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A courtesy distribution service and an open-access archive for nearly 2.4 million scholarly articles in the relevant fields and adjacent fields of physics, mathematics, computer science, quantitative biology, quantitative finance, statistics, electrical engineering and systems science, and economics. 

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  1. arXiv:2312.15134  [pdfother

    q-bio.QM q-bio.TO

    A discrete-to-continuum model for the human cornea with application to keratoconus

    Authors: J. KΓΆryP. S. StewartN. A. HillX. Y. LuoA. Pandolfi

    Abstract…the predictions of the discrete model converge to those of the continuum model. We use the continuum model to simulate the progression of the degenerative disease known as keratoconus, characterized by a localized bulging of the corneal shell. We assign a spatial distribution of damage (i. e., reduction of the stiffness) to the mechanical properties of the… ▽ More

    Submitted 22 December, 2023; originally announced December 2023.

    Comments: 32 pages, 8 figures

    MSC Class: 35J57; 35Q74; 35Q92; 74E10; 74Gxx; 74L15; 74Q15; 92Cxx

  2. arXiv:2311.01996  [pdf

    eess.IV cs.CV cs.LG

    Detection of keratoconus Diseases using deep Learning

    Authors: AKM Enzam-Ul HaqueGolam RabbanyMd. Siam

    AbstractOne of the most serious corneal disorders, keratoconus is difficult to diagnose in its early stages and can result in blindness. This illness, which often appears in the second decade of life, affects people of all sexes and races. Convolutional neural networks (CNNs), one of the deep learning approaches, have recently come to light as particularly promising… ▽ More

    Submitted 3 November, 2023; originally announced November 2023.

  3. arXiv:2306.15018  [pdf

    Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography

    Authors: Gabriel RegnaultMitchell A. KirbyRuikang K. WangTueng T. ShenMatthew O'DonnellIvan Pelivanov

    AbstractCorneal collagen crosslinking (CXL) is commonly used to prevent or treat keratoconus. Although changes in corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic optical coherence elastography (OCE) by tracking mechanical wave propagation, depth dependent changes are still unclear if the cornea is not crosslinked through the whole… ▽ More

    Submitted 26 June, 2023; originally announced June 2023.

    Comments: Submitted to Biomedical Optics Express on June 13th 2023, Manuscript ID: 497970 - Under Review. Manuscript, 10 pages / 6 figures / 2 tables. Supplementary, 7 pages / 4 figures

  4. arXiv:2301.12037  [pdf

    Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography

    Authors: Gabriel RegnaultMitchell A. KirbyRuikang K. WangTueng T. ShenMatthew O'DonnellIvan Pelivanov

    AbstractCollagen crosslinking of the cornea (CXL) is commonly employed to prevent or treat keratoconus. Although the change of corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic Optical Coherence Elastography (OCE) by tracking mechanical wave propagation, the depth dependence of this change is still unclear if the cornea is not crossl… ▽ More

    Submitted 25 April, 2023; v1 submitted 27 January, 2023; originally announced January 2023.

    Comments: Main: 10 Pages, 6 Figures Supplemental: 12 Pages, 3 Figures

  5. arXiv:2209.11803  [pdf


    Compact orthogonal view OCT: clinical exploration of human trabecular meshwork and cornea at cell resolution

    Authors: Viacheslav MazlinKristina IrschVincent BorderieChristophe BaudouinMichel PaquesMathias FinkKate GrieveAlbert Claude Boccara

    Abstract…Future clinical adoption of the device is facilitated by the compact footprint and broad functionality that includes corneal imaging in healthy subjects and patients (with keratoconus, Fuchs endothelial dystrophy) using the same design. ▽ More

    Submitted 12 September, 2022; originally announced September 2022.

