[HTML] An Evaluation of Practitioner Competency and Practices in Diagnosing and Managing Keratoconus in Malawi: A Cross-Sectional Analysis
L Thom, VR Moodley - Vision, 2026
This study assessed eye care practitioners’ competencies, clinical practices, and
barriers related to KC diagnosis and management in Malawi. A national cross-sectional
study was conducted among eye care practitioners in Malawi. Data were collected …
barriers related to KC diagnosis and management in Malawi. A national cross-sectional
study was conducted among eye care practitioners in Malawi. Data were collected …
Ocular Surface Symptoms and Tear-Film Parameters in Keratoconus: A Systematic Review and Meta-Analysis
C Yang, Y Yang, W Deng, N Yang - Frontiers in Medicine
BackgroundOcular-surface abnormalities are increasingly recognized in
keratoconus (KC), but the magnitude and consistency of these changes remain
uncertain. We evaluated ocular-surface symptoms, tear-function parameters, and dry-eye-related …
keratoconus (KC), but the magnitude and consistency of these changes remain
uncertain. We evaluated ocular-surface symptoms, tear-function parameters, and dry-eye-related …
[PDF] Vision-Related Quality of Life in Keratoconus: A KORQ-Based Cross-Sectional Study
AK Sinha, KK Gupta - Adolescência e Saúde, 2026
… Therefore, the present study aims to evaluate the impact of keratoconus on
patients’ quality of life using the Keratoconus Outcomes Research Questionnaire (KORQ).
By analysing activity limitation and symptom burden in individuals diagnosed with …
patients’ quality of life using the Keratoconus Outcomes Research Questionnaire (KORQ).
By analysing activity limitation and symptom burden in individuals diagnosed with …
Your Guide to Keratoconus Treatment Options
S Jagmohan, B Optom, I FIAOMC, OM Prescriber…
If your keratoconus is stable, we usually recommend a review every 6 to 12 months.
Children, teenagers, anyone with suspected progression and people who have
recently had treatment may need to return sooner.
Children, teenagers, anyone with suspected progression and people who have
recently had treatment may need to return sooner.
[HTML] Enhanced Effects of Riboflavin/UVA Crosslinking, N-Acetylcysteine, and Polydatin on Collagenase Resistance in Human Corneal and Scleral Tissue: A Pilot Ex Vivo …
C Mazzotta, F Cappellani, MA Nanavaty, M Zeppieri… - Journal of Clinical Medicine, 2026
… This approach could support future therapeutic strategies targeting corneal
weakening in keratoconus and scleral remodeling in progressive myopia, with
potential extensions to refractive surgery in thin corneas. Further experimental and …
weakening in keratoconus and scleral remodeling in progressive myopia, with
potential extensions to refractive surgery in thin corneas. Further experimental and …
Anterior Corneal Higher-Order Aberrations and Quantitative Macular OCT Angiography Metrics in Healthy Eyes: A Cross-Sectional Study
B BaÅŸkan, Y Evcimen - Seminars in Ophthalmology, 2026
… The closest are reports of reduced macular VD and altered FAZ geometry in
keratoconus, in which corneal optics were not modelled. … Citation24,Citation25
The finding bears on the keratoconus OCTA literature as well. Keratoconus is the …
keratoconus, in which corneal optics were not modelled. … Citation24,Citation25
The finding bears on the keratoconus OCTA literature as well. Keratoconus is the …
Keratoconus Treatment: The Last 10 Years, From Cross-Linking to CAIRS
S Güreser
A decade ago, what I could offer a patient with keratoconus amounted to" let's watch
it, and if it progresses you may need a transplant." What I say today is entirely
different. This is a review of the ground corneal surgery has covered in ten years …
it, and if it progresses you may need a transplant." What I say today is entirely
different. This is a review of the ground corneal surgery has covered in ten years …
[HTML] Longitudinal densitometric and biomechanical changes following accelerated epithelium-off corneal cross-linking for keratoconus
M Ge, H Yu, J Wu, Y Wang, G Xiao, N Li, X Liu, Y Liu… - BMC Ophthalmology, 2026
Background To characterize longitudinal changes in Scheimpflug corneal
densitometry and Corvis ST biomechanical parameters after accelerated epithelium-off
corneal cross-linking (CXL) for keratoconus (KC) and to explore their postoperative …
densitometry and Corvis ST biomechanical parameters after accelerated epithelium-off
corneal cross-linking (CXL) for keratoconus (KC) and to explore their postoperative …
[HTML] Regional corneal epithelial thickness and asymmetry patterns in early keratoconus versus regular astigmatism using MS-39 anterior segment OCT: a comparative …
Y Hadi, FK Kabood, P Abdolalizadeh, L Ghiasian… - BMC ophthalmology, 2026
Background To compare corneal epithelial thickness (CET) profiles among different
types of regular astigmatism and early keratoconus (KCN) using the MS-39 anterior
segment optical coherence tomography (AS-OCT) and to identify disease-specific …
types of regular astigmatism and early keratoconus (KCN) using the MS-39 anterior
segment optical coherence tomography (AS-OCT) and to identify disease-specific …
Anterior Lamellar Keratoplasty and Penetrating Keratoplasty for Keratoconus: An IRIS (Intelligent Research in Sight) Registry Analysis
S Jabbour, A Fujita, A Pollmann, WB Nassrallah… - Cornea, 2026
… Purpose: The aim of this study was to compare preoperative determinants of
procedure selection and long-term outcomes between anterior lamellar keratoplasty
(ALK) and penetrating keratoplasty (PKP) in patients with keratoconus in the United …
procedure selection and long-term outcomes between anterior lamellar keratoplasty
(ALK) and penetrating keratoplasty (PKP) in patients with keratoconus in the United …
[HTML] What Is Normal Topography?
JB Randleman - Journal of Refractive Surgery, 2026
… Topographic pattern normality or abnormality purportedly differentiates preclinical
stages: subclinical keratoconus, forme fruste keratoconus, and keratoconus suspect.
Thus, the impetus to accurately differentiate normal from abnormal topography is clear. …
stages: subclinical keratoconus, forme fruste keratoconus, and keratoconus suspect.
Thus, the impetus to accurately differentiate normal from abnormal topography is clear. …
corneal topography and early
MH Wang, S Qin - Explainable Artificial Intelligence for Trustworthy and …, 2026
Background: Early detection of keratoconus is essential for preventing postoper-ative
complications in refractive surgery and preserving long-term visual function.
Although artificial intelligence has demonstrated strong potential in ophthalmic …
complications in refractive surgery and preserving long-term visual function.
Although artificial intelligence has demonstrated strong potential in ophthalmic …
Beyond Donor Shortage: Tissue Utilization and Resilience in Modern Corneal Transplantation
IA Algouf, HA Daghriri, M Almutlak, R Fairaq… - Frontiers in Medicine
… In keratoconus, earlier diagnosis and interventions that preserve or rehabilitate
the native cornea may delay or avoid keratoplasty in appropriately selected patients.
This represents another dimension of tissue conservation: reserving donor tissue for …
the native cornea may delay or avoid keratoplasty in appropriately selected patients.
This represents another dimension of tissue conservation: reserving donor tissue for …
[HTML] Corneal Wavefront–Guided Transepithelial PRK Aligned to Comatic Axis After Corneal Cross-linking for Keratoconus
L Izquierdo Jr, I Gómez, C Pomatanta, C Bonel… - Journal of Refractive …, 2026
Purpose: To evaluate the clinical outcomes of a comatic axis–adjusted corneal
wavefront–guided transepithelial photorefractive keratectomy (TransPRK) protocol
for visual rehabilitation in patients with keratoconus previously treated with corneal …
wavefront–guided transepithelial photorefractive keratectomy (TransPRK) protocol
for visual rehabilitation in patients with keratoconus previously treated with corneal …
[PDF] Inverse-Designed Anisotropic Intrastromal Corneal Exoskeletons for Keratoconus: A Three-Dimensional Computational Feasibility Study
J Sumaya-Martinez, A Altamirano - arXiv preprint arXiv:2610.08529, 2026
We propose G-EXO, an inverse-designed intrastromal corneal exoskeleton for
keratoconus. Unlike conventional intracorneal ring approaches, G-EXO is conceived
as a patient-customizable, sectorial and anisotropic scaffold whose geometry and …
keratoconus. Unlike conventional intracorneal ring approaches, G-EXO is conceived
as a patient-customizable, sectorial and anisotropic scaffold whose geometry and …
[PDF] Experimental ex vivo Study of Femtosecond-assisted Radial Keratotomy (Femto LDV Z8) in Progressive Keratoconus
SB Izmailova, LL Boltovskaya, SV Novikov, F Muller… - Ophthalmology in Russia, 2026
Purpose Purpose: To assess the technical feasibility and quality of femtosecond
radial keratotomy using the Femto LDV Z8 laser system, as well as to determine the
biomechanical strength of the cornea under static load in ex vivo experiments …
radial keratotomy using the Femto LDV Z8 laser system, as well as to determine the
biomechanical strength of the cornea under static load in ex vivo experiments …
A Systematic Quality Assessment of Online Resources on Keratoconus using the Modified Ensuring Quality Information for Patients (mEQIP)
A Cartabellotta, A Taloni, GG Adamo, M Pellegrini… - Ophthalmic Research
… on keratoconus. Methods: Google, Yahoo and Bing were queried for the
keywords “Keratoconus”, “Keratoconus treatment”, “Keratoconus … Conclusions:
Overall, this study indicates moderate quality of online information regarding …
keywords “Keratoconus”, “Keratoconus treatment”, “Keratoconus … Conclusions:
Overall, this study indicates moderate quality of online information regarding …
[PDF] Epithelium-on Corneal Cross-linking Using a Modified Penetration Enhancer Without Supplemental Oxygen or Iontophoresis
F Hafezi, ME Aydemir, M Hillen, L Kollros, NL Hafezi… - Journal of Refractive …, 2026
… Patients with progressive keratoconus were enrolled in this study between May
2021 and October 2023. All epi-on CXL procedures were … Keratoconus was
considered progressive if anterior keratometry (Kmax) increased by ≥1.00 diopter (D) …
2021 and October 2023. All epi-on CXL procedures were … Keratoconus was
considered progressive if anterior keratometry (Kmax) increased by ≥1.00 diopter (D) …
Five-Year Follow-up of the ELZA-sub400 Protocol: Individualized Corneal Cross-linking With Riboflavin and UV-A in Ultrathin Keratoconic Corneas
EA Torres-Netto, S Kling, RE Akcan, L Kollros… - Journal of Refractive …, 2026
… In this retrospective interventional case series, 39 eyes of 33 patients with
progressive keratoconus or primary ectasia and stromal thickness between 214 and
398 µm underwent CXL using the ELZA-sub400 protocol. Following epithelial …
progressive keratoconus or primary ectasia and stromal thickness between 214 and
398 µm underwent CXL using the ELZA-sub400 protocol. Following epithelial …
[HTML] Anterior Stromal Melt Following Implantation of a Large Size Corneal Allogenic Intrastromal Ring Segment (CAIRS)
KE Asfar, S Jacob, JF Assaf, F Hafezi, ST Awwad - Journal of Refractive Surgery, 2026
… A 62-year-old man with advanced bilateral keratoconus underwent femtosecond
laser–… keratoconus (Amsler–Krumeich stage 3) presented for a routine evaluation
following bilateral CAIRS insertion 10 months ago at our institution. He had a long-lasting …
laser–… keratoconus (Amsler–Krumeich stage 3) presented for a routine evaluation
following bilateral CAIRS insertion 10 months ago at our institution. He had a long-lasting …
[PDF] Femtosecond Laser-Assisted Keratoplasty: A Narrative Review of Technological Evolution, Clinical Evidence, Implementation and Future Directions
Y Du, S Zhang, T Yu, S Yang, C Ge, Y Tao - Clinical Ophthalmology, 2026
Femtosecond laser-assisted keratoplasty (FLAK) enables programmable
photodisruption, customized graft-host configurations, and image-guided corneal
reconstruction. This narrative review synthesizes 107 scholarly publications …
photodisruption, customized graft-host configurations, and image-guided corneal
reconstruction. This narrative review synthesizes 107 scholarly publications …
Automated Classification of Keratoconus from Pentacam Corneal Topographic Maps Using Wavelet-Based Feature Extraction and Light Gradient Boosting Machine.
