for the association of …
Ayurvedic kriyakalpa treatment. … Environmental factors such as Eye rubbing is
being considered an important factor and accounts for the association of …
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[PDF] Effect of Corneal Collagen Cross Linkage on Intra-Ocular Pressure Measurement in Iraqi Patients with Keratoconus
AM Mansour, AM Rasheed, FT Ahmed - Al-Iraqia Medical College Journal, 2026
… a sample of Iraqi patients with keratoconus. This prospective study included 28
patients with bilateral keratoconus (56 eyes) who underwent … In conclusion, in
patients with keratoconus, CXL with riboflavin and UVA irradiation resulted in a …
patients with bilateral keratoconus (56 eyes) who underwent … In conclusion, in
patients with keratoconus, CXL with riboflavin and UVA irradiation resulted in a …
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[HTML] Outcomes of high-fluence (7.2 J/cm2) accelerated collagen cross-linking in advanced keratoconus
A Gürpınar, E Can - Taiwan Journal of Ophthalmology, 2026
PURPOSE: The purpose is to evaluate the effectiveness of accelerated collagen
cross-linking (CXL) in treating eyes with advanced keratoconus. MATERIALS AND
METHODS: This retrospective cohort study included 109 eyes from 96 patients with …
cross-linking (CXL) in treating eyes with advanced keratoconus. MATERIALS AND
METHODS: This retrospective cohort study included 109 eyes from 96 patients with …
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[HTML] The Comparison of Anterior Segment Parameters in School-Aged Children with Laser-Treated Retinopathy of Prematurity, Untreated Preterm Birth, and Full-Term …
BH Unlu, CA Utine, T Ozturk, CD Engin, A Yaman… - Children, 2026
… commonly used in the tomographic assessment of keratoconus; however, their
interpretation in … However, these findings should not be interpreted as evidence of
keratoconus or a definite … , particularly in former preterm children, keratoconus-based …
interpretation in … However, these findings should not be interpreted as evidence of
keratoconus or a definite … , particularly in former preterm children, keratoconus-based …
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Noncommunicable Eye Diseases Trend Related to Artificial Intelligence: A Bibliometric and Visualization Analysis.
MM Daud, W Zaki, LA Ramlan, FM Ali, JK Chaw - International Journal of Advanced …, 2026
In recent years, artificial intelligence (AI) has transformed numerous sectors,
including healthcare, and ophthalmology is no exception. The field has seen
remarkable progress in using AI to detect, diagnose, and manage …
including healthcare, and ophthalmology is no exception. The field has seen
remarkable progress in using AI to detect, diagnose, and manage …
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[HTML] Principles of a Non-orthogonal Optical Surface with Potential for Correction of Irregular Astigmatism
DA Atchison, A Ho - Ophthalmic and Physiological Optics, 2026
… The main purpose of this work is to develop non-orthogonal lens surfaces that
can be used for designing improved ophthalmic lenses in conditions such as
keratoconus. Before doing this, we will show how the power of non-orthogonal …
can be used for designing improved ophthalmic lenses in conditions such as
keratoconus. Before doing this, we will show how the power of non-orthogonal …
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[PDF] Deep-stromal implantation of a double-crosslinked bioengineered porcine collagen implant (BPCDX) in advanced keratoconus: a 12-month study of corneal …
M Jabarvand, A Doostdar, A Jamali, M Rahimi… - Scientific Reports, 2026
To evaluate the efficacy of the Bioengineered Porcine Collagen, Double-Crosslinked
(BPCDX) Implant in patients with advanced keratoconus (KCN). This study included
17 eyes of 17 patients (mean age = 32.29 ± 9.21 years) with stage 3–4 KCN. A …
(BPCDX) Implant in patients with advanced keratoconus (KCN). This study included
17 eyes of 17 patients (mean age = 32.29 ± 9.21 years) with stage 3–4 KCN. A …