  6. arXiv:2205.03702  [pdfother

    eess.IV cs.CV cs.CY

    Keratoconus Classifier for Smartphone-based Corneal Topographer

    Authors: Siddhartha GairolaPallavi JoshiAnand BalasubramaniamKaushik MuraliNipun KwatraMohit Jain

    AbstractKeratoconus is a severe eye disease that leads to deformation of the cornea. It impacts people aged 10-25 years and is the leading cause of blindness in that demography. Corneal topography is the gold standard for… ▽ More

    Submitted 7 May, 2022; originally announced May 2022.

    Comments: 4 pages

  7. arXiv:2111.12520  [pdfother

    Multiscale mechanical model based on patient-specific geometry: application to early keratoconus development

    Authors: ChloΓ© GiraudetJΓ©rome DiazPatrick Le TallecJean-Marc Allain

    AbstractKeratoconus is a pathology of the cornea associated with a tissue thinning and a weakening of its mechanical properties. However, it remains elusive which aspect is the leading cause of the disease. To investigate this question, we combined a multiscale model with a patient-geometry in order to simulate the mechanical response of healthy and pathological cor… ▽ More

    Submitted 24 November, 2021; originally announced November 2021.

  8. arXiv:2111.01354  [pdfother


    SmartKC: Smartphone-based Corneal Topographer for Keratoconus Detection

    Authors: Siddhartha GairolaMurtuza BohraNadeem ShaheerNavya JayaprakashPallavi JoshiAnand BalasubramaniamKaushik MuraliNipun KwatraMohit Jain

    AbstractKeratoconus is a severe eye disease affecting the cornea (the clear, dome-shaped outer surface of the eye), causing it to become thin and develop a conical bulge. The diagnosis of… ▽ More

    Submitted 21 January, 2022; v1 submitted 1 November, 2021; originally announced November 2021.

    Comments: Change Log: + Fixed sim-K computation (updated Section 5.5.3); re-ran our pipeline with the updated sim-K values (updated Figure 7); + Conducted the comparative evaluation with doctors again (total 4 doctors), and got improved results (updated Section 7.2 and Table 2); [Note: This is an updated version of the paper that was accepted for publication in IMWUT 2021.]

  9. arXiv:2107.08208  [pdf

    cs.CE math.NA

    A new Method for the in vivo identification of material properties of the human eye. Feasibility analysis based on synthetic data

    Authors: Stefan MuenchMike RoelligDaniel Balzani

    Abstract…as reference. For this purpose, a finite element model of the human eye is constructed to synthetically generate displacement full-fields from different datasets with keratoconus-like degradations. Then, a new approach based on the equilibrium gap method (EGM) combined with a mechanical morphing approach is proposed and used to identify the material paramete… ▽ More

    Submitted 17 July, 2021; originally announced July 2021.

    Comments: 21 pages, 8 figures

  10. arXiv:2006.10893  [pdf

    Nearly-incompressible transverse isotropy (NITI) of cornea elasticity: model and experiments with acoustic micro-tapping OCE

    Authors: John J Pitre JrMitchell A KirbyDavid S LiTueng T ShenRuikang K WangMatthew O'DonnellIvan Pelivanov

    Abstract…cornea provides the largest refractive power for the human visual system. Its stiffness, along with intraocular pressure (IOP), are linked to several pathologies, including keratoconus and glaucoma. Although mechanical tests can quantify corneal elasticity ex vivo, they cannot be used clinically. Optical coherence elastography (OCE), which launches and track… ▽ More

    Submitted 18 June, 2020; originally announced June 2020.

    Comments: 41 pages, 14 figures, including supplementary notes, JJP and MAK contributed equally to this work

  11. arXiv:2005.13308  [pdf


    Non-invasive detection of nanoscale structural changes in cornea associated with cross-linking treatment

    Authors: Yi ZhouSergey AlexandrovAndrew NolanNandan DasRajib DeyMartin Leahy

    Abstract…UVA irradiation with a riboflavin photosensitizer has grown from an interesting concept to a practical clinical treatment for corneal ectatic diseases globally, such as keratoconus. To characterize the corneal structural changes, existing methods such as X-ray microscopy, transmission electron microscopy (TEM), histology and optical coherence tomography have… ▽ More

    Submitted 27 May, 2020; originally announced May 2020.