PT Geddada, RK Pullagura - Ingénierie des Systèmes d'Information, 2026
… Keratoconus is a progressive corneal disorder characterized by corneal thinning
and irregular deformation, which may lead to visual impairment if not identified at an
early stage. This study proposes an automated multiclass classification framework …
and irregular deformation, which may lead to visual impairment if not identified at an
early stage. This study proposes an automated multiclass classification framework …
Indications for scleral lens prescribing in a single referral contact lens clinic in the Philippines: a 10-year retrospective review
M Romualdez, J Oo - Contact Lens and Anterior Eye, 2026
… Out of the 447 eyes that were fitted, the primary indication for scleral lens fitting for
this clinic was keratoconus 72.9%, followed by corneal … For keratoconus fittings,
72.1% were male and 27.9% female. The mean age of keratoconus patients at the …
this clinic was keratoconus 72.9%, followed by corneal … For keratoconus fittings,
72.1% were male and 27.9% female. The mean age of keratoconus patients at the …
A study of the frequency of corneal ectasia in young children
L Michaud, R Marcotte-Collard, P Simard… - Contact Lens and Anterior …, 2026
… This analysis classified corneal topography maps as normal, suspicious or
positive for keratoconus. Corneal biomechanics were measured … normal or as
presenting with mild, moderate or advanced risk for keratoconus. The frequency of …
positive for keratoconus. Corneal biomechanics were measured … normal or as
presenting with mild, moderate or advanced risk for keratoconus. The frequency of …
A customisable scleral lens system utilising two distinct sagittal depths: real-world clinical experience in cases with limbal asymmetry and scleral toricity
C Gildea - Contact Lens and Anterior Eye, 2026
… In this subset, mean (SD) age was 52.9 (21.9) years, 8/17 were female, 12/17
were White, and the most common diagnosis was keratoconus (12/17). Mean (SD)
horizontal and vertical sagittal depths were 4793 (400) μm and 5092 (439) μm …
were White, and the most common diagnosis was keratoconus (12/17). Mean (SD)
horizontal and vertical sagittal depths were 4793 (400) μm and 5092 (439) μm …
[HTML] Corneal topographic changes after upper eyelid blepharoplasty prior to cataract surgery
K Varna-Tigka, S Göhring, M Böhm, Y Wenner… - International Ophthalmology, 2026
… Exclusion criteria were corneal surface altering diseases such as keratoconus,
pterygium, or contact lens wear; a history of corneal refractive surgery; eyelid
pathologies like upper eyelid ptosis, entropion, ectropion, macular pathology …
pterygium, or contact lens wear; a history of corneal refractive surgery; eyelid
pathologies like upper eyelid ptosis, entropion, ectropion, macular pathology …
Testosterone exposure shifts female baseline phenotypes toward a male-associated tear-nerve-epithelial state in mice
N Feret, AC Megido, S Pernot, M Girard, M Decoudu… - Scientific Reports, 2026
Sex and hormonal status are clinically relevant determinants of ocular-surface
physiology, but whether adult androgen exposure shifts multiple components of the
ocular surface in parallel remains poorly defined. We compared vehicle-treated …
physiology, but whether adult androgen exposure shifts multiple components of the
ocular surface in parallel remains poorly defined. We compared vehicle-treated …
[PDF] Clinical Performance And Patient Satisfaction Following A Duet Procedure With Sulcoflex Trifocal Supplementary Intraocular Lens In Conjunction With Enhanced …
VSMROAI Lens - 2026
Background Patients’ expectations regarding overall visual independence following
cataract surgery are constantly rising. The Duet technique, which combines a
monofocal intraocular lens in the capsular bag with an additional trifocal sulcus lens …
cataract surgery are constantly rising. The Duet technique, which combines a
monofocal intraocular lens in the capsular bag with an additional trifocal sulcus lens …
Actin filament and microtubule-centered cytoskeletal abnormalities are associated with intracellular structural disorder and cellular softening in keratoconus stromal …
X Chen, J Wang, S Zuo, S Li, Y Han, Z Tan, H Zou… - International Journal of …, 2026
Keratoconus (KC) is characterized by progressive corneal thinning and
biomechanical weakening, however, the cellular mechanobiological basis
underlying stromal softening remains poorly understood. In this study, we …
biomechanical weakening, however, the cellular mechanobiological basis
underlying stromal softening remains poorly understood. In this study, we …
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[HTML] Non-contact optical coherence elastography with motion-artifact correction and curvature compensation for quantitative assessment of in vivo keratoconus …
Y Zhu, L Huang, L Wang, N Luo, TEG Alvarez Arenas… - Biomedical Optics Express, 2026
Keratoconus (KC) is a progressive ectatic disorder in which stromal thinning and
apical protrusion culminate in marked biomechanical decompensation of the cornea.
Quantifying these changes in vivo is essential for early detection, monitoring of …
apical protrusion culminate in marked biomechanical decompensation of the cornea.
Quantifying these changes in vivo is essential for early detection, monitoring of …
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[HTML] Interaction of genetic and environmental risk factors in the aetiology of keratoconus
R Hadvina, Y Liu - Open Biology, 2026
Keratoconus (KC) is a multifactorial corneal ectasia disorder that is influenced by
genetic and environmental risk factors. The manner and degree to which any risk
factor contributes mechanistically to KC pathogenesis is not fully understood …
genetic and environmental risk factors. The manner and degree to which any risk
factor contributes mechanistically to KC pathogenesis is not fully understood …
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Task-Adaptive Multi-Prototype Prototypical Networks for keratoconus diagnosis under unbalanced small samples
S Zeng, J Yang, W Lin, X Lin, W Wu, X Chen, F Ye - Biomedical Signal Processing …, 2027
Objective: This study aims to develop and evaluate a meta-learning-based
intelligent diagnostic algorithm for Keratoconus (KC), addressing limited training
samples and class imbalance in corneal topography analysis. Early detection of KC …
intelligent diagnostic algorithm for Keratoconus (KC), addressing limited training
samples and class imbalance in corneal topography analysis. Early detection of KC …
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Machine Learning in Keratoconus: Severity Grading, Progression Prediction, and Surgery Outcomes
J Liang, Z Zhang, A Ilman Qudsi, Q Liang - Frontiers in Cell and Developmental Biology
Aim: To review and evaluate machine learning (ML) and deep learning (DL),
applications in keratoconus (KC), with a focus on severity classification, progression
prediction, and surgical outcome prediction. Methods: A systematic literature search …
applications in keratoconus (KC), with a focus on severity classification, progression
prediction, and surgical outcome prediction. Methods: A systematic literature search …
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[HTML] IOL Power Calculation: A Complete Guide to Modern Formulas, Post-Refractive Eyes, and Keratoconus
RMIMD FRANZCO
Selecting the correct intraocular lens (IOL) power is one of the most consequential
technical steps in cataract surgery. A technically well-executed operation can still
leave a patient with an unwanted refractive outcome if the power calculation was …
technical steps in cataract surgery. A technically well-executed operation can still
leave a patient with an unwanted refractive outcome if the power calculation was …
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[HTML] Measurement Repeatability and Concordance of Corneal Tomography in Keratoconus Using Anterion Versus Pentacam
R Ahmed, KN Reddy, M Mohamed, NS Shekhawat - Bioengineering, 2026
Purpose: This study aimed to compare the repeatability and agreement of corneal
tomographic measurements between the Anterion Cornea App and Pentacam HR in
keratoconus (KCN). Methods: Eyes with KCN were imaged three consecutive times …
tomographic measurements between the Anterion Cornea App and Pentacam HR in
keratoconus (KCN). Methods: Eyes with KCN were imaged three consecutive times …
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Beyond Eye Rubbing: Mechanical Ocular Stimulation Is Highly Prevalent in Keratoconus
S Koh, R Inoue, D Gatinel, K Nishida - Eye & Contact Lens: Science & Clinical …, 2026
… Methods: This prospective study included Japanese outpatients with a clinical
diagnosis of keratoconus in at least one eye. All participants completed a structured
investigator-developed questionnaire assessing current and past mechanical ocular …
diagnosis of keratoconus in at least one eye. All participants completed a structured
investigator-developed questionnaire assessing current and past mechanical ocular …
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Portable and head-mounted corneal cross-linking systems for keratoconus and infectious keratitis: a narrative review
E Wibowo, IT Mahayana, BC Nirmala, MB Sasongko - Annals of Eye Science, 2026
Background and Objective: Corneal collagen cross-linking (CXL) is the standard
treatment for halting the progression of keratoconus. Its role has been explored as
an adjunctive treatment for infectious keratitis through photoactivated chromophore …
treatment for halting the progression of keratoconus. Its role has been explored as
an adjunctive treatment for infectious keratitis through photoactivated chromophore …
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Ultra-Thin Bilateral Keratoconus with Sub-100 Micron Corneas: A Rare Case Report
M Ahmed, M Hamza, A Rehman, J Inam, S Zahid… - Egyptian Journal of …, 2026
… Results: The patient had advanced bilateral keratoconus with central corneal
thickness of 98 µm in the right eye and 180 µm in the left. … Family screening
detected subclinical keratoconus in a sibling.Conclusion: This case underscores the …
thickness of 98 µm in the right eye and 180 µm in the left. … Family screening
detected subclinical keratoconus in a sibling.Conclusion: This case underscores the …
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[PDF] Study of corneal topographical changes in vernal keratoconjunctivitis among pediatric age group attending to eye OPD, Dr. Sushila Tiwari Hospital, Kumaon Region
A Talwalkar¹, N Mehrotra, P Mishra, A Talwalkar - 2026
… was significantly lower in patients with keratoconus (476.8 ± 15.2 μm) compared
with those without keratoconus (514.6 ± 26.8 μm, p = … topographic evidence of
keratoconus, corneal topography identified suspect, early, and established …
with those without keratoconus (514.6 ± 26.8 μm, p = … topographic evidence of
keratoconus, corneal topography identified suspect, early, and established …
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[PDF] Early paradoxical increase in astigmatism after corneal allogeneic intrastromal ring segment implantation: Incidence, predictors, and clinical implications
A Igarashi, FFNK Perk, S Yamagami, A Kılıç, T Hayashi - 2026
… Methods: This retrospective observational study included patients with
keratoconus who underwent CAIRS implantation at a single centre … A total of 109
eyes from patients who underwent CAIRS implantation for keratoconus were …
keratoconus who underwent CAIRS implantation at a single centre … A total of 109
eyes from patients who underwent CAIRS implantation for keratoconus were …
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Combined laser refractory surgery and corneal crosslinking protocols in at-risk patients: current approaches and clinical results| Ukrainian Medical Journal
TM Komarova, DH Rudoi - Combined laser refractory surgery and corneal …, 2026
Purpose: to systematize, based on the available scientific literature, the clinical and
tomographic criteria for selecting patients at increased risk of corneal ectasia and to
summarize the refractive, visual, and topographic outcomes of combined laser vision …
tomographic criteria for selecting patients at increased risk of corneal ectasia and to
summarize the refractive, visual, and topographic outcomes of combined laser vision …
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Impact of Scleral Lens Wear on Intraocular Pressure, Retinal Structure, and Choroidal Vascularity
R EroÄŸlu, G Ozkan, SA Turhan - Eye & Contact Lens: Science & Clinical Practice, 2026
… Nevertheless, data remain limited, particularly in patients with keratoconus who
represent a major population of SL users. … was associated with an increase in IOP
in habitual SL wearers with keratoconus. Secondary exploratory aims were to …
represent a major population of SL users. … was associated with an increase in IOP
in habitual SL wearers with keratoconus. Secondary exploratory aims were to …
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[PDF] Scleral Contact Lens Research in Keratoconus: A Bibliometric Analysis
N Pandya, R Thakur, J Movaliya - Pakistan Journal of Ophthalmology, 2026
This bibliometric study evaluated research trends on binocular vision dysfunction in
keratoconus, with particular emphasis on knowledge gaps related to scleral contact
lenses. A comprehensive Scopus search identified English-language original …
keratoconus, with particular emphasis on knowledge gaps related to scleral contact
lenses. A comprehensive Scopus search identified English-language original …
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[PDF] Repeatability and Reliability of Corneal Tomography in Keratoconus Patients with Corneal Allogenic Intrastromal Ring Segments
U Tunc, D Colak, B Yakut, FFNK Perk…
Objectives: To assess the repeatability and reliability of anterior and posterior
corneal measurements in keratoconus patients who underwent corneal allogenic
intrastromal ring segment (CAIRS) implantation using a Scheimpflug-based …
corneal measurements in keratoconus patients who underwent corneal allogenic
intrastromal ring segment (CAIRS) implantation using a Scheimpflug-based …
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Understanding higher-order aberrations in keratoconus
G Swartz, K Alam, A Gentle, LE Downie - … and vision science: official publication of …, 2026
… However, image quality in eyes with keratoconus remains reduced relative to
nondiseased … optics relating to the ocular wavefront in keratoconus into clinically
relevant insights, examine … clinical care and guiding future approaches to …
nondiseased … optics relating to the ocular wavefront in keratoconus into clinically
relevant insights, examine … clinical care and guiding future approaches to …
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[HTML] Microbubble-assisted pLIFU enhances riboflavin delivery and corneal cross-linking in an in vivo rabbit keratoconus-like model
Q Wang, S Guo, Y Sun, Y Wu, Z Lin, T Wang, X Chen… - Ultrasonics Sonochemistry, 2026
… keratoconus progression but disrupts the epithelial barrier, whereas epithelium-on
CXL is constrained by limited stromal riboflavin loading and insufficient evidence
that physical delivery enhancement improves CXL outcomes in vivo keratoconus… -induced …
CXL is constrained by limited stromal riboflavin loading and insufficient evidence
that physical delivery enhancement improves CXL outcomes in vivo keratoconus… -induced …
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Ophthalmology; Pediatric ophthalmology; Magnifying glasses; Eye drops; Corneal transplantation; Cornea surgery; Newborn screening; Keratoconus
M Palamar
… Topics include the use of surgical loupes, eye drop self-administration
competence among healthcare professionals, neonatal vision screening by family
physicians, pediatric eye conditions such as microtropia and post-cataract surgery …
competence among healthcare professionals, neonatal vision screening by family
physicians, pediatric eye conditions such as microtropia and post-cataract surgery …
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[HTML] Hypoosmolar riboflavin for corneal swelling in thin keratoconic corneas prior to crosslinking: An exploratory study
CY Chang, SR Gollamudi, DG Fuller, C Rasheed - Therapeutic Advances in …, 2026
Background Corneal crosslinking (CXL) treats progressive keratoconus (KCN), but
thin corneas may fall below 400 µm after epithelial removal and riboflavin induction,
risking endothelial damage. Hypoosmolar riboflavin ophthalmic solution (HORF) can …
thin corneas may fall below 400 µm after epithelial removal and riboflavin induction,
risking endothelial damage. Hypoosmolar riboflavin ophthalmic solution (HORF) can …
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[PDF] Comparison of the Outcomes of Implantable Collamer Lens Surgery Performed by Fellows and Consultants in a Tertiary Eye Care Hospital
RS Alshabeeb, F Aljassar, LM AlBathi, K Ahmad - Clinical Ophthalmology, 2026
… Patients who underwent ICL implantation for hyperopia, keratoconus, or postkeratoplasty
were excluded from the study. The outcomes and complication rates were compared
based on whether the primary surgeon was a fellow (fellow group) or a consultant …
were excluded from the study. The outcomes and complication rates were compared
based on whether the primary surgeon was a fellow (fellow group) or a consultant …
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[PDF] Collagen-Based Therapeutics in Ocular Regeneration and Repair: A Comprehensive Review of Corneal and Eyelid Applications
ASS Jasbia, H Aghamolaei, S Shemshadi - The Journal of Applied Tissue …, 2026
… comes in 32 eyes of 22 patients with early keratoconus, … UDVA, CDVA, and
keratometric parameters (K1, K2, Kmean, and Kmax), with no graft rejection,
suggesting Xenia® implantation as a potential alternative to keratoplasty in selected …
keratometric parameters (K1, K2, Kmean, and Kmax), with no graft rejection,
suggesting Xenia® implantation as a potential alternative to keratoplasty in selected …
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[HTML] Gene Therapy for Corneal Diseases
B Bhujel, KS Eah, SS Kang, HS Chung, JY Kim - BioTech, 2026
… Intrastromal injection enables efficient and localized gene transfer to stromal
keratocytes, making it particularly suitable for treating stromal disorders such as
corneal fibrosis, keratoconus, and inherited corneal dystrophies. Intracameral …
keratocytes, making it particularly suitable for treating stromal disorders such as
corneal fibrosis, keratoconus, and inherited corneal dystrophies. Intracameral …
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World Clinical Management of Keratoconus in Europe and the Middle East: A Multicountry Survey on Diagnostic and Surgical Practices (Keratoconus in Mind-KIM …
JL Güell, E Arbabi, N Alejandre, L Fontana… - Cornea, 2026
… Purpose: This study aimed to describe the current management of patients with
keratoconus in European and Middle Eastern countries through the collection of real-world
data from clinicians actively managing keratoconus. … Questionnaire items were …
keratoconus in European and Middle Eastern countries through the collection of real-world
data from clinicians actively managing keratoconus. … Questionnaire items were …
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Clinical characteristics and management strategies of keratoconus in iraqi patients
SM Lafta, Z Noori, HA Aljaberi, AM Naji, S Rahmani - Delta Journal of Ophthalmology, 2026
… The aim of this study was to investigate the clinical characteristics, refractive error
profile, and management approaches in Iraqi patients diagnosed with keratoconus (KC),
emphasizing the disease severity, sex distribution, and visual outcomes …
profile, and management approaches in Iraqi patients diagnosed with keratoconus (KC),
emphasizing the disease severity, sex distribution, and visual outcomes …
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Establishing a precision reference benchmark for corneal epithelial aberration measurements using a new hybrid device across keratoconus stages
Y Yang, R Ning, S Li, X Yang, Y Wang, K Li, G Savini… - Eye and vision (London …, 2026
Background To establish a precision reference benchmark for corneal epithelial
aberration measurements across different stages of keratoconus (KC) by evaluating
the precision of a new spectral-domain optical coherence tomography-Placido disk …
aberration measurements across different stages of keratoconus (KC) by evaluating
the precision of a new spectral-domain optical coherence tomography-Placido disk …
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One-year structural and functional outcomes of accelerated epithelium-off corneal cross-linking in keratoconus
I Ćubela, D Miletić, BK Elabjer, S Ramić, I Pavlović… - International journal of …, 2026
Aim To evaluate the structural and functional outcomes of accelerated epithelium-off
corneal collagen cross-linking (CXL) in patients with keratoconus (KC) 1y after
treatment. Methods This retrospective study included patients who underwent an …
corneal collagen cross-linking (CXL) in patients with keratoconus (KC) 1y after
treatment. Methods This retrospective study included patients who underwent an …
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[HTML] Beyond Diagnosis: Can AI be the Future of Risk Stratification and Access to Keratoconus Care?