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The association between keratoconus and inflammatory bowel disease: A systematic review and meta-analysis
S Lahijanian, H Kandel, R Kha, SL Watson - 2026
… an association between inflammatory bowel disease and keratoconus METHODS:
Our search of five … keratoconus. The aggregate odds ratio of Mendelian
randomisations was 1.24 (95% confidence interval 1.21-1.26) suggesting a …
Our search of five … keratoconus. The aggregate odds ratio of Mendelian
randomisations was 1.24 (95% confidence interval 1.21-1.26) suggesting a …
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Trends in the management of keratoconus in Australia
R Kha, H Kandel, SL Watson - 2026
… Abstract: PURPOSE: Over the past few decades, management options for
keratoconus have evolved to include corneal crosslinking (CXL)… use of
keratoconus management techniques in Australia. METHODS: This cross-sectional …
keratoconus have evolved to include corneal crosslinking (CXL)… use of
keratoconus management techniques in Australia. METHODS: This cross-sectional …
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Patient Perspectives of Surgery in Keratoconus
L Fan, H Kandel, SL Watson - 2026
… surgery for keratoconus is limited. METHODS: Semi-structured interviews were
conducted with patients diagnosed with keratoconus at a … CONCLUSIONS: This
study reveals the varied perspectives patients have towards surgery for keratoconus …
conducted with patients diagnosed with keratoconus at a … CONCLUSIONS: This
study reveals the varied perspectives patients have towards surgery for keratoconus …
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[HTML] Assessment of corneal biomechanical properties using Corvis ST following LASIK, PRK, and CXL
PS Saif, MYS Saif, HMK Abdel Dayem, MOAE Elsayed… - Lasers in Medical Science, 2026
… CXL is a therapeutic approach primarily used for keratoconus and other ectatic
conditions. This procedure enhances the biomechanical strength of the cornea by
inducing collagen cross-linking with riboflavin and ultraviolet-A exposure. Corvis ST–based …
conditions. This procedure enhances the biomechanical strength of the cornea by
inducing collagen cross-linking with riboflavin and ultraviolet-A exposure. Corvis ST–based …
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[HTML] Corneal tomographic and densitometric characteristics in children with allergic conjunctivitis: a comparative pentacam AXL study
A Karakiraz, S Çakmak, B Karakaya, E Altınkurt… - BMC Ophthalmology, 2026
Purpose To explore corneal tomographic and densitometric parameters associated
with subtle corneal alterations in children with allergic conjunctivitis using the
Pentacam AXL system. Methods This cross-sectional study included 64 eyes of 32 …
with subtle corneal alterations in children with allergic conjunctivitis using the
Pentacam AXL system. Methods This cross-sectional study included 64 eyes of 32 …
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Corneal biomechanical parameters as novel predictors of refractive stability after small incision lenticule extraction
L He, Y Zhang, Y Miao, X Tang, J Wang, X Wang… - BMC Ophthalmology, 2026
Purpose To evaluate the predictive value of preoperative corneal biomechanical
parameters for refractive stability after small-incision lenticule extraction (SMILE) and
to develop a multivariate model integrating biomechanical and anatomical factors for …
parameters for refractive stability after small-incision lenticule extraction (SMILE) and
to develop a multivariate model integrating biomechanical and anatomical factors for …
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[HTML] Association of Remnant Cholesterol With the Retinal Capillary Plexus
S Ding, X Zhu, K Yang, Y Wang, Z Wang, Z Li, W Lian… - Translational Vision Science …, 2026
Purpose: Remnant cholesterol (RC) is a well-recognized risk factor for
cardiovascular diseases (CVDs) and an important biomarker of cardiovascular risk.
However, studies on the effects of RC on the early retinal microvasculature are still …
cardiovascular diseases (CVDs) and an important biomarker of cardiovascular risk.