    Comments: 25 pages, 10 figures

  12. arXiv:2001.11653  [pdfother

    stat.ML cs.LG eess.IV

    Deep Learning Based Unsupervised and Semi-supervised Classification for Keratoconus

    Authors: Nicole HallettKai YiJosef DickChristopher HodgeGerard SuttonYu Guang WangJingjing You

    Abstract…the entry of light rays and controlling focusing the movement of the light within the eye. The cornea is critical, contributing to 75% of the refractive power of the eye. Keratoconus is a progressive and multifactorial corneal degenerative disease affecting 1 in 2000 individuals worldwide. Currently, there is no cure for… ▽ More

    Submitted 30 January, 2020; originally announced January 2020.

    Comments: 7 pages, 8 figures, 3 tables

    MSC Class: 62F15; 47N30; 62P10; 92C50; 46N60; 92B20 ACM Class: I.2.6; I.2.1; J.3

  13. arXiv:1901.01789  [pdf

    Keratoconus Recognition Using A Parameter Set Determined from IOP-Matched Scenario

    Authors: Dan LinLei TianShu ZhangLike WangYongjin Zhou

    AbstractPURPOSE: Among the current practices for keratoconus recognition using biomechanical parameters from Corvis ST, matching intra-ocular pressure (IOP) is often required to eliminate the biasing influence; as a result, the combined biomechanical parameters determined from IOP-unmatched scenario possibly bring in confounding influence. This paper was therefore d… ▽ More

    Submitted 7 January, 2019; originally announced January 2019.

  14. arXiv:1901.01772  [pdf

    Evaluation of central corneal thickness in keratoconus and normal corneas during air puff indentation

    Authors: Dan LinLei TianChenglang YuanWenxiu ShiLike WangYongjin Zhou

    AbstractPurpose: This study aimed to investigate the actual changes of central corneal thickness (CCT) in keratoconus and normal corneas during air puff indentation, by using corneal visualization Scheimpflug technology (Corvis ST). Methods: A total of 32 keratoconic eyes and 46 normal eyes were included in this study. Three parameters of CCTinitial, CCTfinal and CC… ▽ More

    Submitted 7 January, 2019; originally announced January 2019.

  15. arXiv:1802.01055  [pdf


    Spatially-resolved Brillouin spectroscopy reveals biomechanical changes in early ectatic corneal disease and post-crosslinking in vivo

    Authors: Peng ShaoAmira M. EltonyTheo G. SeilerBehrouz TavakolRoberto PinedaTobias KollerTheo SeilerSeok-Hyun Yun

    AbstractMounting evidence connects the biomechanical properties of tissues to the development of eye diseases such as keratoconus, a common disease in which the cornea thins and bulges into a conical shape. However, measuring biomechanical changes in vivo with sufficient sensitivity for disease detection has proved challenging. Here, we present a first large-scale s… ▽ More

    Submitted 3 February, 2018; originally announced February 2018.

    Comments: 39 pages, 8 main figures, supplementary information

  16. arXiv:1009.1244  [pdfother

 math.NA physics.optics

    An adaptive algorithm for the cornea modeling from keratometric data

    Authors: Andrei Martinez-FinkelshteinDario Ramos-LopezGracia M. Castro-LunaJorge L. Alio

    Abstract…and corneal power maps from the data collected by keratoscopes, such as the Placido rings based topographers, decisive for an early detection of corneal diseases such as keratoconus. Numerical experiments show that the algorithm exhibits a steady exponential error decay, independently of the level of aberration of the cornea. The complexity of each anisotr… ▽ More

    Submitted 7 September, 2010; originally announced September 2010.

    Comments: 19 pages, 9 figures

    MSC Class: 65D15; 65Z05; 92C50; 92C55; 94A08