M Saeed
Artificial Intelligence (AI) has been increasingly improving in its accuracy and
diagnostic performance in medicine in general. In the context of Keratoconus (KC), it
has been heavily studied in the detection of established KC, with more recent …
diagnostic performance in medicine in general. In the context of Keratoconus (KC), it
has been heavily studied in the detection of established KC, with more recent …
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Evaluation of corneal stromal demarcation line depth after corneal collagen cross-linking with two different UV energy levels in keratoconus: a comparative study using …
T Liang, Q Li, K Zhou, WJ Cao, D Shen, Y Cheng… - International journal of …, 2026
… The high-energy group consisted of participants with progressive keratoconus
who received CXL treatment, while the low-energy group included participants with
refractive errors who underwent femtosecond laser-assisted in situ keratomileusis (FS-LASIK) …
who received CXL treatment, while the low-energy group included participants with
refractive errors who underwent femtosecond laser-assisted in situ keratomileusis (FS-LASIK) …
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Anterior, posterior, and total corneal astigmatism: clinical evidence and implications for ophthalmological practice
CMF Jardim, BS Rodrigues, AC Taleb - Revista Brasileira de Oftalmologia, 2026
… implications in normal eyes, in patients with keratoconus, and in individuals
evaluated in the … tomography in healthy eyes, eyes with keratoconus, or eyes
evaluated in the preoperative … , 3 evaluated eyes with keratoconus, 3 compared …
evaluated in the … tomography in healthy eyes, eyes with keratoconus, or eyes
evaluated in the preoperative … , 3 evaluated eyes with keratoconus, 3 compared …
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Preoperative predictive factors for opaque bubble layer formation and area during small-incision lenticule extraction: predictive models based on machine learning
C Peng, X Chen, Y Yang, H Ren, Y Huang, J Qiu, Y Li… - Eye and vision (London …, 2026
Background We aimed to develop exploratory machine learning (ML)-based
predictive models for the occurrence and area of an opaque bubble layer (OBL)
during small-incision lenticule extraction (SMILE) and identify associated …
predictive models for the occurrence and area of an opaque bubble layer (OBL)
during small-incision lenticule extraction (SMILE) and identify associated …
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Effect of rigid gas-permeable contact lens correction on macular optical coherence tomography measurements in keratoconus eyes
N Elkady, MM Salama, MI Elshazly, R Shalash - Contact Lens and Anterior Eye, 2026
… keratoconus using clinical and tomographic findings and classified it according to
the Collaborative Longitudinal Evaluation of Keratoconus (… We then compared
these changes between the keratoconus and control groups. We applied Holm …
the Collaborative Longitudinal Evaluation of Keratoconus (… We then compared
these changes between the keratoconus and control groups. We applied Holm …
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[PDF] Update on the Physiopathology of Keratoconus
RH Barcelo-Canton, A Rodriguez-Garcia… - Med. Sci, 2026
Keratoconus (KC) is a progressive corneal ectasia characterized by stromal thinning,
steepening, and biomechanical instability. Although historically considered primarily
a structural disorder, current evidence supports a multifactorial pathogenesis …
steepening, and biomechanical instability. Although historically considered primarily
a structural disorder, current evidence supports a multifactorial pathogenesis …
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[HTML] Depth-Dependent Corneal Backscatter Characteristics in Different Stages of Keratoconus and a Novel Composite Backscatter Index for Early Detection
H Tian, C Xu, Y Huo, X Zhang, W Gao, F Deng, Y Wang - … and Photodynamic Therapy, 2026
… depth-dependent distribution of corneal backscatter across keratoconus stages
and controls, and to … keratoconus (FFKC) Methods In this retrospective
comparative study, 213 eyes of 213 participants were enrolled: 65 FFKC, 47 clinical …
and controls, and to … keratoconus (FFKC) Methods In this retrospective
comparative study, 213 eyes of 213 participants were enrolled: 65 FFKC, 47 clinical …
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Ker-S6DSF: Selective State-Space-Based Dual-Stream Fusion for Keratoconus Screening
H Sazak, M Kotan, B Cakir - Arabian Journal for Science and Engineering, 2026
Keratoconus is a progressive eye disease characterized by the gradual thinning and
conical deformation of the cornea, which can lead to permanent vision loss if left
untreated. Identifying it in the early clinical stage remains a significant clinical …
conical deformation of the cornea, which can lead to permanent vision loss if left
untreated. Identifying it in the early clinical stage remains a significant clinical …
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[HTML] Dr. Ahmed Shaarawy: Egypt's Best Cornea Surgeon & Specialist
A Shaarawy
… Keratoconus, Keratoconus is a progressive corneal condition characterized by
corneal thinning and cone-shaped deformation. Dr. Shaarawy evaluates
keratoconus patients using specialized diagnostic techniques and offers …
corneal thinning and cone-shaped deformation. Dr. Shaarawy evaluates
keratoconus patients using specialized diagnostic techniques and offers …
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[HTML] Re: Cui et al.: Current indications and outcomes of penetrating keratoplasty in the United States: an IRIS® Registry Study (Ophthalmology. 2026; 133: 709–719)
D Abdulhussein - Ophthalmology
… Keratoconus commonly presents and progresses most rapidly during
adolescence, and pediatric and young-adult cohorts show high … cross-linking
failure), which are now central to staging keratoconus and other ectasias. Given …
adolescence, and pediatric and young-adult cohorts show high … cross-linking
failure), which are now central to staging keratoconus and other ectasias. Given …
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Bidirectional Association Between Obstructive Sleep Apnea and Keratoconus in Young Adults: A Multicenter Retrospective Cohort Study
FR Butt, J Muayad, T Dhivagaran, T Miller… - Cornea, 2026
… Global incidence and prevalence of keratoconus: a systematic review and meta-analysis.
Cornea. 2025;20. … Association between the prevalence of obstructive sleep
apnoea and the severity of keratoconus. Br J Ophthalmol. 2015;99:1675-1679 …
Cornea. 2025;20. … Association between the prevalence of obstructive sleep
apnoea and the severity of keratoconus. Br J Ophthalmol. 2015;99:1675-1679 …
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[PDF] Corneal Hydrops in Keratoconus: Role of compression suture with intracameral air–A case series
U Islam, M Hasan, AB Sajj, S Sarker - Medivision Journal of Medical and Health …, 2026
Introduction: Acute corneal hydrops (ACH) is a vision threatening complication of
advanced keratoconus caused by tear in Descemet … corneal hydrops in
keratoconus. Method: This retrospective case series include five eyes of five patients …
advanced keratoconus caused by tear in Descemet … corneal hydrops in
keratoconus. Method: This retrospective case series include five eyes of five patients …
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Gradient microneedles with in situ photosynthetic oxygenation for targeted corneal crosslinking
W Li, L Cui, T Chen, Y Chen, G Li, B Ren, L Wang… - Journal of Controlled …, 2026
Keratoconus is a progressive ectatic disorder characterized by focal biomechanical
weakening at the cone apex, yet conventional corneal collagen crosslinking (CXL)
uniformly treats the entire cornea without addressing this spatial heterogeneity …
weakening at the cone apex, yet conventional corneal collagen crosslinking (CXL)
uniformly treats the entire cornea without addressing this spatial heterogeneity …
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“Hybrid Docking” for Femtosecond Laser–assisted Deep Anterior Lamellar Keratoplasty: Combining Nonapplanating Trephination With Liquid Interface and …
L Daas, T Berger, B Seitz - Cornea, 2026
… advanced keratoconus to avoid high postoperative astigmatism. Methods: A proof-of-concept
study included 8 eyes of 7 patients with advanced keratoconus … for patients with
keratoconus: a retrospective analysis from the homburg keratoconus center. Cornea …
study included 8 eyes of 7 patients with advanced keratoconus … for patients with
keratoconus: a retrospective analysis from the homburg keratoconus center. Cornea …
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Compilation of Published Cases and a New Case Report of Corneal Ectasia After Keratorefractive Lenticule Extraction
M Moshirfar, S Molleti, CG Lee-Choi, H Pawlowski… - Cornea, 2026
… a total keratoconus classification of “possible” OD, which may have warranted
further evaluation for subclinical keratoconus (Fig. 1). The … history of eye rubbing,
it is possible that our patient had subclinical keratoconus before surgery. On the …
further evaluation for subclinical keratoconus (Fig. 1). The … history of eye rubbing,
it is possible that our patient had subclinical keratoconus before surgery. On the …
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[PDF] Timeline for corneal crosslinking procedures for keratoconus: A review
A Suliman, A Rubin, T Evans - African Vision and Eye Health, 2026
… Keratoconus usually starts during adolescence and progresses over the next 10–20
years, reaching a plateau in the late 30s or early 40s, with a few exceptions.Keratoconus …
Keratoconus is found not to be associated with systemic inflammation, but rather …
years, reaching a plateau in the late 30s or early 40s, with a few exceptions.Keratoconus …
Keratoconus is found not to be associated with systemic inflammation, but rather …
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[HTML] Peripheral pachymetry, eccentricity, and composite tomographic-biomechanical indices for screening forme fruste/suspect keratoconus
W Zhang, A Li, H Jiang, Y Wei, J Feng, S Li, Y Jiang… - BMC Ophthalmology, 2026
Background Early identification of forme fruste or suspect keratoconus is challenging
because curvature-based parameters may remain near normal. This study
evaluated Pentacam HR- and Corvis ST-derived parameters across normal, forme …
because curvature-based parameters may remain near normal. This study
evaluated Pentacam HR- and Corvis ST-derived parameters across normal, forme …
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[PDF] Visual, Tomographic, and Biomechanical Outcomes of CAIRS with Accelerated Cross-Linking in Moderate to Advanced Keratoconus: A 6-Month Retrospective Case …
N Hashmani, S Hashmani, J Saleem - Clinical Ophthalmology, 2026
… Our findings add to the growing body of literature supporting CAIRS as an
effective and safe intervention for keratoconus. Our study employed a combination
approach — CAIRS plus accelerated CXL — which mirrors the strategy used in early …
effective and safe intervention for keratoconus. Our study employed a combination
approach — CAIRS plus accelerated CXL — which mirrors the strategy used in early …
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OCULAR SURFACE MICROBIOTA IN PEDIATRIC KERATOCONUS: A COMPARATIVE OBSERVATIONAL STUDY
VV Tepleshniuk, IV Barinov - The Ukrainian Scientific Medical Youth Journal, 2026
Aim. To compare the ocular surface microbiota composition in pediatric patients with
keratoconus (KC) and healthy age-matched controls, and to assess the relationship
between microbial dysbiosis and disease progression. Materials and methods. A …
keratoconus (KC) and healthy age-matched controls, and to assess the relationship
between microbial dysbiosis and disease progression. Materials and methods. A …
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Biomechanical Stabilization of the Keratoconic Cornea: a Review of Current Therapeutic Strategies
GM Ragonese, E Grosso, D Carbonaro, E Torta… - Frontiers in Medical Technology
… Keratoconus is a progressive corneal ectatic disorder characterized by stromal
thinning and … Corneal collagen crosslinking represents the reference treatment for
progressive keratoconus… Advancing keratoconus management will require …
thinning and … Corneal collagen crosslinking represents the reference treatment for
progressive keratoconus… Advancing keratoconus management will require …
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[HTML] Scleral lens correction for a patient with macular corneal dystrophy
H Sun, Y Zhang, J Zhang, W Shi - Eye Discovery, 2026
Discussion SLs are well established for the management of complex corneal
disorders, including advanced keratoconus and ocular surface diseases such as
Stevens-Johnson syndrome 1, 2. However, to our knowledge, the use of SLs for …
disorders, including advanced keratoconus and ocular surface diseases such as
Stevens-Johnson syndrome 1, 2. However, to our knowledge, the use of SLs for …
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[HTML] Dynamic corneal parameter changes and safety in patients with moderate to high risk of corneal ectasia 12 months after SMILE Xtra surgery
Z Miao, J Mo, Q Lu, Q Li - Chin J Exp Ophthalmol, 2026
… Uncorrected distance visual acuity (UDVA), manifest refraction spherical
equivalent (MRSE), intraocular pressure (IOP), maximum keratometry (Kmax), mean
keratometry (Kmean), corneal morphological indices including central keratoconus …
equivalent (MRSE), intraocular pressure (IOP), maximum keratometry (Kmax), mean
keratometry (Kmean), corneal morphological indices including central keratoconus …
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[HTML] Preservation and Reuse of KLEx Lenticules: From Biobanking to Therapeutic and Refractive Innovations
R Christodoulou, S Ferrari, D Ponzin, M Nubile… - Bioengineering, 2026
… This report offers an alternative approach for lenticule implantation in keratoconus,
reducing surgical trauma and providing a simpler postoperative course compared
with traditional anterior lamellar or full-thickness corneal transplantation, while still …
reducing surgical trauma and providing a simpler postoperative course compared
with traditional anterior lamellar or full-thickness corneal transplantation, while still …
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[PDF] Evidence-Based Clinical Practice Guideline for Diagnosis, Treatment, and Follow-Up of Keratoconus Patients
A Bustamante-Arias, A Rosas-Apraez, CA Restrepo… - Clinical Ophthalmology, 2026
… Abstract: Keratoconus is a progressive corneal ectatic disorder characterized by
focal stromal thinning and conical … keratoconus or a personal history of allergic
disease, we suggest performing corneal tomography or topography to support early …
focal stromal thinning and conical … keratoconus or a personal history of allergic
disease, we suggest performing corneal tomography or topography to support early …
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[HTML] Anterior Segment Optical Coherence Tomography in Diseases Of The Ocular Surface And Cornea
S Sharma, S Murthy, L Share
… Corneal epithelial thickness maps have been useful in the early diagnosis of
keratoconus. [24] Apical epithelial thinning in the typical inferotemporal cone has a
corresponding epithelial thickening in the superonasal area. In the non-ectatic …
keratoconus. [24] Apical epithelial thinning in the typical inferotemporal cone has a
corresponding epithelial thickening in the superonasal area. In the non-ectatic …
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[HTML] Living Well with Keratoconus: Implications for Person-Centred Eye Care
E Lundanes, EA Brembo, L Leren, V Sundling - Ophthalmic and Physiological Optics, 2026
… the life experiences of persons living with keratoconus remains limited. Gaining
insights to … The aim of this study is to explore how persons living with keratoconus
experience vision-… -structured individual interviews with persons with keratoconus …
insights to … The aim of this study is to explore how persons living with keratoconus
experience vision-… -structured individual interviews with persons with keratoconus …
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Corneal Cross-linking Protocols in the Treatment of Progressing Keratoconus: A Comparative Systematic Review
O Shapira, Y Weill, D Zadok - International Journal of Keratoconus and Ectatic …, 2026
… -linking (CXL) protocols for progressive keratoconus with the standard corneal
cross-linking (S-… studies evaluating CXL protocols for progressive keratoconus.