However, studies on the effects of RC on the early retinal microvasculature are still …
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Association between refractive status and quantitative corneal subbasal nerve plexus parameters in young adults
Y Liang, X Zhang, H Wang, W Li - BMC Ophthalmology, 2026
Background To evaluate the association between refractive status and quantitative
corneal subbasal nerve plexus (SBNP) parameters in healthy young adults, and to
explore their relationships with ocular biometric measures. Methods: This cross-sectional …
corneal subbasal nerve plexus (SBNP) parameters in healthy young adults, and to
explore their relationships with ocular biometric measures. Methods: This cross-sectional …
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[HTML] Applications of advanced in vitro ocular models
BJ Groenewald, M Blignaut, B Loos, N Chellan - In vitro models, 2026
… Pathologies like keratoconus can also alter the morphology of certain structures
in the eye. Keratoconus is characterised by progressive thinning and cone like
morphology of the cornea in a bilateral manner [52]. Lastly, other systemic …
in the eye. Keratoconus is characterised by progressive thinning and cone like
morphology of the cornea in a bilateral manner [52]. Lastly, other systemic …
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Natural History and Progression of Untreated Keratoconus: An Updated Systematic Review and Meta-Analysis
TH Tsai, JH Hsu, CL Tsai, SC Shao, CH Hsiao, KK Lin - Current Eye Research, 2026
… untreated keratoconus, which can facilitate the earlier detection of progressive
keratoconus … that (1) included patients with untreated keratoconus who were
followed up for ≥6 months, (… keratoconus eyes, and (3) reported both baseline …
keratoconus … that (1) included patients with untreated keratoconus who were
followed up for ≥6 months, (… keratoconus eyes, and (3) reported both baseline …
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[HTML] Evaluation of Microcirculation at the Optic Nerve Head in Eyes With Keratoconus
S Ichinohasama, H Namba, T Shiba, T Kobayashi… - … Ophthalmology & Visual …, 2026
… diagnosed with keratoconus, and an additional 1.46% were classified as
keratoconus suspects. These findings indicate that keratoconus is … LSFG
measurements are difficult to obtain in advanced keratoconus, this study mainly …
keratoconus suspects. These findings indicate that keratoconus is … LSFG
measurements are difficult to obtain in advanced keratoconus, this study mainly …
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Long-term follow up (≥ 10 years) of penetrating keratoplasty versus deep anterior lamellar keratoplasty for keratoconus
S Feizi, MA Javadi, K Bayat, M Janani, Z Khorrami… - Graefe's Archive for Clinical …, 2026
… such as keratoconus, stromal dystrophies, and stromal scars. DALK has become
the preferred approach for advanced keratoconus due to … this study was to
compare long-term (≥ 10 years) clinical outcomes and graft survival between PK …
the preferred approach for advanced keratoconus due to … this study was to
compare long-term (≥ 10 years) clinical outcomes and graft survival between PK …
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[PDF] “Aye, there's the rub”–ocular allergy and keratoconus
ZLBBM MD, EWTCPD FRANZCO
… had keratoconus) in quantitative meta-analyses; and 7 studies (6 cross-sectional,
1 basic science) with 899 participants (709 of which had keratoconus) in descriptive
analyses. Three meta-analyses were performed to synthesise the associations …
1 basic science) with 899 participants (709 of which had keratoconus) in descriptive
analyses. Three meta-analyses were performed to synthesise the associations …
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[HTML] A Study of Clinical Patterns and Risk Factors of Amblyopia in Children at a Tertiary Care Government Hospital
R Yenugandula, D Quraishi, UM Ram - International Journal of Medical and …, 2026
… , including silent traumatic cataract and anisomyopia associated with keratoconus.
These findings broaden the conventional understanding of … Similarly, the
presence of keratoconus in paediatric patients is of particular concern because …
These findings broaden the conventional understanding of … Similarly, the
presence of keratoconus in paediatric patients is of particular concern because …
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Wavefront-guided contact lens corrections for the highly aberrated eye
JD Marsack, RA Applegate - Handbook of Visual Optics, Volume Two, 2026
… For the keratoconic, this burden can be put into context if one considers the point
in life when the aberrations associated with keratoconus generally impact the
individual. Keratoconus typically becomes apparent to the patient in the late teens or …
in life when the aberrations associated with keratoconus generally impact the
individual. Keratoconus typically becomes apparent to the patient in the late teens or …
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[PDF] Risk Factors of Keratoconus in High School Students in Trinidad and Tobago: A Cross‐Sectional Study
NE Ezinne, MA Kwarteng, S Phagoo… - Health Science Reports, 2026
Background Keratoconus (KC) is the most common form of keratectasia that is
associated with impaired vision and reduced quality of life, especially in adolescents.
