Korean Team Develops Epithelial Preserving Corneal Cross-linking

A research team from Korea, spearheaded by Severance Hospital, has created an innovative platform for treating keratoconus and correcting the weakening behind the vision loss, while preserving the integrity of the corneal epithelium. This advancement provides patients with a  less invasive option compared to contemporaneous procedures.

Schematic representation of NIR-to-UV/blue light conversion using UCNPs integrated into a contact lens (UCL) for corneal crosslinking. Photographic images demonstrating UV/blue light upconversion under NIR irradiation. The photonic process involving UCNPs and corneal cross-linking stimulated by hyaluronate-riboflavin (HA-RF) conjugates.

The team has created a corneal cross-linking technique that preserves the epithelium and circumvents previous limitations. Their approach is based on two essential innovations: a lens that converts light and a photochemical agent that penetrates the cornea.

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