Protocols were categorized as S-… the reference standard for durable keratoconus …
cross-linking (S-… studies evaluating CXL protocols for progressive keratoconus.
Protocols were categorized as S-… the reference standard for durable keratoconus …
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[HTML] Dry Eye Disease: Our Latest Insights for Improved Outcomes
OD Melissa Barnett, F FSLS, OD Jessilin Quint
… She’s one of the foremost experts in the treatment of dry eye disease and has
special interests in keratoconus, presbyopia, and specialty contact lenses. Dr. Quint
is a board-certified optometrist and public speaker. …
special interests in keratoconus, presbyopia, and specialty contact lenses. Dr. Quint
is a board-certified optometrist and public speaker. …
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[PDF] Tear MicroRNA-Based Molecular Signature for Keratoconus Stratification: A Cross-Cohort Integration Study
SH Chang, KH Hung, HF Tsai, CP Ma, HC Chiang… - Bioinformatics and Biology …, 2026
Keratoconus (KC) is a progressive corneal ectatic disorder characterized by
structural remodeling and immune-associated molecular alterations. However,
whether tear-derived microRNAs reflect corneal molecular changes remains unclear …
structural remodeling and immune-associated molecular alterations. However,
whether tear-derived microRNAs reflect corneal molecular changes remains unclear …
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Vision in the valley, debuts in the desert: An AOA 2026 recap
J Joy - Optometry Times, 2026
… to potentially treat keratoconus less invasively. Additionally, he weighed in on
patient misconceptions regarding keratoconus. … They see the information on how
eye rubbing is related to-or at least is part of the cause for-keratoconus and rethink …
patient misconceptions regarding keratoconus. … They see the information on how
eye rubbing is related to-or at least is part of the cause for-keratoconus and rethink …
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[HTML] Is Kmax a Reliable Endpoint for Evaluating Outcomes after CAIRS?
M Friedrich, D Kyroudis, D Goldblum, DJ Gunn… - Ophthalmology and Therapy, 2026
In ectatic corneas such as keratoconus, maximum keratometry (Kmax) is commonly
used to identify the cone apex and monitor disease severity and progression.
However, with the advent of tissue-additive corneal-reshaping surgical techniques …
used to identify the cone apex and monitor disease severity and progression.
However, with the advent of tissue-additive corneal-reshaping surgical techniques …
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Agreement between Sirius Scheimpflug-Placido tomography and Anterion swept-source OCT in keratoconic eyes stratified by prior corneal cross-linking: a …
K Erdogan, M Unlu, F Ozer - International Ophthalmology, 2026
… keratoconus. Therefore, further clarification is required regarding the differences
between the two devices at specific stages of keratoconus. The … of the present
study was to ascertain the degree of agreement between the Sirius and Anterion …
between the two devices at specific stages of keratoconus. The … of the present
study was to ascertain the degree of agreement between the Sirius and Anterion …
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[HTML] 2026 Annual GP and Custom Soft Lens Report
JS FOGT
… lenses specifically designed for keratoconus. Soft custom lenses are most
frequently used for astigmatism, and sales of multifocal and medically necessary
lenses for keratoconus, aphakia, and postsurgical cases have shown growth over …
frequently used for astigmatism, and sales of multifocal and medically necessary
lenses for keratoconus, aphakia, and postsurgical cases have shown growth over …
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[HTML] Biomechanical assessments of high-fluence corneal cross-linking with supplemental oxygen using optical coherence elastography in ex vivo rabbit eyes
V Thompson, KA Beckman, R Rajpal, B Tavakol… - Journal of Biomedical Optics, 2026
… Keratoconus is a type of corneal ectasia in which progressive thinning and
irregular … Keratoconus results in symptoms such as blurred or distorted vision,
which interfere with a … target the underlying corneal biomechanical changes seen …
irregular … Keratoconus results in symptoms such as blurred or distorted vision,
which interfere with a … target the underlying corneal biomechanical changes seen …
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[HTML] Ophthalmic manifestations of trisomy 21 syndrome in the pediatric age group: a cross-sectional study from Cairo University Specialized Pediatric Hospital
EW Abdelmohsen, IE Abdel Meguid, RR Kassem… - Egyptian Pediatric …, 2026
… The absence of keratoconus in this study group may be due to the young mean (1–9
year), as keratoconus typically develop in adolescence and early adulthood [17].
Strabismus was found in 25% of our study group, mainly esotropia (12.5%) …
year), as keratoconus typically develop in adolescence and early adulthood [17].
Strabismus was found in 25% of our study group, mainly esotropia (12.5%) …
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[HTML] Ocular Biometry: Measurements, IOL Calculations and What to Expect
VP July
Modern swept-source optical biometers and newer IOL formulas have improved
refractive accuracy. Nevertheless, refractive prediction remains less reliable in eyes
with unusual anatomy or previous corneal surgery, and no method can guarantee a …
refractive accuracy. Nevertheless, refractive prediction remains less reliable in eyes
with unusual anatomy or previous corneal surgery, and no method can guarantee a …
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[PDF] Pentacam multimodal topography-based radiomics for early keratoconus screening and staging
Q Gong, Y Dai, W Wang, D Wang, L Fang, J Li - Scientific Reports, 2026
Early keratoconus (KC) is characterized by insidious progression, which significantly
hinders clinical screening. This study introduces a radiomics analysis framework
based on Pentacam multimodal topographic maps and evaluates its efficacy in …
hinders clinical screening. This study introduces a radiomics analysis framework
based on Pentacam multimodal topographic maps and evaluates its efficacy in …
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Tomographic and densitometric corneal alterations in asymptomatic offspring of patients with keratoconus: a Turkish cross-sectional study
HI Atesoglu, MT Atesoglu, H Kızıltoprak, P Kosekahya… - International ophthalmology, 2026
… , 56 offspring of patients with keratoconus and 60 age- and sex-matched healthy
controls without a family history of keratoconus underwent comprehensive
ophthalmic examination and Pentacam HR imaging. Participants diagnosed with …
controls without a family history of keratoconus underwent comprehensive
ophthalmic examination and Pentacam HR imaging. Participants diagnosed with …
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Quantitative evaluation of choroidal thickness and vascularity in subclinical keratoconus: a cross-sectional EDI-OCT study
H Kiziltoprak, B Ören, DO Kocabas, E Yetkin, K Tekin - International ophthalmology, 2026
… A prospective, cross-sectional analysis was performed on 42 participants of
unilateral keratoconus (KC), defined by clinical keratoconus (CK) in one eye and SK
in the contralateral eye along with 42 age- and sex-matched healthy control …
unilateral keratoconus (KC), defined by clinical keratoconus (CK) in one eye and SK
in the contralateral eye along with 42 age- and sex-matched healthy control …
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Keratokonuslu Hastalarda Keratoplasti Sonrası Skleral Kontakt Lenslerle Görsel Rehabilitasyon: Uzun Dönem Sonuçlarının Diğer Göz ile Karşılaştırılması.
Ç ERKAN POTA, YS ATLIHAN, O ÖCAL, A CEYLAN - MN Opthalmology/MN …, 2026
Objective: To compare scleral contact lens (ScL) parameters, visual outcomes,
ocular surface findings, and patient comfort between eyes that underwent
keratoplasty and fellow non-operated eyes in patients with bilateral keratoconus (KC) …
ocular surface findings, and patient comfort between eyes that underwent
keratoplasty and fellow non-operated eyes in patients with bilateral keratoconus (KC) …
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Keratokonus Hastalarında Karotis İntima-Media Kalınlığı ile Abdominal Aort Çapının Değerlendirilmesi.
B ÖZDEMİR, S KARACA, G ZENGİN, F ESEN - MN Opthalmology/MN Oftalmoloji, 2026
Objective: Keratoconus (KC) is a progressive corneal disease; however, recent
studies suggest that it may also be associated with systemic and vascular diseases.
Carotid intima-media thickness (CIMT) and abdominal aortic diameter are indicators …
studies suggest that it may also be associated with systemic and vascular diseases.