This study aims to identify and assess the risk factors associated with KC among …
associated with impaired vision and reduced quality of life, especially in adolescents.
This study aims to identify and assess the risk factors associated with KC among …
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Evolution of keratoconus diagnostic methods
LA Sultygova, MR Taevere, AA Shpak - Ophthalmology Reports, 2026
… of keratoconus is the most important objective of an ophthalmologist. Early
detection and timely treatment reduce the risk of progression, poor prognosis, and
unnecessary refractive procedures. This review discusses current methods for …
detection and timely treatment reduce the risk of progression, poor prognosis, and
unnecessary refractive procedures. This review discusses current methods for …
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[PDF] Replacement of Synthetic Intracorneal Ring Segments by Corneal Allogenic Intrastromal Ring Segments (CAIRS) in Keratoconus: A Narrative Review with Systematic …
A Barbara - 2026
… corneal ring segments (ICRS) have a longer history of use in keratoconus and
achieve … keratoconus and ICRS implanted 20 years prior. After stromal thinning
was identi ed, the lower … advanced bilateral keratoconus whose right eye had …
achieve … keratoconus and ICRS implanted 20 years prior. After stromal thinning
was identi ed, the lower … advanced bilateral keratoconus whose right eye had …
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[HTML] The effects on visual functions and vision-related quality-of-life after fitting of scleral lenses in keratoconus
SM Roten, E Lundanes, V Sundling - Scandinavian Journal of Optometry and Visual …, 2026
The purpose of this study was to explore the effects of fitting scleral lenses on visual
acuity (VA), contrast sensitivity (CS) and vision-related quality-of-life (VR-QoL) in
persons with keratoconus. An intervention study was undertaken, with a clinical …
acuity (VA), contrast sensitivity (CS) and vision-related quality-of-life (VR-QoL) in
persons with keratoconus. An intervention study was undertaken, with a clinical …
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Paradigm Shift: Intrastromal Ring Implantation in Advanced Keratoconus (Kmax≥ 75 D)—An Alternative to Transplantation?—Case Series
GEA do Nascimento, LRN Cirillo, AIRM Moreira… - … Journal of Keratoconus and …, 2026
… keratoconus who presented with poor visual acuity and an indication for
keratoplasty. Materials and methods: This case series included four patients with
advanced keratoconus (… A 20-year-old male (case 1) with enantiomorphic …
keratoplasty. Materials and methods: This case series included four patients with
advanced keratoconus (… A 20-year-old male (case 1) with enantiomorphic …
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Evaluation of the corneal endothelium in clear grafts after deep anterior lamellar keratoplasty using specular microscopy
EE Sahin, M Faiz Turan, Y Koçluk, B Kasım Tekdemir - International Ophthalmology, 2026
… lamellar keratoplasty (DALK) due to keratoconus (KC), macular corneal dystrophy
(MCD), lattice corneal dystrophy (LCD), or corneal scarring. … Consequently, DALK
is widely performed in conditions without endothelial involvement, such as …
(MCD), lattice corneal dystrophy (LCD), or corneal scarring. … Consequently, DALK
is widely performed in conditions without endothelial involvement, such as …
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[HTML] Proteomic Analysis of Human Corneal Keratocytes Reveals Mechanical Strain–Dependent Changes in Cellular Function
Q Zhang, S Zhu, A Mateus, W Zhang, P Danielson… - … Ophthalmology & Visual …, 2026
… Given reports of increased corneal deformation in ocular disorders such as
glaucoma, keratoconus, and corneal injury, our findings highlight the detrimental
impact of high corneal strain on keratocyte function and tissue homeostasis. These …
glaucoma, keratoconus, and corneal injury, our findings highlight the detrimental
impact of high corneal strain on keratocyte function and tissue homeostasis. These …
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[HTML] Epidemiology of Keratoconus in India: A Systematic Review and Meta-Analysis of Indian Study Populations
M Ripa, C Schipa, P Aceto, S Prasad, NA Shah - Vision, 2026
… Therefore, we aimed to synthesize available evidence on the prevalence of
keratoconus (KC… , the diagnostic procedures used to identify keratoconus were
not clearly reported. This lack … the currently available evidence on keratoconus …