Carotid intima-media thickness (CIMT) and abdominal aortic diameter are indicators …
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[HTML] Cumulative Atopic Disease Burden and Keratoconus: Cross-Sectional and Longitudinal Associations in the All of Us Research Program
J Muayad, F Abid, W Nassrallah, B Tao, Y Ahmed… - American Journal of …, 2026
… Main Outcome Measures Incident keratoconus (longitudinal) and prevalent
keratoconus (cross-sectional). Results Baseline atopic burden … associated with
incident keratoconus in a reproducible, dose-dependent manner, with atopy coding …
keratoconus (cross-sectional). Results Baseline atopic burden … associated with
incident keratoconus in a reproducible, dose-dependent manner, with atopy coding …
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Sclerals and the Long Game
OD Melissa Barnett - Contact Lens Spectrum, 2026
Scleral lenses are an important option for the management of irregular astigmatism
in individuals who have keratoconus (KC) and can provide significant visual and
therapeutic benefits. However, complications may occur with long-term scleral lens …
in individuals who have keratoconus (KC) and can provide significant visual and
therapeutic benefits. However, complications may occur with long-term scleral lens …
| | | |
Refractive Errors
D Baker, N Hussain, N Alfahad, G Bellamy Plaice… - Ophthalmology in 1000 …, 2026
… are generally not effective in correcting the irregular astigmatism seen in
keratoconus. Rigid gas-permeable (RGP) lenses, … keratoconus. While silicone
hydrogels have superior oxygen permeability and are suitable for extended wear …
keratoconus. Rigid gas-permeable (RGP) lenses, … keratoconus. While silicone
hydrogels have superior oxygen permeability and are suitable for extended wear …
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Cornea and Conjunctiva
D Baker, N Hussain, N Alfahad, G Bellamy Plaice… - Ophthalmology in 1000 …, 2026
… This chapter examines the structure and function of both the cornea and
conjunctiva, common disorders, such as keratitis, conjunctivitis, corneal dystrophies,
pterygium, and ectasia (eg, keratoconus), and the … The rest are procedures that …
conjunctiva, common disorders, such as keratitis, conjunctivitis, corneal dystrophies,
pterygium, and ectasia (eg, keratoconus), and the … The rest are procedures that …
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[HTML] Keratoconus and Corneal Ectasias: Current Concepts in Diagnosis and Management
HH Ozkan - 2026
Keratoconus (KC) is a progressive thinning of the cornea that causes it to bulge
outward into a cone, distorting vision and causing photophobia. It is usually
diagnosed in adolescence, and early diagnosis is important to manage the condition …
outward into a cone, distorting vision and causing photophobia. It is usually
diagnosed in adolescence, and early diagnosis is important to manage the condition …
| | | |
[PDF] Association of Keratoconus with Elevated Serum Low-Density Lipoprotein (LDL): A Cross-Sectional Comparative Study
AB Sajj, M Hasan, S Rahman, T Sharmin… - The Journal of Ad-din …, 2026
Background: Keratoconus (KC/KCN) is a progressive corneal ectasia traditionally
considered a localized biomechanical disorder; however, emerging evidence
highlights the role of systemic metabolic factors and oxidative stress in its …
considered a localized biomechanical disorder; however, emerging evidence
highlights the role of systemic metabolic factors and oxidative stress in its …
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[PDF] Topographic, Aberrometric and Visual Changes After Symmetrical and Asymmetrical Intrastromal Corneal Ring Implantation in Patients with Keratoconus
R Bella-Gala, J Carballo-Alvarez, RC Sardiña - 2026
Purpose of the study: To evaluate the short-term effects of two 6.0-mm Intrastromal
Corneal Ring Segment (ICRS) designs Symmetrical (S-ICRS) and Asymmetrical (AICRS)
on visual performance corneal morphology and optical quality in patients with …
Corneal Ring Segment (ICRS) designs Symmetrical (S-ICRS) and Asymmetrical (AICRS)
on visual performance corneal morphology and optical quality in patients with …
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[PDF] Comparison of Contact and Non-contact Pachymeters in the Measurement of Central Corneal Thickness (CCT)
NP Uwagboe, OM Odigie, AO Shuaibu, HA Ewanshiha - JOURNAL OF OPTOMETRY …, 2026
The Central Corneal Thickness (CCT) examination assists in the diagnosis of ocular
diseases such as glaucoma, keratoconus and Fuch’s dystrophy (FD). Several
instruments used for the measurement of CCT include the ultrasound pachymeter …
diseases such as glaucoma, keratoconus and Fuch’s dystrophy (FD). Several
instruments used for the measurement of CCT include the ultrasound pachymeter …
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PMW Nkoana, N Makgatho, RR Lekgau, MM Randima… - Clinical Optometry, 2026
Background Keratoconus (KC) is a progressive corneal ectatic disorder
characterised by thinning and irregular steepening, which may lead to visual
impairment if not detected early. Most diagnostic thresholds are derived from non-African …
characterised by thinning and irregular steepening, which may lead to visual
impairment if not detected early. Most diagnostic thresholds are derived from non-African …
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Influence of Riboflavin-UV-A illumination on the Expression of pro-and anti-apoptotic Markers in Human Corneal Fibroblasts from Healthy and Keratoconus Corneas
MDJ Kahlert, MDM Berger, MDB Seitz, PDS Suiwal… - Experimental Eye Research, 2026
Purpose Corneal crosslinking (CXL) using riboflavin and ultraviolet A (UV-A)
illumination is widely used to stabilize progressive ectatic corneal disorders such as
keratoconus. However, the photochemical reaction generates oxidative stress and …
illumination is widely used to stabilize progressive ectatic corneal disorders such as
keratoconus. However, the photochemical reaction generates oxidative stress and …
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A novel ZEB1 splice-site variant causing early-onset type 3 posterior polymorphous corneal dystrophy and suspected corneal ectasia
N Rani, SK Padhy, S Mandal - Ophthalmic Genetics, 2026
Posterior polymorphous corneal dystrophy type 3 (PPCD3) is an autosomal
dominant endothelial dystrophy caused by variations in the ZEB1 gene. We report a
pediatric case presenting with progressive visual impairment associated with …
dominant endothelial dystrophy caused by variations in the ZEB1 gene. We report a
pediatric case presenting with progressive visual impairment associated with …
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[HTML] Cumulative Atopic Disease Burden and Keratoconus: Cross-Sectional and Longitudinal Associations in the All of Us Research Program
FR Butt, T Dhivagaran, T Miller, J Muayad, SA Al-Burak… - American Journal of …
… In conclusion, cumulative atopic burden was associated with incident
keratoconus in a reproducible, dose-dependent manner, most clearly in early
adulthood, with atopy coding preceding keratoconus in a majority of co-affected …
keratoconus in a reproducible, dose-dependent manner, most clearly in early
adulthood, with atopy coding preceding keratoconus in a majority of co-affected …
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[HTML] Custom Soft Lenses for the Win
J HARTHAN
… His ocular history was significant for bilateral penetrating keratoplasties
performed for keratoconus. Although he had previously worn corneal GP lenses, he
reported poor comfort with them. Manifest refraction improved his visual acuities to …
performed for keratoconus. Although he had previously worn corneal GP lenses, he
reported poor comfort with them. Manifest refraction improved his visual acuities to …
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Tissue-Specific Mitochondrial Dysfunction in Keratoconus: An Integrated Structural, Genomic, and Functional Analysis
MSS Sharma, PDL Singh, PDMK Singh, MDTC Nag… - The Ocular Surface, 2026
Purpose Keratoconus (KC) is a progressive corneal ectasia characterized by stromal
thinning, conical protrusion, and irregular astigmatism, leading to visual impairment.
Although oxidative stress is implicated in KC, the role of mitochondrial dysfunction …
thinning, conical protrusion, and irregular astigmatism, leading to visual impairment.
Although oxidative stress is implicated in KC, the role of mitochondrial dysfunction …
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Postkeratoplasty Astigmatism: The Role of Intracorneal Ring Segments in Visual Rehabilitation and Corneal Biomechanics—A Narrative Review
R Albertazzi, L Perrone, F Perrone - International Journal of Keratoconus and Ectatic …, 2026
Aims and background: Postkeratoplasty astigmatism remains a major barrier to
visual rehabilitation following corneal transplantation, often persisting despite suture
modulation, optical correction, or laser-based refractive strategies. Intracorneal ring …
visual rehabilitation following corneal transplantation, often persisting despite suture
modulation, optical correction, or laser-based refractive strategies. Intracorneal ring …
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[HTML] Amniotic Membrane Treatment
I Can
… Rose Optometry also accepts referrals for keratoconus and scleral lens fitting, and
is a founding member of the Dry Eye Specialist Group. … We regularly see patients
from Auckland, Tauranga, Rotorua, Taupo, Taranaki and the lower North Island for …
is a founding member of the Dry Eye Specialist Group. … We regularly see patients
from Auckland, Tauranga, Rotorua, Taupo, Taranaki and the lower North Island for …
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[HTML] ESCRS guideline for cataract surgery 2024: executive summary
JC Wanten, V Till, O Findl, B Cochener-Lamard… - Journal of Cataract and …, 2026
… In eyes with keratoconus, all formulas tend to overestimate the IOL power, which
may result in a hyperopic refractive outcome if not … /T and to use keratoconus-specific
formulas for more accurate outcomes. The Barrett true-K and Kane formulas for …
may result in a hyperopic refractive outcome if not … /T and to use keratoconus-specific
formulas for more accurate outcomes. The Barrett true-K and Kane formulas for …
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Pachymetric Thresholds for Keratoconus Progression Based on MS-39 Measurement Precision
R Ning, Y Wang, X Yang, X Huang, J Li, G Savini… - … and Physiological Optics, 2026
… keratoconus progression are redefined in this study using a hybrid tomographic
device. ● This study sought to establish measurement thresholds for different
grades of keratoconus, … adaptive thresholds further improved the precision of …
device. ● This study sought to establish measurement thresholds for different
grades of keratoconus, … adaptive thresholds further improved the precision of …
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[PDF] Socioeconomic and Clinical Factors Associated a Tertiary Referral Cohort with Keratoconus Severity and Follow-Up in a Tertiary Referral Cohort
T Wang - Clinical Ophthalmology, 2026
I read with great interest the article by Alrefai and colleagues entitled “Socioeconomic
and Clinical Factors Associated with Keratoconus Severity and Follow-Up in a
Tertiary Referral Cohort”, recently published in Clinical Ophthalmology. 1 The …
and Clinical Factors Associated with Keratoconus Severity and Follow-Up in a
Tertiary Referral Cohort”, recently published in Clinical Ophthalmology. 1 The …
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[PDF] Eyelid laxity characteristics in Japanese patients with keratoconus: Implications for the evaluation of floppy eyelid syndrome
M Ikeda, H Namba, Y Chida, T Usui - 2026
… Floppy eyelid syndrome (FES), characterized by eyelid laxity, has been
increasingly recognized in association with keratoconus. This study aimed to
investigate the characteristics of eyelid laxity in Japanese patients with keratoconus …
increasingly recognized in association with keratoconus. This study aimed to
investigate the characteristics of eyelid laxity in Japanese patients with keratoconus …
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Rizzuti's sign in advanced keratoconus
RK Jha, S Seth - Arquivos Brasileiros de Oftalmologia, 2026
A 24-year-old male presented with progressive, painless visual decline in the right
eye, with a best-corrected visual acuity of 20/80. Slit-lamp photographs obtained
with temporal illumination demonstrated a sharply demarcated conical light reflex on …
eye, with a best-corrected visual acuity of 20/80. Slit-lamp photographs obtained
with temporal illumination demonstrated a sharply demarcated conical light reflex on …
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212 Pediatric keratoconus diagnosis by corneal tomography: a large-scale validation study
A Romanelli - Journal of American Association for Pediatric …, 2026
… Of these, 1,738 were normal corneas and 831 had a diagnosis of keratoconus.
Multiple tomographic variables obtained from Pentacam (… K2 and Kmax are the
most robust and clinically valuable Pentacam parameters for diagnosing pediatric …
Multiple tomographic variables obtained from Pentacam (… K2 and Kmax are the
most robust and clinically valuable Pentacam parameters for diagnosing pediatric …
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[HTML] Serum thrombospondin-1, growth differentiation factor-15, and resolvin D1 and E1 levels in the pathogenesis of keratoconus
R Kılıç, ŞG Konuk, M Katar, G Bektur - Arquivos Brasileiros de Oftalmologia, 2026
… -15, resolvin D1, and resolvin E1 in patients with keratoconus. Methods: Thirty-five
patients with keratoconus and 35 control subjects of similar age and sex were
evaluated. The keratoconus group was divided into four stages according to the …
patients with keratoconus and 35 control subjects of similar age and sex were
evaluated. The keratoconus group was divided into four stages according to the …
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Obesity and Eye Diseases
P Kamila, B Anna, M Małgorzata - Nutrients, 2026
… BMI on keratoconus [34], while a large population-based study among
adolescents also found an association between BMI and keratoconus [… oxidative
stress and altered antioxidant responses are characteristic features of keratoconus [39] …
adolescents also found an association between BMI and keratoconus [… oxidative
stress and altered antioxidant responses are characteristic features of keratoconus [39] …
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[HTML] Non-Invasive Longitudinal Imaging of the Cornea in Pathophysiological Conditions Across Mice and Humans Using Self-Referenced Optical Coherence Microscopy
HF Pattan - 2026
… Although the etiology of keratoconus remains unknown, recent studies have
reported damage to corneal nerves associated with the rupture of the Bowman’s
layer within the keratoconus area, leading to a direct interaction between epithelial …
reported damage to corneal nerves associated with the rupture of the Bowman’s
layer within the keratoconus area, leading to a direct interaction between epithelial …
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Photorefractive Keratectomy in Keratoconus: Long-Term Outcomes from a Pre-Cross-Linking Era Cohort
GE Tamayo, N Moros, EJ Polania-Baron, C Castell… - Journal of Cataract & …, 2026
… The purpose of this study was to describe long-term visual, refractive, and
topographic outcomes of a small cohort of patients with keratoconus who underwent
PRK prior to CXL availability, with follow-up exceeding 20 years. Given the …
topographic outcomes of a small cohort of patients with keratoconus who underwent
PRK prior to CXL availability, with follow-up exceeding 20 years. Given the …
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305 Comparative analysis of anterior and posterior corneal tomographic parameters in normal and keratoconus pediatric eyes using Scheimpflug imaging
A Katz, C Anderson, N Morales-Mancillas, L Perilloux… - Journal of American …, 2026
Methods This retrospective chart review included patients< 19 with keratoconus and
controls who underwent Scheimpflug tomography. Diagnosis of keratoconus
followed established criteria. Data collected included visual acuity, manifest …
controls who underwent Scheimpflug tomography. Diagnosis of keratoconus
followed established criteria. Data collected included visual acuity, manifest …
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025 Corneal crosslinking in children with keratoconus ages 3 to 16 years: topographic diagnostic criteria and surgical outcomes
N Pereyra-Munoz, F Bautista-Mendoza, S Brizuela… - Journal of American …, 2026
Methods Between August of 2022 and September of 2025, a PentacamHR was
obtained from 540 children ages 3-16 years with an astigmatism≥+ 3.0 D. Twenty-seven
children (54 eyes) were diagnosed with KC and ACXL was performed in 14 children …
obtained from 540 children ages 3-16 years with an astigmatism≥+ 3.0 D. Twenty-seven
children (54 eyes) were diagnosed with KC and ACXL was performed in 14 children …
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320 Association of Down syndrome with keratoconus in pediatric population: a retrospective cohort analysis
R Shahrokni, I Abboud, A Elhusseiny, H Saeed - Journal of American Association for …, 2026
Methods We performed a retrospective cohort study using TriNetX database.
Children≤ 18 years with≥ 5 ophthalmology encounters and a diagnosis of Down
syndrome (ICD-10: Q90) were compared with a control cohort without the diagnosis …
Children≤ 18 years with≥ 5 ophthalmology encounters and a diagnosis of Down
syndrome (ICD-10: Q90) were compared with a control cohort without the diagnosis …
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027 Noninvasive epithelium-on oxygen-enriched corneal collagen crosslinking for the treatment of pediatric patients with keratoconus
M Raizman - Journal of American Association for Pediatric …, 2026
Methods 30 eyes of pediatric patients aged 12 to 17 years were randomized 2: 1 to
CXL treatment (n= 19) or Sham procedure (n= 11). The primary efficacy endpoint
evaluated the mean change in maximum corneal curvature (Kmax) from baseline to …
CXL treatment (n= 19) or Sham procedure (n= 11). The primary efficacy endpoint
evaluated the mean change in maximum corneal curvature (Kmax) from baseline to …
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[HTML] Management of Double Anterior Chamber After Deep Anterior Lamellar Keratoplasty Using Descemetopexy with Corneal Patch: A Case Report
MDD Icaza, MDJC Cadavid, MDGR Vera-Duarte - American Journal of …, 2026
… Observations A 45-year-old man with advanced keratoconus underwent DALK
using the type 2 big-bubble technique. A small peripheral Descemet membrane (DM)
rupture occurred intraoperatively without evident aqueous leakage, and surgery was …
using the type 2 big-bubble technique. A small peripheral Descemet membrane (DM)
rupture occurred intraoperatively without evident aqueous leakage, and surgery was …
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335 Increased vitreous chamber depth associated with high myopia in children
B Devine, N Shaikh, M Stec, L Nichols, SWJ Shin… - Journal of the American …, 2026
Methods Retrospective review of pediatric patients (3-17 years) with myopia< 0.00 D.
Baseline axial length and keratometry were stratified by cycloplegic refraction,
myopia control treatment, race, and ethnicity for analysis. Patients with pseudophakia …
Baseline axial length and keratometry were stratified by cycloplegic refraction,
myopia control treatment, race, and ethnicity for analysis. Patients with pseudophakia …
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072 Phenotypic and genotypic characterization of posterior polymorphous corneal dystrophy in children: a 13 year clinical review
M Gagrani, E Franco, A Abuseif, K Tripi, H Scanga… - Journal of American …, 2026
Methods We retrospectively reviewed patients with PPCD from 2012 to 2025.
Clinical data included demographics, presenting symptoms, visual acuity, refraction,
slit-lamp findings, intraocular pressure, comorbidities, family history, and …
Clinical data included demographics, presenting symptoms, visual acuity, refraction,
slit-lamp findings, intraocular pressure, comorbidities, family history, and …
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077 Socioeconomic and racial disparities in pediatric ophthalmology referrals: insights from the UCSD EyeMobile program
L Hennein, N Ramesh, A Legala, R Lee, S Borooah… - Journal of American …, 2026
… Leading referral reasons included strabismus (18.4%), high refractive error (17.1%),
and suspicion for keratoconus (14.3%). Referral rates declined from 0.69% in very
low COI areas to 0.34% in very high COI areas (P= 0.008). Higher COI was …
and suspicion for keratoconus (14.3%). Referral rates declined from 0.69% in very
low COI areas to 0.34% in very high COI areas (P= 0.008). Higher COI was …
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[HTML] Prediction of Maximum Keratometry Progression With Stratified Progression Criteria in Keratoconus Patients Using Machine Learning
A Schlatter, L Pomberger, A Honeder, J Zeilinger… - Translational Vision Science …, 2026
Purpose: The aim of this study was to use machine learning to predict 12-months
progression of maximum keratometry (K max) within stratified repeatability limits
based on a baseline topography/optical coherence tomography measurement in …
progression of maximum keratometry (K max) within stratified repeatability limits
based on a baseline topography/optical coherence tomography measurement in …
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[PDF] Keratoconus severity detection using LSTM and machine learning techniques
ST Ozyer - 2026
… Keratoconus(KC) is a common degenerative condition of the cornea delineated
by corneal steeping caused by corneal protrusion and … the advancement of
keratoconus. In this study, machine learning (ML) algorithms were employed to …
by corneal steeping caused by corneal protrusion and … the advancement of
keratoconus. In this study, machine learning (ML) algorithms were employed to …
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36 CAIRS–a biological game-changer in keratoconus management? Early clinical outcomes of cor-neal allogenic intrastromal ring segments
J Kahlert, T Berger, B Seitz, L Daas - 2026
Purpose To evaluate short-term visual and topographic outcomes of Corneal
Allogenic Intrastromal Ring Segments (CAIRS) in patients with keratoconus after 3
months.Methods This prospective case series included 5 eyes of 5 patients with …
Allogenic Intrastromal Ring Segments (CAIRS) in patients with keratoconus after 3
months.Methods This prospective case series included 5 eyes of 5 patients with …
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Changing trends in keratoplasty: a 20-year analysis from a tertiary referral center in Türkiye
AS Balci, A Kirgiz, B Altindis, S Liman Uzun… - International Ophthalmology, 2026
… The proportion of keratoplasty performed for keratoconus decreased over time,
whereas pseudophakic bullous keratopathy and regraft … The proportion of
keratoplasty performed for keratoconus declined, while pseudophakic bullous …
whereas pseudophakic bullous keratopathy and regraft … The proportion of
keratoplasty performed for keratoconus declined, while pseudophakic bullous …
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[HTML] Penetran Keratoplastinin Orta-Dönem Sonuçlarının Değerlendirilmesi
M YILDIRIM, FTY ÖZTÜRK - Fırat Tıp Dergisi, 2026
… Conclusion: In this study, the most common indication for PK over a 5-year period
was keratoconus and representing the initial experiences of … Keratoconus is a
leading indication with a frequency ranging from 7-31% in many studies (14, 2628) …
was keratoconus and representing the initial experiences of … Keratoconus is a
leading indication with a frequency ranging from 7-31% in many studies (14, 2628) …
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28 Evaluation of electron-beamed, pre-cut corneal allogenic intrastromal ring segments (e-CAIRS) in a rabbit model: implications for biocompatibility and standardized …
RC Shoufani, E Han, TLQ Ying, F Giuliano, AK Riau… - 2026
Purpose Keratoconus management using CAIRS offers a biologically compatible
alternative to synthetic ring seg-ments. However, current … reliable and efficient
alternative to freshly cut CAIRS, and thereby broadening access to therapeutic …
alternative to synthetic ring seg-ments. However, current … reliable and efficient
alternative to freshly cut CAIRS, and thereby broadening access to therapeutic …
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[PDF] Uncertainty-Aware Artificial Intelligence for Automatic Detection of Ophthalmic Diseases from Medical Images
D Furman
… Diego Ponzin) at the Venice Eye Bank Foundation and the University of Brescia
contributed directly to the keratoconus part of this dissertation, especially to Chapter
4, which presents an uncertainty-aware pipeline for keratoconus support …
contributed directly to the keratoconus part of this dissertation, especially to Chapter
4, which presents an uncertainty-aware pipeline for keratoconus support …
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31 Diverging global trends in anterior lamellar keratoplasty: a comparative analysis of eye bank tissue distribution and implications for increasing tissue availability …
V Jünger, A Margarella, G Visioli, C Nucci, F Scarinci… - 2026
… Ectatic disorders such as keratoconus are optimally treated with ALK, whereas
endothelial dysfunction is treated with EK. Despite these advances, global access to
corneal tissues remains limited by persistent donor shorta-ges and regional …
endothelial dysfunction is treated with EK. Despite these advances, global access to
corneal tissues remains limited by persistent donor shorta-ges and regional …
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Short-term retinal microvascular and structural changes after epi-on and epi-off corneal cross-linking assessed by SD-OCTA
S Yorukoglu Kayabas, IE Ay, T Horozoglu Ceran… - International Ophthalmology, 2026
… with more advanced keratoconus, whereas epi-on CXL was selected for eyes
with better visual acuity and milder disease. This clinical allocation resulted in
baseline differences, particularly worse BCVA and thinner CCT in the epi-off group …
with better visual acuity and milder disease. This clinical allocation resulted in
baseline differences, particularly worse BCVA and thinner CCT in the epi-off group …
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15 A 100-year-old donor saves 2 cases of fungal sclerokeratitis associated with panendophthalmitis
T Garcin, S Essadiq, S Begnaud, B Birebent, L Merabet… - 2026
… The woman’s background was bilateral keratoconus 6 previous penetra-ting
keratoplasty (PK) in the infected right eye including 5 during the last 9 months due to
Paecilomy-ces lilacinus keratitis. Last PK was done 1 month and half ago with …
keratoplasty (PK) in the infected right eye including 5 during the last 9 months due to
Paecilomy-ces lilacinus keratitis. Last PK was done 1 month and half ago with …
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[HTML] Prevalence and determinants of keratoconus in Kilimanjaro region: a population-based evaluation
FP Maro, VR Moodley - BMC Ophthalmology, 2026
Purpose of the study The study aimed to determine the distribution and determinants
of keratoconus (KC) among individuals aged 12–45 years in the Kilimanjaro region,
where epidemiological data are currently lacking. Materials and methods A cross-sectional …
of keratoconus (KC) among individuals aged 12–45 years in the Kilimanjaro region,
where epidemiological data are currently lacking. Materials and methods A cross-sectional …
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[HTML] Longitudinal biomechanical changes and progression-associated parameters in subclinical keratoconus: a prospective study
Y Han, X Chen, S Li, J Li, S Zuo, Y Wang - BMC Ophthalmology, 2026
Purpose In this longitudinal study, we assessed biomechanical changes in eyes with
subclinical keratoconus (SKC) and explored features associated with progression.
Methods A total of 283 patients were included. The mean follow-up was 24.8 ± 13.7 …
subclinical keratoconus (SKC) and explored features associated with progression.
Methods A total of 283 patients were included. The mean follow-up was 24.8 ± 13.7 …
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Interobserver Variability in the Identification of Keratoconus Suspects Among Teenagers and Young Adults: Comparison With Scheimpflug Tomographic Indices
S Georgiadou, A Zisimopoulos, CH Karabatsas… - Cornea, 2026
… of keratoconus (KCN) and keratoconus-suspect (KCN-S), but primarily addresses
the normal-versus-suspect KC boundary. The demonstrated variability between the
2 experienced corneal experts (CHK and AJK) in their assessment of such eyes …
the normal-versus-suspect KC boundary. The demonstrated variability between the
2 experienced corneal experts (CHK and AJK) in their assessment of such eyes …
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[PDF] Corneal transplantation in the Amazon: a 10-year retrospective study
MJ Cohen, SVA Cohen, LMP da Silva, APL Anders… - Arq Bras Oftalmol, 2026
… , keratoconus is consistently reported as the leading indication for corneal
transplantation(8,10,12). In contrast, Carvalho et al.(13) identified leucoma as the
most common indication in Amazonas in 1996, followed by keratoconus …
transplantation(8,10,12). In contrast, Carvalho et al.(13) identified leucoma as the
most common indication in Amazonas in 1996, followed by keratoconus …
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Effect of Green Light-Mediated Corneal Cross-Linking on the Delivery of Rose Bengal and Vancomycin in Staphylococcus aureus-Infected Eyes
SE George, A Roy, PK Sharma, S Upadhyay… - ACS Applied Bio Materials
Rose Bengal (RB)-green light (GL) cross-linking (RGX), a phototherapy used to treat
infectious keratitis, activates RB to generate reactive oxygen species (ROS),
promoting bacterial killing and corneal strengthening through collagen cross-linking …
infectious keratitis, activates RB to generate reactive oxygen species (ROS),
promoting bacterial killing and corneal strengthening through collagen cross-linking …
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[HTML] Repeatability and Agreement between novel SS-OCT VG2 and CASIA2 in Anterior Segment Parameters
Z Qu, Y Huo, R Xie, Y Jiang, Y Li, H Lu, Y Wu, G Zhao… - … and Photodynamic Therapy, 2026
… The samples we included did not involve populations with diseases or
postoperative populations, such as those with keratoconus or individuals
undergoing follow-up after refractive surgery. Therefore, the repeatability and …
postoperative populations, such as those with keratoconus or individuals
undergoing follow-up after refractive surgery. Therefore, the repeatability and …
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[HTML] Safety and Efficacy of Optimal Keratoplasty in Reduction of Hyperopia and Hyperopic Presbyopia: A Retrospective Observational Study
KJ Rodgers, HG Glen, MJ Berry - Clinical Ophthalmology, 2026
… Exclusion criteria included nystagmus; uncontrolled uveitis, severe blepharitis,
lagophthalmos; moderate to severe dry eye disease; corneal pathology and/or
shape disorders such as keratoconus; previous ocular surgery; autoimmune disease; …
lagophthalmos; moderate to severe dry eye disease; corneal pathology and/or
shape disorders such as keratoconus; previous ocular surgery; autoimmune disease; …
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[HTML] Defocus Spectacle Lenses: How Special Glasses Help Slow Childhood Myopia
VP July
Defocus Spectacle Lenses: How Special Glasses Help Slow Childhood Myopia - Dr.