keratoconus (KC… , the diagnostic procedures used to identify keratoconus were
not clearly reported. This lack … the currently available evidence on keratoconus …
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[PDF] Humanistic and Economic Burden of Patients With Keratoconus
M Dionysopoulou, J Makripoulias, N Kotsopoulos… - Cureus, 2026
… Keratoconus is a chronic, progressive corneal disease that occurs primarily in
people of working age and significantly affects visual … The primary objective of this
study was to assess the impact of keratoconus on VRQoL and work productivity …
people of working age and significantly affects visual … The primary objective of this
study was to assess the impact of keratoconus on VRQoL and work productivity …
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[HTML] 200 KERATOCONJUNCTIVITIS SICCA AND SJÖGREN'S SYNDROME
AD Irvine, LD Corden, O Swensson
… Keratoconus is a noninflammatory corneal disorder that involves abnormal
thinning of the corneal stroma; thinning usually occurs in either … True unilateral
keratoconus is infrequent. Keratoconus affects approximately 1 in 2000 and is the …
thinning of the corneal stroma; thinning usually occurs in either … True unilateral
keratoconus is infrequent. Keratoconus affects approximately 1 in 2000 and is the …
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[PDF] Pre-Medicine Internship Program
Y Nakada-Sasaki
… At sixteen, I was diagnosed with keratoconus, a progressive eye condition that
causes the cornea to thin and change shape, leading to blurred vision. The exact
cause of keratoconus remains uncertain, with both genetic and environmental …
causes the cornea to thin and change shape, leading to blurred vision. The exact
cause of keratoconus remains uncertain, with both genetic and environmental …
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[HTML] Clinical Experience with Scleral Lens Wear After Corneal Cross-Linking in Keratoconus: Longitudinal Keratometric Outcomes
YY Jeon, N Park, YE Lee, J Han, CM Lee, C Yu… - Journal of Clinical Medicine, 2026
… use prevents keratoconus progression, as 23 eyes (14.6%) of 157 patients with
keratoconus experienced a … keratoconus progression but also provide visual
correction, this study aimed to investigate the effectiveness of scleral lenses …
keratoconus experienced a … keratoconus progression but also provide visual
correction, this study aimed to investigate the effectiveness of scleral lenses …
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Visual outcomes following implantation of intracorneal rings with sharp and round triangular cross-section designs in keratoconus
S Soleimani, S Pirhadi, K Jadidi, A Mirzajani… - International Ophthalmology, 2026
… Forty eyes from 40 keratoconus patients with the age range of 21 to 43 years
participated in this study, 20 eyes in the Keratacx Plus group and 20 eyes in the
Keraring group. The mean age in the Keratacx Plus and Keraring groups was 30.3 ± …
participated in this study, 20 eyes in the Keratacx Plus group and 20 eyes in the
Keraring group. The mean age in the Keratacx Plus and Keraring groups was 30.3 ± …
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Prevalence of floppy eyelid syndrome and keratoconus in Egyptian patients with obstructive sleep apnea
ISH Ahmed, A Ramadan, KM Khamis, AY Bahgat… - International Ophthalmology, 2026
… We excluded patients with any ocular disease that may interfere with the
diagnosis of keratoconus (KC) (eg, prior refractive surgery, corneal opacity, patients
with history of atopic eye disease), prior recurrent eyelid infections, tumors, surgery …
diagnosis of keratoconus (KC) (eg, prior refractive surgery, corneal opacity, patients
with history of atopic eye disease), prior recurrent eyelid infections, tumors, surgery …
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Demarcation line following additive stromal keratoplasty
M Afzal, SK Mishra, A Sati - Eye, 2026
… The procedure was carried out in a paediatric patient with advanced keratoconus,
with a minimum corneal thickness of 312 µm after de-epithelialisation. …
with a minimum corneal thickness of 312 µm after de-epithelialisation. …
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Complications and graft rejection after keratoplasty: clinical outcomes and risk factors in a tertiary ophthalmology service
T Danilov, A Paduca - Cells and Tissues Transplantation. Actualities and …, 2026
Introduction. Corneal blindness is a major cause of visual impairment, and
keratoplasty is often the only option to restore corneal transparency and function.
Despite advances in surgical techniques, postoperative complications and graft …
keratoplasty is often the only option to restore corneal transparency and function.
Despite advances in surgical techniques, postoperative complications and graft …
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Evaluation of the landscape of corneal transplants in Brazil: a retrospective analysis of the last 10 years
LS Loureiro, TP Naves, CO Avila, LEP Silva… - Rev. bras. oftalmol., 2026
Objective: To describe the epidemiological characteristics of corneal transplants in
Brazil between 2014 and 2023. Methods: This is a descriptive, retrospective
epidemiological study with a quantitative approach. Data were collected from the SIA/SUS …
Brazil between 2014 and 2023. Methods: This is a descriptive, retrospective
epidemiological study with a quantitative approach. Data were collected from the SIA/SUS …
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[HTML] “Eye-Conic” Spatial Transcriptomics Reveals the Layer-Specific Molecular Alterations in Corneas of Patients With Keratoconus
A Wysocka, K Jaskiewicz-Rajewicz, J Wozniak… - … Ophthalmology & Visual …, 2026
Purpose: Due to the structural complexity of the human cornea as well as the
characteristic histopathological changes occurring in keratoconus (KTCN) cornea,
there is a need to identify the associated cellular and molecular layer-specific …
characteristic histopathological changes occurring in keratoconus (KTCN) cornea,
there is a need to identify the associated cellular and molecular layer-specific …
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Ophthalmological Abnormalities in syndromic or non-syndromic Epidermal Differentiation Disorders: a cross-sectional study
P Fournié, B Bonneau, H Texier, V Soler… - British Journal of …, 2026
… aimed to evaluate the incidence of keratoconus and other ophthalmologic
abnormalities in patients with congenital ichthyosis compared to controls. Seventy-two
patients with ichthyosis and 72 sex-matched controls were included. Keratoconus …
abnormalities in patients with congenital ichthyosis compared to controls. Seventy-two
patients with ichthyosis and 72 sex-matched controls were included. Keratoconus …
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Identification of Key Genes Associated with Butyrate Metabolism in Keratoconus through Mendelian Randomization and Transcriptomic Analysis
N Gao, H Huang, Y Tian, J Hu, W Wang, H Ye, X Dong - Experimental Eye Research, 2026
Background Keratoconus (KC) is a degenerative corneal disease with a complex
etiology that severely affects vision. Butyrate is a saturated short-chain fatty acid with
anti-inflammatory properties. Accumulating evidence underscores a significant role …
etiology that severely affects vision. Butyrate is a saturated short-chain fatty acid with
anti-inflammatory properties. Accumulating evidence underscores a significant role …
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[HTML] Serum Markers of Oxidative Stress and Antioxidant Status in Keratoconus: Ischemia-Modified Albumin, Malondialdehyde, and Total Thiol Levels
S Tekin, E Seven, C Demir, H Demir, M Batur, MD Özer… - Medicina, 2026
… patients with keratoconus compared to healthy controls, suggesting a disruption
of antioxidant defense mechanisms in keratoconus. This … , and stromal thinning,
which are characteristic features of keratoconus. Consistent with previous studies …
of antioxidant defense mechanisms in keratoconus. This … , and stromal thinning,
which are characteristic features of keratoconus. Consistent with previous studies …
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[HTML] Epioxa: The First FDA-Approved epithelium-on-cross-linking therapy for keratoconus
E Maryam, A Rafique, B Malik, I Shareef, W Batool… - Annals of Medicine and …, 2026