Val Phua Skip to main content Hit enter to search or ESC to close Search Close
Search Dr. Val Phua Dr. Val Phua Menu About Dr Val Phua Technology Procedures …
Val Phua Skip to main content Hit enter to search or ESC to close Search Close
Search Dr. Val Phua Dr. Val Phua Menu About Dr Val Phua Technology Procedures …
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Empirical Evaluation of Virtual Fonts With Enhanced Out-of-Focus Legibility in the Presence of Inaccurate or Incomplete Eye Accommodation Demand
J Kim - 2026
One of the key challenges in optical see-through (OST) augmented reality (AR)
environments is accommodation mismatch caused by the fixed focal plane of
commercial head-mounted displays (HMDs). Devices such as the Microsoft …
environments is accommodation mismatch caused by the fixed focal plane of
commercial head-mounted displays (HMDs). Devices such as the Microsoft …
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Vibration Event Identification Technology in Φ-OTDR Based on a Gated Residual Fusion and Frequency Encoding Dual-Path Backbone Neural Network
C Ying, B Feng, S Wan, J Yu - IEEE Sensors Journal, 2026
This paper studies the vibration event recognition task for Φ-OTDR systems and
proposes a dual-path backbone network named GRF-FEDPBNet (Gated Residual
Fusion-Frequency Encoding Dual Path Backbone Network). The core novelty of this …
proposes a dual-path backbone network named GRF-FEDPBNet (Gated Residual
Fusion-Frequency Encoding Dual Path Backbone Network). The core novelty of this …
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Adipose-Derived Stem Cells in Ophthalmic Regenerative Medicine: From Cell Replacement to Precision Engineering
B Li, L Ling, R Liu, X Zhang, Y Kang, J Guo - Stem Cell Reviews and Reports, 2026
… Preliminary trials of intrastromal implantation of autologous ASCs for advanced
keratoconus and corneal scars demonstrated … Assessment of the effects of
intrastromal injection of adipose-derived stem cells in keratoconus patients. Int J …
keratoconus and corneal scars demonstrated … Assessment of the effects of
intrastromal injection of adipose-derived stem cells in keratoconus patients. Int J …
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[HTML] A large language models-assisted and expert-corrected workflow for preoperative anesthesia assessment drafts: A single-centre exploratory feasibility study
S Gu, J Ping, H Lin, H Xu, F Fang, D Su, X Kang - Medicina ClÃnica, 2026
Background Large language models (LLMs) may help organize clinical information,
but their use in perioperative settings requires careful evaluation because errors
may have immediate safety implications. This study aimed to describe the feasibility …
but their use in perioperative settings requires careful evaluation because errors
may have immediate safety implications. This study aimed to describe the feasibility …
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A Syed - Eye, 2026
… inflammatory and metabolic factors in keratoconus risk [1]. Their findings confirm
a substantially higher risk of keratoconus in patients with atopic … A plausible
mechanistic bridge links the atopy, rheumatoid arthritis, and Crohn’s disease findings …
a substantially higher risk of keratoconus in patients with atopic … A plausible
mechanistic bridge links the atopy, rheumatoid arthritis, and Crohn’s disease findings …
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Relationship between Atopy and Keratoconus: Study of Contributing Factors and Involved Mechanisms
AN Sari Yanez, M Rodriguez, S Maria - Opuntia Brava, 2026
El queratocono es una ectasia corneal progresiva cuya fisiopatologÃa, previamente
considerada no inflamatoria, ha sido reevaluada debido a la evidencia que vincula
los procesos inflamatorios y los fenómenos atópicos con su desarrollo y progresión …
considerada no inflamatoria, ha sido reevaluada debido a la evidencia que vincula
los procesos inflamatorios y los fenómenos atópicos con su desarrollo y progresión …
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[PDF] Rapid Growth and Persistent Geographic Concentration of Recorded Outpatient Corneal Cross-Linking Production in Brazil's Unified Health System, 2017-2025
MG Maués, V Amin, M Rezende, L Rodrigues - Cureus, 2026
… Corneal cross-linking (CXL) is the principal intervention used to stabilize
progressive keratoconus. The procedure was incorporated into Brazil's Unified
Health System (Sistema Único de Saúde (SUS)) in 2016 and became operational in …
progressive keratoconus. The procedure was incorporated into Brazil's Unified
Health System (Sistema Único de Saúde (SUS)) in 2016 and became operational in …
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Outcomes of wavefront-guided scleral lenses in keratoconus patients
OH Masoud, CY Chang, BB Meghpara, ZA Syed - Optometry and vision science …, 2026
Purpose This study investigated the change in higher order aberrations (HOAs) and
visual acuity with wavefront-guided scleral lenses (WFGSLs) in the management of
patients with keratoconus. Methods A total of 22 eyes from 13 patients with …
visual acuity with wavefront-guided scleral lenses (WFGSLs) in the management of
patients with keratoconus. Methods A total of 22 eyes from 13 patients with …
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[HTML] Nfe2l2-knockout mouse model exhibits oxidative stress-associated stromal degeneration and inflammatory activation resembling keratoconus pathology
X Li, J Gu, X Sun, Y Liang, S Mao, Y Chen, X Wang… - PeerJ, 2026
Oxidative stress is central to keratoconus (KC) pathogenesis, and NRF2 is a key
antioxidant regulator. However, an in vivo model linking NRF2 loss to KC has been
lacking. We generated CRISPR/Cas9 Nfe2l2-knockout (KO) mice and assessed 4-month-old …
antioxidant regulator. However, an in vivo model linking NRF2 loss to KC has been
lacking. We generated CRISPR/Cas9 Nfe2l2-knockout (KO) mice and assessed 4-month-old …
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Epithelial Thickness and Stromal Changes in Keratoconus Patients after Intra Corneal Ring Implantation
OMH Sayed, AAE Nassar, MS Ibrahim - Al-Azhar International Medical Journal, 2026
Background: The most common kind of primary corneal ectasia is keratoconus (KC),
which is marked by bilateral and asymmetric corneal … ), we aimed to examine
stromal alterations and epithelial thickness maps in keratoconus patients both …
which is marked by bilateral and asymmetric corneal … ), we aimed to examine
stromal alterations and epithelial thickness maps in keratoconus patients both …
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[PDF] Refractive prediction errors of Barrett KCN, Kane KCN, SRK/T, and a customized approach in moderate-to-severe keratoconus after cataract surgery
SD Saad, K Jadidi, M Khodaparast, S Pirhadi, F Nejat… - Scientific Reports, 2026
… These challenges are especially pronounced in moderate and severe
keratoconus, where … Several approaches have been introduced to improve IOL
power calculation in keratoconus… recently, keratoconus-specific formulas such as …
keratoconus, where … Several approaches have been introduced to improve IOL
power calculation in keratoconus… recently, keratoconus-specific formulas such as …
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Management of astigmatism in keratoconus with therapeutic refractive surgery
H Zhang, JL Alió del Barrio, Q Bao, MD Alio… - Frontiers in Medicine
Astigmatism is a major determinant of visual impairment in keratoconus (KC), yet in
this setting it cannot be understood as a simple cylindrical refractive error. Instead, it
reflects a complex optical phenotype generated by anterior and posterior corneal …
this setting it cannot be understood as a simple cylindrical refractive error. Instead, it
reflects a complex optical phenotype generated by anterior and posterior corneal …
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[PDF] Bridging inflammation, metabolism, and mechanics in keratoconus: a mechanistic perspective
A Syed - Eye (London, England)
… inflammatory and metabolic factors in keratoconus risk [1]. Their findings confirm
a substantially higher risk of keratoconus in patients with atopic … A plausible
mechanistic bridge links the atopy, rheumatoid arthritis, and Crohn’s disease findings …
a substantially higher risk of keratoconus in patients with atopic … A plausible
mechanistic bridge links the atopy, rheumatoid arthritis, and Crohn’s disease findings …
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Long-term outcome of collagen cross-linking (CXL) for progressive keratoconus with coexistent Fuchs endothelial corneal dystrophy
N Balakrishnan, R Deshmukh - BMJ case reports, 2026
Corneal endothelial toxicity leading to corneal oedema or endothelial
decompensation is a potential concern after corneal collagen cross-linking,
especially in patients with susceptible corneas, such as in cases of Fuchs …
decompensation is a potential concern after corneal collagen cross-linking,
especially in patients with susceptible corneas, such as in cases of Fuchs …
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[PDF] Vision-Related Quality of Life and Work Productivity in Patients With Keratoconus and Glaucoma: A Comparative Cross-Sectional Study
M Dionysopoulou, N Kotsopoulos, E Karampli… - Cureus, 2026
… , they differ in pathophysiology, with keratoconus affecting corneal optics and
POAG causing … This study compared patient-reported outcomes between
individuals with keratoconus and … 102 with keratoconus and 51 with POAG) …
POAG causing … This study compared patient-reported outcomes between
individuals with keratoconus and … 102 with keratoconus and 51 with POAG) …
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Automated Detection and Classification of Keratoconus Using Deep Learning with ResNet-50
P Nasra, GR Kiran, P Negi, PK Mishra, T Sharma - 2026 5th OPJU International …, 2026
Keratoconus is a progressive eye disorder causing thinning and … Keratoconus
with a 96.8-percent accuracy. The suggested model is trained on a variety of data
comprising of cornea topography images that belong to three categories, including …
with a 96.8-percent accuracy. The suggested model is trained on a variety of data
comprising of cornea topography images that belong to three categories, including …
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[PDF] Polarimetric interferometry-derived isogyre parameters correlate with keratoconus severity: a retrospective observational study
G Beschi, I Pezzagno, S Vaccaro, M Rovati, L Grezzi… - Scientific Reports, 2026
… Keratoconus involves progressive corneal thinning and stromal collagen
disorganization … We conducted a retrospective observational study of 95
keratoconus patients and 21 healthy … arm (AUC 0.87) differentiated keratoconus …
disorganization … We conducted a retrospective observational study of 95
keratoconus patients and 21 healthy … arm (AUC 0.87) differentiated keratoconus …
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[PDF] Keratoconus false-positive screening rates in eyes with pterygium: tomographic and biomechanical artifacts
PF Rodrigues, FAC dos Santos, BK Moscovici… - Arq Bras Oftalmol, 2026
… We hypothesized that pterygium-related abnormalities in keratoconus screening
indices are … early keratoconus, including elevated BAD-D and increased
keratoconus screening indices (particularly TBI). However, no participant met the …
indices are … early keratoconus, including elevated BAD-D and increased
keratoconus screening indices (particularly TBI). However, no participant met the …
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[PDF] Novel Treatments for Keratoconus
C Paik - inSIGHT, 2026
… Keratoconus is a progressive condition … The management of keratoconus has
evolved significantly over the past two decades, with novel therapeutic approaches …
This review examines the latest advances in keratoconus treatment, focusing on …
evolved significantly over the past two decades, with novel therapeutic approaches …
This review examines the latest advances in keratoconus treatment, focusing on …
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[HTML] OCT Eye Scans: What They Show, How They Work and What the Results Mean
VP July
The scan must therefore be interpreted together with the patient’s symptoms, visual
acuity, clinical examination and other investigations. OCT artefacts are common
enough to cause both false diagnoses and missed progression if the underlying …
acuity, clinical examination and other investigations. OCT artefacts are common
enough to cause both false diagnoses and missed progression if the underlying …
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Global Prevalence of Keratoconus in the Adult Population: A Systematic Review
K Cenková, M Å Ãn, J TesaÅ™, I NÄ›mcová, V Fridman… - Bratislava Medical Journal, 2026
Purpose To synthesize contemporary estimates of adult keratoconus prevalence
worldwide and determine how geography, demographics, and study methodology
shape reported rates. Methods We systematically reviewed original studies (2019–2024) …
worldwide and determine how geography, demographics, and study methodology
shape reported rates. Methods We systematically reviewed original studies (2019–2024) …
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Clinical Profile, Risk factors and Topographic Characteristics of Keratoconus at a Tertiary Eye Hospital: An Observational Study.
P Shrestha, B Thapa, L Singh, S Paudel - Journal of the Nepal Medical Association, 2026
… of cases had unilateral keratoconus, while 43.9% had bilateral keratoconus,
whereas a study conducted in Malaysia showed that around 77% of cases had
bilateral keratoconus.Population-based studies have reported a higher percentage …
whereas a study conducted in Malaysia showed that around 77% of cases had
bilateral keratoconus.Population-based studies have reported a higher percentage …
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Targeting Higher Order Aberrations Alone in Keratoconus: A Tissue-Saving Alternative to Established Protocols
ST Awwad, KE Asfar, S Arba-Mosquera, N Wahoud… - Journal of Refractive …, 2026
Purpose: To evaluate cone stromal ablation depth with varying optical zones using
different customized ablation strategies in keratoconus. Methods: This retrospective
computational analysis assessed 59 eyes from 59 patients with mild to moderate …
different customized ablation strategies in keratoconus. Methods: This retrospective
computational analysis assessed 59 eyes from 59 patients with mild to moderate …
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[PDF] One‐Year Results of Accelerated Transepithelial Corneal Cross‐Linking for Progressive Keratoconus: A Prospective Interventional Study
RA Fayyadh, OS Mahmood, AB Abdulelah… - Eye & ENT Research, 2026
… Method: This prospective interventional study included 126 eyes from 63 patients
with documented progressive keratoconus. Both eyes of … parameters in this
prospective cohort of eyes with progressive keratoconus. These findings should be …
with documented progressive keratoconus. Both eyes of … parameters in this
prospective cohort of eyes with progressive keratoconus. These findings should be …
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Corneal Allograft Intrastromal Ring Segment (CAIRS) in Modern Practice for Management of Keratoconus
MA Sallam, MM Macky, RA Albairmani, BM Basheer… - Korean journal of ophthalmology …
This review discusses the role of Corneal Allograft Intrastromal Ring Segments (CAIRSs)
in the treatment of keratoconus and ectatic corneal disease, covering their
mechanisms, techniques, outcomes, and prospects. The technique was developed …
in the treatment of keratoconus and ectatic corneal disease, covering their
mechanisms, techniques, outcomes, and prospects. The technique was developed …
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Edge-Deployed Vision Transformer
MM Daud, WMDW Zaki, FM Ali, HA Mutalib - … of the Third International Conference on …, 2026
… In this paper, we present an edgecomputing mobile application for the automatic
classification of keratoconus using a Vision Transformer (ViT) … The presented
method provides a workflow that can sort input images into two classes, keratoconus …
classification of keratoconus using a Vision Transformer (ViT) … The presented
method provides a workflow that can sort input images into two classes, keratoconus …
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Stromal Lenticule Addition Keratoplasty (SLAK) for the Management of Severe Corneal Flattening After Corneal Cross-linking
GD Kymionis, VA Tsagkogiannis, DG Vakalopoulos… - Journal of Refractive …, 2026
… Nubile et al7 evaluated 15 eyes with advanced keratoconus treated with SLAK
and reported a significant increase in corneal thickness, … Although previous
studies have primarily demonstrated reduction of excessive steepening in …
and reported a significant increase in corneal thickness, … Although previous
studies have primarily demonstrated reduction of excessive steepening in …
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Oral Riboflavin for Sunlight-Induced Corneal Cross-linking: Efficacy Assessment in a Rabbit Model In Vivo Using Extensometry and OCT Elastography
EA Torres-Netto, ME Aydemir, NJ Lu, S Kling, N Hafezi… - Journal of Refractive …, 2026
… of keratoconus,7 eye rubbing can certainly exacerbate its progression.Corneal
cross-linking (CXL)9 is the current standard of care for halting keratoconus …
riboflavin combined with daily sunlight exposure might stabilize keratoconus without …
cross-linking (CXL)9 is the current standard of care for halting keratoconus …
riboflavin combined with daily sunlight exposure might stabilize keratoconus without …
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OPTICAL IMAGING AND CHARACTERIZATION OF OPHTHALMIC TISSUE AND DEVICES
PL Sawyers - 2026
The work presented in this dissertation spans the full range of the eye, with projects
relating to three elements of the eye: the cornea, the crystalline lens, and the retina.
The majority of the cornea’s biomechanical properties are defined by the stroma, the …
relating to three elements of the eye: the cornea, the crystalline lens, and the retina.
The majority of the cornea’s biomechanical properties are defined by the stroma, the …
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[HTML] The Matricellular Protein CCN1 Induces Corneal Stromal Cells Senescence and Inflammation to Trigger Extracellular Matrix Remodeling in Keratoconus
L Zhang, C Wei, Y Li, J Shi, Y Chi, Y Zhang, Q Bao… - … Ophthalmology & Visual …, 2026
Purpose: Keratoconus (KC) is a multifactorial corneal degenerative disorder
characterized by reduced extracellular matrix (ECM) and cellular content. This study
investigates the role and mechanism of cellular communication network factor 1 (CCN1) …
characterized by reduced extracellular matrix (ECM) and cellular content. This study
investigates the role and mechanism of cellular communication network factor 1 (CCN1) …
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A Hybrid Deep Learning and Machine Learning Approach for Keratoconus Detection Using
SR Bakall, NS Bansod, SR Sankaye¹, AD Kadam¹… - Proceedings of International …
Accurate and early diagnosis of Keratoconus, a moderate corneal thin-ning disorder,
is important to prevent serious vision loss. This research paper presents a composite
proposal that utilizes the ability of deep learning to extract the features and uses …
is important to prevent serious vision loss. This research paper presents a composite
proposal that utilizes the ability of deep learning to extract the features and uses …
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[PDF] Clinical Evolution and Multimodal Imaging of Late Onset Severe Focal Stromal Degeneration After Corneal Collagen Cross-Linking for Keratoconus
A Mularoni, L Rania, E Fabbri, K Mularoni, G Mussoni… - Cornea Open, 2026
… She had previously undergone bilateral corneal CXL using standard Dresden
protocol for progressive keratoconus performed in an external clinic 9 years earlier
by one of the authors (AM). Prior corneal CXL, K1 amounted 53.42 D and K2 50.32 D …
protocol for progressive keratoconus performed in an external clinic 9 years earlier
by one of the authors (AM). Prior corneal CXL, K1 amounted 53.42 D and K2 50.32 D …
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[PDF] Imagining the future: Imaging for surgical planning
Y Feng
… This is particularly crucial for cases involving keratoconus (KC) or post-refractive
surgery … underlying stromal changes, as seen in keratoconus and other ectatic
disorders. Our findings … For instance, for Keratoconus Management, ETM reveals …
surgery … underlying stromal changes, as seen in keratoconus and other ectatic
disorders. Our findings … For instance, for Keratoconus Management, ETM reveals …
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Risk factors for keratoconus: a systematic review and meta-analysis
R Chen, X Ou, Q Zeng - BMC Ophthalmology, 2026
Purpose Keratoconus (KC) is a sight-threatening disease with unclear etiology.
Understanding its risk factors is essential for prevention and mechanistic insight.
This study presents a comprehensive systematic review and meta-analysis to …
Understanding its risk factors is essential for prevention and mechanistic insight.
This study presents a comprehensive systematic review and meta-analysis to …
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[PDF] Prevalence and Risk Factors of Keratoconus Among Refractive Surgery Candidates in Iraq: Findings from a Multicenter Cross-Sectional Study
YS Yasin, RA Fayyadh, OS Mahmood, AB Abdulelah… - Benha Medical Journal, 2026
Objective: The goal of this study is to determine the prevalence of keratoconus (KC)
among candidates for refractive surgery in Iraq, the prevalence of demographic and
clinical risk factors of relevance, and the effectiveness of current screening methods …
among candidates for refractive surgery in Iraq, the prevalence of demographic and
clinical risk factors of relevance, and the effectiveness of current screening methods …
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[HTML] Still Seeing Poorly After Cataract Surgery: It Was Undiagnosed Keratoconus
JFB Logroño
… When we studied the cornea with tomography, the real cause appeared: bilateral
keratoconus that had never been diagnosed. Keratoconus is not a rare disease. The
classic figure places it at around 1 in 2,000 people, although more recent …
keratoconus that had never been diagnosed. Keratoconus is not a rare disease. The
classic figure places it at around 1 in 2,000 people, although more recent …
| | | |
E Bonacci, C Pagnacco, A Fasolo, F Barzaghi… - International Ophthalmology, 2026
… In this small prospective pilot study, bilateral implantation of a non-diffractive
EDOF IOL was associated with favourable short-term visual outcomes in highly
selected patients with stable early keratoconus. These preliminary findings suggest …
EDOF IOL was associated with favourable short-term visual outcomes in highly
selected patients with stable early keratoconus. These preliminary findings suggest …
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[HTML] Early Ocular and Systemic Markers of Keratoconus: A Mini-Review
FU Khan, S Ullah, M Shahzadi, M Noor - CME Journal Geriatric Medicine, 2026
… Keratoconus (KC) is a progressive corneal ectatic disorder characterized by
stromal thinning… This review consolidates current evidence on the earliest markers
of keratoconus, encompassing … Emerging data suggest that keratoconus should …
stromal thinning… This review consolidates current evidence on the earliest markers
of keratoconus, encompassing … Emerging data suggest that keratoconus should …
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Research progress on intraocular lens power calculation in cataract patients with keratoconus
YX Zhu, XH Xie, JQ Zhang, LX Luo - [Zhonghua yan ke za zhi] Chinese journal of …, 2026
Keratoconus (KCN) is a progressive corneal ectasia disorder characterized by
thinning and steepening of the cornea. Intraocular lens (IOL) power calculation in
cataract patients with KCN often leads to a significant hyperopic prediction error …
thinning and steepening of the cornea. Intraocular lens (IOL) power calculation in
cataract patients with KCN often leads to a significant hyperopic prediction error …
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[PDF] Clinical outcomes after implantation of a combination of intrastromal corneal ring segments in different optical zones in advanced keratoconus
JSB Soares, ML Dos Santos, LT Costa, EM Almodin… - Indian Journal of …, 2026
… Purpose: To evaluate the efficacy and safety of combined intrastromal corneal ring
segment (ICRS) implantation in different optical zones for advanced keratoconus.
Methods: This retrospective study analyzed 32 eyes from 30 patients who underwent …
segment (ICRS) implantation in different optical zones for advanced keratoconus.
Methods: This retrospective study analyzed 32 eyes from 30 patients who underwent …
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A Novel Chaos-inspired Artificial Intelligence-based Model for Keratoconus Prediction
S Adib-Moghaddam, N Nassiri, M Bahman, M Mohebbi… - Journal of Ophthalmic and …, 2026
… discrimination between keratoconus and normal eyes. Conclusion: Given the
complex and nonlinear behavior of keratoconus progression, … Model) capable of
accurately detecting keratoconus. Although the findings are promising, further …
complex and nonlinear behavior of keratoconus progression, … Model) capable of
accurately detecting keratoconus. Although the findings are promising, further …
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Chinese expert consensus on the early screening and diagnosis of keratoconus (2026)
Refractive Surgery Group of Chinese Ophthalmologist … - … ke za zhi] Chinese journal of …, 2026
Keratoconus is a common blinding corneal disease among young adults. A large
number of … accurate screening and diagnostic system for keratoconus has
important clinical significance for … on confusing concepts and terms related to …
number of … accurate screening and diagnostic system for keratoconus has
important clinical significance for … on confusing concepts and terms related to …
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Evaluation of keratoconus patients with or without surgery by both sub-scales of “Keratoconus End-Points Assessment Questionnaire”
B Akbulut Yagci, O Ozkan, Z Ozbek, CA Utine - EUROPEAN EYE RESEARCH
… was to evaluate the results of Keratoconus End-Points Assessment Questionnaire
(KEPAQ) in patients who did or did not have any surgery for keratoconus. METHODS:
This cross-sectional, single-center, observational study included 127 patients with …
(KEPAQ) in patients who did or did not have any surgery for keratoconus. METHODS:
This cross-sectional, single-center, observational study included 127 patients with …
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The declining need for keratoplasty in keratoconus: Are we entering the era of corneal preservation?
PR Srivatsa - Journal of Clinical Ophthalmology and Research, 2026
… , keratoconus patients progressed through spectacles and rigid contact lenses,
ultimately to corneal transplantation, which is regarded as the definitive treatment for
advanced keratoconus… Genetic therapy in keratoconus holds the potential to …
ultimately to corneal transplantation, which is regarded as the definitive treatment for
advanced keratoconus… Genetic therapy in keratoconus holds the potential to …
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[HTML] Interventional Keratoconus: A New Era of Early Action and Advanced Treatment
V Thompson, W Trattler, OD Elise Kramer, F FSLS…
… “We all know that keratoconus leads to irreversible corneal damage, and it's our
job to recognize it early. In my opinion, we don't want to just wait and observe.” …
Keratoconus is a progressive corneal ectatic disorder, not a dystrophy, meaning the …
job to recognize it early. In my opinion, we don't want to just wait and observe.” …
Keratoconus is a progressive corneal ectatic disorder, not a dystrophy, meaning the …
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[PDF] Evaluation of keratoconus patients with or without surgery by both sub-scales of “Keratoconus End-Points Assessment Questionnaire”
BA Yagci, O Ozkan, Z Ozbek, CA Utine - Vol. 6/No 2/August 2026
… results of Keratoconus End-Points Assessment Questionnaire (KEPAQ) in
patients who did or did not have any surgery for keratoconus. … Herein, we aimed to
evaluate the results of KEPAQ in patients who did or did not have any keratoconus …
patients who did or did not have any surgery for keratoconus. … Herein, we aimed to
evaluate the results of KEPAQ in patients who did or did not have any keratoconus …
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K Ekemiri, C Ekemiri, D Singh, R Seemongal-Dass… - Vision, 2026
Purpose: Keratoconus is a progressive corneal ectatic disorder that causes visual
impairment, particularly in adolescents and young adults. Evidence on its
epidemiology in Latin America and the Caribbean remains limited. This study aimed …
impairment, particularly in adolescents and young adults. Evidence on its
epidemiology in Latin America and the Caribbean remains limited. This study aimed …
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[HTML] Anterior Segment and Corneal Disorders
SE Acar - 2026
… across infectious keratitis, keratoplasty, keratoconus, refractive surgery, phakic
intraocular lens … DL models achieve diagnostic accuracies exceeding 95% in
keratoconus and fungal keratitis … Furthermore, AI-driven models identify …
intraocular lens … DL models achieve diagnostic accuracies exceeding 95% in
keratoconus and fungal keratitis … Furthermore, AI-driven models identify …
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[HTML] Evaluating the rationale and outcomes of crosslinking corneal stromal lenticules: a systematic review with exploratory pooled analysis
RB Radulescu, S Ferrari, AE Ranetti, HT Stanca… - Graefe's Archive for Clinical …, 2026
… Preliminary clinical data suggest possible benefit in selected advanced
keratoconus cases. However, current evidence remains insufficient to establish
efficacy. Controlled trials are warranted to standardize protocols and validate long-term …
keratoconus cases. However, current evidence remains insufficient to establish
efficacy. Controlled trials are warranted to standardize protocols and validate long-term …
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[HTML] Corneal Cross-Linking: Suitability, Procedure, Risks and Recovery By drvaladmin July 29, 2026 No Comments
V Phua
… High-quality randomised trials and an American Academy of Ophthalmology
evidence review support epithelium-off CXL as an effective treatment for progressive
keratoconus and post-refractive-surgery ectasia. Long-term studies show that …
evidence review support epithelium-off CXL as an effective treatment for progressive
keratoconus and post-refractive-surgery ectasia. Long-term studies show that …
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[HTML] Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care
L Buzzonetti, C Mazzotta, M Iester, M Pauklin… - Ophthalmology and Therapy, 2026
… the diagnosis, monitoring and management of paediatric keratoconus. Paediatric
keratoconus is a corneal ectasia that typically presents … diagnostic criteria, risk
factors and classification systems of paediatric keratoconus. It outlines strategies for …
keratoconus is a corneal ectasia that typically presents … diagnostic criteria, risk
factors and classification systems of paediatric keratoconus. It outlines strategies for …
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Factors Associated with Pediatric Keratoconus–A Population-Based Nested Case–Control Study
O Ben-Shaul, S Schwartz, A Segal, N Stein, M Hyams… - Ophthalmic Epidemiology, 2026
… the factors associated with the development of keratoconus. Results: Overall,
1953 pediatric keratoconus patients with a mean age of 14.2 … consistent predictors
of keratoconus severity and the frequency of corneal transplantation in the adult …
1953 pediatric keratoconus patients with a mean age of 14.2 … consistent predictors
of keratoconus severity and the frequency of corneal transplantation in the adult …
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[PDF] Corneal allogenic intrastromal ring segments for the treatment of keratoconus
R Barbara, G De Salvo, R Hanna, A Sepetis… - Scientific Reports, 2026
To assess the clinical outcomes of Corneal Allogenic Intrastromal Ring Segments (CAIRS)
as a therapeutic approach for keratoconus (KC), with a focus on visual acuity,
refractive status, and corneal topographic parameters. In this retrospective analysis …
as a therapeutic approach for keratoconus (KC), with a focus on visual acuity,
refractive status, and corneal topographic parameters. In this retrospective analysis …
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Stage-dependent alterations in corneal epithelium, stromal keratocyte density, and subbasal nerve plexus in keratoconus: an in vivo confocal microscopy study
T Kucukbalci, BS Uysal, D Balaban, MC Ozmen… - Graefe's Archive for Clinical …, 2026
… Therefore, IVCM plays an important role in improving our understanding of
keratoconus … the keratoconus group were age between 18 and 65 years with a
diagnosis of keratoconus and … Patients with keratoconus who wore rigid contact …
keratoconus … the keratoconus group were age between 18 and 65 years with a
diagnosis of keratoconus and … Patients with keratoconus who wore rigid contact …
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Challenges to the Access and Utilization of Corneal Cross-Linking in Keratoconus Patients in the United States
ABJJ Jo, MDY Bian, MWD Chamberlain, MDM Chen… - American Journal of …, 2026
… This essay reflects on experiences from all authors in their care for keratoconus
patients, a historical summary of CXL in the United States, … shortcomings in
effectively screening keratoconus in at-risk patients in the United States. Although …
patients, a historical summary of CXL in the United States, … shortcomings in
effectively screening keratoconus in at-risk patients in the United States. Although …
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Aberration-guided Intraocular Lens Power Calculation in Keratoconus: Ray Tracing Optimization
MMS Vandevenne, J Aramberri, T Berendschot… - Journal of Cataract & …, 2026
… adjusted for these cases: Kane keratoconus,20 Holladay 2 with keratoconus
adjustment21 and the Barrett True K formula for keratoconus.The Kane keratoconus
formula minimizes the influence of corneal power in estimating the effective lens position …
adjustment21 and the Barrett True K formula for keratoconus.The Kane keratoconus
formula minimizes the influence of corneal power in estimating the effective lens position …
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[PDF] Keratoconus
S Papadopoulos - 2026
Keratoconus is a noninflammatory corneal ectatic disease that leads to a conical,
bulgingshaped cornea by way of corneal thinning. In the early stages, it is usually
asymptomatic but as the disease progresses, irregular astigmatism, haze and …
bulgingshaped cornea by way of corneal thinning. In the early stages, it is usually
asymptomatic but as the disease progresses, irregular astigmatism, haze and …
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![[Video] Adverse Eye Rubbing in Keratoconus](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg4HRiK6MvFtia856foWYkBDP2bCVe0NB-S445VtbzLVYY19KJ6Pma-J-xabIQgjfE3RyTgr5C7Y9IvGs6PZ2ofcR13vtnGSwqghFJv40mZdjUD4VyOfjGN03Fhyphenhyphenziai2VNOASlDExTi77TdfDrh2yKeS735QlfIwwLZhn0xilsHeLiGDvhshth384ZzgBu/w72-h72-p-k-no-nu/keratoconus-pathogenesis.jpg)
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