Keratoconus is a degenerative eye disorder characterized by progressive thinning
and anterior bulging, which leads to visual distortion. Corneal collagen cross-linking
(CXL) is now considered the standard of care for preventing further disease …
and anterior bulging, which leads to visual distortion. Corneal collagen cross-linking
(CXL) is now considered the standard of care for preventing further disease …
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Current Perspectives in Surgical Correction of Myopia
T Chauhan, K Bhardwaj, KS Hikkalagutti - Manual of Myopia Control
Myopia, commonly known as near-sightedness, affects a significant proportion of the
global population especially in the East and Southeast Asia where rates have
reached epidemic proportions. Recent studies have suggested that by 2050, almost …
global population especially in the East and Southeast Asia where rates have
reached epidemic proportions. Recent studies have suggested that by 2050, almost …
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[TXT] Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Park Road, Auckland, New …
IP Loh, JCF Gaskin, T Sherwin, CNJ McGhee
… Keratoconus is a degenerative ectatic disease, with both a genetic … corneal
hydrops with a giant intrastromal cleft secondary to keratoconus. Clin Exp …
Detection of specific collagen types in normal and keratoconus corneas. Invest …
hydrops with a giant intrastromal cleft secondary to keratoconus. Clin Exp …
Detection of specific collagen types in normal and keratoconus corneas. Invest …
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[PDF] Effect of Laser-Assisted in Situ Keratomileusis versus Trans Photo Refractive Keratectomy on Corneal Endothelial Cell Count
O Irfan, S Parveen, T Azeem, A Fawad, AI Sheen - Pakistan Journal of Ophthalmology, 2026
… The study excluded patients who had Fuchs' dystrophy, keratoconus, pregnancy,
diabetes, glaucoma, past ocular surgery, trauma or any other corneal and ocular
pathology. Endothelial cells count (ECC) was assessed at baseline and at 12 …
diabetes, glaucoma, past ocular surgery, trauma or any other corneal and ocular
pathology. Endothelial cells count (ECC) was assessed at baseline and at 12 …
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[PDF] Asymmetric whole eye movement during non-contact tonometry: independent validation and implications for corneal biomechanical parameters
D Oehring, P Buckhurst, C Purslow, H Buckhurst - 2026
Purpose The Corvis ST non-contact tonometer calculates whole eye movement (WEM)
to isolate corneal deflection from globe displacement, assuming symmetrical
retraction. This study aimed to validate the Corvis ST WEM parameter against an …
to isolate corneal deflection from globe displacement, assuming symmetrical
retraction. This study aimed to validate the Corvis ST WEM parameter against an …
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[PDF] Mechanical Activation of PIEZO1 Drives AP-1–Dependent PTGS2/PGE2 Signaling and Corneal Inflammation
Z Zou, X Qian, J Ren, Y Wang, Y Liu, A Luo, M Guo… - iScience, 2026
… Given that eye rubbing is a significant high-risk factor for the onset of keratoconus,
we 237 analyzed single-cell corneal data from patients with keratoconus (GSE285060)5. …
keratoconus exhibit higher levels of PGE2 compared to healthy individuals …
we 237 analyzed single-cell corneal data from patients with keratoconus (GSE285060)5. …
keratoconus exhibit higher levels of PGE2 compared to healthy individuals …
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![[Video] Adverse Eye Rubbing in Keratoconus](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg4HRiK6MvFtia856foWYkBDP2bCVe0NB-S445VtbzLVYY19KJ6Pma-J-xabIQgjfE3RyTgr5C7Y9IvGs6PZ2ofcR13vtnGSwqghFJv40mZdjUD4VyOfjGN03Fhyphenhyphenziai2VNOASlDExTi77TdfDrh2yKeS735QlfIwwLZhn0xilsHeLiGDvhshth384ZzgBu/w72-h72-p-k-no-nu/keratoconus-pathogenesis.jpg)
